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2022

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Articles 1561 - 1590 of 1814

Full-Text Articles in Biology

The Bgs 13 Mutant Of Pichia Pastoris And Its Effect On Structural Changes Of The Reporter Protein B-Lactogolbulin, Bushra Irshad Jan 2022

The Bgs 13 Mutant Of Pichia Pastoris And Its Effect On Structural Changes Of The Reporter Protein B-Lactogolbulin, Bushra Irshad

University of the Pacific Theses and Dissertations

Pichia pastoris, a methylotrophic yeast, is an ideal host for recombinant protein expression. It has the capability of performing many eukaryotic post-translational modifications and grows to high cell densities. However, P. pastoris’s secretion properties are not always efficient, and its secretory pathway mechanisms have not been thoroughly elucidated. A previously identified mutant strain, bgs13, was found to efficiently secrete most recombinant proteins tested, raising the possibility that this bgs13 mutant is a universal super secreter and understanding its secretion process is needed. In this study, we used a reporter protein, ?-lactoglobulin (b-LG), to perform structural analysis and comparisons of protein …

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Leveraging Queueing Theory To Develop Advanced Synthetic Biological Circuits, Prajakta K. Jadhav Jan 2022

Leveraging Queueing Theory To Develop Advanced Synthetic Biological Circuits, Prajakta K. Jadhav

Electronic Theses and Dissertations

The complexity and redundancy in the network topology of the cell hinder our understanding of the natural system, making it challenging to engineer living organisms with the desired functionality. The long-term goal of synthetic biology and bioengineering is to engineer cells to perform specific functions with increased robustness. The robust engineered systems can be easily applied to different species with the same outcome. An effective approach is a bottom-up approach where we tease apart the biological pathways and study them independently. Understanding the underlying mechanisms of biological pathways can be further applied to construct complex biological circuits that function similarly …

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Characterizing The Lir Domain Of Abin1 And Identifying Its Role As A Regulator Of Mitophagy, Andrew Rhiner Jan 2022

Characterizing The Lir Domain Of Abin1 And Identifying Its Role As A Regulator Of Mitophagy, Andrew Rhiner

Electronic Theses and Dissertations

A20 Inhibitor of NF-κB (ABIN1/TNIP1) is a known regulator of TNFα signaling induced cell death and inflammation. The regulatory activity has been attributed to ABIN1’s recruitment of the ubiquitin editing enzyme TNF-α-induced protein 3 (TNFAIP3/A20) to Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). The regulation of RIPK1 by ABIN1 and A20 relies on a third player, linear ubiquitin chain assembly complex (LUBAC), which is involved in the recruitment of ABIN1 to RIPK1. Loss of LUBAC or ABIN1 is embryonic lethal, but loss of A20 is not embryonic lethal. The embryonic lethality due to loss of ABIN1, paired with the lack of lethality …

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New Baraminological Methods Confirm Monobaraminic Status Of The Horses (Perissodactyla: Equidae) And Preliminary Analyses Of New Datasets Suggest The Possibility Of Discontinuity Between Horses And Various Outgroup Taxa, Timothy R. Brophy, Jack Gregory, Mary-Elizabeth Tallman, Kara Ray Jan 2022

New Baraminological Methods Confirm Monobaraminic Status Of The Horses (Perissodactyla: Equidae) And Preliminary Analyses Of New Datasets Suggest The Possibility Of Discontinuity Between Horses And Various Outgroup Taxa, Timothy R. Brophy, Jack Gregory, Mary-Elizabeth Tallman, Kara Ray

Faculty Publications and Presentations

No abstract provided.

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Modeling The Flow And Creep Compliance Properties Of Ice-Cream Mixes, Hiran Ranaweera Jan 2022

Modeling The Flow And Creep Compliance Properties Of Ice-Cream Mixes, Hiran Ranaweera

Electronic Theses and Dissertations

This work documented the influence of the protein source (MPC80 and WPC80), protein content (4-12%), and temperature (5-35ºC) on the rheological behavior (flow curve, frequency sweep, and creep-recovery) of ice-cream mixes (ICM). For each protein source, the viscosity of the ICM was satisfactorily modeled (𝑅2>0.98, 𝑅2 𝑎𝑑𝑗>0.98, and E0.99), while the recovery phase was represented by an empirical model. The percentage of recovery (%R) of the ICM significantly decreased with the protein content.

