Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Ecology and Evolutionary Biology (87)
- Education (86)
- Social and Behavioral Sciences (69)
- Animal Sciences (51)
- Physical Sciences and Mathematics (50)
-
- Science and Mathematics Education (50)
- Medicine and Health Sciences (48)
- Plant Sciences (47)
- Library and Information Science (44)
- Biochemistry, Biophysics, and Structural Biology (39)
- Cell and Developmental Biology (39)
- Genetics and Genomics (39)
- Curriculum and Instruction (38)
- Collection Development and Management (35)
- Microbiology (31)
- Arts and Humanities (30)
- Pharmacology, Toxicology and Environmental Health (30)
- Entomology (29)
- Marine Biology (29)
- Cell Biology (24)
- Physiology (24)
- Evolution (23)
- Gifted Education (22)
- Environmental Sciences (21)
- Higher Education (21)
- Genetics (19)
- Biochemistry (18)
- Botany (18)
- Institution
-
- Providence College (114)
- Pepperdine University (62)
- University of South Carolina (62)
- Wright State University (54)
- Washington University in St. Louis (49)
-
- University of Rhode Island (47)
- Longwood University (46)
- University of the Pacific (38)
- City University of New York (CUNY) (28)
- Illinois Math and Science Academy (27)
- Southern Adventist University (27)
- Central Washington University (19)
- Cleveland State University (19)
- GALILEO, University System of Georgia (19)
- Touro College and University System (19)
- University of Southern Maine (19)
- Virginia Commonwealth University (16)
- Roger Williams University (12)
- University of Nebraska - Lincoln (11)
- Whittier College (11)
- Old Dominion University (10)
- Utah State University (10)
- Claremont Colleges (9)
- Illinois Wesleyan University (9)
- Jacksonville State University (9)
- Seton Hall University (9)
- Butler University (8)
- DePauw University (8)
- Otterbein University (8)
- The University of Akron (8)
- Publication Year
- Publication
-
- Biology Student Scholarship (101)
- Featured Research (57)
- Faculty Publications (55)
- Browse all Theses and Dissertations (53)
- Biology Faculty Research (49)
-
- Library Impact Statements (43)
- University of the Pacific Theses and Dissertations (38)
- Fall Showcase for Research and Creative Inquiry (32)
- Open Educational Resources (28)
- Lifelines - Biology Department Newsletter (26)
- The Science Journal of the Lander College of Arts and Sciences (19)
- ETD Archive (18)
- All Master's Theses (16)
- All Student Scholarship (13)
- Biology Faculty Publications (13)
- Spring Showcase for Research and Creative Inquiry (13)
- UROP Posters (13)
- Arts & Sciences Faculty Publications (12)
- Biological Sciences Grants Collections (12)
- Whittier Scholars Program (11)
- Evolution (10)
- Honors Program: Senior Projects (Public) (9)
- Seton Hall University Dissertations and Theses (ETDs) (9)
- Ecosystem Disruption & Climate Change (8)
- Electronic Theses and Dissertations (8)
- Scholarship (8)
- Honors Theses (7)
- JSU Student Symposium 2022 (7)
- Life Line - The Biology Department Newsletter (7)
- Nature of Science (7)
- Publication Type
Articles 871 - 900 of 1043
Full-Text Articles in Biology
Full Issue: Volume 4, Number 1
Full Issue: Volume 4, Number 1
The Science Journal of the Lander College of Arts and Sciences
No abstract provided.
Mathematical Biology At An Undergraduate Liberal Arts College, Stephen C. Adolph, Lisette G. De Pillis
Mathematical Biology At An Undergraduate Liberal Arts College, Stephen C. Adolph, Lisette G. De Pillis
All HMC Faculty Publications and Research
Since 2002 we have offered an undergraduate major in Mathematical Biology at Harvey Mudd College. The major was developed and is administered jointly by the mathematics and biology faculty. In this paper we describe the major, courses, and faculty and student research and discuss some of the challenges and opportunities we have experienced.
Full Issue: Volume 3, Number 1
Full Issue: Volume 3, Number 1
The Science Journal of the Lander College of Arts and Sciences
No abstract provided.
