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2023

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Articles 1531 - 1560 of 1823

Full-Text Articles in Biology

Ser14-Rpn6 Phosphorylation Mediates The Activation Of 26s Proteasomes By Cyclic Amp And Protects Against Cardiac Proteotoxic Stress In Mice, Liuqing Yang Jan 2023

Ser14-Rpn6 Phosphorylation Mediates The Activation Of 26s Proteasomes By Cyclic Amp And Protects Against Cardiac Proteotoxic Stress In Mice, Liuqing Yang

Dissertations and Theses

A better understanding of how proteasome activity is regulated can facilitate the search for proteasome enhancement strategies for disease treatment. A cell culture study shows cAMP-dependent protein kinase (PKA) activates 26S proteasomes by phosphorylating Ser14 of RPN6 (pS14-RPN6), but this discovery and its physiological significance remain to be established in vivo. To test the hypothesis that pS14-RPN6 mediates the activation of proteasomes by PKA and reduces proteotoxicity in animals, two knock-in mouse models with Ser14 of endogenous Rpn6 mutated to either Ala (S14A) or Asp (S14D) to respectively block or mimic pS14-Rpn6 were created. In a PKA-dependent manner, cAMP augmentation …

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Characterisation Of Selected Microbes In Terrestrial And Simulated Extraterrestrial Habitats: Human Health And Environmental Applications, Daniel Joseph Keaney Jan 2023

Characterisation Of Selected Microbes In Terrestrial And Simulated Extraterrestrial Habitats: Human Health And Environmental Applications, Daniel Joseph Keaney

Theses

The rapid development of the Space industry and associated technologies over the past decade is leading to the inevitable consideration of establishing human-based colonies on extra-terrestrial bodies such as the moon and Mars. With Mars being the focus of not only this body of work, but current New Space Age travel (NASA and SpaceX), a significant issue posed by Martian colonists includes establishing a safe and sustainable food source. Owing to its constantly evolving prehistoric landscape, the soils of Mars are contaminated with sodium perchlorate, a water-soluble salt that is toxic to humans, leftover from once inferred brine seeps that …

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Meta-Analysis Of The Effects Of Insect Pathogens: Implications For Plant Reproduction, Wilnelia Recart Gonzalez, Rover Bernhard, Isabella Ng, Katherine Garcia, Arietta E. Fleming-Davies Jan 2023

Meta-Analysis Of The Effects Of Insect Pathogens: Implications For Plant Reproduction, Wilnelia Recart Gonzalez, Rover Bernhard, Isabella Ng, Katherine Garcia, Arietta E. Fleming-Davies

Biology: Faculty Scholarship

Despite extensive work on both insect disease and plant reproduction, there is little research on the intersection of the two. Insect-infecting pathogens could disrupt the pollination process by affecting pollinator population density or traits. Pathogens may also infect insect herbivores and change herbivory, potentially altering resource allocation to plant reproduction. We conducted a meta-analysis to (1) summarize the literature on the effects of pathogens on insect pollinators and herbivores and (2) quantify the extent to which pathogens affect insect traits, with potential repercussions for plant reproduction. We found 39 articles that fit our criteria for inclusion, extracting 218 measures of …

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Forensic Microbiome Evidence: Fourth Amendment Applications And Court Acceptance, Trason Lasley Jan 2023

Forensic Microbiome Evidence: Fourth Amendment Applications And Court Acceptance, Trason Lasley

Catholic University Journal of Law and Technology

No abstract provided.

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Cleome Serrulata, Rocky Mountain Beeweed, Uses By Native Americans, Marielle Gomez, John Ubelaker Jan 2023

Cleome Serrulata, Rocky Mountain Beeweed, Uses By Native Americans, Marielle Gomez, John Ubelaker

Research

This paper examines the use of beeweed (Cleome serrulata), a native annual commonly called Rocky Mountain beeplant, as a traditional dye and paint source for pottery in Northern New Mexico.