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Spatio-Temporal Movement Patterns Of Sub-Adult Adfluvial Bull Trout, Aimee Taylor Jan 2022

Spatio-Temporal Movement Patterns Of Sub-Adult Adfluvial Bull Trout, Aimee Taylor

All Master's Theses

Bull Trout in the Yakima River basin of Washington are primarily adfluvial, often using managed lakes as habitat. Kachess Lake, composed of Big and Little Kachess Lakes, is managed by the Bureau of Reclamation (BOR) for water storage. BOR plans to build a structure that can withdraw an additional 200,000 acre-feet of water in drought years, which would disconnect the two basins for multiple years. This study examined the spatio-temporal movement of sub-adult Bull Trout in Kachess Lake to understand distribution patterns and the effects of environmental variables. We sought to answer 1) does time (week of the year), diel …

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Standardized Neon Organismal Data For Biodiversity Research, Daijiang Li, Sydne Record, Eric R. Sokol, Matthew E. Bitters, Melissa Y. Chen, Y. Anny Chung, Matthew R. Helmus, Ruvi Jaimes, Lara Jansen, Marta A. Jarzyna, Michael G. Just, Jalene M. Lamontagne, Brett A. Melbourne, Wynne Moss, Kari E. A. Norman, Stephanie M. Parker, Natalie Robinson, Bijan Seyednasrollah, Colin Smith, Sarah Spaulding, Thilina D. Surasinghe, Sarah K. Thomsen, Phoebe L. Zarnetske Jan 2022

Standardized Neon Organismal Data For Biodiversity Research, Daijiang Li, Sydne Record, Eric R. Sokol, Matthew E. Bitters, Melissa Y. Chen, Y. Anny Chung, Matthew R. Helmus, Ruvi Jaimes, Lara Jansen, Marta A. Jarzyna, Michael G. Just, Jalene M. Lamontagne, Brett A. Melbourne, Wynne Moss, Kari E. A. Norman, Stephanie M. Parker, Natalie Robinson, Bijan Seyednasrollah, Colin Smith, Sarah Spaulding, Thilina D. Surasinghe, Sarah K. Thomsen, Phoebe L. Zarnetske

Biology Faculty Research and Scholarship

Understanding patterns and drivers of species distribution and abundance, and thus biodiversity, is a core goal of ecology. Despite advances in recent decades, research into these patterns and processes is currently limited by a lack of standardized, high-quality, empirical data that span large spatial scales and long time periods. The NEON fills this gap by providing freely available observational data that are generated during robust and consistent organismal sampling of several sentinel taxonomic groups within 81 sites distributed across the United States and will be collected for at least 30 years. The breadth and scope of these data provide a …

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Rapid Radiation Of Zeiformes Revealed Through Comparison Of Jaw Morphologies, Jeffrey Peters Jan 2022

Rapid Radiation Of Zeiformes Revealed Through Comparison Of Jaw Morphologies, Jeffrey Peters

Master's Theses

Zeiformes (e.g., Dories, Lookdown dories, Tinselfishes, Oreos) are a deep (1000 m) to mid-water (100 m) marine order of acanthomorph fishes with a circumpolar distribution, and a fossil record extending back to the Late Cretaceous. The order consists of 33 species across six families. The phylogenetic placement of the Zeiformes within Teleostei has been debated, but more recent studies based on both molecular and morphological data place Zeiforms within Paracanthopterygii closely related to Gadiformes. Zeiformes are characterized by anal and dorsal profiles that contain a variable number of fin rays and spines. They are mostly deep bodied, highly compressed fishes …

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Investigating The Bactericidal Activity Of Lactobacillus Crispatus Cell-Free-Supernatant, Omar Majed Abdul-Rahim Jan 2022

Investigating The Bactericidal Activity Of Lactobacillus Crispatus Cell-Free-Supernatant, Omar Majed Abdul-Rahim