Building Better Scientists Through Cross-Disciplinary Collaboration In Synthetic Biology: A Report From The Genome Consortium For Active Teaching Workshop 2010, Michael J. Wolyniak, Consuelo J. Alvarez, Vidya Chandrasekaran, Theresa M. Grana, Andrea Holgado, Christopher J. Jones, Robert W. Morris, Anil L. Pereira, Joyce Stamm, Talitha M. Washington, Yixin Yang
Building Better Scientists Through Cross-Disciplinary Collaboration In Synthetic Biology: A Report From The Genome Consortium For Active Teaching Workshop 2010, Michael J. Wolyniak, Consuelo J. Alvarez, Vidya Chandrasekaran, Theresa M. Grana, Andrea Holgado, Christopher J. Jones, Robert W. Morris, Anil L. Pereira, Joyce Stamm, Talitha M. Washington, Yixin Yang
Biological Sciences Research
A common problem faced by primarily undergraduate institutions is the lack of funding and material support needed to adequately expose students to modern biology, including synthetic biology. To help alleviate this problem, the Genome Consortium for Active Teaching (GCAT) was founded in 2000 by Malcolm Campbell at Davidson College to bring genomics into the undergraduate curriculum. GCAT’s first tangible activity was to serve as a central clearinghouse both for the purchase and reading of DNA microarrays and for information on how to execute genomics experiments at undergraduate institutions. In response to the evolution of molecular biology in the last decade, …
Introduction: Protistan Biology, Horizontal Gene Transfer, And Common Descent Uncover Faulty Logic In Intelligent Design, Avelina Espinosa
Introduction: Protistan Biology, Horizontal Gene Transfer, And Common Descent Uncover Faulty Logic In Intelligent Design, Avelina Espinosa
Arts & Sciences Faculty Publications
THE International Society of Protistologists (ISOP) organized a pre-meeting workshop entitled ‘‘Horizontal Gene Transfer and Phylogenetic Evolution Debunk Intelligent Design,’’ as part of the 1st North American Section meeting held June 11–13, 2009, at Roger Williams University, Bristol, RI, USA. This workshop focused on the acceptance of Darwinian evolution in the United States and the role of intelligent design (ID) in the ongoing controversy between scientific knowledge and popular belief. Intelligent design, a doctrine born in the 1980s, proposes that a ‘‘Designer’’ is responsible for the complexity in biological systems and that Darwinism cannot explain holistically the origin and evolution …
Bacterial Acquisition In Juveniles Of Several Broadcast Spawning Coral Species, Koty H. Sharp, Kim B. Ritchie
Bacterial Acquisition In Juveniles Of Several Broadcast Spawning Coral Species, Koty H. Sharp, Kim B. Ritchie
Arts & Sciences Faculty Publications
Coral animals harbor diverse microorganisms in their tissues, including archaea, bacteria, viruses, and zooxanthellae. The extent to which coral-bacterial associations are specific and the mechanisms for their maintenance across generations in the environment are unknown. The high diversity of bacteria in adult coral colonies has made it challenging to identify species-specific patterns. Localization of bacteria in gametes and larvae of corals presents an opportunity for determining when bacterial-coral associations are initiated and whether they are dynamic throughout early development. This study focuses on the early onset of bacterial associations in the mass spawning corals Montastraea annularis, M. franksi, M. faveolata, …
Apparent Competition With An Invasive Plant Hastens The Extinction Of An Endangered Lupine, Emily M. Dangremond, Eleanor A. Pardini, Tiffany M. Knight
Apparent Competition With An Invasive Plant Hastens The Extinction Of An Endangered Lupine, Emily M. Dangremond, Eleanor A. Pardini, Tiffany M. Knight
Biology Faculty Research
Invasive plants may compete with native plants by increasing the pressure of native consumers, a mechanism known as "apparent competition." Apparent competition can be as strong as or stronger than direct competition, but the role of apparent competition has rarely been examined in biological invasions. We used four years of demographic data and seed-removal experiments to determine if introduced grasses caused elevated levels of seed consumption on native plant species in a coastal dune system in California, USA. We show that the endangered, coastal dune plant Lupinus tidestromii experiences high levels of pre-dispersal seed consumption by the native rodent Peromyscus …
Seed Dispersal By Pulp Consumers, Not ‘‘Legitimate’’ Seed Dispersers, Increases Guettarda Viburnoides Population Growth, Andrea P. Loayza, Tiffany M. Knight
Seed Dispersal By Pulp Consumers, Not ‘‘Legitimate’’ Seed Dispersers, Increases Guettarda Viburnoides Population Growth, Andrea P. Loayza, Tiffany M. Knight
Biology Faculty Research
