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2017

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Articles 751 - 780 of 1882

Full-Text Articles in Biology

Livin’ On A Prayer: An Analysis Of Intercessory Prayer Studies, Savannah Vincent May 2017

Livin’ On A Prayer: An Analysis Of Intercessory Prayer Studies, Savannah Vincent

Dialogue & Nexus

A meta-analysis of intercessory prayer studies was done. Current studies fail to account for the numerous variables and limitations posed by these studies; nevertheless, it is possible to reach the conclusion that the prospect of prayer as an alternative medicine is, at best, limited. The boundaries of faith and science need to be respected. The essential takeaway from this discussion is to look deeper into what sounds like simple and well-designed scientific studies on faith. These studies are often either inconclusive or have varying results when compared to similar studies.

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Human Evolution And Divine Agency, Alexandra Rakestraw May 2017

Human Evolution And Divine Agency, Alexandra Rakestraw

Dialogue & Nexus

Modern Christians often find themselves at a crossroads when confronted with the two predominant understandings of human and universal origins. Plain sense readings of Genesis lead many to believe in a historical six-day creation that occurred in the past ten thousand years while proponents on the other side of the spectrum use current scientific understanding to support a creation that occurs through evolutionary means. How one views human origins has a profound impact on one’s concept of how God works in the cosmos. In this paper, I will lay out a background to better understand the characters of Adam and …

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Deism Revisited: A Modern Approach, Tina Johnson May 2017

Deism Revisited: A Modern Approach, Tina Johnson

Dialogue & Nexus

An evaluation of the history of Deism and its modern counterpart, Moralistic Therapeutic Deism, in light of Theistic Naturalism is done in order to place the several forms of deism into a proper context in modern society. My hoped for outcome is that perhaps we can view Deism as a progressive rather than an archaic belief system that still has a purpose in American religious culture.

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Moral Awareness, Original Sin And The Atonement, Tanner Gregory May 2017

Moral Awareness, Original Sin And The Atonement, Tanner Gregory

Dialogue & Nexus

I will explore how evolution impacts the Christian notion of The Fall of man, and, ultimately, the atonement. Various theories of atonement in the Christian tradition generally assume universal and individual sinfulness in humanity. In some cases, this sinfulness is thought to be the result of a distinct moment of rebellion against God, and is transmitted to all of the descendants of Adam. Here, atonement involves Christ’s sacrifice as the means liberate humanity from the bondage of our sinful nature. Evolution collides with these traditional models. Instead of a creation originally void of death and later corrupted by sin, evolution …

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Mollifying Neuroscience And Christian Faith: An Emergent Monistic Claim For Free Will And The Soul, Paul Figel May 2017

Mollifying Neuroscience And Christian Faith: An Emergent Monistic Claim For Free Will And The Soul, Paul Figel

Dialogue & Nexus

Modern neuroscience makes it difficult for one to support a case for substance dualism regarding the existence of a soul and free will. The neuroscientific evidence stems from several experiments in which test subjects were instructed to perform a simple voluntary movement. Scientists consistently observed neurological antecedents preceding the subject’s conscious decision to perform the action. An examination of these experiments and the conclusions drawn will show several key inconsistencies that weaken the extreme anti-conscious will claim. However, it is important to not reject the neurological evidence against substance dualism, but instead discover a new perspective (e.g. emergent monism) that …

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End Of Life Care For The Incarcerated, Codie Robinson May 2017

End Of Life Care For The Incarcerated, Codie Robinson

Dialogue & Nexus

As the prison population ages, a new need has come to light – caring for those who are in the final stage of life. This paper will examine the current end of life services provided to those in prison throughout the United States. After a general awareness of the system is presented, a more complete discussion of end of life care for prisoners will be considered, in light of ethics, social justice, and the Christian perspective. The two care options presented, hospice care and compassionate release, are observed through these lenses. In order to make a decision on how to …

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Race Relations: A Dialogue Between Science And Theology On The Basis Of Race, Shanice Latham May 2017