Dissertations

Antimicrobial-resistant (AMR) microorganisms are an increasingly seriousproblem worldwide, accounting for thousands of fatalities annually. The current literature on combating AMR pathogens often centers on commensal microbes such as Lactobacillus species, which are most frequently found in asymptomatic ‘healthy’ patients and are believed to elicit protective effects. In this dissertation, I sought to investigate the protective effect of Lactobacillus crispatus, utilizing our vast collection of clinical isolates. Previous work from our lab had found that cell-free-supernatant (CFS) of L. crispatus is robustly bactericidal, and that this killing activity does not depend on hydrogen peroxide or lactic acid. We identified phenyl-lactic acid …

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Comparing Physiological Responses To Hot And Cold Stress In A Cnidarian–Algal Holobiont, Exaiptasia Diaphana, Nicole Capozzi, Eyananda Ahmed, Ezra Curtis, Olivia Grandbois, Dominique Kelly, Kadin Kristjansson, Natalie Morgan, Louis Schlecker, Rachel M. Wright Jan 2022

Comparing Physiological Responses To Hot And Cold Stress In A Cnidarian–Algal Holobiont, Exaiptasia Diaphana, Nicole Capozzi, Eyananda Ahmed, Ezra Curtis, Olivia Grandbois, Dominique Kelly, Kadin Kristjansson, Natalie Morgan, Louis Schlecker, Rachel M. Wright

Other Student Projects

Coral bleaching—the breakdown of the cnidarian–algal symbiosis—is a major cause of reef decline. The sea anemone Exaiptasia diaphana, commonly known as Aiptasia, is used as a model to study cnidarian-algal symbiosis in laboratory settings. Aiptasia can live with or without symbionts, which allows scientists to study the host combined and separate from the influence of the symbionts. Scientists are able to trigger the breakdown of the symbiosis using heat or cold stress. Cold stress is more commonly used to render aposymbiotic Aiptasia because it seems to be less harmful to the host than bleaching under heat stress. Is cold …

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A Gene-Based Capture Assay For Surveying Patterns Of Genetic Diversity And Insecticide Resistance In A Worldwide Group Of Invasive Mosquitoes, Matthew L. Aardema, Michael G. Campana, Nicole E. Wagner, Francisco C. Ferreira, Dina M. Fonseca Jan 2022

A Gene-Based Capture Assay For Surveying Patterns Of Genetic Diversity And Insecticide Resistance In A Worldwide Group Of Invasive Mosquitoes, Matthew L. Aardema, Michael G. Campana, Nicole E. Wagner, Francisco C. Ferreira, Dina M. Fonseca

Department of Biology Faculty Scholarship and Creative Works

Understanding patterns of diversification, genetic exchange, and pesticide resistance in arthropod disease vectors is necessary for effective population management. With the availability of next-generation sequencing technologies, one of the best approaches for surveying such patterns involves the simultaneous genotyping of many samples for a large number of genetic markers. To this end, the targeting of gene sequences of known function can be a cost-effective strategy. One insect group of substantial health concern are the mosquito taxa that make up the Culex pipiens complex. Members of this complex transmit damaging arboviruses and filariae worms to humans, as well as other pathogens …

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Three-Dimensional Mesenchymal Stem Cell Laden Scaffold Of Icariin Sustained-Release For Bone Regeneration, Yanbing Liu, Yan Fang Jan 2022

Three-Dimensional Mesenchymal Stem Cell Laden Scaffold Of Icariin Sustained-Release For Bone Regeneration, Yanbing Liu, Yan Fang

Turkish Journal of Biology

Background/aim: Icariin (ICA)-loaded zein/PLGA nanofiber membrane combined with MSCs was prepared by coaxial electrospinning and bioelectrospraying. Materials and methods: SEM and TEM were used to evaluate the surface morphology and microstructure of the fiber membrane. Ultraviolet spectrophotometry was used to detect drug release. A LIVE/DEAD Viability/Cytotoxicity Kit and fluorescence staining were used to detect cell morphology and activity. Alkaline phosphatase and calcium mineralization deposition were used to evaluate the osteoinductive activity of the scaffold. Dynamic mechanical analysis was used to determine the Young's modulus, maximum load, and maximum elongation of the prepared scaffold. Western blot was used to detect the …