We examined the effect of seed dispersal by Purplish Jays (Cyanocorax cyanomelas; pulp consumers) and the Chestnut-eared Araçari (Pteroglossus castanotis; "legitimate" seed dispersers) on population growth of the small tree Guettarda viburnoides (Rubiaceae) in northeastern Bolivian savannas. Because each bird species differs with respect to feeding and post-feeding behavior, we hypothesized that seed dispersal by each species will contribute differently to the rate of increase of G. viburnoides, but that seed dispersal by either species will increase population growth when compared to a scenario with no seed dispersal. To examine the effects of individual dispersers on the future population size …
Bryostatins: Biological Context And Biotechnological Prospects, Amaro E. Trindade-Silva, Grace E. Lim-Fong, Koty H. Sharp
Bryostatins: Biological Context And Biotechnological Prospects, Amaro E. Trindade-Silva, Grace E. Lim-Fong, Koty H. Sharp
Arts & Sciences Faculty Publications
Coral animals harbor diverse microorganisms in their tissues, including archaea, bacteria, viruses, and Bryostatins are a family of protein kinase C modulators that have potential applications in biomedicine. Found in miniscule quantities in a small marine invertebrate, lack of supply has hampered their development. In recent years, bryostatins have been shown to have potent bioactivity in the central nervous system, an uncultivated marine bacterial symbiont has been shown to be the likely natural source of the bryostatins, the bryostatin biosynthetic genes have been identified and characterized, and bryostatin analogues with promising biological activity have been developed and tested. Challenges in …
A Three-Dimensional Computer Simulation Model Reveals The Mechanisms For Self-Organization Of Plant Cortical Microtubules Into Oblique Arrays, Ezgi Can Eren, Ram Dixit, Natarajan Gautam
A Three-Dimensional Computer Simulation Model Reveals The Mechanisms For Self-Organization Of Plant Cortical Microtubules Into Oblique Arrays, Ezgi Can Eren, Ram Dixit, Natarajan Gautam
Biology Faculty Research
The noncentrosomal cortical microtubules (CMTs) of plant cells self-organize into a parallel three-dimensional (3D) array that is oriented transverse to the cell elongation axis in wild-type plants and is oblique in some of the mutants that show twisted growth. To study the mechanisms of CMT array organization, we developed a 3D computer simulation model based on experimentally observed properties of CMTs. Our computer model accurately mimics transverse array organization and other fundamental properties of CMTs observed in rapidly elongating wild-type cells as well as the defective CMT phenotypes observed in the Arabidopsis mor1-1 and fra2 mutants. We found that CMT …
Population Ecology And Reproductive Biology Of The Diamondback Watersnake, Nerodia Rhombifer (Serpentes: Colubridae), In Southernmost Texas, Ruben D. Zamora
Population Ecology And Reproductive Biology Of The Diamondback Watersnake, Nerodia Rhombifer (Serpentes: Colubridae), In Southernmost Texas, Ruben D. Zamora
Theses and Dissertations - UTB/UTPA
Nerodia rhombifer is a polytypic, semi-aquatic snake with a broad geographical distribution ranging from the American Midwest southward to Chiapas, Mexico. Although relatively abundant throughout much of its range, few ecological studies of the species have been conducted. This study provides basic population ecology information in a subtropical habitat. Population data were obtained in a mark-recapture study at Santa Ana National Wildlife Refuge, Hidalgo County, Texas, from August 1995 to December 1998. Specimens taken elsewhere in Hidalgo County provided information on the reproductive biology. This study provides the first absolute density estimates from anywhere within the species’ range. Quantitative information …
An Intertidal Sea Star Adjusts Thermal Inertia To Avoid Extreme Body Temperatures, Sylvain Pincebourde, Eric Sanford, Brian Helmuth
An Intertidal Sea Star Adjusts Thermal Inertia To Avoid Extreme Body Temperatures, Sylvain Pincebourde, Eric Sanford, Brian Helmuth
Faculty Publications
The body temperature of ectotherms is influenced by the interaction of abiotic conditions, morphology, and behavior. Although organisms living in different thermal habitats may exhibit morphological plasticity or move from unfavorable locations, there are few examples of animals adjusting their thermal properties in response to short-term changes in local conditions. Here, we show that the intertidal sea star Pisaster ochraceus modulates its thermal inertia in response to prior thermal exposure. After exposure to high body temperature at low tide, sea stars increase the amount of colder than-air fluid in their coelomic cavity when submerged during high tide, resulting in a …
Lifelines Fall 2009, Southern Adventist University
Lifelines Fall 2009, Southern Adventist University
Lifelines - Biology Department Newsletter
The Fall 2009 issue of Lifelines includes articles on Southern's Ancient DNA Project, an alumni feature, student research, and news from the Pre-Dent Club.
