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Full-Text Articles in Biology

What Does Self-Reported Likability For Fruit And Vegetables Tell Us About Skin Carotenoid Levels?, Kurtis Hauck, Madison Hauck, Damon Joyner, Heidi Wengreen Mar 2017

What Does Self-Reported Likability For Fruit And Vegetables Tell Us About Skin Carotenoid Levels?, Kurtis Hauck, Madison Hauck, Damon Joyner, Heidi Wengreen

Biology Posters

In most cases, individuals who have a higher likeability of fruits and vegetables will consume more and reap health-related benefits because of it. However, other factors influence how the body digests, absorbs, and metabolizes the beneficial nutrients found in fruits and vegetables. Biomarkers, like carotenoids are measurable indicators of some biological state or condition. They can be helpful in understanding the relationships between dietary intake of nutrients and the other factors that may influence how a nutrient is being used in the body. Other factors known to influence skin carotenoids include body composition, exposure to environmental pollutants, or illness. Carotenoids …


Internship At Cache Meadow Veterinary Clinic, Andrea Nelson Mar 2017

Internship At Cache Meadow Veterinary Clinic, Andrea Nelson

Biology Posters

I was able to assist on multiple emergency surgeries, some including: an abdominal exploratory and a caesarean section. These procedures allowed me to learn proper surgical techniques as well as radiography techniques.


Extreme Makeover: Fern Edition, Tanner A. Robison, Paul G. Wolf Mar 2017

Extreme Makeover: Fern Edition, Tanner A. Robison, Paul G. Wolf

Biology Posters

With a few exceptions, all plants have chloroplasts. Chloroplasts are the organelles responsible for photosynthesis in plants. Interestingly, chloroplasts have their own genome -- called a plastome -- which is separate from the nuclear genome. The genetic composition of ferns, gymnosperm, and angiosperm plastomes are remarkably similar, revealing very little change over evolutionary time. There are however a few notable exceptions to the apparent stability of the plastome. A few lineages of both angiosperm and gymnosperm show dramatically higher rates of mutation and genetic rearrangement than those of their relatives, suggesting major genome destabilization. Vittariods are a group of ferns …


Hla-G 14bp Polymorphism In Autism, Cameron Page, Michael Benson, Thayne Sweeten, Anthony Torres, Martin Kharrazi, Lisa Croen Mar 2017

Hla-G 14bp Polymorphism In Autism, Cameron Page, Michael Benson, Thayne Sweeten, Anthony Torres, Martin Kharrazi, Lisa Croen

Biology Posters

Autism Spectrum Disorder (ASD) is a neurodevelopment disorder characterized by deficits in communicative and social behaviors (Meltzer, 2017) . As of 2012 the CDC reported that 1 of 68 children born in the U.S. have ASD (Christensen, 2016). The immune systems of mother and child can be important in ASD. A signaling molecule, HLA-G, helps regulate maternal natural killer cell interaction with the fetus. A defect in HLA-G could increase NK cell activity, leading to abnormal neurodevelopment in the fetus (Carosella, 2008). Our study focuses on a 14 base pair insertion/deletion found in the HLA-G gene of autistic subjects and …


Spidentistry: The Intersection Of Dentistry And Spider Silk, Deven C. Smuin, Thomas I. Harris, Justin A. Jones, Randolph V. Lewis Mar 2017

Spidentistry: The Intersection Of Dentistry And Spider Silk, Deven C. Smuin, Thomas I. Harris, Justin A. Jones, Randolph V. Lewis

Biology Posters

Spider silks are an ideal material for periodontal chips/gels because they are biocompatible, biodegradable, lightweight, strong, and create no immune response. Furthermore, the various silks types and forms allow for tunable materials and properties. Spider silk materials may have an advantage over other products because of the ability to release medication more consistently over a longer period of time and be adjusted as needed. Unlike products currently on the market, our chip/gels are biocompatible, which aids in reducing the bodies immune response to periodontal treatment. The ability to incorporate multiple bioactive compounds into the spider silk materials allows them to …


Life History Differences Across A Latitudinal Gradient In Side-Blotched Lizards (Uta Stansburiana), G. D. Smith, P. A. Zani, S. S. French Mar 2017

Life History Differences Across A Latitudinal Gradient In Side-Blotched Lizards (Uta Stansburiana), G. D. Smith, P. A. Zani, S. S. French

Biology Posters

Latitudinal variation has long been known to affect life history. Bergmann and Allen made latitudinal “rules” for mammalian anatomy and Lack, Skutch, and Moreau described differences in life history in birds. Trade-offs occur between important life history processes, like self maintenance (immunity) and other expensive but necessary processes. It is likely that trade-offs occur mostly when resources are limited. Side-blotched lizards have a wide geographic range, and more northerly lizards have been observed to have longer lifespans than their southern conspecifics. We hypothesized that northern sideblotched lizards would invest more energy into self-maintenance compared to shorter-lived southern animals.


