Biology Commons^™

An Environmental History Of The Bear River Range, 1860-1910, Bradley Paul Hansen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The study of environmental history suggests that nature and culture change all the time, but that the rate and scale of such change can vary enormously. During the late 19th and early 20th centuries, Anglo settlement in the American West transformed landscapes and ecologies, creating new and complex environmental problems. This transformation was particularly impressive in Cache Valley, Utah's Bear River Range. From 1860 to 1910, Mormon settlers overused or misused the Bear River Range's lumber, grazing forage, wild game, and water resources and introduced invasive plant and animal species throughout the area.

By the turn of the 20th century, …

Evaluating Eriogonum Corymbosum Tolerance To Frequent Irrigation And Evaluating Its Significant Morphological Variations For Potential Cultivars, Graham C. Hunter

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Eriogonum corymbosum (Lacy Buckwheat) is an attractive subshrub species native to low rainfall areas of the Colorado Plateau and suitable for low water landscapes in the Intermountain West (IMW). Low water use landscapes can contribute to water conservation in arid climates; developing a palette of plants that are both attractive and drought tolerant can promote the acceptance of low water use landscapes as an alternative to the traditional bluegrass landscapes of the IMW. In 2007 a strip plot design containing four repetitions with four randomly assigned plants each of Eriogonum corymbosum, Eriogonum thompsoniae, and the control species Cornus …

Kisspeptins - Expression, Purification, And Biological Assays, Mathew Puthayathu Kurian

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Kisspeptins are hormones involved in the onset of puberty in adolescents and maintenance of reproductive function in adults. Defects in kisspeptin signaling are associated with many reproductive disorders. Kisspeptins were originally discovered as metastasis suppressors and have been found to suppress the metastasis of certain cancers. Unfortunately, many aspects of kisspeptin action at a cellular level remain unknown. Kisspeptins, therefore, are attractive candidates for large-scale production for use as research and therapeutic reagents. We developed a simple and cost effective method to express and purify kisspeptins in large quantities. We also tested the biological activity of kisspeptins on cells expressing …

Reproductive Biology And Impacts Of Energy Development On Physaria Congesta And Physaria Obcordata (Brassicaceae), Two Rare And Threatened Plants In The Piceance Basin, Colorado, Sarah Lynn Clark

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Oil and gas development has increased profoundly over the last 20 years in the United States. A large underground deposit of natural gas has been found in the Piceance Basin, which is located in the northwestern part of the state of Colorado. This deposit occurs in an area inhabited by two rare mustard species commonly named the Dudley Bluffs bladderpod and the Dudley Bluffs twinpod. These two plant species are also listed as threatened by the US Fish and Wildlife Service. Concerns about gas development effects on these rare plants have motivated research that quantifies these potential impacts. Through funding …

Local And Regional Drivers Of Biodiversity: From Life-History Traits To System-Level Properties, Sarah R. Supp

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Biodiversity research includes the study of where species occur, the commonness and rarity of species, the number of species, and the diversity of life-history traits that occur in a single location, or community. Research is increasingly recognizing that a combination of local and regional scale processes influence community dynamics over ecological and evolutionary time-scales. However, ecologists currently lack a comprehensive understanding of the mechanisms driving biodiversity in different systems and at different spatial scales. This presents a critical problem because without understanding the important mechanisms that determine and maintain biodiversity, it is difficult to accurately predict community response to environmental …

A Data-Intensive Assessment Of The Species Abundance Distribution, Elita Baldridge

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

One of the most commonly observed patterns in ecology is the fact that at most locations there are a large number of relatively rare species, composed of only a few individuals per species, and a small number of relatively common species. This pattern of commonness and rarity is quantified by the species abundance distribution. As one of the most commonly observed patterns in ecology, it has been studied intensively for over 100 years.

