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Articles 451 - 480 of 498
Full-Text Articles in Biology
The Effects Of Omega-3 Fatty Acids On Saccharomyces Cerevisiae Inositol Pathway Mutants, Daniel Antonio Colon Hidalgo, Marlene Murray-Nseula
The Effects Of Omega-3 Fatty Acids On Saccharomyces Cerevisiae Inositol Pathway Mutants, Daniel Antonio Colon Hidalgo, Marlene Murray-Nseula
Honors Theses
Bipolar disease is a severe and chronic debilitating mental disorder affecting 1-3% of the population. Omega-3-fatty acids have been shown to relieve symptoms of bipolar disorder and are not associated with the negative side effects of lithium and valproate, two of the commonly used drugs for treating this condition. The mechanism of action of omega-3-fatty acids remains unknown. Therefore the purpose of this study was to determine if, like lithium and valproate, omega-3-fatty acids affect inositol metabolism. This was accomplished by investigating the effect of the omega-3-fatty acid docosahexanoic acid (DHA) on the growth of inositol pathway mutants. To measure …
Microbial Stoichiometry And Homeostasis Of Nutrient Ratios In Fungi, Desiree Leach
Microbial Stoichiometry And Homeostasis Of Nutrient Ratios In Fungi, Desiree Leach
Honors Theses
Stoichiometry is the ratio of elements in a substance or microbial biomass. This paper investigates microbial stoichiometry and the responses of microbes to dissolved nutrient concentrations and ratios. The current work assesses both autrotrophic and heterotrophic responses to nutrient enrichment: autotrophic and heterotrophic states are defined mainly by ecosystem primary production and respiration. In ecosystems dominated by autotrophic microbes, nutrient enrichment can lead to increased biomass and biomass-specific rates of primary production. Heterotrophic ecosystems rely on subsides of organic carbon from outside the system. Their enrichment with N and/or P can accelerate microbial respiration rates and result in carbon losses …
Growth Rate Of Mugil Cephalus From Two Isolated Ponds In Huntington Beach State Park, South Carolina, Matthew Vincent
Growth Rate Of Mugil Cephalus From Two Isolated Ponds In Huntington Beach State Park, South Carolina, Matthew Vincent
Honors Theses
Measurement of growth of the euryhaline teleost Mugil cephalus is quite common in open ocean settings, but growth rates of M. cephalus in isolated areas is non-existent. Two isolated ponds in Huntington Beach State, Horry County, South Carolina were selected to study the growth rate of M. cephalus; Sandpiper Pond with virtual no hydrologic connection to the ocean and Jetty Pond with adequate hydrologic connection to the ocean were the sites of sample collection. Scales from M. cephalus in both ponds were collected then aged by two readers, where agreeing ages were kept in the dataset. A von Bertalanffy growth …
A River Palimpsest: The Interdisciplinary Value Of Water, Katie Norris
A River Palimpsest: The Interdisciplinary Value Of Water, Katie Norris
Honors Theses
Water is an invaluable natural resource to both human and ecological communities, and is currently threatened by global and local pollution and availability. Hypoxia, climate change and local issues all strain river systems to beyond repair. In light of this, communities and scientists must come together to understand the quality and value of natural resources, such as the Great Miami River, in order to inform policy, management and societal perceptions. The overall purpose of this thesis research project is to utilize interdisciplinary areas together to create a valuable, spatially lateral and chronological baseline picture of the Great Miami River. The …
The Role Of Taabf1 In Abscisic Acid-Mediated Suppression Of 𝒶-Amylase Gene Expression In Cereal Grains, Lauren J. Harris
The Role Of Taabf1 In Abscisic Acid-Mediated Suppression Of 𝒶-Amylase Gene Expression In Cereal Grains, Lauren J. Harris
Honors Theses
The phytohormones gibberellin (GA) and abscisic acid (ABA) regulate important developments events in germinating seeds. Specifically, GA induces the expression of hyrolase genes, like the α-amylase gene Amy32b, which mobilizes starch reserves to be used by the embryo, and ABA suppresses this induction. Recent advancements identified ABA and GA receptors and key components in the signaling pathways, however, the mechanism of crosstalk between the hormones remains largely unknown. To further elucidate the mechanism of ABA suppression of GA-induced genes, we focused on the transcription factor TaABF1, a member of the ABA response element binding factor family. TaABF1 has been shown …