Got Bugs In Your Kefir?, Julienne Henrie Mar 2017

Got Bugs In Your Kefir?, Julienne Henrie

Biology Posters

What is Kefir ? Kefir is a type of fermented milk that is cultured with Kefir grains. Kefir grains make up the probiotic culture used to produce Kefir. These cauliflower-like grains contain mostly lactobacilli bacteria and yeasts held together by Kefiran, an exopolysaccharide structure. (Korsak et al. 2014). Kefir grains are Mesophilic. Mesophilic starters are cultured at room temperature, which allows the probiotics to remain active when consumed. Properties of mesophilic starters also give Kefir the liquid consistency it is known for. (Sarah, 2016). Kefir originated in the Caucasus Mountains thousands of years ago, the name coming from the Turkish …


Murder She Wrote: Death And Drama In Nesting Woodpeckers, Taylor Albrecht, Blake Christensen, Sammy Cowell, Phil Fischer, Ryan Gallegos, Teresa Lorenz, Mariah Panoussi, Taryn Rodman, Ryan Sabel, Allison Stassel, Kim Sullivan Mar 2017

Murder She Wrote: Death And Drama In Nesting Woodpeckers, Taylor Albrecht, Blake Christensen, Sammy Cowell, Phil Fischer, Ryan Gallegos, Teresa Lorenz, Mariah Panoussi, Taryn Rodman, Ryan Sabel, Allison Stassel, Kim Sullivan

Biology Posters

Woodpeckers serve as primary cavity excavators in fire-dominated forests. Secondary cavity users (SCU’s) rely heavily on cavities excavated by woodpeckers. Woodpecker species are declining, and some are now locally threatened. Management needs answers. How is woodpecker reproductive success impacted by the behavior of woodpeckers, SCU’s, and predators?


Culturing Viruses From Wild Deer In Utah, Brennan Winkler, Justin Moscon, Eric Dewart, Annette Roug, Bart Tarbet Mar 2017

Culturing Viruses From Wild Deer In Utah, Brennan Winkler, Justin Moscon, Eric Dewart, Annette Roug, Bart Tarbet

Biology Posters

In the Spring of 2016, two deer showing clinical signs of neurological illness were reported to the Utah Division of Wildlife Resources. The animals were euthanized and post-mortem tissues collected for identification of any disease causing agents. Brain and spleen samples were sent to Dr. Eric Delwart, University of California-San Francisco for metagenomics evaluation. Mobukvirus (described once) and novel picornavirus and bovine parvovirus were tentatively identified. However, cell culture of the viruses is necessary for further characterization and genomic sequencing. If these novel viruses can be cultured, it may be possible to develop serologic tests for additional field investigations in …


Mass Action In Two-Sex Population Models: Encounters, Mating Encounters And The Associated Numerical Correction, Katherine Snyder, Brynja R. Kohler, Luis F. Gordillo Mar 2017

Mass Action In Two-Sex Population Models: Encounters, Mating Encounters And The Associated Numerical Correction, Katherine Snyder, Brynja R. Kohler, Luis F. Gordillo

Mathematics and Statistics Faculty Publications

Ideal gas models are a paradigm used in Biology for the phenomenological modelling of encounters between individuals of different types. These models have been used to approximate encounter rates given densities, velocities and distance within which an encounter certainly occurs. When using mass action in two-sex populations, however, it is necessary to recognize the difference between encounters and mating encounters. While the former refers in general to the (possibly simultaneous) collisions between particles, the latter represents pair formation that will produce offspring. The classical formulation of the law of mass action does not account this difference. In this short paper, …


Collaborative Research: The Interplay Between Fluctuating Selection On Symbionts And Life Cycle Evolution In Sap-Sucking Insects, Carol Von Dohlen Mar 2017

Collaborative Research: The Interplay Between Fluctuating Selection On Symbionts And Life Cycle Evolution In Sap-Sucking Insects, Carol Von Dohlen

Funded Research Records

No abstract provided.


Invasive Species Control And Perennial Plant Establishment In Antelope Pasture, Pocatello, Blm, Kari E. Veblen Feb 2017

Invasive Species Control And Perennial Plant Establishment In Antelope Pasture, Pocatello, Blm, Kari E. Veblen

Funded Research Records

No abstract provided.