An Examination Of The Correlation Between Shoot Apical Meristem Size And Leaf Heterophylly In Pisum Sativum, Cynthia Mary Halfman
An Examination Of The Correlation Between Shoot Apical Meristem Size And Leaf Heterophylly In Pisum Sativum, Cynthia Mary Halfman
Undergraduate Honors Thesis Collection
This study is a quantitative examination of the ramifications of leaf development as influenced by the size of the shoot apical meristem. I wish not to delve into a genetic examination of the shoot apical meristem but rather into the possible correlation between the apical meristem size and leaf heterophylly. If changes in shoot apical meristem size influence heterophylly in leaves, then as shoot apical meristem changes, leaf characteristics will change. This change may result from two different relationships.
An Analysis Of The Environmental And Hormonal Effects On The Growth And Development Of The Moss Ceratodon Purpureus, Megan Knight
An Analysis Of The Environmental And Hormonal Effects On The Growth And Development Of The Moss Ceratodon Purpureus, Megan Knight
Undergraduate Honors Thesis Collection
Ceratodon has not been documented in scientific literature as thoroughly as other species of moss such as Funaria or Tortula. Commonly known as fire moss or purple horned moss, Ceratodon is often reddish or yellow-brown and the spore capsules are usually purple (Crum, 1983). A picture of the species growing in its natural habitat is shown in Figure 4. Ceratodon often grows in tufts and is considered a weed, often thriving in polluted or disturbed areas and frequently invading after a fire (Crum 1983). Ceratodon belongs to the class Bryopsida, which also contains the previously mentioned Funaria and Tortula species. …
Common-Path Multimodal Optical Microscopy, Marla Tipping, Chandra S. Yelleswarapu, Sri-Rajasekhar Kothapalli, Alexey Veraksa, D.V.G.L.N. Rao
Common-Path Multimodal Optical Microscopy, Marla Tipping, Chandra S. Yelleswarapu, Sri-Rajasekhar Kothapalli, Alexey Veraksa, D.V.G.L.N. Rao
Biology Faculty Publications
We have developed a common-path multimodal optical microscopy system that is capable of using a single optical source and a single camera to image amplitude, phase, and fluorescence features of a biological specimen. This is achieved by varying either contrast enhancement filters at the Fourier plane and/or neutral density/fluorescence filters in front of the CCD camera. The feasibility of the technique is demonstrated by obtaining brightfield, fluorescence, phase-contrast, spatially filtered, brightfield + fluorescence, phase +fluorescence, and edge-enhanced+fluorescence images of the same Drosophila embryo without the need for image registration and fusion. This comprehensive microscope has the capability of providing both …
Stem Cell Order Was Immoral And Unnecessary, Nicanor Austriaco
Stem Cell Order Was Immoral And Unnecessary, Nicanor Austriaco
Theology Faculty Publications
No abstract provided.
Faculty Should Consider Peer Review As A Means Of Improving Students' Scientific Reasoning Skill, Briana Eileen Timmerman, Denise Strickland
Faculty Should Consider Peer Review As A Means Of Improving Students' Scientific Reasoning Skill, Briana Eileen Timmerman, Denise Strickland
Faculty Publications
The following article provides highlights of a larger body of work on the impact of peer review on undergraduate biology students’ scientific reasoning, scientific writing and attitudes. Results suggest that undergraduates, even freshman can be effective peer reviewers and that peer review improves scientific writing, content knowledge, and scientific reasoning skills. Students report peer review to be a beneficial experience both within the course and in terms of helping them to develop as aspiring scientists. Science faculty are therefore encouraged to consider incorporating peer review as a regular part of instruction.
Children Should Be Begotten And Not Made, Nicanor Austriaco
Children Should Be Begotten And Not Made, Nicanor Austriaco
Theology Faculty Publications
No abstract provided.
