Biology Commons^™

A New Social Gene In Dictyostelium Discoideum, Chtb, Lorenzo A. Santorelli, Adam Kuspa, Gad Shaulsky, David C. Queller, Joan E. Strassmann

Biology Faculty Research

BACKGROUND:

Competitive social interactions are ubiquitous in nature, but their genetic basis is difficult to determine. Much can be learned from single gene knockouts in a eukaryote microbe. The mutants can be competed with the parent to discern the social impact of that specific gene. Dictyostelium discoideum is a social amoeba that exhibits cooperative behavior in the construction of a multicellular fruiting body. It is a good model organism to study the genetic basis of cooperation since it has a sequenced genome and it is amenable to genetic manipulation. When two strains of D. discoideum are mixed, a cheater strain …

“Culling The Herd”: Eugenics And The Conservation Movement In The United States, 1900–1940, Garland E. Allen

Biology Faculty Research

While from a late twentieth- and early twenty-first century perspective, the ideologies of eugenics (controlled reproduction to eliminate the genetically unfit and promote the reproduction of the genetically fit) and environmental conservation and preservation, may seem incompatible, they were promoted simultaneously by a number of figures in the progressive era in the decades between 1900 and 1950. Common to the two movements were the desire to preserve the ‘‘best’’ in both the germ plasm of the human population and natural environments (including not only natural resources, but also undisturbed nature preserves such as state and national parks and forests). In …

Greater Sexual Reproduction Contributes To Differences In Demography Of Invasive Plants And Their Noninvasive Relatives, Jean H. Burns, Eleanor A. Pardini, Michele R. Schutzenhofer, Y Anny Chung, Katie J. Seidler, Tiffany M. Knight

Biology Faculty Research

An understanding of the demographic processes contributing to invasions would improve our mechanistic understanding of the invasion process and improve the efficiency of prevention and control efforts. However, field comparisons of the demography of invasive and noninvasive species have not previously been conducted. We compared the in situ demography of 17 introduced plant species in St. Louis, Missouri, USA, to contrast the demographic patterns of invasive species with their less invasive relatives across a broad sample of angiosperms. Using herbarium records to estimate spread rates, we found higher maximum spread rates in the landscape for species classified a priori as …

Sturgis And Kay Mckeever Papers, Zach S. Henderson Library Special Collections

Finding Aids

This collection consists of the papers of Georgia Southern University biology professor Sturgis McKeever and other materials related to the McKeever family, particularly his wife, Kay McKeever, and his brothers Ivan and Kermit McKeever. The materials span 1935–2005 and are predominantly professional in nature, including numerous research reprints and publications on animal species across North America, correspondence between McKeever and other researchers, and handwritten graphs, charts, and research notes. The collection also contains photographic materials, including photographic slides and negatives documenting his research. The recent accrual expands the collection to include personal correspondence between Sturgis and Kay McKeever, as well …

A Bacterial Symbiont Is Converted From An Inedible Producer Of Beneficial Molecules Into Food By A Single Mutation In The Gaca Gene, Pierre Stallforth, Debra A. Brock, Alexandra M. Cantley, Xiangjun Tian, David C. Queller, Joan E. Strassmann, Jon Clardy

Biology Faculty Research

Stable multipartite mutualistic associations require that all partners benefit. We show that a single mutational step is sufficient to turn a symbiotic bacterium from an inedible but host-beneficial secondary metabolite producer into a host food source. The bacteria's host is a "farmer" clone of the social amoeba Dictyostelium discoideum that carries and disperses bacteria during its spore stage. Associated with the farmer are two strains of Pseudomonas fluorescens, only one of which serves as a food source. The other strain produces diffusible small molecules: pyrrolnitrin, a known antifungal agent, and a chromene that potently enhances the farmer's spore production and …

Full Issue: Volume 6, Number 2

The Science Journal of the Lander College of Arts and Sciences

No abstract provided.

Full Issue: Volume 7, Number 1

The Science Journal of the Lander College of Arts and Sciences

No abstract provided.

Likely Successors Of Ash Species In Response To The Emerald Ash Borer In Ohio Forests, Brian Michael Good

Browse all Theses and Dissertations

Invasive species have the capability to alter landscapes and change the composition of a forest in a very short time. The recent invasive pest, Agrilus planipennis, emerald ash borer, was unintentionally introduced to the United States via ship route to Michigan. The pest attacks and kills all five native ash species in Ohio. This study focused on an area in west central Ohio not yet affected by the borer. Ash centered plots were used to record all species and sizes (diameter at breast height) within a 5m radius of a central ash tree. Plots ranged in topography and all five …

Flying Speed In Drosophila Melanogaster Selected For Fast Flight, Jess Wheeler Ms

All Student Scholarship

The aim of this study was to quantify the increase in flying speed in two replicate lines of Drosophila melanogaster (AA1 and AA2), after approximately 520 generations of selection for fast flight in a wind tunnel.