More New Records Of Spider Wasps From Colombia (Hymenoptera, Pompilidae), Caleb T. Walker, Fernando Fernández, Valentina Castro-Huertas, Juanita Rodriguez, James P. Pitts Feb 2017

More New Records Of Spider Wasps From Colombia (Hymenoptera, Pompilidae), Caleb T. Walker, Fernando Fernández, Valentina Castro-Huertas, Juanita Rodriguez, James P. Pitts

Biology Faculty Publications

Aporinellus Banks, Austrochares Banks and Dicranoplius Haupt are new generic records for Colombia, as well as the species Dipogon ariel Banks, Evagetes peruana Banks, and Euplaniceps notabilis (Smith). Five new combinations are formally endorsed: Aimatocare argentinica (Banks), comb. n.;Aimatocare longula (Banks), comb. n.; Aimatocare imitator (Evans), comb. n.; Aimatocare impensa (Evans), comb. n.; Aimato-care vitrea (Fox), comb. n. Although these names have been used in Pompilidae, no formal nomenclatural act had been proposed. The presence of Chirodamus paramicola Roig-Alsina, previously reported with uncertainty, is confirmed. Finally, a new combination for Euplaniceps notabilis (Smith), comb. n. …


Identification And Characterization Of An Efficient Acyl-Coa:Diacylglycerol Acyltransferase 1 (Dgat1) Gene From The Microalga Chlorella Ellipsoidea, Xuejie Guo, Chengming Fan, Yuhong Chen, Jingqiao Wang, Weibo Yin, Richard R. C. Wang, Zanmin Hu Feb 2017

Identification And Characterization Of An Efficient Acyl-Coa:Diacylglycerol Acyltransferase 1 (Dgat1) Gene From The Microalga Chlorella Ellipsoidea, Xuejie Guo, Chengming Fan, Yuhong Chen, Jingqiao Wang, Weibo Yin, Richard R. C. Wang, Zanmin Hu

Forage and Range Research Laboratory Publications

Background: Oil in the form of triacylglycerols (TAGs) is quantitatively the most important storage form of energy for eukaryotic cells. Diacylglycerol acyltransferase (DGAT) is considered the rate-limiting enzyme for TAG accumulation. Chlorella, a unicellular eukaryotic green alga, has attracted much attention as a potential feedstock for renewable energy production. However, the function of DGAT1 in Chlorella has not been reported.

Results: A full-length cDNA encoding a putative diacylglycerol acyltransferase 1 (DGAT1, EC 2.3.1.20) was obtained from Chlorella ellipsoidea. The 2,142 bp open reading frame of this cDNA, designated CeDGAT1, encodes a protein of 713 amino acids showing …


Hosts, Nesting Behavior, And Ecology Of Some North American Spider Wasps (Hymenoptera: Pompilidae), Ii, Frank E. Kurczewski, Glavis B. Edwards, James P. Pitts Jan 2017

Hosts, Nesting Behavior, And Ecology Of Some North American Spider Wasps (Hymenoptera: Pompilidae), Ii, Frank E. Kurczewski, Glavis B. Edwards, James P. Pitts

Biology Faculty Publications

This monograph is a continuation of a multiyear study of the genera and species of North American spider wasps (Pompilidae) and their spider host families, genera and species, nesting behavior, ecology, and natural communities. The study enlarges and enhances host preference, nesting behavior, and ecological information for 77 North American pompilid taxa. The first North American Pompilidae records for the families Tengellidae and Segestriidae, both from central coastal California, are reported herein. New host spider genera and species are listed for many of the pompilid species, including the first North American host record for Dipogon (Dipogon) g. graenicheri …


A Computational Study Of Vegf Production By Patterned Retinal Epithelial Cell Colonies As A Model For Neovascular Macular Degeneration, Qanita Bani Baker, Gregory J. Podgorski, Elizabeth Vargis, Nicholas Flann Jan 2017

A Computational Study Of Vegf Production By Patterned Retinal Epithelial Cell Colonies As A Model For Neovascular Macular Degeneration, Qanita Bani Baker, Gregory J. Podgorski, Elizabeth Vargis, Nicholas Flann

Biology Faculty Publications

Background: The configuration of necrotic areas within the retinal pigmented epithelium is an important element in the progression of age-related macular degeneration (AMD). In the exudative (wet) and non-exudative (dry) forms of the disease, retinal pigment epithelial (RPE) cells respond to adjacent atrophied regions by secreting vascular endothelial growth factor (VEGF) that in turn recruits new blood vessels which lead to a further reduction in retinal function and vision. In vitro models exist for studying VEGF expression in wet AMD (Vargis et al., Biomaterials 35(13):3999–4004, 2014), but are limited in the patterns of necrotic and intact RPE epithelium they can …