From Cells To Coastlines: How Can We Use Physiology To Forecast The Impacts Of Climate Change?, Brian Helmuth
From Cells To Coastlines: How Can We Use Physiology To Forecast The Impacts Of Climate Change?, Brian Helmuth
Faculty Publications
The interdisciplinary fields of conservation physiology, macrophysiology, and mechanistic ecological forecasting have recently emerged as means of integrating detailed physiological responses to the broader questions of ecological and evolutionary responses to global climate change. Bridging the gap between large-scale records of weather and climate (as measured by remote sensing platforms, buoys and ground-based weather stations) and the physical world as experienced by organisms (niche-level measurements) requires a mechanistic understanding of how ‘environmental signals’ (parameters such as air, surface and water temperature, food availability, water flow) are translated into signals at the scale of the organism or cell (e.g. body temperature, …
Biology And Conservation Of Horseshoe Crabs, John T. Tanacredi, Mark L. Bottom, David R. Smith
Biology And Conservation Of Horseshoe Crabs, John T. Tanacredi, Mark L. Bottom, David R. Smith
School of Marine and Environmental Sciences Faculty and Staff Publications and Presentations
We dedicate this book to Drs. Carl N. Shuster, Jr. and Koichi Sekiguchi for their life-long contributions to the biology and conservation of the magnificent horseshoe crab.
Lifelines Winter 2009, Southern Adventist University
Lifelines Winter 2009, Southern Adventist University
Lifelines - Biology Department Newsletter
The Winter 2009 issue of Lifelines features articles on RAM Clinics, Dr. Earl Aagaard's retirement, the addition of Richard Seidel to the faculty, and a pictorial directory of the 2009 biology and allied health graduates.
Coiled-Coil-Mediated Dimerization Is Not Required For Myosin Vi To Stabilize Actin During Spermatid Individualization In Drosophila Melanogaster, Tatsuhiko Nogushi, Deborah J. Frank, Mamiko Isaji, Kathryn G. Miller
Coiled-Coil-Mediated Dimerization Is Not Required For Myosin Vi To Stabilize Actin During Spermatid Individualization In Drosophila Melanogaster, Tatsuhiko Nogushi, Deborah J. Frank, Mamiko Isaji, Kathryn G. Miller
Biology Faculty Research
Myosin VI is a pointed-end-directed actin motor that is thought to function as both a transporter of cargoes and an anchor, capable of binding cellular components to actin for long periods. Dimerization via a predicted coiled coil was hypothesized to regulate activity and motor properties. However, the importance of the coiled-coil sequence has not been tested in vivo. We used myosin VI's well-defined role in actin stabilization during Drosophila spermatid individualization to test the importance in vivo of the predicted coiled coil. If myosin VI functions as a dimer, a forced dimer should fully rescue myosin VI loss of function …
Biology In Mathematics At The University Of Richmond, Lester Caudill
Biology In Mathematics At The University Of Richmond, Lester Caudill
Department of Math & Statistics Faculty Publications
In an effort to meet the needs of science students for modeling skills, three new courses have been created at the University of Richmond: Scientific Calculus I and II, and Mathematical Models in Biology and Medicine. The courses are described, and lessons learned and future directions are discussed.
Numerical Modeling Of Hemodynamics In The Thoracic Aorta And Alterations By Dacron Patch Treatment Of Aortic Coarctation, Ronak Jashwant Dholakia
Numerical Modeling Of Hemodynamics In The Thoracic Aorta And Alterations By Dacron Patch Treatment Of Aortic Coarctation, Ronak Jashwant Dholakia
Master's Theses (2009 -)
Coarctation of the aorta (CoA) is a major congenital heart disease, characterized by a severe stenosis of the proximal descending thoracic aorta. Traditionally, surgery has been the treatment of choice for CoA. Dacron patch aortoplasty gained increased popularity after its introduction in the mid-twentieth century due to its advantages over other surgical treatment methods available at the time. A major complication with Dacron patch aortoplasty has been the formation of late aneurysm with as much as 51% incidence reported in follow up studies. The change in aortic morphology and formation of aneurysms after Dacron patch surgery could lead to local …
Ngasp - The Nematode Genome Annotation Assessment Project, Avril Coghlan, Tristan J. Fiedler, Sheldon J. Mckay, Paul R. Flicek, Todd W. Harris, Darin Blasiar, Lincoln D. Stein
Ngasp - The Nematode Genome Annotation Assessment Project, Avril Coghlan, Tristan J. Fiedler, Sheldon J. Mckay, Paul R. Flicek, Todd W. Harris, Darin Blasiar, Lincoln D. Stein
Biomedical Engineering and Sciences Faculty Publications