A major emphasis of this research has been developing models to try to understand the forces that generate such a general pattern. As a result, there are …

Modulation Of The Host Response To Tacaribe Arenavirus Infection In Ag129 Mice By My-24, Eric Sefing

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

MY-24 is a new antiviral compound recently shown to protect immunocompromised mice from lethal challenge with Tacaribe virus (TCRV). Tacaribe virus is incapable of causing disease to humans, but is closely related to the highly pathogenic New World arenaviruses that cause often-fatal viral hemorrhagic fever syndromes. Remarkably, MY-24 prevents mortality without reducing virus burden in the circulation or tissues. To investigate the mechanism by which MY-24 protects AG129 mice against Tacaribe virus infection, we first characterized the natural history of disease in the model with an emphasis on host immune response and blood vessel function to establish the best times …

Clark's Nutcracker Seed Harvest Patterns In Glacier National Park And A Novel Method For Monitoring Whitebark Pine Cones, Monika E. Maier

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Clark's Nutcracker (Nucifraga columbiana) is the primary seed disperser of whitebark pine (Pinus albicaulis), which is in decline throughout its range. There is concern that a decline in whitebark pine will lead to a subsequent decline in local populations of Clark's Nutcracker. Because natural regeneration depends on the presence of Clark's Nutcracker, the process of harvesting whitebark pine seeds needs to be fully understood. In addition, resource managers need a cost-effective method for monitoring nutcracker occurrence in whitebark pine stands during the seed harvest season. I visited eleven study sites in Glacier National Park, Montana, where …

Characterization Of The Function And Interaction Of Proteins Involved In Exopolysaccharide Synthesis In Streptococcus Thermophilus, Streptococcus Iniae, And Lactococcus Lactis Subsp. Cremoris, Angela D. Cefalo

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Many microorganisms produce capsules of repeating sugar units that surround the cell called exopolysaccharides. The synthesis of these capsules is a complex process that involves numerous protein components. A better understanding of the way these proteins function and interact with one another will benefit many industrial processes by aiding in the construction of bacterial strains with enhanced properties and could also lead to new treatment strategies against microbial pathogens in which capsule production is important in their ability to cause disease. In this study, the function of one of the proteins involved in the regulation of capsule synthesis in the …

Social Organization And Decision Making In North American Bison: Implications For Management, Ryan A. Shaw

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Social organization varies widely among herbivores, and the level of social organization in bison is widely debated. I hypothesized that when mother-daughter relationships are allowed to develop, bison form long-term associations. In my study, 25 treatment mothers were selected from a free-ranging herd and kept together with their calves, while 25 control females had their calves forcefully removed. Treatment mothers and offspring had by far the greatest number of associations with a greater percentage of individuals with a half weight index (HWI) > 0.50. The strongest associations (HWI > 0.31) were among treatment mothers and their offspring. Moreover, these associations persisted over …

Caddisfly Larvae (Limnephilidae) As Predators Of Newt (Taricha Granulosa) Eggs: Another Player In The Coevolutionary Arms Race Revolving Around Tetrodotoxin?, Brian G. Gall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Some populations of newts (Taricha granulosa) possess large quantities of the neurotoxin tetrodotoxin (TTX) in their skin and eggs. Many populations of garter snake (Thamnophis sirtalis) are resistant to this toxin and can consume large numbers of newts with no negative effects. Despite the wealth of information acquired on the interaction between newts and their predator, garter snakes, very little research has been conducted on possible interactions between newts and other predators. I conducted a suite of experiments examining for the presence of other predators on newts, specifically focusing on predators of their eggs and larvae. …

The Biogeography Of Marbled Godwit (Limosa Fedoa) Populations In North America, Bridget E. Olson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The mission of the U.S. Fish and Wildlife Service (USFWS) is working with others to conserve, protect, and enhance fish, wildlife, plants, and their habitats for the continuing benefit of the American people. Toward fulfillment of that mission, a priority of the USFWS is conservation and management of migratory birds. Effective conservation actions to ensure the continued existence of a species on the landscape cannot be designed without first understanding basic life history characteristics of a species. It is common in the case of migratory birds, that we lack understanding of some of their elemental biological traits.

