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Full-Text Articles in Integrative Biology
Evidence Of Compromised Blood-Spinal Cord Barrier In Early And Late Symptomatic Sod1 Mice Modeling Als, Svitlana N. Garbuzova-Davis, Samuel Saporta, Edward M. Haller, Irina Kolomey, Steven P. Bennett, Huntington Potter, Paul R. Sanberg
Evidence Of Compromised Blood-Spinal Cord Barrier In Early And Late Symptomatic Sod1 Mice Modeling Als, Svitlana N. Garbuzova-Davis, Samuel Saporta, Edward M. Haller, Irina Kolomey, Steven P. Bennett, Huntington Potter, Paul R. Sanberg
Integrative Biology Faculty and Staff Publications
Background: The blood-brain barrier (BBB), blood-spinal cord barrier (BSCB), and blood-cerebrospinal fluid barrier (BCSFB) control cerebral/spinal cord homeostasis by selective transport of molecules and cells from the systemic compartment. In the spinal cord and brain of both ALS patients and animal models, infiltration of T-cell lymphocytes, monocyte-derived macrophages and dendritic cells, and IgG deposits have been observed that may have a critical role in motor neuron damage. Additionally, increased levels of albumin and IgG have been found in the cerebrospinal fluid in ALS patients. These findings suggest altered barrier permeability in ALS. Recently, we showed disruption of the BBB and …
The Origin Of 2 Sexes Through Optimization Of Recombination Entropy Against Time And Energy, Bo Deng
The Origin Of 2 Sexes Through Optimization Of Recombination Entropy Against Time And Energy, Bo Deng
Department of Mathematics: Faculty Publications
Sexual reproduction in nature requires two sexes, which raises the question why the reproductive scheme did not evolve to have three or more sexes. Here we construct a constrained optimization model based on the communication theory to analyze trade-offs among reproductive schemes with arbitrary number of sexes. More sexes on one hand lead to higher reproductive diversity, but on the other hand incur greater cost in time and energy for reproductive success. Our model shows that the two-sexes reproduction scheme maximizes the recombination entropy-to-cost ratio, and hence is the optimal solution to the problem.