Family Matters: An Analysis Of Genetic Relatedness Of Tetraclita Rubescens (The Pink Volcano Barnacle) Over Several Spatial Scales At Monterey And Bodega Bay, California, Kelly N. Chang

Scripps Senior Theses

Inbreeding involves the mating of closely related individuals at a higher frequency than at random; this can decrease the average fitness of populations and individuals by reducing the presence of heterozygotes and augmenting the expression of deleterious genes. Since marine invertebrates exhibit widespread dispersal, their potential for inbreeding is often disregarded. The adult sessile state of barnacles creates the potential for inbreeding as a result of necessary copulation between neighboring individuals. Depending on the degree of mixing that occurs during dispersal, closely related individuals or siblings may settle in close proximity, generating the possibility of kin aggregation and consequent inbreeding. …

A Mesh Generation And Machine Learning Framework For Drosophila Gene Expression Pattern Image Analysis, Wenlu Zhang, Daming Feng, Rongjian Li, Andrey Chernikov, Nikos Chrisochoides, Christopher Osgood, Charlotte Konikoff, Stuart Newfeld, Sudhir Kumar, Shuiwang Ji

Computer Science Faculty Publications

Background: Multicellular organisms consist of cells of many different types that are established during development. Each type of cell is characterized by the unique combination of expressed gene products as a result of spatiotemporal gene regulation. Currently, a fundamental challenge in regulatory biology is to elucidate the gene expression controls that generate the complex body plans during development. Recent advances in high-throughput biotechnologies have generated spatiotemporal expression patterns for thousands of genes in the model organism fruit fly Drosophila melanogaster. Existing qualitative methods enhanced by a quantitative analysis based on computational tools we present in this paper would provide …

Comparing Biology Grades Based On Instructional Delivery And Instructor At A Community College: Face-To-Face Course Versus Online Course., Amanda Rosenzweig

LSU New Orleans Theses and Dissertations

Through distance learning, the community college system has been able to serve more students by providing educational opportunities to students who would otherwise be unable to attend college. The community college of focus in the study increased its online enrollments and online course offerings due to the growth of overall enrollment. The need and purpose of the study is to address if there is a difference in students’ grades between face-to-face and online biology related courses and if there are differences in grades between face-to-face and online biology courses taught by different instructors and the same instructor. The study also …

Secondary Structure, A Missing Component Of Sequence- Based Minimotif Definitions, David P. Sargeant, Michael R. Gryk, Mark W. Maciejewsk, Vishal Thapar, Vamsi Kundeti, Sanguthevar Rajasekaran, Pedro Romero, Keith Dunker, Shun-Cheng Li, Tomonori Kaneko, Martin Schiller

Life Sciences Faculty Research

Minimotifs are short contiguous segments of proteins that have a known biological function. The hundreds of thousands of minimotifs discovered thus far are an important part of the theoretical understanding of the specificity of protein-protein interactions, posttranslational modifications, and signal transduction that occur in cells. However, a longstanding problem is that the different abstractions of the sequence definitions do not accurately capture the specificity, despite decades of effort by many labs. We present evidence that structure is an essential component of minimotif specificity, yet is not used in minimotif definitions. Our analysis of several known minimotifs as case studies, analysis …

Lifelines Fall 2012, Southern Adventist University

Lifelines - Biology Department Newsletter

The Fall 2012 issue of Lifelines features articles on undergraduate research in biology, field ecology, and the addition of Dr. Aaron Corbit to the faculty.

Integrating Technology, Field Experience And Collaboration In An Undergraduate Biology Research Course, Melissa M. Grigione, Dan Farkas

Cornerstone 3 Reports : Interdisciplinary Informatics

No abstract provided.

Characterization Of The Stem Cell Niche In Drosophila Testes, Vittorio Mena Jr.

Seton Hall University Dissertations and Theses (ETDs)

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Achieving High Accuracy Prediction Of Minimotifs, Tian Mi, Sanguthevar Rajasekaran, Jerlin Camilus Merlin, Michael R. Gryk, Martin Schiller

Life Sciences Faculty Research

The low complexity of minimotif patterns results in a high false-positive prediction rate, hampering protein function prediction. A multi-filter algorithm, trained and tested on a linear regression model, support vector machine model, and neural network model, using a large dataset of verified minimotifs, vastly improves minimotif prediction accuracy while generating few false positives. An optimal threshold for the best accuracy reaches an overall accuracy above 90%, while a stringent threshold for the best specificity generates less than 1% false positives or even no false positives and still produces more than 90% true positives for the linear regression and neural network …

Endoplasmic Reticulum Involvement In Yeast Cell Death, Nicanor Austriaco

Biology Faculty Publications

Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation. Though significant research has focused on mitochondrial involvement in this phenomenon, more recent work with both Saccharomyces cerevisiae and Schizosaccharomyces pombe has also implicated the endoplasmic reticulum (ER) in yeast PCD. This minireview provides an overview of ER stress-associated cell death (ER-SAD) in yeast. It begins with a description of ER structure and function in yeast before moving to a discussion of ER-SAD in both mammalian and yeast cells. Three examples of …

Library Impact Statement For Nrs/Bio 417 Herpetology, Michael A. Cerbo Ii

Library Impact Statements

Library Impact Statement for NRU/BIO 417 Herpetology new course proposal. No new library resources are needed to support this course. Responding library faculty member: Michael A. Cerbo II. Requesting faculty member: Nancy E. Karraker.

