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Articles 1 - 8 of 8
Full-Text Articles in Integrative Biology
Functional Investigation Of Shaggy, An Inhibitor Of Canonical Wnt Signaling, In The Tardigrade Hypsibius Exemplaris, Raul A. Chavarria
Functional Investigation Of Shaggy, An Inhibitor Of Canonical Wnt Signaling, In The Tardigrade Hypsibius Exemplaris, Raul A. Chavarria
UNF Graduate Theses and Dissertations
Tardigrades have a highly simplified anteroposterior (AP) axis. The mechanisms that regulate the development of this secondarily simplified AP axis are not known. In many animals, the canonical Wnt (cWnt) signaling pathway regulates primary axis establishment through antagonistic interactions with inhibitors of cWnt signaling. This study investigated the roles of shaggy, an inhibitor of cWnt signaling, in regulating development in the tardigrade Hypsibius exemplaris. Gene expression patterns of shaggy and other components of the cWnt signaling pathway were analyzed alongside markers of anterior and posterior identity using Hybridization Chain Reaction in situ in H. exemplaris. RNA interference …
Effects Of Seasonal Environment On Abundance, Behavior, Visual Signaling, And Perception In Prairie Butterflies, Grace Elizabeth Hirzel
Effects Of Seasonal Environment On Abundance, Behavior, Visual Signaling, And Perception In Prairie Butterflies, Grace Elizabeth Hirzel
Graduate Theses and Dissertations
Phenotypic plasticity is a widespread mechanism that allows animals to respond quickly to seasonal changes in their environment. However, the depth and complexity of these plastic responses is still being discovered. One aspect of seasonal physiology that is relatively unstudied is changes to sensory physiology and how it may explain changes in behavior. To determine how changes in seasonal conditions affect behavior, coloration, and vision, I examined populations of wild butterflies in Northwest Arkansas. Focusing on a single species, the common buckeye Junonia coenia, I found that seasonal coloration covaries with thermoregulating behavior and is accompanied by changes in visual …
Understanding The Effects Of Embryonic Hyperglycemia On Retinal Development And Maintenance, Kayla Titialii-Torres
Understanding The Effects Of Embryonic Hyperglycemia On Retinal Development And Maintenance, Kayla Titialii-Torres
Theses and Dissertations--Biology
Hundreds of millions of people are affected by diabetes worldwide. Whether they are diagnosed with prediabetes or Type I or II diabetes, there are a variety of mechanisms in the pathogenesis of diabetes. Diabetes is a disease which consists of recurring states of hyperglycemia that can be difficult to manage due to either lack of insulin production or improper utilization of insulin. While these mechanisms of action differ, complications induced by diabetes occur in both poorly regulated Type I and II. Common complications of diabetes include nerve damage, kidney damage, and eye damage. Eye damage specifically is called diabetic retinopathy …
Cbd & Ethanol Disrupt Early Embryonic Development, Janasha Goffigan-Holmes
Cbd & Ethanol Disrupt Early Embryonic Development, Janasha Goffigan-Holmes
Master of Science in Integrative Biology Theses
The heavily conserved neural circuits that govern the vertebrate reward system, receive sensory stimuli and produce appropriate, self-preserving responses that correspond to experience-based learning and are driven by the communication of dopamine. Many of these circuits lie within the endocannabinoid system (ECS). At the most basic level, the ECS drives homeostatic behaviors, such as seeking nutrients, avoiding danger, and reproductive function. Unfortunately, this system can be hijacked by psychoactive drugs which ultimately alter the expression of dopamine. Cannabis sativa has two main active ingredients, THC and CBD, which modify the ECS receptor’s ability to bind to hormones and neurotransmitters such …
Play Behavior And The Development Of Boldness And Caution In Juvenile Belding’S Ground Squirrels (Urocitellus Beldingi), Madelene Shehan
Play Behavior And The Development Of Boldness And Caution In Juvenile Belding’S Ground Squirrels (Urocitellus Beldingi), Madelene Shehan
Master's Theses
The ubiquity of play among juvenile mammals suggests it provides adaptive benefits, potentially through influences on the development of temperament in young animals. Juvenile Belding’s ground squirrels (Urocitellus beldingi) must balance competing demands for boldness and caution imposed by the fundamental trade-off between their short active season and their vulnerability to predation. In this study, I evaluated whether play helps to facilitate the development of an appropriate balance between boldness and caution in juvenile U. beldingi.I observed the play behavior of juvenile U. beldingiand conducted flight-initiation distance tests to measure boldness-caution at the beginning and toward …
The Effects Of Amphetamine Exposure On Neurodevelopment And Behavior In Early Life Stages Of Danio Rerio, Jennifer D. Bullard
The Effects Of Amphetamine Exposure On Neurodevelopment And Behavior In Early Life Stages Of Danio Rerio, Jennifer D. Bullard
Master of Science in Integrative Biology Theses
Amphetamines are frequently prescribed to young children for attention deficit hyperactivity disorder (ADHD). Due to the recent rise in ADHD diagnoses and the resulting increase in amphetamine intake in children, we investigated how amphetamine exposure impacts the development of stereotyped behaviors and the neural circuit that governs these behaviors. The zebrafish (Danio rerio) was used as our model organism because of the extensively studied developmental milestones these fish provide. Using escape responses as a behavior model, we exposed embryos to three doses of amphetamine (10 μg/ml, 20 μg/ml, and 30 μg/ml) environmentally during the first 48 hours of …
The Role Of Daf-19 In Non-Ciliated Neurons: How Is Neural Development Regulated By Different Daf-19 Isoforms?, Zabdiel Ek Vazquez
The Role Of Daf-19 In Non-Ciliated Neurons: How Is Neural Development Regulated By Different Daf-19 Isoforms?, Zabdiel Ek Vazquez
Lawrence University Honors Projects
A degenerative disease-like phenotype, specifically reduction in synaptic protein levels in adult worms, is correlated with loss-of-function of the only RFX transcription factor gene, daf-19, in C. elegans. This gene encodes four known transcription factor isoforms, two of which are correlated with particular functions. The DAF-19C isoform activates genes responsible for cilia development, while DAF-19M is needed for cilia specification in males. A comparison of the transcriptome of daf-19 null and isogenic wild type adult worms suggests both positive and negative regulation of gene expression is correlated with the presence of DAF-19 proteins. We have assessed DAF-19 regulation …
Effects Of Prenatal Environment Are Revealed By Post-Natal Challenges: Embryonic Hormone Exposure, Adrenocortical Function And Food In Seabird Chicks, Z. Morgan Benowitz-Fredericks, Jannik Schultner, Alexander S. Kitaysky
Effects Of Prenatal Environment Are Revealed By Post-Natal Challenges: Embryonic Hormone Exposure, Adrenocortical Function And Food In Seabird Chicks, Z. Morgan Benowitz-Fredericks, Jannik Schultner, Alexander S. Kitaysky
Faculty Journal Articles
The interaction between prenatal environments and postnatal environments is an important source of phenotypic variability. We examined the ability of prenatal steroid exposure and postnatal energy restriction to explain adrenocortical function and fledging age in captive seabird chicks. We proposed and tested two hypotheses: (1) the strength of prenatal effects is attenuated by challenging postnatal environments (postnatal override) and (2) the strength of prenatal effects increases with the severity of postnatal challenges (postnatal reveal). We reared common murre (Uria aalge) chicks and measured prenatal exposure to corticosterone (CORT) and testosterone (T) from allantoic waste. Adrenocortical function was assessed after 10 …