Dynamic Acquisition And Loss Of Dual-Obligate Symbionts In The Plant-Sap-Feeding Adelgidae (Hemiptera: Sternorrhyncha: Aphidoidea), Carol D. Von Dohlen, Usha Spaulding, Kistie B. Patch, Ethan P. White, Robert G. Foottit, Nathan P. Havill, Gaelen R. Burke Jan 2017

Dynamic Acquisition And Loss Of Dual-Obligate Symbionts In The Plant-Sap-Feeding Adelgidae (Hemiptera: Sternorrhyncha: Aphidoidea), Carol D. Von Dohlen, Usha Spaulding, Kistie B. Patch, Ethan P. White, Robert G. Foottit, Nathan P. Havill, Gaelen R. Burke

Biology Faculty Publications

Sap-sucking insects typically engage in obligate relationships with symbiotic bacteria that play nutritional roles in synthesizing nutrients unavailable or in scarce supply from the plant-sap diets of their hosts. Adelgids are sap-sucking insects with complex life cycles that involve alternation between conifer tree species. While all adelgid species feed on spruce during the sexual phase of their life cycle, each adelgid species belongs to a major lineage that feeds on a distinct genus of conifers as their alternate host. Previous work on adelgid symbionts had discovered pairs of symbionts within each host species, and unusual diversity across the insect family, …


Animating And Exploring Phylogenies With Fibre Plots, William D. Pearse Nov 2016

Animating And Exploring Phylogenies With Fibre Plots, William D. Pearse

Biology Faculty Publications

Despite the progress that has been made in many other aspects of data visualisation, phylogenies are still represented in much the same way as they first were by Darwin. In this brief essay, I give a short review of what I consider to be some recent major advances, and outline a new kind of phylogenetic visualisation. This new graphic, the fibre plot, uses the metaphor of sections through a tree to describe change in a phylogeny. I suggest it is a useful tool in gaining an rapid overview of the timing and scale of diversification in large phylogenies.


Importance Of Heat And Pressure For Solubilization Of Recombinant Spider Silk Proteins In Aqueous Solution, Justin A. Jones, Thomas I. Harris, Paula F. Oliveira, Brianne E. Bell, Abdulrahman Alhabib, Randolph V. Lewis Nov 2016

Importance Of Heat And Pressure For Solubilization Of Recombinant Spider Silk Proteins In Aqueous Solution, Justin A. Jones, Thomas I. Harris, Paula F. Oliveira, Brianne E. Bell, Abdulrahman Alhabib, Randolph V. Lewis

Biology Faculty Publications

The production of recombinant spider silk proteins continues to be a key area of interest for a number of research groups. Several key obstacles exist in their production as well as in their formulation into useable products. The original reported method to solubilize recombinant spider silk proteins (rSSp) in an aqueous solution involved using microwaves to quickly generate heat and pressure inside of a sealed vial containing rSSp and water. Fibers produced from this system are remarkable in their mechanical ability and demonstrate the ability to be stretched and recover 100 times. The microwave method dissolves the rSSPs with dissolution …


Better Late Than Never: Effective Air-Borne Hearing Of Toads Delayed By Late Maturation Of The Tympanic Middle Ear Structures, Molly C. Womack, Jakob Christensen-Dalsgaard, Kim L. Hoke Oct 2016

Better Late Than Never: Effective Air-Borne Hearing Of Toads Delayed By Late Maturation Of The Tympanic Middle Ear Structures, Molly C. Womack, Jakob Christensen-Dalsgaard, Kim L. Hoke

Biology Faculty Publications

Most vertebrates have evolved a tympanic middle ear that enables effective hearing of airborne sound on land. Although inner ears develop during the tadpole stages of toads, tympanic middle ear structures are not complete until months after metamorphosis, potentially limiting the sensitivity of post-metamorphic juveniles to sounds in their environment. We tested the hearing of five species of toads to determine how delayed ear development impairs airborne auditory sensitivity. We performed auditory brainstem recordings to test the hearing of the toads and used micro-computed tomography and histology to relate the development of ear structures to hearing ability. We found a …


A Novel Qtl Associated With Dwarf Bunt Resistance In Idaho 444 Winter Wheat, Jianli Chen, Mary J. Guttieri, Junli Zhang, David Hole, Edward Souza, Blair Goates Sep 2016

