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Articles 31 - 34 of 34
Full-Text Articles in Cancer Biology
Cytotoxic And Anti-Human Papillomavirus Activites In Selected Vegetables., Maizatul Azmah Ab. Latiff
Cytotoxic And Anti-Human Papillomavirus Activites In Selected Vegetables., Maizatul Azmah Ab. Latiff
Student Works (2010-2019)
An appropriate way to control cancer is chemoprevention as a large number of compounds have been observed to prevent the occurrence of cancer and variety of mechanisms exists for producing such protective effects. Numerous epidemiological studies have shown that diets rich in vegetables are associated with a decreased risk of cancer. Chemoprevention involves the use of natural or laboratory made substances to prevent cancer or reduce risk cancer.The E6 oncoprotein from oncogenic Human papillomaviruses (HPVs) has exhibit functions in tumorigenesis, regulation of transcriptions and apoptosis. E6 product from oncogenic viral type like HPV 16 can bind the tumor suppressor p53 …
Cytoprotective And Genoprotective Effects Of Aqueous Extracts Of Processed Pleurotus Sajor-Caju Fruiting Bodies On Hydrogen Peroxide-Induced Damage Of Human Peripheral Blood Mononuclear Cells., Mohamad Fairus Abdul Kadir
Cytoprotective And Genoprotective Effects Of Aqueous Extracts Of Processed Pleurotus Sajor-Caju Fruiting Bodies On Hydrogen Peroxide-Induced Damage Of Human Peripheral Blood Mononuclear Cells., Mohamad Fairus Abdul Kadir
Student Works (2010-2019)
Pleurotus sajor-caju authority is one of the mushroom species that is widely grown in Malaysia. The present study was undertaken to evaluate the antioxidant, cytotoxic, cytoprotective, genotoxic and genoprotective activities of crude water extracts of this mushroom. Crude aqueous extracts were prepared from the fruiting bodies that had been processed at different temperatures such as P1: blanching (95°C ± 2°C), P2: sun drying (30°C ± 2°C), P3: freeze drying (-46°C ± 3°C) and different temperatures of oven drying (P4: 45°C, P5: 50°C, P5: 55°C and P6: 60°C ± 2°C respectively). Antioxidant capacity of all the extracts was determined using ferric …
Ornithine Decarboxylase (Odc) Regulation By Mtor: New Insights From Tsc1 Knockout Cells, Alyssa Mae Cates
Ornithine Decarboxylase (Odc) Regulation By Mtor: New Insights From Tsc1 Knockout Cells, Alyssa Mae Cates
Honors Program Theses
The polyamine pathway, when improperly regulated, is one central cause of skin carcinogenesis. The purpose of this project was to investigate the relationship between two biochemical signaling pathways, the mTOR (mammalian target of rapamycin) pathway and the polyamine pathway. It is known that the protein mTOR serves to regulate a key protein in the polyamine pathway, ornithine decarboxylase (ODC), but the precise mechanism remains unclear. It has been postulated that mTOR acts to regulate ODC through two RNA binding proteins, HuR (a member of the Hu family of proteins) and TIP (tristetraprolin). The project entailed characterizing that relationship using TSCl …
Adjacent Slice Prostate Cancer Prediction To Inform Maldi Imaging Biomarker Analysis, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)
Adjacent Slice Prostate Cancer Prediction To Inform Maldi Imaging Biomarker Analysis, Shao-Hui Chuang, Xiaoyan Sun, Lisa Cazares, Julius Nyalwidhe, Dean Troyer, O. John Semmes, Jiang Li, Frederic D. Mckenzie, Nico Karssemeijer (Ed.), Ronald M. Summers (Ed.)
Electrical & Computer Engineering Faculty Publications
Prostate cancer is the second most common type of cancer among men in US [1]. Traditionally, prostate cancer diagnosis is made by the analysis of prostate-specific antigen (PSA) levels and histopathological images of biopsy samples under microscopes. Proteomic biomarkers can improve upon these methods. MALDI molecular spectra imaging is used to visualize protein/peptide concentrations across biopsy samples to search for biomarker candidates. Unfortunately, traditional processing methods require histopathological examination on one slice of a biopsy sample while the adjacent slice is subjected to the tissue destroying desorption and ionization processes of MALDI. The highest confidence tumor regions gained from the …