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Assessment Of Digital Imaging Flow Cytometry In Its Application Of Harmful Algal Blooms Monitoring, Melissa Mazzaro Jan 2022

Assessment Of Digital Imaging Flow Cytometry In Its Application Of Harmful Algal Blooms Monitoring, Melissa Mazzaro

Theses, Dissertations and Culminating Projects

As harmful algal blooms (HABs) are becoming an increasing global threat to the health of people, animals, and aquatic ecosystems, finding ways to efficiently detect and manage blooms is critical. Traditional methods of identifying and enumerating phytoplankton cells involve light microscopy; however, this is a time-consuming and labor-intensive process. Meanwhile, digital imaging flow cytometry is a relatively novel and rapid method of enumerating and identifying particles within phytoplankton samples. Previous studies have documented comparable digital flow cytometry results to microscopy results; however, there are concerns relating to the underestimation of cells and misidentification of particles with their automated classification systems. …

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Evaluation Of Aquatic Plant Survey Methods For Efficacy In Invasive Species Detection, Izaac Cooper Jan 2022

Evaluation Of Aquatic Plant Survey Methods For Efficacy In Invasive Species Detection, Izaac Cooper

Legacy Theses & Dissertations (2009 - 2024)

Aquatic invasive plants can often be ecologically devastating to ecosystems where they are introduced. This devastation has been widely apparent in the United States, including many locations in New York State over many decades, following anthropogenic transport of species from their native ranges. Due to the difficulty involved in eradicating these plants once they have become fully established, there is keen interest in strategies for early detection to assist with prevention and monitoring to mitigate future management costs. Invasive species detection research aims to find methods for detecting new invaders more effectively. I evaluated three detection methods for their effectiveness …

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Mechanisms Underlying Pre- And Postnatal Development Of The Mouse Vomeronasal Organ, Raghu Ram Katreddi Jan 2022

Mechanisms Underlying Pre- And Postnatal Development Of The Mouse Vomeronasal Organ, Raghu Ram Katreddi

Legacy Theses & Dissertations (2009 - 2024)

The Vomeronasal organ (VNO) is a specialized olfactory sensory organ located in the ventral region of the nasal cavity in rodents. The vomeronasal epithelium (VNE) of rodents is composed of 2 major types of vomeronasal sensory neurons (VSNs): 1) VSNs distributed in the apical VNE regions that express vomeronasal type-1 receptors (V1Rs) and the G protein subunit Gi2, and 2) VSNs in the basal territories of the VNE that express vomeronasal type-2 receptors (V2Rs) and the G subunit Go. Besides these two neuronal types, VNE also accommodate a third non-neuronal cell type called Sustentacular cells that lie anatomically above apical …

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Synthesis Of Oligonucleotides Containing Unnatural Backbone And Regulation Of Crispr Activity Using Inverse Electron Demand Diels-Alder Chemistry, Alyssa Hoy Jan 2022

Synthesis Of Oligonucleotides Containing Unnatural Backbone And Regulation Of Crispr Activity Using Inverse Electron Demand Diels-Alder Chemistry, Alyssa Hoy

Legacy Theses & Dissertations (2009 - 2024)

This thesis describes the synthesis of an oligonucleotide containing an unnatural neutralbackbone. The backbone was constructed using bio-orthogonal inverse electron demand Diels- Alder chemistry between trans-cyclooctene (TCO) and tetrazine (Tz). A TCO phosphoramidite was synthesized and attached to solid support for strand propagation. Uridine monomers containing either bis-TCO or bis-Tz were also synthesized. The oligonucleotide strand was formed by sequential ligation of the bis-Tz and bis-TCO monomers. The oligonucleotide was analyzed using mass spectrometry. This thesis also describes the synthesis of sgRNAs containing non-canonical nucleobases, m1A, m6A, s2U and s4U using the ‘split-and-click’ methodology. The synthetic sgRNAs were assembled using …