Contribution Of Candida Albicans To The Synthesis Of The Volatile Organic Compound Ethanol In Putrefied Bodies, Chelsey Mozingo
Contribution Of Candida Albicans To The Synthesis Of The Volatile Organic Compound Ethanol In Putrefied Bodies, Chelsey Mozingo
Honors Theses
This experiment sought to determine if Candida albicans contributed to the production of the volatile organic compound ethanol in decomposing beef livers. The results this experiment proved to be inconclusive. This experiment showed no correlation between the amount the presence of Candida albicans and the production of the volatile organic compound ethanol based on the standard addition method. This may be indicative that VOC analysis is not an appropriate method for determining time of death based on a quantitative analysis of volatile organic compounds. However, the experimental design most likely needs be altered to accommodate a more accurate method of …
Identification Of Potentially Pathogenic Yeast Species In Seagull Guano By Molecular Techniques, Tobias L. Banks
Identification Of Potentially Pathogenic Yeast Species In Seagull Guano By Molecular Techniques, Tobias L. Banks
Honors Theses
Although studies have been performed identifying bacteria present in seagull guano, limited studies have been done with fungi, leaving a significant gap in our knowledge of a potentially significant reservoir of human disease. If pathogenic fungi are being deposited by seagulls in their feces then it is possible that the Department of Health might elect to monitor sand, as well as water, for a broad spectrum of disease-causing microbes. Currently only water is tested for the presence of coliform bacteria. It is hypothesized that there are pathogenic yeast-like fungi present in the guano of seagulls, that these fungi are deposited …
The Effect Of Glutamate On Neurite Outgrowth In Fiddler Crab (Uca Pugilator) X-Organ Cells, Ruth B. Langton
The Effect Of Glutamate On Neurite Outgrowth In Fiddler Crab (Uca Pugilator) X-Organ Cells, Ruth B. Langton
Honors Theses
Glutamate is the primary excitatory neurotransmitter in the mammalian central nervous system. It is of particular interest because of its supposed role in the processes of learning and memory, and also because of its potential toxic effects that have been linked to neurodegenerative diseases, such as Alzheimer’s and Parkinson’s. Although glutamate is necessary for normal cell functioning, high levels of glutamate receptor activation can result in cell death, a phenomenon known as excitotoxicity. It has been suggested that glutamate also plays an important role in the insect and crustacean nervous systems, allowing for the examination of excitotoxicity in these organisms. …
Adrenergic Receptor Expression On Raw264.7 Macrophages, Lindsay Ward
Adrenergic Receptor Expression On Raw264.7 Macrophages, Lindsay Ward
Honors Theses
In this study, AR surface expression patterns and regulation via AR-catecholamine interactions were characterized. Macrophage function was shown to be regulated by catecholamines through both Alpha- and Beta-ARs, as evidenced by corresponding alterations in cytokine production. Treatment of activated macrophages with NE, a general catecholamine, or fomoterol, a P-AR agonist, produced significant decreases in TNF and IL-6 secretion. The effecis of clonidine, an Alpha-AR agonist, produced less consistent results, but clonidine-mediated enhancement of cytokine secretion appears to be mediated by Alpha-AR signaling. LPS was shown to noticeably change the surface expression ofboth types of ARs in RAW264.7 macrophages. However, NE …
Exploring The Role Of Iscsua And Suf Operon In Shigella Flexneri Invasion And Resistance To Oxidative Stress, Benjamin R. Lloyd
Exploring The Role Of Iscsua And Suf Operon In Shigella Flexneri Invasion And Resistance To Oxidative Stress, Benjamin R. Lloyd
Honors Theses
Shigella flexneri is a facultative intracellular pathogen capable of causing dysentery, a condition that afflicts many around the world, especially in developing countries. There are several aspects of Shigella pathogenesis that are not well understood, including a number of genetic and cellular changes that allow Shigella to adapt to stresses encountered while invading and replicating within the eukaryotic cytosol. It was the goal of this research to examine the roles of iscSUA and suf, gene systems predicted to encode for iron-sulfur cluster biosynthesis proteins, in Shigella surviving exposure to oxidative stress agents and during Shigella invasion and plaque formation …