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Behavioral, Morphological And Genetic Differentiation Among Populations Of Enyaliopsis, Laura Macamo Jan 2023

Behavioral, Morphological And Genetic Differentiation Among Populations Of Enyaliopsis, Laura Macamo

Electronic Theses and Dissertations, 2020-2023

The study of biodiversity is a fundamental part of the study of the ecosystem's function and stability and how changes in the habitat shape the interaction between species. In recent years, the classification of species benefited from the analysis of several types of data to aid the distinction of morphologically similar species. Enyaliopsis iaculator (Naskrecki and Guta, 2019) is a species endemic to central Mozambique. Different populations of E. iaculator were reported to exhibit differences in the time of the day the mating call is displayed, but no morphological differences were reported. Since call behavior tends to be species specific …

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The Effect Of Larval Competition On Adult Life History Traits And The Immune Response Of Adult Cat Fleas (Ctenocephalides Felis), Piper N. Zellner, Lisa D. Brown Jan 2023

The Effect Of Larval Competition On Adult Life History Traits And The Immune Response Of Adult Cat Fleas (Ctenocephalides Felis), Piper N. Zellner, Lisa D. Brown

Honors College Theses

In holometabolous insects, conditions during the larval stage can affect the adult stage. For instance, in mosquitoes, reduced larval food and high density can make adults more susceptible to infection. Fleas (Siphonaptera), like mosquitoes, go through complete metamorphosis and have adult stages that exclusively feed on the blood of vertebrates, including humans. However, flea larvae have chewing mandibles and rely on nutrients from dried fecal matter containing vertebrate blood proteins. Their limited mobility and unique nutritional needs confine their development to specific areas, likely leading to frequent larval competition in natural conditions. Yet, the influence of larval density on the …

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Examining The Immune Regulation Of Nlrp12 Through Novel Protein Interactions, Catherine Rippe Jan 2023

Examining The Immune Regulation Of Nlrp12 Through Novel Protein Interactions, Catherine Rippe

Graduate Theses/Dissertations

NOD-like receptors (NLRs) are intracellular proteins that play an important role in the regulation of the innate immune response to pathogens. Since being identified, various functions for NOD-like receptor pyrin domain containing 12 (NLRP12) have been suggested. It has been shown to negatively regulate the inflammatory response through canonical and noncanonical NF-kB signaling pathways, control tumorigenesis and gut homeostasis and exacerbate inflammation through the formation of a multi-protein complex called an inflammasome. Due to the varying roles established for NLRP12, the mechanisms by which it functions remain poorly understood. In this study, I sought to confirm a novel protein-protein interaction …

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Propagation, Physiology And Biomass Of Giant Cane (Arundinaria Gigantea) For Conservation And Restoration, Sanjeev Sharm Jan 2023

Propagation, Physiology And Biomass Of Giant Cane (Arundinaria Gigantea) For Conservation And Restoration, Sanjeev Sharm

Graduate Theses/Dissertations

Giant cane (Arundinaria gigantea) is a native species to 22 states in the U.S. The species and its ecosystem are considered critically endangered, and the species has been reduced to 2% of its original extent. The species has a long cultural and conservation history. Large canebrakes were commonly found in Missouri in bottomland forests, stream and riverbanks, and margins of lakes. My research goals were to: 1) examine methods for propagation success from field to greenhouse to field; 2) examine the physiology of cane at one of the few current canebrakes, for greenhouse propagated plants, and field planted …

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Tissue And Sex-Dependent Regulation Of Innate Immunity And Rna Editing In Mice, Kelsey R. Kendrick Jan 2023

Tissue And Sex-Dependent Regulation Of Innate Immunity And Rna Editing In Mice, Kelsey R. Kendrick

Graduate Theses/Dissertations

Inflammation occurs as a result of insult or infection within the body. Individual cells respond to inflammation by upregulating genes that help mediate the immune response, such as ADAR1. ADAR1 helps regulate the immune response but also catalyzes a process called RNA editing. RNA editing alters the sequence of select mRNAs to alter the encoded proteins. The result is altered function of the encoded protein, which is often beneficial for the cell. Our goal was to determine how inflammation affects the function of ADAR1. Since we know that the effects of inflammation vary between different organs and sexes, we examined …

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Cul3 Negatively Regulates Nlrp12-Mediated Inhibition Of The Canonical Nf-Κb Signaling Pathway, Inyeong Lee Jan 2023

Cul3 Negatively Regulates Nlrp12-Mediated Inhibition Of The Canonical Nf-Κb Signaling Pathway, Inyeong Lee