Race Relations: A Dialogue Between Science And Theology On The Basis Of Race, Shanice Latham

Dialogue & Nexus

When the topic of race is breached the emotions expressed can range from extreme feelings of guilt to extreme feelings of anger. Why is a word that is, today, commonly associated with a person’s skin color and other physical characteristics responsible for such strong emotional reactions? Much of the violence, poverty, injustice, and hurt in the world has been and is caused by racial division. With the continued use of such an arbitrary system as race these issues will continue to persist and deteriorate. This paper will explore the origin, as well as scientific and theological perspectives of race and …

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Feminism In Biology And Belief, Rachel Hurst May 2017

Feminism In Biology And Belief, Rachel Hurst

Dialogue & Nexus

As feminism has become more hotly-contested in today’s society, the need to analyze the movement’s claims from a scientific and theological perspective has developed. Labor statistics and sociological research reveal that income inequality persists between the sexes. Neuroscience and evolutionary psychology show that subtle differences exist between male and female brains, and these slight variations can potentially be traced to the differing selective pressures between the genders. Ultimately, the biological differences that favor power differentials must be overcome to remedy inequality and injustice. Although Christians have historically upheld these differences and viewed women as inferior, a more modern theological understanding …

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“Bone Of My Bones And Flesh Of My Flesh”: A Feminist Analysis Of Christianity, Evolutionary Theory, And The Provenance Of Patriarchy, Heather Bishop May 2017

“Bone Of My Bones And Flesh Of My Flesh”: A Feminist Analysis Of Christianity, Evolutionary Theory, And The Provenance Of Patriarchy, Heather Bishop

Dialogue & Nexus

While perceived by many as conflicting in nearly every sphere, science and religion both play an important role in the promotion of patriarchal ideologies. My research has found that neither Christianity nor evolutionary theory are inherently patriarchal, neither do they justify patriarchy. Instead, it is the misinterpretation and misuse of these subjects that contribute to the justification of patriarchy for the deep-seated goal of reproductive power. I will show this by analyzing theological themes present throughout the Christian scriptures, as well as investigating findings of evolutionary psychology and hominid ancestry. The implication of this study is that there is no …

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Science And Religion On Sexual Orientation, A.N. Scout May 2017

Science And Religion On Sexual Orientation, A.N. Scout

Dialogue & Nexus

An analysis of scientific and religious perspectives on sexual orientation will show that the scientific data support a biological origin of sexual orientation that is influenced but not determined by environmental conditions. Religious perspectives will show values affirming equality and integrity are of greater importance than the conditioned attitudes that condemn homosexuality. As a result, forgiveness and acceptance are paramount in dealing with others as they struggle to know Christ. Commitment within a relationship is paramount regardless of the couple’s orientation.

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Science, God, And Sexual Orientation, Devin Baker May 2017

Science, God, And Sexual Orientation, Devin Baker

Dialogue & Nexus

Sexual orientation is a modern and complex term for sexual attractions and behaviors that have been experienced throughout history. Science and religion have both taken stances on the origin and ethics of sexual orientation. Research done in both fields has begun to shed light on the fact that there is an innate biological cause for sexual orientation, and that the Bible might offer a more positive view on non-heterosexual orientations than previously thought.

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Volume 3 Editorial, Daniel Brannan May 2017

Volume 3 Editorial, Daniel Brannan

Dialogue & Nexus

No abstract provided.