The Marbled Godwit, …

Effect Of Voluntary Exercise And Diet On The Unfolded Protein Response In The Brain Of Mice, Yu Ho Kim

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The medical costs for many chronic diseases are increasing dramatically and placing a major financial burden on nations and individuals in both developed and developing countries. A number of chronic diseases, such as obesity, type 2 diabetes and some neurodegenerative diseases are all attenuated by a history of physical activity suggesting that they may be interconnected in some way. It has been suggested that cellular stress is a major factor promoting these chronic diseases.

Cellular stress occurs in a specific compartment within the cell, the endoplasmic reticulum, whose normal function is in the synthesis and folding of proteins into the …

Relative Importance Of Environmental Variables For Spawning Cues And Tributary Use By An Adfluvial Lake Sucker, Brian A. Hines

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The endangered June sucker (Chasmistes liorus mictus), which is only found in Utah Lake, UT, historically spawned in all streams flowing into the lake, but due to human-caused changes their spawning is restricted to the Provo River. The purpose of this study was to gain a better understanding of the spawning and early life-history of the
June sucker for recovery purposes. My specific objectives were to determine:

1. what environmental factors attract or deter June suckers to certain Utah Lake tributaries for spawning,
2. what cues June suckers to migrate upstream to spawn,
3. if June suckers use more than one …

The Decline And Conservation Status Of North American Bumble Bees, Jonathan B. Koch

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Several reports of North American bumble bee (Bombus Latreille) decline have been documented across the continent, but no study has fully assessed the geographic scope of decline. In this study I discuss the importance of Natural History Collections (NHC) in estimating historic bumble bee distributions and abundances, as well as in informing current surveys. To estimate changes in distribution and relative abundance I compare historic data assembled from a >73,000 specimen database with a contemporary 3-year survey of North American bumble bees across 382 locations in the contiguous U.S.A. Based on my results, four historically abundant bumble bees, B. …

The Role Of Phosphoinositide Signaling In Breast Cancer Metastasis Suppressor 1-Mediated Metastasis Suppression Of Human Breast Carcinoma Cells, Sitaram Harihar

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Breast cancer is the most common non-skin cancer in women and the second most common cause of cancer-related death in U.S. women. Despite numerous advances in treatment strategies against breast cancer, the presence of undetected distant metastasis of the primary tumor remains the main cause of mortality. Current screening and detection methods such as mammograms are simply not sensitive enough to detect formation of metastasis. Further, currently available therapies against metastatic breast cancer do not provide a complete cure for the disease. Thus, understanding the biology and molecular factors involved in cancer metastasis will help aid in preventing the onset …

Characterization And Application Of Dynamic In Vitro Models Of Human Airway, Hemangkumar J. Patel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In recent years, respiratory diseases have emerged as a leading cause of mortality across the globe. In the United States alone respiratory diseases are the fourth leading cause of deaths annually. Moreover, with the rapid increase of industrialization and urbanization, the occurrences of respiratory diseases are expected to remain high with strong chances of increasing in the future. To ameliorate the epidemic of respiratory disease, it is first important to understand its underlying mechanisms.

Respiratory research studies in animals have elucidated the chronological order of the pathological events and systemic responses inside the lung, but understanding the response of individual …

Design Of A BiobrickTm Compatible Gene Expression System For Rhodobacter Sphaeroides, Junling Huo

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The concept of introducing engineering principles of abstraction and standardization into synthetic biology has received increasing attention in the past several years and continues to be in the forefront of synthetic biology. One direction being pursued by synthetic biologists is creation of modular biological parts (BioBrick^TM) that can be readily synthesized and mixed together in different combinations. However, most standard BioBrick^TM parts in the Registry were designed for E. coli, although synthesis of specific BioBrick^TM parts for other bacteria, such as for yeast and cyanobacteria, have begun. Besides, at the present time, there are only …

A Study On The Applications And Toxicity Assessments Of Carbon Nanotubes In Tissue Engineering, Rena Baktur

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Carbon nanotubes (CNTs) are one of the most popular nanomaterials. There has been increasing interest in the development and applications of carbon nanotubes due to their huge potential in industrial and medical applications. Recent applications of carbon nanotubes include development of scaffolds and drug delivery systems. Despite rapidly emerging applications of CNTs, little is known about the impact of CNTs on cellular processes, especially mesenchymal stem cell (MSC)'s differentiation. Also, the effects of nanoparticle exposure under different conditions on cellular responses have not been well characterized yet.