Graduate Theses/Dissertations

Nod-like receptor family pyrin domain-containing protein 12 (NLRP12) is mainly known for its inhibitory function on NF-κB signaling in innate immune cells, and more recently, for its ability to regulate chemokine signaling and ubiquitination of the immune receptor RIG-I. Through a yeast 2-hybrid screen, the Lupfer lab previously discovered that NLRP12 interacts with other ubiquitin-associated proteins including Cullin 3 (CUL3) and RING finger protein 2 (RNF2). This research was conducted to mainly investigate the interaction between NLRP12 and CUL3 in human cells and examine the role in regulating NF-κB signaling. Previously, co-immunoprecipitation, followed by western blot analysis, and confocal microscopy …

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What Kills The Virtually Immortal Palms Of The Florida Scrub?, Warren G. Abrahamson Ii Jan 2023

What Kills The Virtually Immortal Palms Of The Florida Scrub?, Warren G. Abrahamson Ii

Faculty Journal Articles

Premise: Life span varies greatly across plants, with some species being capable of extreme longevity. Yet even long‐lived individuals are susceptible to climatic events, fire, and other challenges. We examined rare mortality events and their causes in two long‐lived palmettos over four decades. Methods: We monitored the survival of the clonal Serenoa repens and non‐clonal, Florida‐endemic Sabal etonia from 1981 to 2022 in four habitats along an elevational gradient within the globally imperiled Florida scrub ecosystem. We considered several challenges to palmetto survival, including extreme fires, shading due to lack of fire, droughts, periods of high precipitation, and possible pathogens. …

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Building A High-Throughput Yeast Two-Hybrid Assay To Screen For Novel Chronic Hepatitis B Drugs, Benjamin Glazer Jan 2023

Building A High-Throughput Yeast Two-Hybrid Assay To Screen For Novel Chronic Hepatitis B Drugs, Benjamin Glazer

Lawrence University Honors Projects

Hepatitis B is a vaccine preventable liver disease caused by hepatitis B virus (HBV). Chronic hepatitis B currently affects about 296 million people around the world, killing 820,000 annually. There is currently no cure for chronic hepatitis B, but research over the last decade has identified hepatitis B X protein (HBx) as a promising therapeutic target. Specifically, inhibiting the interaction between HBx and human protein DDB1 could disrupt HBx function. An essential step in the drug development process is to create an assay that is capable of high-throughput screening millions of compounds for activity against HBx-DDB1. This research aims to …

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Investigating Neuroanatomical Evolution Through Proliferative Cells In The Astyanax Mexicanus, Sophie Staeger Jan 2023

Investigating Neuroanatomical Evolution Through Proliferative Cells In The Astyanax Mexicanus, Sophie Staeger

Pitzer Senior Theses

The Astyanax mexicanus is a single species of fish that has two very distinct morphs, the cave fish and the surface fish. 200,000 years ago, cave fish ancestors entered the dark and challenging cave environment of Mexico and were forced to adapt in order to survive. Such adaptions include larger fat reserves, more sensitive olfaction, increased neuromasts, and a unique nervous system structure. Yet, other functions regressed, as they lost their eyes and pigmentation. The Duboué lab has established a clear reciprocal relationship between the volume of structures involved in the neuronal adaptations, but the biological mechanisms underlying the development …

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Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner Jan 2023

Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner

Scripps Senior Theses

Pregnancy prevention and female reproductive freedom have been some of the most contested political issues for decades. Abortion, a fundamental part of women’s healthcare, divides liberals and conservatives on an international scale. The consequences of unintended pregnancy without safe and reliable contraception are widespread, disproportionately impacting women of color, trans and non-binary folks, and poorer communities. The birth control pill is the most common form of oral contraception (OC) globally. Many people with ovaries begin the pill or other hormonal contraceptive (HC) methods as young as 11 years old. Exogenous progesterone and estrogen are known to impact mood, affect, physiology, …

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The Effect Of Blue Mussel (Mytilus Edulis) Extinction On Ecosystem Function In The Gulf Of Maine Rocky Intertidal, Sophia K. Montague Jan 2023

The Effect Of Blue Mussel (Mytilus Edulis) Extinction On Ecosystem Function In The Gulf Of Maine Rocky Intertidal, Sophia K. Montague