Characterization Of Sox Family Members In Sponge Stem Cells And During Development, Karen E. Leeds
Characterization Of Sox Family Members In Sponge Stem Cells And During Development, Karen E. Leeds
Honors Theses
Sponges are considered the oldest and most basal part of the metazoan lineage and therefore possess a unique set of gene families that are highly conserved among all animals. One of these gene families is known as Sox transcription factors. Sox genes are known to play important roles in complex animals such as the specification of the primary layers of the body, determination of sex, and most recently induction of induced pluirpotent stem cells (iPS cells) from both human and mouse fibroblasts with the help of three other transcription factors. We have found that two different demosponge species Halichondria bowerbanki …
Use Of Phylogenetic Stains To Determine The Feeding Preferences Of Microbivorous Soil Nematodes, E. Harlan Michelle
Use Of Phylogenetic Stains To Determine The Feeding Preferences Of Microbivorous Soil Nematodes, E. Harlan Michelle
Honors Theses
Due to their numerous and diverse roles in soil ecological processes – most notably decomposition and nutrient mineralization – nematodes have long been recognized as important biotic indicators of soil health (Ekschmitt et al., 2001; Ritz and Trudgill, 1999). The predominate means of assessing the information that these organisms might contain has been through nematode community analyses, a methodology that seeks to convert the vast amount of data regarding features such as diversity, maturity and richness into a series of indices which can be used to evaluate soil health and make comparisons across samples. Performance of these analyses typically involves …
Cytotoxicity Of Diepoxybutane And Epichlorohydrin In Relation To Stages Of The Cell Cycle, Megan L. Watts
Cytotoxicity Of Diepoxybutane And Epichlorohydrin In Relation To Stages Of The Cell Cycle, Megan L. Watts
Honors Theses
Work conducted in the Millard Biochemistry Research Laboratory examines the dual nature of molecules as carcinogens and anti-tumor agents through the molecular mechanisms of duplex DNA damage by bifunctional alkylating agents. Diepoxybutane (DEB) and epichlorohydrin (ECH) are polar molecules that form covalent DNA interstrand lesions by cross-linking the N7 position of deoxyguanosine residues. A recent experiment indicated that ECH preferentially targets nuclear DNA over mitochondrial DNA, whereas DEB shows similar rates of lesion formation for both loci. It was concluded that preferential targeting of nuclear DNA results from relatively poor uptake of ECH across the mitochondrial membrane. The objective of …
Microhabitat Selection By The Tortoiseshell Limpet, Tectura Testudinalis (Müller), In Tide Pools On The Mid-Maine Coast, Emily R. Lyczkowski
Microhabitat Selection By The Tortoiseshell Limpet, Tectura Testudinalis (Müller), In Tide Pools On The Mid-Maine Coast, Emily R. Lyczkowski
Honors Theses
Microhabitat selection of the limpet Tectura testudinalis, an important grazer along the rocky Maine coast is examined using both mensurative and manipulative experiments. T. testudinalis substrate selection is essential to its survival in the unpredictable and harsh regime of the intertidal zone. At three sites studied in the Gulf of Maine, T. testudinalis selectively inhabits tidal pools and vertically oriented substrates. Both of these microhabitats reduce the degree of environmental stress (desiccation, extreme temperature, and hypersaline conditions) and predation experienced by individuals. Differences among sites are common, indicating the importance of varying environmental factors in regulating and influencing habitat selection …
Modulation Of Fast-Inactivating Potassium Channels By Accessory Subunits And Fatty Acids : A Role For Calcium?, Michelle M. Drzewiecki
Modulation Of Fast-Inactivating Potassium Channels By Accessory Subunits And Fatty Acids : A Role For Calcium?, Michelle M. Drzewiecki
Honors Theses
Potassium channel interacting proteins (KChIPs) co-assemble with Kv4 a subunits to form native complexes that encode considerable components of neuronal somatodendritic A- type K+current (Is,J in neurons, and transient outward current (ho) in cardiac myocytes. The binding of KChIPs to the cytoplasmic N-termini of Kv4 a subunits enhances surface expression by facilitating intracellular trafficking, stimulates subunit assembly, and regulates the functional gating properties of Kv4 channels. KChIPs, like many other neuronal calcium sensor proteins, contain four EF-hand calcium binding sites; two of which (EF-3 and 4) have particularly high affinity for calcium. Because Ca2+ is an important signaling molecule for …