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Rna-Seq Data Analysis Of A Human Lung Carcinoma Cell Line (A549) And Investigating The Role Of Nf-Kappa B As An Effector Of Atf3 During Zika Virus Infection, Theodora Pearl De-Veer Jan 2022

Rna-Seq Data Analysis Of A Human Lung Carcinoma Cell Line (A549) And Investigating The Role Of Nf-Kappa B As An Effector Of Atf3 During Zika Virus Infection, Theodora Pearl De-Veer

Legacy Theses & Dissertations (2009 - 2024)

The 2015 Zika virus (ZIKV) outbreak amassed international concern due to its association with the high incidence of devastating neurological conditions- microcephaly and Guillain-Barré Syndrome. Reportedly affecting over 5,000 fetal newborns, imaging studies have unveiled the pernicious effects of ZIKV infection on the fetal brain, which include cortical malformations, micrencephaly, hydrocephalus, and focal inflammation.

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Fluorescent Biosensors : Engineering And Applications, Monica Rodriguez Jan 2022

Fluorescent Biosensors : Engineering And Applications, Monica Rodriguez

Legacy Theses & Dissertations (2009 - 2024)

Neurons in the brain communicate via electrical and chemical synapses, whereneurotransmitters are released. Traditional methods to detect synaptic transmission rely on single-cell patch-clamp recordings from target neurons, but these can only provide an indirect readout of the lifetime of neurotransmitters in the extracellular space. More recently, this task has been aided by developing fluorescent biosensors with high sensitivity and large dynamic ranges. Fluorescent biosensors are typically composed of a neurotransmitter binding protein tagged with fluorescent reporter molecules. Fluorescence biosensors come in different forms, including FRET-based biosensors. These can be built using different intracellular signaling molecules and neurotransmitter binding domains. Here, …

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Analysis Of Mitochondrial Codon Usage, Shelina Begum Jan 2022

Analysis Of Mitochondrial Codon Usage, Shelina Begum

Legacy Theses & Dissertations (2009 - 2024)

The human mitochondrial genome is circular and encodes for its own two ribosomal RNAs, 22 tRNAs and 13 proteins needed for oxidative phosphorylation. Although the mitochondria require nuclear proteins and machinery for transcription and translation, the translation of 13 mRNAs occurs within the mitochondria. The dysregulation of mitochondrial translation is associated with diseases like MELAS (Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) and MERRF (Myoclonic epilepsy with ragged-red fibers), which can be caused by tRNA defects and lead to decreased translation of mitochondrial complex I proteins (MELAS). We have analyzed the codon usage of human mitochondrial genes and compared them …

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Genomic Epidemiology Of Clinical Salmonella Enterica In New Hampshire, 2017-2020, Madison R. Turcotte Jan 2022

Genomic Epidemiology Of Clinical Salmonella Enterica In New Hampshire, 2017-2020, Madison R. Turcotte

Legacy Theses & Dissertations (2009 - 2024)

Antimicrobial resistance in Salmonella enterica remains a challenging public health threat. We aim to characterize the population structure and evolutionary history of 394 genomes of S. enterica isolates recovered from human clinical cases in New Hampshire, USA from 2017 to 2020. The population is phylogenetically diverse, consisting of 78 STs and 67 serotypes. We detected 61 genes associated with resistance to14 different antimicrobial classes. Rather than a single multidrug resistant clone expanding in the state, we found multiple lineages carrying different combinations of independently acquired resistance determinants. New or emerging lineages can therefore rapidly spread over relatively short timeframes. In …

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Length–Weight Relation For Seven Neotropical Freshwater Fish Species (Actinopterygii) Endemic To Central America, Justin C. Bagley, Maria Florencia Breitman, Jerald B. Johnson Jan 2022

Length–Weight Relation For Seven Neotropical Freshwater Fish Species (Actinopterygii) Endemic To Central America, Justin C. Bagley, Maria Florencia Breitman, Jerald B. Johnson