Library Impact Statement For Nrs/Bio 517 Herpetology, Michael A. Cerbo Ii

Library Impact Statements

Library Impact Statement for NRS/BIO 517 Herpetology. No new library resources are needed to support this course. Responding library faculty member: Micael A. Cerbo II. Requesting faculty member: Nancy E. Karraker.

Reducing False-Positive Prediction Of Minimotifs With A Genetic Interaction Filter, Jerlin Camilus Merlin, Sanguthevar Rajasekaran, Tian Mi, Martin Schiller

Life Sciences Faculty Research

Background

Minimotifs are short contiguous peptide sequences in proteins that have known functions. At its simplest level, the minimotif sequence is present in a source protein and has an activity relationship with a target, most of which are proteins. While many scientists routinely investigate new minimotif functions in proteins, the major web-based discovery tools have a high rate of false-positive prediction. Any new approach that reduces false-positives will be of great help to biologists.

Methods and Findings

We have built three filters that use genetic interactions to reduce false-positive minimotif predictions. The basic filter identifies those minimotifs where the source/target …

Library Impact Statement For Bio 501 Advanced Scientific Ethics, Michael A. Cerbo Ii

Library Impact Statements

Library Impact Statement for BIO 501 Advanced Scientific Ethics new course proposal. No new resources are required to support this course. Responding library faculty member: Michael A. Cerbo II. Requesting faculty member: Chris Lane.

Library Impact Statement For Bio 502 Advanced Scientific Communication, Michael A. Cerbo Ii

Library Impact Statements

Library Impact Statement for BIO 502 Advanced Scientific Communication new course proposal. No new resources are needed to support this course. Responding library faculty member: Michael A. Cerbo II. Requesting faculty member: Chris Lane.

Library Impact Statement For Bio 553 Regulatory Processes In Eucaryotic Cells, Michael A. Cerbo Ii

Library Impact Statements

Library Impact Statement for BIO 553 Regulatory Processes in Eucaryotic Cells new course proposal. No new library resources are needed to support this course. Responding library faculty member: Michael A. Cerbo II. Requesting faculty member: Joanna Norris.

Library Impact Statement For Bio 485x Salt Marsh Ecology, Michael A. Cerbo Ii

Library Impact Statements

Library Impact Statement for BIO 485X Salt Marsh Ecology new course proposal. No new library resources are needed to support this course. Responding library faculty member: Michael A. Cerbo II. Requesting faculty member: Serena Moseman-Valtierra.

Library Impact Statement For Bio 585x Salt Marsh Ecology, Michael A. Cerbo Ii

Library Impact Statements

Library Impact Statement for BIO 585X Salt Marsh Ecology new course proposal. No new library resources are needed to support this course. Responding library faculty member: Michael A. Cerbo II. Requesting faculty member: Serena Moseman-Valtierra.

It’S My Body: The Biomedical Ethics Of Cell And Organ Harvest, Christina Perri

Common Reading Essay Contest Winners

First Place

Chemotherapy: The Physiological Cost Of A Cure, Megan Ellis

A with Honors Projects

This project focuses on the common long term side effects of cancer treatments, apart from cure. In addition to physiological function changes, it focuses on the chemical composition of chemotherapy drugs.

In Depth Analysis Of An Anterior Cruciate Ligament Tear: Effects On The Mind And Body, Keimi Lew

Whittier Scholars Program

Injuries have always been a major concern for athletes; anterior cruciate ligament (ACL) injuries are among the most common serious injuries around. With the increase in reported ACL injuries, this has become a sort of epidemic especially among female athletes. Female athletes are three times more likely to experience a knee injury than a male athlete competing in the same sport. Since this increase in the last decade, researchers have developed several different hypotheses as to why females are more likely to experience these injuries. With these injuries there is a physical aspect, however, it is much more than that, …

Multi-Partner Interactions In Corals In The Face Of Climate Change, Koty H. Sharp, Kim B. Ritchie

Arts & Sciences Faculty Publications

Recent research has explored the possibility that increased sea-surface temperatures and decreasing pH (ocean acidification) contribute to the ongoing decline of coral reef ecosystems. Within corals, a diverse microbiome exerts significant influence on biogeochemical and ecological processes, including food webs, organismal life cycles, and chemical and nutrient cycling. Microbes on coral reefs play a critical role in regulating larval recruitment, bacterial colonization, and pathogen abundance under ambient conditions, ultimately governing the overall resilience of coral reef systems. As a result, microbial processes may be involved in reef ecosystem-level responses to climate change. Developments of new molecular technologies, in addition to …