Honors Theses

Stressors associated with climate change including thermal stress and ocean acidification inhibit the growth and reproduction of many species, including the ecologically and economically important blue mussel species in the Gulf of Maine (GOM). Established scaling relationships between mussel size, abundance, and water filtration suggests that the decline of mussels will stunt GOM water filtration. This change in the rate of water filtration could have large effects on the abundance of phytoplankton, abundance of invertebrate larvae, abundance of nutrients and organic material, food web stability, and biodiversity. Overall, this thesis explores the effect of blue mussel (Mytilus edulis) …

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Biomechanics Of Mantis Prey Capture, Danielle S. Taylor Jan 2023

Biomechanics Of Mantis Prey Capture, Danielle S. Taylor

Honors Theses

Mantis species have a variety of different morphologies, so do the extreme forms of mantis limbs trade prey catching capability for camouflage? We hypothesize that some extreme forms of mantis limbs that are associated with cryptic species may be associated with a tradeoff of the capability of those limbs. Previous research has developed 2D morphologies of several hundred species of mantises. We are creating a 3D morphology by using micro dissection, micro CT imaging to construct our 3D biomechanical model. We found the attachment points of the ligaments and muscles from a Tenodera forearm and have constructed a 2D biomechanical …

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A Bioinformatics Approach For Evaluating Evolutionary Convergence Of Gene Family Size In Hematophagous Insects, Mbemba Ceesay Jan 2023

A Bioinformatics Approach For Evaluating Evolutionary Convergence Of Gene Family Size In Hematophagous Insects, Mbemba Ceesay

Theses, Dissertations and Culminating Projects

The act of blood-feeding can be nutritionally rewarding for blood-feeding arthropods. However, blood digestion can release pro-oxidant molecules such as heme and iron at potentially harmful levels. If left uncontrolled, this heme/iron can cause oxidative damage and eventually cell death. This has led to the evolution of various adaptations that protect blood-feeding arthropods against iron- and heme-associated damage. Here I postulate that the signature of this adaptation can be observed in patterns of gene family size. To test this hypothesis, I explore convergent evolutionary expansions and contractions of gene families in distinct lineages of hematophagous insects. Specifically, I compare the …

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Blacktip Shark (Carcharhinus Limbatus) Jaw, Laura D. Nicolas, David W. Kerstetter Jan 2023

Blacktip Shark (Carcharhinus Limbatus) Jaw, Laura D. Nicolas, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Jaw from blacktip shark (Carcharhinus limbatus)

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Experimentally Broadcasted Wind-Turbine Sound Drastically Alters Songbirds' Habitat Selection And Vocal Communication In A Natural Environment, Yael Lehnardt, Tom Klein, Jesse R. Barber, Oded Berger-Tal Jan 2023

Experimentally Broadcasted Wind-Turbine Sound Drastically Alters Songbirds' Habitat Selection And Vocal Communication In A Natural Environment, Yael Lehnardt, Tom Klein, Jesse R. Barber, Oded Berger-Tal

Biology Faculty Publications and Presentations

The sound of wind turbines is a potential threat to songbirds, who use vocal communication to transfer information and rely on acoustic cues from the environment. Previous studies have shown decreased bird density around wind-farms, but the exact causes for this decline have not yet been fully recognized. We investigated the effects of wind-turbine sound on songbird populations by deploying a "Phantom Turbine": broadcasting wind-turbine sound (102dB) at a site without actual turbines. We conducted the experiment in cycles of three stages: 'before', 'noise-treatment', and 'after'. We monitored birds' abundance using mist-netting and recorded freely-flying birds' communication and background noise …

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Characterization Of Parp1-Dependent Poly-Adp-Ribosylation Of Sprtn, Quincee Simonson Jan 2023

Characterization Of Parp1-Dependent Poly-Adp-Ribosylation Of Sprtn, Quincee Simonson

Electronic Theses and Dissertations

DNA-protein crosslinks (DPCs) are a type of DNA lesion that form when proteins become covalently linked to DNA. It is estimated that replicating cells experience approximately 6,000 DPCs per day per genome during exponential growth (Ruggiano & Ramadan, 2021). If left unrepaired, DPCs can be lethal to cells. For this reason, cells have evolved multiple pathways to repair or bypass DPCs to survive. One such pathway involves SPRTN, a nuclear metalloprotease that plays a key role in the repair of DPCs through direct proteolysis (Lopez-Mosqueda et al., 2016; Vaz et al., 2016). Once SPRTN degrades the bulky protein component of …