The Exploration Of Novel Symbiotic Bacteria That May Have Influential Roles In Sponge Life History, Brittany E. West
The Exploration Of Novel Symbiotic Bacteria That May Have Influential Roles In Sponge Life History, Brittany E. West
Honors Theses
Sponges produce an impressive variety of secondary metabolites that perform a variety of ecological functions. Many marine sponges even harbor diverse carotenoid compounds, an unusual class of secondary metabolites that animals are incapable of producing. Furthermore, sponges serve as hosts to an astonishingly diverse microbial community that can occupy up to sixty percent of a sponge's biomass. Our research ultimately hopes to link microbial species to the production of secondary compounds, like carotenoids, and to assess the ecological role of such compounds and their effect on sponge life history strategy. This study describes the ecological distribution of two species of …
Movement Patterns And Feeding Behavior Of The Limpet Tectura Testudinalis (Müller) Along The Mid-Maine Coast, Joshua Lord
Movement Patterns And Feeding Behavior Of The Limpet Tectura Testudinalis (Müller) Along The Mid-Maine Coast, Joshua Lord
Honors Theses
Tectura testudinalis is a limpet that lives in the mid-intertidal zone along the coast of Maine and grazes on a variety of encrusting algae. A previous study asserted that T. testudinalis preferred to feed and rest on the encrusting alga Clathromorphum circumscriptum and that this species of limpet displayed homing behavior. However, I show that T. testudinalis does not home or return to any specific substrate while resting. Conclusive evidence was found for nocturnal movement. I show that C. circumscriptum was the preferred food source for this limpet, closely followed by Hildenbrandia rubra, another encrusting alga. Field and lab experiments …
Influence Of Juvenile Hormone On Territorial And Aggressive Behavior In The Painted Lady (Vanessa Cardui) And Eastern Black Swallowtail (Papilio Polyxenes), Tara Bergin
Honors Theses
Competition is important in environments with limited resources. Males of many insect species are territorial and will defend resources, such as a food source or egg-laying site, against intruders, or even compete to attract a mate. In insects, evidence suggests that juvenile hormone acts as an aggression mediator, much like testosterone in other animal species. In this study I tested this idea using a group of male Painted Lady butterflies, Vanessa cardui, and Eastern Black Swallowtail butterflies, Papilio polyxenes, that were treated prior to metamorphosis with either a high or low dose of methoprene acid (a juvenile hormone mimic). Male-male …
A Broad-Spectrum Mer Operon In A Multi-Drug Resistant Strain Of The Fish Pathogen, Aeromonas Salmonicida, Erin Parry
A Broad-Spectrum Mer Operon In A Multi-Drug Resistant Strain Of The Fish Pathogen, Aeromonas Salmonicida, Erin Parry
Honors Theses
Aeromonas salmonicida AS03, a potential fish pathogen, was isolated from Atlantic salmon, Salmo salar, in 2003. This strain was found to be resistant to ≥1000 mM HgCl2 and ≥32 mM phenylmercuric acetate as well as multiple antimicrobials. Mercury (Hg) and antibiotic resistance genes are often located on the same mobile genetic elements, so the genetic determinants of both resistances and the possibility of horizontal gene transfer were examined. Specific PCR primers were used to amplify and sequence distinctive regions of the mer operon. A. salmonicida AS03 was found to have a pDU1358-like broad-spectrum mer operon, containing merB as well as …
Resistance Of Forest Community Types To Structural And Compositional Change Following Beech Bark Disease Infestation, Sarah Ann Hoskinson
Resistance Of Forest Community Types To Structural And Compositional Change Following Beech Bark Disease Infestation, Sarah Ann Hoskinson
Honors Theses
Pathogens change forest composition and structure by selectively eliminating susceptible individuals and species. Caused by a complex between an exotic scale insect and fungi, beech bark disease has infected mature American beech (Fagus grandifolia) trees through most of the species range. Before succumbing to the disease, infected trees generate root sprouts, transforming beech from a dominant canopy species into an abundant subcanopy species. Root sprouting can create dense beech thickets that interfere with the regeneration of other species. Exclusion of species from the understory has ecological and economic implications. This study compared forest community types for their resistance to compositional …
