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Articles 1 - 10 of 10
Full-Text Articles in Cancer Biology
Metformin Represses Bladder Cancer Progression By Inhibiting Stem Cell Repopulation Via Cox2/Pge2/Stat3 Axis, Q. Liu, W. Yuan, D. Tong, G. Liu, W. Lan, Diangzheng Zhang, H. Xiao, Y. Zhang, J. Yang, J. Zhang
Metformin Represses Bladder Cancer Progression By Inhibiting Stem Cell Repopulation Via Cox2/Pge2/Stat3 Axis, Q. Liu, W. Yuan, D. Tong, G. Liu, W. Lan, Diangzheng Zhang, H. Xiao, Y. Zhang, J. Yang, J. Zhang
PCOM Scholarly Papers
Cancer stem cells (CSCs) are a sub-population of tumor cells playing essential roles in initiation, differentiation, recurrence, metastasis and development of drug resistance of various cancers, including bladder cancer. Although multiple lines of evidence suggest that metformin is capable of repressing CSC repopulation in different cancers, the effect of metformin on bladder cancer CSCs remains largely unknown. Using the N-methyl-N-nitrosourea (MNU)-induced rat orthotropic bladder cancer model, we demonstrated that metformin is capable of repressing bladder cancer progression from both mild to moderate/severe dysplasia lesions and from carcinoma in situ (CIS) to invasive lesions. Metformin also can arrest bladder cancer cells …
Fibronectin Deposition Participates In Extracellular Matrix Assembly And Vascular Morphogenesis, Abigail Hielscher, Kim Ellis, Connie Qiu, Josh Porterfield, Sharon Gerecht
Fibronectin Deposition Participates In Extracellular Matrix Assembly And Vascular Morphogenesis, Abigail Hielscher, Kim Ellis, Connie Qiu, Josh Porterfield, Sharon Gerecht
PCOM Scholarly Papers
The extracellular matrix (ECM) has been demonstrated to facilitate angiogenesis. In particular, fibronectin has been documented to activate endothelial cells, resulting in their transition from a quiescent state to an active state in which the cells exhibit enhanced migration and proliferation. The goal of this study is to examine the role of polymerized fibronectin during vascular tubulogenesis using a 3 dimensional (3D) cell-derived de-cellularized matrix. A fibronectin-rich 3D de-cellularized ECM was used as a scaffold to study vascular morphogenesis of endothelial cells (ECs). Confocal analyses of several matrix proteins reveal high intra- and extra-cellular deposition of fibronectin in formed vascular …
Management Of Hypercalcemia Of Malignancy, Sonia Thomas, Soo-Hwan Chung
Management Of Hypercalcemia Of Malignancy, Sonia Thomas, Soo-Hwan Chung
PCOM Scholarly Papers
Malignancy is one of the most common causes of hypercalcemia, particularly in cancer associated with bone metastases. Hypercalcemia occurs in up to 20% to 30% of cancer patients at some time during the course of their disease. Clinical manifestations of hypercalcemia vary in calcium level in blood. Signs and symptoms of hypercalcemia occur when the serum calcium level rises above those ranges. Fluids are first-line treatment with hypercalcemia followed by bisphosphanates if the calcium is high and the patient is experiencing symptoms. Various other medications are used as second-line agents in hypercalcemia of malignancy.
Effects Of A Particular Heptapeptide On The Ifn-Α-Sensitive Cml Cells, Fulan Yang, Fangzhi Chen, Xinxing Wan, Xi Zhou, Meijuan Zhou, Hanchun Chen, Junjiang Fu, Dianzheng Zhang
Effects Of A Particular Heptapeptide On The Ifn-Α-Sensitive Cml Cells, Fulan Yang, Fangzhi Chen, Xinxing Wan, Xi Zhou, Meijuan Zhou, Hanchun Chen, Junjiang Fu, Dianzheng Zhang
PCOM Scholarly Papers
Abstract: Using the phage display biopanning technique, we have previously identified a heptapeptide KLWVIPQ which specifically bind to the surface of the IFN-α sensitive but not the IFN-α-resistant CML cells. The effects of this heptapeptide to the IFN-α-sensitive CML cells were investigated in the present study. IFN-α-sensitive KT-1/A3 and IFN-α-resistant KT-1/A3R CML cells were transfected by pEGFP KLWVIPQ expression vector and/or induced by IFN-α. WST-1 cell proliferation assay, flow cytometry and western blotting were performed to determine the effects of this heptapeptide and/or IFN-α on CML cells. The viability of the KT-1/A3 cells w as inhibited and apoptosis was induced …
A Physical Sciences Network Characterization Of Non-Tumorigenic And Metastatic Cells, Abigail Hielscher, D. Wirtz, Et Al.
A Physical Sciences Network Characterization Of Non-Tumorigenic And Metastatic Cells, Abigail Hielscher, D. Wirtz, Et Al.