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Strong Linkages Between Surface And Deep-Water Dissolved Organic Matter In The East/Japan Sea, Tae-Hoon Kim, Guebuem Kim, Yuan Shen, Ronald Benner May 2017

Strong Linkages Between Surface And Deep-Water Dissolved Organic Matter In The East/Japan Sea, Tae-Hoon Kim, Guebuem Kim, Yuan Shen, Ronald Benner

Faculty Publications

Vertical and horizontal distributions of total dissolved amino acids (TDAAs), dissolved organic carbon (DOC), and dissolved organic nitrogen (DON) were measured in the East/Japan Sea (EJS). The euphotic zone of this sea is N-limited, and the N : P ratio is ∼ 13 below 200 m depth. Elevated TDAA concentrations (137 ± 34 nM) and DOC-normalized yields (0.8 ± 0.2 % of DOC) were observed in deep waters ( ≥  1000 m) of the EJS and compared with those in the deep North Pacific Ocean. Significantly high TDAA concentrations and yields were observed in a region of deep-water formation, indicating …

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Sexual Selection, Speciation And Constraints On Geographical Range Overlap In Birds, Christopher Cooney, Joseph A. Tobias, Jason T. Weir, Carlos A. Botero, Nathalie Seddon May 2017

Sexual Selection, Speciation And Constraints On Geographical Range Overlap In Birds, Christopher Cooney, Joseph A. Tobias, Jason T. Weir, Carlos A. Botero, Nathalie Seddon

Biology Faculty Research

The role of sexual selection as a driver of speciation remains unresolved, not least because we lack a clear empirical understanding of its influence on different phases of the speciation process. Here, using data from 1306 recent avian speciation events, we show that plumage dichromatism (a proxy for sexual selection) does not predict diversification rates, but instead explains the rate at which young lineages achieve geographical range overlap. Importantly, this effect is only significant when range overlap is narrow (< 20%). These findings are consistent with a ‘differential fusion’ model wherein sexual selection reduces rates of fusion among lineages undergoing secondary contact, facilitating parapatry or limited co-existence, whereas more extensive sympatry is contingent on additional factors such as ecological differentiation. Our results provide a more mechanistic explanation for why sexual selection appears to drive early stages of speciation while playing a seemingly limited role in determining broad-scale patterns of diversification.

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Mitigating The Conflict Between Pitfall-Trap Sampling And Conservation Of Terrestrial Subterranean Communities In Caves, Peter Kozel, Tanja Pipan, Nina Šajna, Slavko Polak, Tone Novak May 2017

Mitigating The Conflict Between Pitfall-Trap Sampling And Conservation Of Terrestrial Subterranean Communities In Caves, Peter Kozel, Tanja Pipan, Nina Šajna, Slavko Polak, Tone Novak

International Journal of Speleology

Subterranean habitats are known for their rich endemic fauna and high vulnerability to disturbance. Many methods and techniques are used to sample the biodiversity of terrestrial invertebrate fauna in caves, among which pitfall trapping remains one of the most frequently used and effective ones. However, this method has turned out to be harmful to subterranean communities if applied inappropriately. Traditionally, pitfall traps have been placed in caves solely on the ground. Here we present an optimized technique of pitfall trapping to achieve a balance between sampling completeness and minimal disturbance of the fauna in the cave. Monthly we placed traps …

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Effective Population Size, Demography, And Viability Of Eastern Massasaugas (Sistrurus Catenatus) In Southwest Michigan, Danielle R. Bradke May 2017

Effective Population Size, Demography, And Viability Of Eastern Massasaugas (Sistrurus Catenatus) In Southwest Michigan, Danielle R. Bradke

Masters Theses

As humans increasingly exploit natural areas, wildlife populations face a growing number of threats that often result in population decline and isolation. Small, isolated populations are vulnerable to extirpation due to both genetic and demographic factors. Yet, low detectability of many imperiled species often precludes the collection of population-level data important for assessing population viability and implementing successful conservation. The eastern massasauga (Sistrurus catenatus) is a cryptic pitviper that has been extirpated throughout much of its historic range due to agricultural conversion of wetland habitat and other synergistic threats. Consequently, this species is federally listed as threatened in both the …

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Structural, Biophysical, And Functional Studies Of Trem2 In Neurodegenerative Disease, Daniel L. Kober May 2017

Structural, Biophysical, And Functional Studies Of Trem2 In Neurodegenerative Disease, Daniel L. Kober