The Presence, Prevalence And Antibiotic Resistance Of Microbes In The Pamunkey River Basin, Christina Mcdowell
The Presence, Prevalence And Antibiotic Resistance Of Microbes In The Pamunkey River Basin, Christina Mcdowell
Honors Theses
This project examined the presence, prevalence and antibiotic resistance of Coliforms (mainly Escherichia coli), Staph/occocus aureus, fecal Streptococcus, andEnterobacteriacae found in the water samples taken from three selected sites on the North Anna, South Anna, and Little Rivers of the Pamunkey River Basin. The diversity and concentration of the microbes isolated from these sites was evaluated in late January and late March allowing for a comparison of the occurrence of microbes at different times and between the different sites. Over the course of two months the concentration of colonies increased based on colony counts from Nutrient agar. The rate of …
The Effects Of P53 Status And Egf On Timp-2 And Other Proteins Related To Migration In Human Glioblastoma Cell Cultures, Lisa M. Lint
The Effects Of P53 Status And Egf On Timp-2 And Other Proteins Related To Migration In Human Glioblastoma Cell Cultures, Lisa M. Lint
Honors Theses
The effects of epidermal growth factor (EGF) on proteins that have been implicated in the migration of the Grade IV brain tumor, glioblastoma multiforme, were investigated in this study. Differential expression levels of TIMP-2, MMP-2, and MT1-MMP in response to EGF treatment were compared by immunoprecipitation, and immunoblotting. This study involved two different cultured glioma cell lines, U87, which expresses wild-type p53, and T98, which has a mutation in the p53 gene, in order to determine if the status of the p53 tumor suppression gene is a factor in the regulation of proteins involved in this migration pathway. It was …
The Effect Of Tgf-B And Egf On Mmp-2 Activation And Mt1-Mmp Phosphorylation In U87mg And T98g Human Glioma Cells, Jacquelyn B. Knupp
The Effect Of Tgf-B And Egf On Mmp-2 Activation And Mt1-Mmp Phosphorylation In U87mg And T98g Human Glioma Cells, Jacquelyn B. Knupp
Honors Theses
Glioblastoma multiforme (GBM), a high-grade, malignant brain tumor of astrocyte origin, invades normal brain tissue and most often results in death ofthe patient withinayearofdiagnosis. In order to invade the surrounding tissue and thereby metastasize, these tumor cells must migrate through the extracellular matrix. The pmpose ofthis research project is to investigate the family ofmatrix metalloproteinases responsible for extracellular degradation. Specifically, this investigation looks at MMP-2 activation via MT 1-MMP and the possible importance of phosphorylation of the tyrosine residue on the cytoplasmic tail of MTl-MMP. U87wildtypegliomacellsaswellasT98 p53 mutant glioma cells were treated with transforming growth factor beta (TGF-P). Preliminary results …
Development Of Proliferation Assays To Explore The Role Of Calcium Activated Potassium Channels In Cell Proliferation, Sean Foster
Development Of Proliferation Assays To Explore The Role Of Calcium Activated Potassium Channels In Cell Proliferation, Sean Foster
Honors Theses
Due to the large variety of K† channel families implicated in cancer cell proliferation, it is desirable to develop techniques capable of quickly and reliably screening a variety of potential channels for a role in proliferation. While there are many established cell counting procedures, the time-consuming nature of such protocols limits their usefulness in broadly identifying particular channels in uncharacterized cell lines. For this reason, a primary goal of the present research was the development of techniques capable of implicating particular ion channels in proliferation with both qualitative and quantitative data. Once this goal was accomplished, the project sought …
Type Of Muscle Present In Adult Amphibian Lymphatic Heart Based On The Dna Sequence Of The Myosin Heavy Chain, Maribeth Morral
Type Of Muscle Present In Adult Amphibian Lymphatic Heart Based On The Dna Sequence Of The Myosin Heavy Chain, Maribeth Morral
Honors Theses
Water and plasma are forced from the capillaries into the interstitial fluid. This fluid is useful l as it moves materials between cells. Most of this fluid is collected in the capillarie of a second circulatory system, the lymphatic system. The first function of such a system is returning the excess blood plasma, now o as lymph, that has accumulated in the tissue spaces. Lymph flows from small lymph capillaries into lymph vessels that are similar to veins in having valves that prevent back flow. Lymph vessels collect to lymph nodes, lymph organs, or to the cardiovascular system at the …