PCOM Scholarly Papers
To investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences-Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of the non-tumorigenic MCF-10A and metastatic MDA-MB-231 breast epithelial cell lines, commonly used as models of cancer metastasis. Experiments were performed in 20 laboratories from 12 PS-OCs. Each laboratory was supplied with identical aliquots and common reagents and culture protocols. Analyses of these measurements revealed dramatic differences in their mechanics, migration, adhesion, oxygen response, and proteomic profiles. Model-based multi-omics approaches identified key differences between these cells' regulatory networks involved in morphology and survival. These results …
Matrigel Modulates A Stem Cell Phenotype And Promotes Tumor Cell Formation In A Mantle Cell Lymphoma Cell Line, Abigail Hielscher, Timothy Mcguire, Dennis Weisenburger, John Graham Sharp
Matrigel Modulates A Stem Cell Phenotype And Promotes Tumor Cell Formation In A Mantle Cell Lymphoma Cell Line, Abigail Hielscher, Timothy Mcguire, Dennis Weisenburger, John Graham Sharp
PCOM Scholarly Papers
Tumors may be maintained by subpopulations of cells possessing stem cell-like properties. We evaluated the stem cell-like and tumor-forming properties of side population (SP) and CD133+/ CD44+ cells in Granta 519, a human mantle cell lymphoma cell line. The in-vitro Cobblestone Area Forming Cell (CAFC) assay, designed to detect stem and progenitor cells, revealed that SP cells contained the greatest proportion of stem cell-like cells. The addition of Matrigel to CAFC assays of SP and non-SP cells both increased their respective stem cell frequencies in comparison to those cultures without Matrigel, and additionally resulted in observed stem cell frequencies which …
Hypoxia Affects The Structure Of Breast Cancer Cell Derived Matrix To Support Angiogenic Responses Of Endothelial Cells, Abigail Hielscher, Connie Qiu, Josh Porterfield, Quinton Smith, Sharon Gerecht
Hypoxia Affects The Structure Of Breast Cancer Cell Derived Matrix To Support Angiogenic Responses Of Endothelial Cells, Abigail Hielscher, Connie Qiu, Josh Porterfield, Quinton Smith, Sharon Gerecht
PCOM Scholarly Papers
Hypoxia, a common feature of the tumor environment and participant in tumor progression, is known to alter gene and protein expression of several Extracellular Matrix (ECM) proteins, many of which have roles in angiogenesis. Previously, we reported that ECM deposited from co cultures of Neonatal Fibroblasts (NuFF) with breast cancer cells, supported 3-dimensional vascular morphogenesis. Here, we sought to characterize the hypoxic ECM and to identify whether the deposited ECM induce angiogenic responses in Endothelial Cells (ECs). NuFF and MDAMB 231 breast cancer cells were co-cultured, subjected to alternating cycles of 24 hours of 1% (hypoxia) and 21% (atmospheric) oxygen …
Cordyceps Mushroom: A Potent Anticancer Nutraceutical, Md. Asaduzzaman Khan, Mousumi Tania, Dianzheng Zhang, Hanchun Chen
Cordyceps Mushroom: A Potent Anticancer Nutraceutical, Md. Asaduzzaman Khan, Mousumi Tania, Dianzheng Zhang, Hanchun Chen
PCOM Scholarly Papers
The Cordyceps mushrooms have a long history as medicinal fungi. In Traditional Chinese Medicine, Cordyceps have been used to treat several conditions including cancers for thousand of years. Extracts from both mycelium and fruiting bodies of C. sinensis, C. militaris and other Cordyceps species showed significant anticancer activities by various mechanisms such as, modulating immune system and inducing cell apoptosis. Some polysaccharide components and cordycepin (3' -deoxyadenosine) have been isolated from C. sinensis and C. militaris, which acted as potent anticancer components. This review article aims to further elucidate the importance of Cordyceps mushrooms by summarizing the findings of some …
Overexpression Of Truncated Erg From Tmprss2-Erg Fusion And Prostate Cancer Development , Melanie Leong, Wenfeng Shi, Jun Tian, Ellen Cho, Abbas Raza, Saquib A. Siddiqi, Abdulhafez Selim, Hanchun Chen, Dianzheng Zhang
Overexpression Of Truncated Erg From Tmprss2-Erg Fusion And Prostate Cancer Development , Melanie Leong, Wenfeng Shi, Jun Tian, Ellen Cho, Abbas Raza, Saquib A. Siddiqi, Abdulhafez Selim, Hanchun Chen, Dianzheng Zhang
PCOM Scholarly Papers
No abstract provided.
Repressive Effects Of Resveratrol On Androgen Receptor Transcriptional Activity, Wenfeng Shi, Melanie Leong, Ellen Cho, Joseph Farrell, Hanchun Chen, Jun Tian, Dianzheng Zhang
Repressive Effects Of Resveratrol On Androgen Receptor Transcriptional Activity, Wenfeng Shi, Melanie Leong, Ellen Cho, Joseph Farrell, Hanchun Chen, Jun Tian, Dianzheng Zhang
PCOM Scholarly Papers
Background: The chemopreventive effects of resveratrol (RSV) on prostate cancer have been well established; the androgen receptor (AR) plays pivotal roles in prostatic tumorigenesis. However, the exact underlying molecular mechanisms about the effects of RSV on AR have not been fully elucidated. A model system is needed to determine whether and how RSV represses AR transcriptional activity. Methodology: The AR cDNA was first cloned into the retroviral vector pOZ-N and then integrated into the genome of ARnegative HeLa cells to generate the AR(+) cells. The constitutively expressed AR was characterized by monitoring hormonestimulated nuclear translocation, DNA binding, and transcriptional activation, …