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Seroprevalence Of Sars-Cov-2 Antibodies Among Rural Healthcare Workers, Jordan Neises Jan 2023

Seroprevalence Of Sars-Cov-2 Antibodies Among Rural Healthcare Workers, Jordan Neises

Electronic Theses and Dissertations

The objective of this longitudinal cohort study was to determine the seroprevalence of antibodies to severe acute respiratory syndrome coronavirus-2 (SARSCoV- 2) in healthcare workers employed at healthcare clinics in three rural counties in eastern South Dakota and western Minnesota from May 13, 2020 through December 22, 2020. Three blood draws were performed at five clinical sites and tested for the presence of antibodies against the SARS-CoV-2 virus. Serum samples were tested for the presence of antibodies using a fluorescent microsphere immunoassay (FMIA), neutralization of SARS-CoV-2 Spike-pseudotyped particles (SARS-CoV-2pp) assay, and serum virus neutralization (SVN) assay. The seroprevalence was determined …

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Behavioral Diversity And Biomechanical Determinants Of The Outcome Of A Fish Predator–Prey Interaction, Milton Q.G.A., Iii, Philip Bergmann Jan 2023

Behavioral Diversity And Biomechanical Determinants Of The Outcome Of A Fish Predator–Prey Interaction, Milton Q.G.A., Iii, Philip Bergmann

Biology

Predator–prey interactions are ubiquitous and under strong selection because of the consequences experienced by both predator and prey if they lose the interaction. Biomechanics and behavior play important roles in the outcome of these interactions, but many studies focus on the prey, restrict the range of behaviors considered, and the role of prey boldness in the outcome is not understood. We used high-speed video to test for effects of multiple measures of performance and kinematics of both the predator and prey, and boldness of prey on the outcome of interactions between Pike Cichlids (Crenicichla sp.) and Guppies (Poecilia reticulata). We …

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Transcriptomic Responses Of Females To Consumption Of Nuptial Food Gifts As A Potential Mediator Of Sexual Conflict In Decorated Crickets, Bert Foquet, James Rapkin, Manmohan D. Sharma, Ben M. Sadd, Scott K. Sakaluk, John Hunt Jan 2023

Transcriptomic Responses Of Females To Consumption Of Nuptial Food Gifts As A Potential Mediator Of Sexual Conflict In Decorated Crickets, Bert Foquet, James Rapkin, Manmohan D. Sharma, Ben M. Sadd, Scott K. Sakaluk, John Hunt

Faculty Publications – Biological Sciences

Nuptial food gift provisioning by males to females at mating is a strategy in many insects that is thought to be shaped by sexual conflict or sexual selection, as it affords males access to a female's physiology. While males often attempt to use these gifts to influence female behaviour to their own advantage, females can evolve counter mechanisms. In decorated crickets, the male's nuptial gift comprises part of the spermatophore, the spermatophylax, the feeding on which deters the female from prematurely terminating sperm transfer. However, ingested compounds in the spermatophylax and attachment of the sperm-containing ampulla could further influence female …

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Evaluating Non-Point Source Microplastic Pollution And Its Impact On Biota In The Huron River, Morgan H. Chaudry Jan 2023

Evaluating Non-Point Source Microplastic Pollution And Its Impact On Biota In The Huron River, Morgan H. Chaudry

Master's Theses and Doctoral Dissertations

Contaminants of emerging concern (CECs), like microplastics and pharmaceuticals, are a growing threat to aquatic ecosystems across the globe. Microplastics can be transported into waterways through a myriad of sources, including point sources such as wastewater treatment plants (WWTPs) and nonpoint sources, such as runoff. Microplastics can act as vectors for other CECs, such as non-steroidal anti-inflammatory drugs (NSAIDs), into biota. The goal of this study was to evaluate 1) the importance of non-point sources of microplastic pollution to the Huron River, 2) if aquatic filter feeders ingest microplastics, and 3) how the interaction of microplastics and pharmaceuticals affect filter …

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Can Host Traits And Environmental Conditions Predict Helminth Fecundity And Length?, Finley Melnikoff Jan 2023

Can Host Traits And Environmental Conditions Predict Helminth Fecundity And Length?, Finley Melnikoff