Comparative Population Dynamics Of Freshwater Dinoflagellates Of The Genera Peridinium And Peridiniopsis, Andy Canion
Comparative Population Dynamics Of Freshwater Dinoflagellates Of The Genera Peridinium And Peridiniopsis, Andy Canion
Honors Theses
Freshwater dinoflagellates, like their marine relatives, have the potential to reach large population sizes known as blooms. Though they are not toxic like some marine forms, freshwater blooms may have a large impact in their respective ecosystem. This study investigated the temporal and spatial changes in population density of four Peridinium species (P. deflandrei, P. volzii, P. wisconsinense, and P. limbatum) and one Peridiniopsis species (Peridiniopsis polonicium) in Boondoggle Lake, a shallow lake (4.5 m) in northern Mississippi (Lafayette Co.). On each sampling date, measurements of the abiotic environment were made, including dissolved oxygen, temperature, pH, and turbidity. Also, water …
Fecal Coliforms And Antibiotic Resistance Of Tuckahoe Creek, Catherine C. Parker
Fecal Coliforms And Antibiotic Resistance Of Tuckahoe Creek, Catherine C. Parker
Honors Theses
The Tuckahoe Creek has been classified impaired by the Virginia Department of Environmental Quality (DEQ) indicating that one of the following parameters exceed the accepted limits: pH, temperature, dissolved oxygen (DO), phosphates, nitrates, and concentration of fecal coliforms. Throughout the course of this study, two selected sites have been monitored monthly in order to measure these parameters. Route 288 is located near a construction site, and Route 621 is near Sycamore Creek Golf Course in a more rural area. The results from this study have shown that the fecal coliforms have been uniformly within the set legal limit of 1,000 …
Effects Of Melatonin On Hemolymph Glucose And Lactate Concentrations In The Fiddler Crab, Uca Pugilator, Kathryn M. Dalton
Effects Of Melatonin On Hemolymph Glucose And Lactate Concentrations In The Fiddler Crab, Uca Pugilator, Kathryn M. Dalton
Honors Theses
Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone produced by the pineal gland that works to regulate sleep/wake cycles and activity rhythms. The effects of melatonin in metabolism are far from understood. Melatonin was injected into the fiddler crab, Uca pugilator, to investigate the effects of melatonin on hemolymph glucose and lactate levels. Following injection at t=O, hemolymph samples were collected at t=O.5, 1.0, 1.5 and 5.0 hours. Melatonin caused a decrease in the stress response to injection and also caused delayed hyperglycemia. Melatonin-injected crabs also retained the glucose and lactate rhythymicity when compared to saline-injected crabs. Glucose and lactate rhythms followed …
Complement Resistance In Agrobacterium Tumefaciens Isolates, Michael E. Mccormick
Complement Resistance In Agrobacterium Tumefaciens Isolates, Michael E. Mccormick
Honors Theses
The word "pathogen" ofen brings to mind morose images and other words such as "illness," "malaria," and "outbreak": words associated with animal pathogens, in particular, the ones that make us humans sick. However, some pathogens also affect another major kingdom, plants, and one of the more devastating pathogens to the plant kingdom is the bacteria Agrobacterium tumefaciens. This organism has a Type IV Secretion System that allows it to transfer a piece of t-DNA into the host cell; this DNA integrates into the eukaryotic genome and establishes in ction by utilizing the host's transcription machinery. This unique and effective means …
Characterization Of A Non-Ribosomal Peptide From Agrobacterium Tumefaciens, Graham Strub
Characterization Of A Non-Ribosomal Peptide From Agrobacterium Tumefaciens, Graham Strub
Honors Theses
The current efforts underway to sequence the genome of Agrobacterium tumefaciens have led to the discovery of a large region of DNA (52kb) with a strong homology to several polyketide synthetase genes. This was a matter of great interest to the Agrobacterium project; no current literature documents the production of a polyketide or non:iibosomal peptide from Agrobacterium. Furthermore, the multi-domain enzymes coded by these polyketide synthetase genes in other bacterial species are responsible for synthesizing several toxins, many which act as antibiotic agents {8, 9, 12, 16). This was also of great interest, since Agrobacterium is not known to produce …