Research, Publications & Creative Work

In the presently reported study, we estimated length–weight relation (LWRs) for seven species of freshwater fishes from Central America. Samples were collected using seines from 60 sites across Nicaragua, Costa Rica, and Panama during field expeditions conducted between 1997 and 2012. The fishes were preserved and transported to the lab, where their total weight (W) was measured (to nearest 0.0001 g) and standard lengths were taken (to nearest 0.01 mm). Data were collected from four livebearers (Poeciliidae), Alfaro cultratus (Regan, 1908), Phallichthys amates (Miller, 1907), Poecilia gillii (Kner, 1863), and Priapichthys annectens (Regan, 1907); the cichlids (Cichlidae), Parachromis dovii (Günther, …

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Supplement : Abstract Proceedings Of The 7th International Congress Of The Molecular Biology Association Of Turkey Jan 2022

Supplement : Abstract Proceedings Of The 7th International Congress Of The Molecular Biology Association Of Turkey

Turkish Journal of Biology

No abstract provided.

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Doxorubicin-Induced Transcriptome Meets Interactome: Identification Of New Drug Targets, Hi̇lal Taymaz-Ni̇kerel Jan 2022

Doxorubicin-Induced Transcriptome Meets Interactome: Identification Of New Drug Targets, Hi̇lal Taymaz-Ni̇kerel

Turkish Journal of Biology

The working mechanism of the chemotherapeutic drug doxorubicin, which is frequently used in cancer treatment, its effects on cell metabolism, and pathways activated solely by doxorubicin are not fully known. Understanding these principles is important both in improving existing therapies and in finding new drug targets. Here, I describe a systems-biology approach to find a generalizable working principle for doxorubicin by superimposition of human interactome over gene datasets commonly expressed among various cancer types. The common ?in at least two different diseases?transcriptional response of distinctive cancer cell lines to doxorubicin was reflected via 199 significantly and differentially expressed genes, mostly …

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Analyzing The Viability Of Direct Pcr For Use In Conjunction With Cyanoacrylate Enhanced Fingerprints, Coral M. Smith Jan 2022

Analyzing The Viability Of Direct Pcr For Use In Conjunction With Cyanoacrylate Enhanced Fingerprints, Coral M. Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

Efficient methods for DNA analysis are desperately needed in laboratories due to the influx in DNA analysis requests. The current DNA processing methods are costly, time consuming, and involve multiple tube changes, increasing the risk of contamination. However, the use of direct PCR can simplify the DNA analysis process by eliminating the extraction, purification and quantitation steps. Presently, the FBI Quality Assurance Standard 9.4 requires all evidence samples to be quantitated. As a result, the direct PCR method of DNA processing cannot be implemented on evidence samples at this time. Direct PCR presents the opportunity to provide efficient DNA analysis, …

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Cancer Testis Antigen Pasd1 Expression And Immunogenicity In Human Colorectal Cancer And Polyps, Nur Fazilah Sukor, Azyani Yahaya, Ismail Sagap, Rahman Jamal, Nor Adzimah Johdi Jan 2022

Cancer Testis Antigen Pasd1 Expression And Immunogenicity In Human Colorectal Cancer And Polyps, Nur Fazilah Sukor, Azyani Yahaya, Ismail Sagap, Rahman Jamal, Nor Adzimah Johdi

Turkish Journal of Biology

Colorectal cancer (CRC) is a malignant tumor arising from a human inner colon lining that may spread to other organs such as the liver and lungs. Per ARNT Sim domain containing 1 (PASD1) is a cancer-testis antigen expressed in cancers including CRC but not in normal tissues except for normal testes. This study aims to study PASD1 protein as a potential target for CRC immunotherapy. A total of 90 CRC and polyps tissue samples were investigated for PASD1 RNA and protein expression using a real-time polymerase chain reaction and immunohistochemical staining, respectively. Matched patients? peripheral blood mononuclear cells were pulsed …

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Xpo1 As A Therapeutic Target In Gastric Cancer, Rachel Sexton Jan 2022