To characterize the effects of CNTs on creating nanoscale scaffolds for tissue engineering, …

The Status Of Dwarfed Populations Of Short-Horned Lizards (Phrynosoma Hernandesi) And Great Plains Toads (Anaxyrus Cognatus) In The San Luis Valley, Colorado, Megan E. Lahti

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The San Luis Valley is a large valley formation in Colorado surrounded on either side by mountain ranges exceeding 4,267 m. Within the Valley, two of the 14 amphibian and reptile species are dwarfed: the short-horned lizard (Phrynosoma hernandesi) and the Great Plains toad (Anaxyrus cognatus). Since its initial reporting in 1968 and confirmation in 1981, no research further investigating this dwarfism has been conducted. I collected morphological measurements to determine the extent and patterns of dwarfism of both species. I then investigated the genetics of both species using mitochondrial DNA to determine whether they are …

Historical Biogeography Of Velvet Ants (Hymenoptera: Mutillidae) In The North American Deserts And Arid Lands, Joseph S. Wilson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

For centuries, scientists have been intrigued by the high amount of biodiversity that is found in the deserts of North America. Recently, several studies have investigated the causes of the high diversity found in desert-dwelling mammals, reptiles, and amphibians. These studies have found that many of these organisms seem to have diversified in response to the same historical events. Little work has been done, however, on diverse desert-dwelling insect groups. In this dissertation, I investigate the patterns of genetic diversity in four groups of nocturnal wasps called velvet ants. I compare the patterns of genetic diversity to the historical events …

Learning Ability And Factors Influencing Nest Establishment Of The Solitary Bees Osmia Lignaria And Megachile Rotundata (Hymenoptera: Megachilidae), Cory A. Vorel

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Over the last several decades, the use of solitary bees as an alternative to honey bees (Apis mellifera L.) for pollination of commercial crops has increased, in part as a response to ongoing problems faced by commercial honey bee populations. Two solitary bee species have exhibited great commercial potential: the blue orchard bee, Osmia lignaria Say, and the alfalfa leafcutting bee, Megachile rotundata Fabricius (Hymenoptera: Megachilidae). However, growth of O. lignaria and M. rotundata populations is limited in commercial systems, mainly due to low establishment of females at provided nesting sites, possibly due to mortality, dispersal, or other causes. …

Targeting Fatty Acid-Activated Pathways In The Somatosensory System, Tian Yu

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Given the dramatic rise in obesity and the diseases linked with it, it is becoming increasingly important to understand the mechanisms that underlie the body's ability to recognize fat. The chemoreception of dietary fat in the oral cavity has largely been attributed to activation of the somatosensory system that relays the textural properties of fat. However, the ability of fatty acids, which are believed to represent the proximate stimulus for fat taste, to activate trigeminal ganglionic neurons has remained unexplored. In general, my research has provided the first evidence of fatty acids activating the somatosensory system by increasing the intracellular …

Coyote Diet And Movements In Relation To Winter Recreation In Northwestern Wyoming: Implications For Lynx Conservation, Jennifer L. Burghardt Dowd

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Increased snowmobile use in mountainous terrain has been highlighted as a conservation concern for some Canada lynx (Lynx canadensis) populations. Snow compaction resulting from winter recreation may potentially facilitate access by coyotes (Canis latrans) to habitats used by lynx during winter. Increased interactions could result in either exploitation or interference competition between the two species. Two recent, yet geographically distinct, studies showed contrasting findings regarding coyote movements and their use of snow-compacted trails during the winter. These findings suggest coyote association with snow-compacted trails may be regionally specific and dependent upon ecosystem dynamics and snow characteristics. …

Survival Of Mycoplasma Species In Recycled Bedding Sand And Possible Implications For Disease Transmission To Ruminants, Anne E. Justice-Allen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Mycoplasmas are a group of bacteria which are small in size, lack a cell wall, and have small genomes in comparison to other bacteria. The members of the group that are pathogenic utilize several mechanisms to evade the host's immune system. These processes affect surveillance and control mechanisms such as serologic testing and vaccination. Many of these organisms cause diseases of livestock, which heavily impact production parameters such as weight gain, milk yield, and egg production. Mycoplasmas also cause disease in people.