Pitzer Senior Theses

Helminths are some of the most common parasites in the world, infecting anything from humans to plants to mice. These parasites can play a massive role in determining a host's fitness and ultimately can have consequences on their body condition, reproductive ability, and infection transmission potential. Many factors influence the potential burden helminths have on their hosts–from host traits to environmental conditions–yet helminth fecundity and length have been studied very little in relation to these factors. Helminth fecundity–or how many eggs each female worm has in its ovaries–determines the transmission of the parasite, and helminth length is correlated with fecundity, …

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Determining Species-Specific False-Positive Rates Using Visual And Auditory Cues: A Case Study With Sagebrush Steppe Songbirds, Amelia K. Evavold Jan 2023

Determining Species-Specific False-Positive Rates Using Visual And Auditory Cues: A Case Study With Sagebrush Steppe Songbirds, Amelia K. Evavold

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Errors in wildlife field data threaten to bias resulting abundance and occupancy estimates if not properly accounted for or minimized. Methods to account for false-positive errors in wildlife data have not been as thoroughly developed as those for false-negative errors despite false-positives being present across diverse wildlife taxa and study systems. The calibration method to account for false-positives involves assessing the field detection method to determine how often false-positive errors occur in the field data. Rates can then be incorporated into estimations based on the field data to improve estimation accuracy. This study presents an application of the calibration approach …

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Vitamin D Receptor Mediates Liver Ischemia And Reperfusion Injury By Autophagy-Regulated M2 Macrophage Polarization, Mingming Fang, Chen Zhong Jan 2023

Vitamin D Receptor Mediates Liver Ischemia And Reperfusion Injury By Autophagy-Regulated M2 Macrophage Polarization, Mingming Fang, Chen Zhong

Turkish Journal of Biology

Liver ischemia and reperfusion (IR) injury is the major complication of liver-related operations. Macrophage polarization has an essential effect on the mechanism of liver IR injury. Vitamin D receptor (VDR) has been found to regulate macrophage polarization and alleviate IR injury. Nevertheless, the correlation between VDR and macrophage polarization in liver IR injury has not been clearly elucidated. VDR knockout mice and wild-type littermates underwent partial liver ischemia for 90 min and reperfusion for 6 h. RAW264.7 cells were also used to verify the influence of VDR on macrophage polarization in vitro. VDR activation could promote M2 macrophage polarization and …

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Antiadipogenic And Antiobesogenic Effects Of Pterostilbene In 3t3-L1 Preadipocyte Models, Bi̇rgül Gülnar, İpek Canatar, Si̇bel Özdaş Jan 2023

Antiadipogenic And Antiobesogenic Effects Of Pterostilbene In 3t3-L1 Preadipocyte Models, Bi̇rgül Gülnar, İpek Canatar, Si̇bel Özdaş

Turkish Journal of Biology

Since obesity causes at least 2.8 million death each year and is a major risk factor for many diseases, it is critical to evaluate alternative treatment approaches. In this context, studies on the research of natural product-based therapeutics in the fight against obesity are increasing. In this study, it was aimed to evaluate the antiadipogenic and antiobesogenic efficacy of pterostilbene a natural phenolic compound in 3T3-L1 cells. The mature 3T3-L1 adipocytes were exposed to pterostilbene at different concentrations and half-maximum inhibitory concentrations (IC50) were determined by MTT assay. Oil-Red-O staining was applied to determine lipid accumulation. Phase contrast microscopy, Giemsa, …

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Optimizing Crispr/Cas9 Transfection Protocol To Generate A Tet-On Inducible Sk-Mel 24 Cell Lines To Better Study Icer, Abdulkader Hallak Jan 2023

Optimizing Crispr/Cas9 Transfection Protocol To Generate A Tet-On Inducible Sk-Mel 24 Cell Lines To Better Study Icer, Abdulkader Hallak

Theses, Dissertations and Culminating Projects

Inducible cAMP Early Repressor (ICER) is a dominant transcription repressor of the cAMP Responsive Element Modulator (CREM) and cAMP Responsive Element Protein (CREB) family of transcription factors. ICER isoforms are differently expressed in various cell types and are involved in essential functions including hormonal regulation, circadian rhythm, spermatogenesis, and immune response. In the context of cancer, ICER is proposed as a tumor suppressor in leukemia, prostate, pituitary cancers, and melanoma. In melanoma, ICER is targeted for degradation during tumorigenesis and highly upregulated during regression, further highlighting its potency as a tumor suppressor. Inside the nucleus, ICER targets oncogenes and key …

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