Arts & Sciences Graduate Student Theses and Dissertations

Alzheimer's disease (AD) and other neurodegenerative diseases present a large and growing challenge to global health. The immune system, particularly the innate immune system, is increasingly recognized as having a major role in these pathologies. The innate immune system is responsible to contain disease and promote healing. However, immune misregulation exacerbates disease. The innate immunomodulatory receptor Triggering receptor expressed on myeloid cells-2 (TREM2) is expressed on myeloid cells such as dendritic cells, macrophages, and in the brain, on microglia. TREM2 is a single-pass transmembrane receptor with an extracellular Ig domain that mediates ligand binding. This protein regulates inflammation in vitro …

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Regulation Of The Pro-Tumorigenic Senescence-Associated Secretory Phenotype, Kevin Flanagan May 2017

Regulation Of The Pro-Tumorigenic Senescence-Associated Secretory Phenotype, Kevin Flanagan

Arts & Sciences Graduate Student Theses and Dissertations

Tumorigenesis results from the convergence of cell autonomous mutations and corresponding stromal changes that promote tumor cell growth. Mutations and stromal changes both accumulate with age and together account for the dramatic increase in cancer incidence with age. One change that occurs with age is the accumulation of stromal senescent cells. Senescent stromal cells secrete pro-tumorigenic factors collectively termed the senescence-associated secretory phenotype (SASP). The SASP impacts every stage of tumorigenesis and is a promising therapeutic target. As such, it is important to understand how the SASP is regulated. Many but not all SASP factors are regulated transcriptionally by NF-kB …

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Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming, Michael Buck May 2017

Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming, Michael Buck

Arts & Sciences Graduate Student Theses and Dissertations

Activated effector T (TE) cells augment anabolic pathways of metabolism, such as aerobic glycolysis, while memory T (TM) cells engage catabolic pathways, like fatty acid oxidation (FAO). However, signals that drive these differences remain unclear. Mitochondria are metabolic organelles that actively transform their ultrastructure. Therefore, we questioned whether mitochondrial dynamics controls T cell metabolism. We show that TE cells have punctate mitochondria, while TM cells maintain fused networks. The fusion protein Opa1 is required for TM, but not TE cells after infection, and enforcing fusion in TE cells imposes TM cell characteristics and enhances antitumor function. Our data suggest that, …

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Factors That Contribute To De Novo Protein Misfolding And Prion Formation In Saccharomyces Cerevisiae, Kathryn Morgan Keefer May 2017

Factors That Contribute To De Novo Protein Misfolding And Prion Formation In Saccharomyces Cerevisiae, Kathryn Morgan Keefer

Arts & Sciences Graduate Student Theses and Dissertations

Protein misfolding is a common phenomenon that can have severe consequences on cellular and organismal health. Despite this, the causes of protein misfolding remain poorly understood. Prions are a class of proteins that, when misfolded, can convert other molecules into a heritable, non-native conformation. The yeast Saccharomyces cerevisiae naturally harbors several diverse prion-forming proteins; thus, it is an ideal model with which to investigate the factors that influence misfolding and aggregation.This thesis utilizes the yeast prions [PSI+] and [RNQ+] to investigate two distinct steps of the protein misfolding pathway: interactions with chaperones and their cofactors, and heterologous templating by other …

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The Role Of Rna Interference In The Control Of Leishmania Rna Virus 1 Infection, Erin Acino Brettmann May 2017

The Role Of Rna Interference In The Control Of Leishmania Rna Virus 1 Infection, Erin Acino Brettmann

Arts & Sciences Graduate Student Theses and Dissertations

The presence of Leishmania RNA virus 1 (LRV1) in parasites of the Leishmania (Viannia) subgenus increases the virulence of the parasite in mouse models of leishmaniasis and is correlated with treatment failure, relapse, and the development of mucocutaneous disease in humans. LRV1 is not shed or infectious; rather, the infection is persistent, and as yet it is unknown how the parasite controls virus levels. Many eukaryotic organisms use RNA interference (RNAi) to limit virus replication, and Leishmania (Viannia) parasites have an active RNAi pathway. To determine whether Leishmania are capable of using RNAi to control LRV1, we sequenced sRNAs from …