Xpo1 As A Therapeutic Target In Gastric Cancer, Rachel Sexton

Wayne State University Dissertations

Gastric cancer is a leading cause of cancer related deaths worldwide. Throughout the world, there is around one million new diagnosed cases per year and only an approximate 25% survival rate. This disease is highly heterogeneous, chemotherapy resistant and deadly. Currently there is no gold standard for care but rather it is physician’s choice. Various chemotherapeutic agents can be used including microtubule inhibitors, DNA damaging agents and anti-metabolite compounds. We have found that nuclear export protein 1 (XPO1) is overexpressed in gastric cancer patients and cell lines compared to normal gastric tissues leading to an aggressive cancerous phenotype that is …

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A Serological Analysis Of Sars-Cov-2 Infection In The Obstetric Population, Sophia Rose Jan 2022

A Serological Analysis Of Sars-Cov-2 Infection In The Obstetric Population, Sophia Rose

CMC Senior Theses

In December 2019, the surfacing and spread of a novel coronavirus, SARS-CoV-2, resulted in the global COVID-19 pandemic. As a viral antigen, SARS-CoV-2 poses a particular threat to the obstetric population due to physiological and immunological changes that women face during pregnancy. While recent studies have found that SARS-CoV-2 may have better clinical outcomes as compared to other betacoronaviruses, adverse pregnancy events such as ICU admission, preeclampsia, and/or preterm birth have been associated with COVID-19. Progress has been made in better understanding the pathophysiology of SARS-CoV-2 in pregnancy, but there is still much to be known about the interaction …

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Physician Assisted Dying (Pad): An Investigation Into The Mechanistic Action Of Opioid, Benzodiazepine, And Barbiturate Administration As An Alternative Measure To Forgoing Life Sustaining Treatment And Aggressive Palliation., Jordana Chanel Deighton Jan 2022

Physician Assisted Dying (Pad): An Investigation Into The Mechanistic Action Of Opioid, Benzodiazepine, And Barbiturate Administration As An Alternative Measure To Forgoing Life Sustaining Treatment And Aggressive Palliation., Jordana Chanel Deighton

CMC Senior Theses

Whilst modern medicine has increased longevity, the rise in life expectancy has brought about new struggles, namely that of aging and age related disease. Thus, humanity has been presented with a new problem: at what point is death preferable to aggressive life-prolonging treatment in the face of inevitable death? And if so, what right do individuals have to control the circumstances of their death? In the West, traditionally, individuals who seek to end their own lives in the face of terminal illness opt for forgoing artificial hydration and nutrition. Driven by an increase in desire for autonomous dignified death, a …

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Effects Of Drought On Habitat Quality For Native Bees In Residential Gardens Of Claremont, Ca, Max Proctor Jan 2022

Effects Of Drought On Habitat Quality For Native Bees In Residential Gardens Of Claremont, Ca, Max Proctor

CMC Senior Theses

Over 1,500 of the 4000 bee species found in North America inhabit California. Native bees are declining however, largely due to climate change and agricultural intensification. Previous research shows that cities can sustain diverse bee communities, due to the diversity of ornamental flowers. Urban green space represents an opportunity for native bee conservation. Residential gardens provide lots of green space and are urban pollinator hotspots. Managing yards for increased floral resources and nesting habitat can benefit native bee communities. Turfgrass provides few floral or nesting resources and negatively correlates with bee diversity. The 2011-2017 California drought caused many homeowners to …

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Time Course Investigation Of The Dermal Leukocyte Response To Lipoteichoic Acid In Chickens, Ian M. Gilbert, Jossie M. Santamaria, Gisela F. Erf Jan 2022

Time Course Investigation Of The Dermal Leukocyte Response To Lipoteichoic Acid In Chickens, Ian M. Gilbert, Jossie M. Santamaria, Gisela F. Erf

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Lipoteichoic acid (LTA) is a cell-wall polymer in Gram-positive bacteria that stimulates inflammation. Few studies have investigated in vivo immune response to LTA, and none of the in vivo studies have been performed in birds. For this project, the pulp (a skin derivative) of growing feathers (GF) of chickens was used to investigate the in vivo effects of intradermally injected LTA. In Study 1, GF of chickens were injected with 10 μL of differing concentrations of LTA (0.1, 1.0, 10, 100 or 250 μg LTA/mL; 3 chickens/dose). Growing feathers were plucked before injection (0 h) and at 6, 24, 48, …

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