While the C. elegans genome is extensively annotated, relatively little information is available for other Caenorhabditis species. The nematode genome annotation assessment project (nGASP) was launched to objectively assess the accuracy of protein-coding gene prediction software in C. elegans, and to apply this knowledge to the annotation of the genomes of four additional Caenorhabditis species and other nematodes. Seventeen groups worldwide participated in nGASP, and submitted 47 prediction sets across 10 Mb of the C. elegans genome. Predictions were compared to reference gene sets consisting of confirmed or manually curated gene models from WormBase. Results: The most accurate gene-finders were …
Estimating Total Phosphorus And Total Suspended Solids Loads From High Frequency Data, Amber Spackman Jones
Estimating Total Phosphorus And Total Suspended Solids Loads From High Frequency Data, Amber Spackman Jones
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Frequently measured turbidity was examined as a surrogate for total phosphorus (TP) and total suspended solids (TSS) loads at two locations in the Little Bear River, Utah, USA. Using regression techniques, equations were developed for TP and TSS as functions of turbidity. The equations accounted for censored data, and additional explanatory variables to represent hydrological conditions were considered for inclusion in the equations. By using the resulting surrogate relationships with high frequency turbidity measurements, high frequency estimates of TP and TSS concentrations were calculated. To examine the effect of sampling frequency, reference loads were determined from the concentration records for …
Community-Based Inquiry Improves Critical Thinking In General Education Biology, Ian J. Quitadamo, Celia L. Faiola, James E. Johnson, Martha J. Kurtz
Community-Based Inquiry Improves Critical Thinking In General Education Biology, Ian J. Quitadamo, Celia L. Faiola, James E. Johnson, Martha J. Kurtz
All Faculty Scholarship for the College of the Sciences
National stakeholders are becoming increasingly concerned about the inability of college graduates to think critically. Research shows that, while both faculty and students deem critical thinking essential, only a small fraction of graduates can demonstrate the thinking skills necessary for academic and professional success. Many faculty are considering nontraditional teaching methods that incorporate undergraduate research because they more closely align with the process of doing investigative science. This study compared a research-focused teaching method called community-based inquiry (CBI) with traditional lecture/laboratory in general education biology to discover which method would elicit greater gains in critical thinking. Results showed significant critical-thinking …
Evolution Of The Holozoan Ribosome Biogenesis Regulon, Seth J. Brown, Michael D. Cole, Albert J. Erives
Evolution Of The Holozoan Ribosome Biogenesis Regulon, Seth J. Brown, Michael D. Cole, Albert J. Erives
Dartmouth Scholarship
The ribosome biogenesis (RiBi) genes encode a highly-conserved eukaryotic set of nucleolar proteins involved in rRNA transcription, assembly, processing, and export from the nucleus. While the mode of regulation of this suite of genes has been studied in the yeast, Saccharomyces cerevisiae, how this gene set is coordinately regulated in the larger and more complex metazoan genomes is not understood. Here we present genome-wide analyses indicating that a distinct mode of RiBi regulation co-evolved with the E(CG)-binding, Myc:Max bHLH heterodimer complex in a stem-holozoan, the ancestor of both Metazoa and Choanoflagellata, the protozoan group most closely related to animals. These …
Lis1 And Ndel1 Influence The Timing Of Nuclear Envelope Breakdown In Neural Stem Cells, Sachin Hebbar, Mariano T. Mesngon, Aimee M. Guillotte, Bhavim Desai, Ramses Ayala, Deanna S. Smith
Lis1 And Ndel1 Influence The Timing Of Nuclear Envelope Breakdown In Neural Stem Cells, Sachin Hebbar, Mariano T. Mesngon, Aimee M. Guillotte, Bhavim Desai, Ramses Ayala, Deanna S. Smith
Faculty Publications
Lis1 and Ndel1 are essential for animal development. They interact directly with one another and with cytoplasmic dynein. The developing brain is especially sensitive to reduced Lis1 or Ndel1 levels, as both proteins influence spindle orientation, neural cell fate decisions, and neuronal migration. We report here that Lis1 and Ndel1 reduction in a mitotic cell line impairs prophase nuclear envelope (NE) invagination (PNEI). This dyneindependent process facilitates NE breakdown (NEBD) and occurs before the establishment of the bipolar spindle. Ndel1 phosphorylation is important for this function, regulating binding to both Lis1 and dynein. Prophase cells in the ventricular zone (VZ) …