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The Effects Of The Gut Microbiota On The Host Chromatin Landscape, Nicholas Semenkovich May 2017

The Effects Of The Gut Microbiota On The Host Chromatin Landscape, Nicholas Semenkovich

Arts & Sciences Graduate Student Theses and Dissertations

The human gut microbiota is home to tens of trillions of microbes belonging to all three domains of life. The structure and expressed functions of this community have myriad effects on host physiology, metabolism, and immune function. My studies focused on a facet of host-microbial interactions and mutualism that has not been explored to a significant degree in part because of the absence of suitable tools: namely, if, when, and how the gut microbiota produces durable effects on host biology through its impact on the epigenome. To address this area, I turned to gnotobiotic mice and developed a variety of …

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Biophysical Studies Of The Intracellular Domains Of The Egfr Family Of Receptor Tyrosine Kinases, Kwabena A N Sarpong May 2017

Biophysical Studies Of The Intracellular Domains Of The Egfr Family Of Receptor Tyrosine Kinases, Kwabena A N Sarpong

Arts & Sciences Graduate Student Theses and Dissertations

The epidermal growth factor receptor and its three orthologues, HER2, HER3 and HER4 have been the subject of intensive basic, clinical and translational research due to their involvement in cancers. These proteins are part of elaborate networks that interact with a myriad of other molecules to effect diverse signaling pathways and affect cellular processes such as migration, apoptosis, cell differentiation and so on. In addition to the formation of preformed dimers, it is well established that ligand engagement leads to receptor dimerization in all family members, except HER2. In the past decade, it has been shown that their intracellular domains …

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Epigenetic Activation Of The Mouse T Cell Receptor Beta Recombination Center, Jiangyang Zhao May 2017

Epigenetic Activation Of The Mouse T Cell Receptor Beta Recombination Center, Jiangyang Zhao

Arts & Sciences Graduate Student Theses and Dissertations

Lymphocytes are the work horses of adaptive immunity. Compared to the B lymphocyte lineage, early stage progenitors of T lymphocytes maintain considerable potential for differentiation into other hematopoietic lineages. T lineage commitment requires the continuous coordination of transcription factors (TFs) by Notch1 signaling after multi-potent progenitors (MPPs) migrate to thymus. One of the first hall marks of T lineage commitment is expression of the T cell receptor β (TCRβ), which is encoded by the Tcrb locus following its assembly by V(D)J recombination, a somatic shuffling of the genome that joins one V, one D, and one J gene segment. Tcrb …

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Functional Brain Organization In Space And Time, Timothy Laumann May 2017

Functional Brain Organization In Space And Time, Timothy Laumann

Arts & Sciences Graduate Student Theses and Dissertations

The brain is a network functionally organized at many spatial and temporal scales. To understand how the brain processes information, controls behavior and dynamically adapts to an ever-changing environment, it is critical to have a comprehensive description of the constituent elements of this network and how relationships between these elements may change over time. Decades of lesion studies, anatomical tract-tracing, and electrophysiological recording have given insight into this functional organization. Recently, however, resting state functional magnetic resonance imaging (fMRI) has emerged as a powerful tool for whole-brain non-invasive measurement of spontaneous neural activity in humans, giving ready access to macroscopic …

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Mitochondrial Damage Accumulation In Oocytes – A Potential Link Between Maternal Obesity And Increased Cardiometabolic Disease Risk In Offspring., Anna Louise Boudoures May 2017

Mitochondrial Damage Accumulation In Oocytes – A Potential Link Between Maternal Obesity And Increased Cardiometabolic Disease Risk In Offspring., Anna Louise Boudoures