Mycoplasma spp. can cause mastitis, metritis, pneumonia, and arthritis. The currently documented routes of transmission of Mycoplasma spp. …

Seed Banks Of Sagebrush Communities Seeded With Crested Wheatgrass, Kevin L. Gunnell

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Crested wheatgrass (Agropyron cristatum [L.] Gaertn.) is one of the most commonly seeded exotic species in the western United States. Although many degraded Wyoming big sagebrush (Artemisia tridentata ssp. wyomingensis) plant communities have been seeded with crested wheatgrass during rehabilitation efforts, seed banks of these communities have not been characterized. I sought to characterize and explain the variation among 33 seeded communities in the northeastern Great Basin. Hierarchical clustering and principal components analysis identified four possible seed bank categories in these communities. Seed bank categories varied from high to low crested wheatgrass dominance. The crested wheatgrass-dominated category …

Consumer-Driven Nutrient Recycling In Arctic Alaskan Lakes: Controls, Importance For Primary Productivity, And Influence On Nutirient Limitation, Cody R. Johnson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

In lakes, fish and zooplankton can be both sources and sinks of nitrogen (N) and phosphorus (P) through the consumption of organic N and P, and subsequent excretion of bioavailable inorganic forms. These source/sink dynamics, known as consumer-driven nutrient recycling (CNR), may, in turn, control the availability of potentially limiting nutrients for algal primary production. In this dissertation I investigate the importance and controls of CNR as a source of inorganic N and P for primary production (Chapter 2). I then examine zooplankton CNR as a mechanism for increasing nutrient mean resident time (MRT) in the mixed layer of lakes …

Watershed-Scale Analysis Of Riparian Buffer Function, Molly Van Appledorn

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The ability of riparian buffers to filter undesirable nutrients from upland sources has long been recognized as an important ecosystem service for maintaining or improving water quality, and as a result, many land management strategies have been built around the preservation or restoration of buffer zones. Newly derived flow-path metrics have shown great promise as a way to assess riparian buffer function at the watershed scale but a thorough investigation of metric performance was necessary. The goals of this study were to: 1) test the independence of flow-path metrics from traditional metrics using a spatially extensive, independent sample of watersheds, …

The Regulation Of Epithelial Sodium Channels In Mammalian Taste Receptor Cells, Arian F. Baquero Gonzalez

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Nutrient recognition is one of the main physiological roles of the gustatory system. In mammals, it is well established that the taste of sodium salts is primarily mediated by sodium influx through the epithelial sodium channel. The epithelial sodium channel is a sodium-specific ion channel that is expressed across a wide range of transporting epithelia such as colon, kidney, and taste. In addition to its role as a salt taste receptor, sodium influx through the epithelial sodium channel is important systemically for maintaining sodium balance and blood pressure. Following our earlier work on the endocrine regulation of salt taste at …

Targeting Fat-Sensitive Pathways In Enteroendocrine Cells Using Nanoparticle-Mediated Drug Delivery, Bhavik P. Shah

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The current epidemic of obesity has been linked to an increase in fat intake associated with the Western diet. Nutrient-induced stimulation of enteroendocrine cells in the small intestine leads to the release of hormones that contribute to satiety and the control of food intake. In particular, ingested fat, specifically in the form of free fatty acids, is potent activator of enteroendocrine cells in the proximal small intestine. However, the underlying signaling cascade that free fatty acids initiate in these enteroendocrine cells, which leads to secretion of satiety hormones, is not known. In general, my research is focused on identifying nutrient-responsive …