Arts & Sciences Graduate Student Theses and Dissertations

The developmental origins of health and disease (DoHAD) hypothesis suggests that negative maternal lifestyle choices, such as obesity, affect the health of her offspring. Clinical and laboratory studies support this hypothesis – offspring born to obese mothers are at increased risk for health conditions including cardiometabolic syndrome and congenital abnormalities. Maternal obesity damages the oocytes, contributing to the increased disease risk by transmitting damaged organelles and epigenetic modifications to the offspring. Mitochondria, the most abundant organelle in the oocyte, are damaged in oocytes from obese females. However, we do not understand if mitochondrial damage in oocytes is reversible nor why …

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Genetic And Genomic Dissections Of Myelinating Glial Cell Development, Breanne Leigh Harty May 2017

Genetic And Genomic Dissections Of Myelinating Glial Cell Development, Breanne Leigh Harty

Arts & Sciences Graduate Student Theses and Dissertations

Myelin is a multilamellar sheath made by specialized glial cells that iteratively spiral and compact their plasma membranes around axon segments. In vertebrate nervous systems, myelination facilitates rapid action propagation and provides trophic support critical for neuronal survival. In the central nervous system (CNS), oligodendrocytes (OLs) extend many processes to simultaneously ensheath multiple axons, while in the peripheral nervous system (PNS), myelinating Schwann cells (SCs) pair 1:1 with a single axon segment. Elaboration of the myelin sheath is one of the most exquisite and complex examples of massive coordinated cellular shape changes in the vertebrate nervous system. Furthermore, the importance …

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Epigenetic Regulation Of Lymphocyte Development And Transformation, Yue Huang May 2017

Epigenetic Regulation Of Lymphocyte Development And Transformation, Yue Huang

Arts & Sciences Graduate Student Theses and Dissertations

Cell identity and function rely on intricately controlled programs of gene regulation, alterations of which underlie many diseases, including cancer. Epigenetic analyses of normal and diseased cells have started to elucidate different facets of epigenetic mechanisms for gene regulation. These include changes in nucleosome density, histone modifications, factor binding and chromosomal architecture. All of these aspects contribute to the activities of regulatory elements conferring promoter, enhancer and insulator functions and the cis-regulatory circuits formed by these elements. Despite this progress, an urgent need remains to profile these features and to study how they cooperatively function in normal and pathogenic settings. …

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Mechanisms Of G Protein Regulation By Rgs Proteins And Small Molecule Inhibitors, Stanley Michinobu Kanai May 2017

Mechanisms Of G Protein Regulation By Rgs Proteins And Small Molecule Inhibitors, Stanley Michinobu Kanai

Arts & Sciences Graduate Student Theses and Dissertations

G protein coupled receptors transduce diverse extracellular signals like hormones, neurotransmitters, and photons to specific cellular responses through heterotrimeric G proteins. G proteins activate numerous effectors and signal transduction pathways, and therefore the regulation of G proteins is crucial for faithful propagation of specific cellular and physiological responses. A better understanding of the mechanisms that regulate G proteins should provide new insight into signaling pathways that govern healthy and disease states, and also provide opportunities for discovery of novel therapeutic targets.Regulator of G protein signaling (RGS) proteins are crucial regulators of G proteins, for they control amplitude and duration of …

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The Rpl13a Snorna U33 Forms Novel Snornps During Lipotoxicity, Miquia Sherree Henderson May 2017

The Rpl13a Snorna U33 Forms Novel Snornps During Lipotoxicity, Miquia Sherree Henderson

Arts & Sciences Graduate Student Theses and Dissertations

Lipid overload contributes to the pathogenesis of diabetic complications, causing tissue damage and cell death in a number of organ systems. This process is termed lipotoxicity. Animal and cell culture studies have demonstrated that oxidative stress and endoplasmic reticulum stress are major pathways engaged in the lipotoxic response. However, the molecular mechanisms of lipotoxicity are not well understood. A genetic screen revealed that small nucleolar RNAs (snoRNAs) encoded in the introns of the Rpl13a locus are critical for cell death in response to lipotoxicity. Initial studies have suggested that the Rpl13a snoRNAs function in this pathway through non-canonical modes of …

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