A Novel Qtl Associated With Dwarf Bunt Resistance In Idaho 444 Winter Wheat, Jianli Chen, Mary J. Guttieri, Junli Zhang, David Hole, Edward Souza, Blair Goates

Green Canyon Environmental Research Area, Logan Utah

Dwarf bunt [Tilletia controversa J.G. Kühn [as ‘contraversa’], in Rabenhorst, Hedwigia 13: 188 (1874)] is a destructive disease of wheat (Triticum aestivum L.) that reduces grain yield and quality. A number of distinct genes conferring resistance to dwarf bunt have been used by breeding programs for nearly 100 years. However, few markers were identified that can be used in selection of dwarf bunt resistance. A recombinant inbred line (RIL) population derived from the bunt-resistant germplasm, Idaho 444 (IDO444), and the susceptible cultivar, Rio Blanco, was evaluated for phenotypic reaction to dwarf bunt inoculation in four trials in …


Secondary Structure Adopted By The Gly-Gly-X Repetitive Regions Of Dragline Spider Silk, Geoffrey M. Gray, Arjan Van Der Vaart, Chengchen Guo, Justin A. Jones, David Onofrei, Brian R. Cherry, Randolph V. Lewis, Jeffery L. Yarger, Gregory P. Holland Sep 2016

Secondary Structure Adopted By The Gly-Gly-X Repetitive Regions Of Dragline Spider Silk, Geoffrey M. Gray, Arjan Van Der Vaart, Chengchen Guo, Justin A. Jones, David Onofrei, Brian R. Cherry, Randolph V. Lewis, Jeffery L. Yarger, Gregory P. Holland

Biology Faculty Publications

Solid-state NMR and molecular dynamics (MD) simulations are presented to help elucidate the molecular secondary structure of poly(Gly-Gly-X), which is one of the most common structural repetitive motifs found in orb-weaving dragline spider silk proteins. The combination of NMR and computational experiments provides insight into the molecular secondary structure of poly(Gly-Gly-X) segments and provides further support that these regions are disordered and primarily non-β-sheet. Furthermore, the combination of NMR and MD simulations illustrate the possibility for several secondary structural elements in the poly(Gly-Gly-X) regions of dragline silks, including β-turns, 310-helicies, and coil structures with a negligible population of α-helix observed.


Convergence In Nitrogen Deposition And Cryptic Isotopic Variation Across Urban And Agricultural Valleys In Northern Utah, Steven J. Hall, E. M. Ogata, Samantha R. Weintraub, Michelle A. Baker, James R. Ehleringer, C I. Czimczik, David R. Bowling Sep 2016

Convergence In Nitrogen Deposition And Cryptic Isotopic Variation Across Urban And Agricultural Valleys In Northern Utah, Steven J. Hall, E. M. Ogata, Samantha R. Weintraub, Michelle A. Baker, James R. Ehleringer, C I. Czimczik, David R. Bowling

Biology Faculty Publications

The extent to which atmospheric nitrogen (N) deposition reflects land use differences and biogenic versus fossil fuel reactive N sources remains unclear yet represents a critical uncertainty in ecosystem N budgets. We compared N concentrations and isotopes in precipitation-event bulk (wet + dry) deposition across nearby valleys in northern Utah with contrasting land use (highly urban versus intensive agriculture/low-density urban). We predicted greater nitrate (NO3−) versus ammonium (NH4+) and higher δ15N of NO3− and NH4+ in urban valley sites. Contrary to expectations, annual N deposition (3.5–5.1 kg N ha−1 yr−1) and inorganic N concentrations were similar within and between valleys. …


Human Observers Differ In Ability To Perceive Insect Diversity, Joseph S. Wilson, Joshua P. Jahner, Matthew L. Forister Aug 2016

Human Observers Differ In Ability To Perceive Insect Diversity, Joseph S. Wilson, Joshua P. Jahner, Matthew L. Forister

Biology Faculty Publications

Human perception of biological variation is an important and understudied issue in the conservation and management of natural resources. Here, we took a novel approach by asking 1152 participants, primarily college biology students, to score examples of insect mimicry by the number of distinct kinds of animals they saw. Latent class analysis successfully separated participants based on their accuracy of perception as well as demographic information and opinions about biodiversity. Contrary to expectations, factors such as childhood experience (growing up in urban, suburban or rural areas) did not affect the ability to see biodiversity as much as political views (location …


System-Aware Smart Network Management For Nano-Enriched Water Quality Monitoring, Bassem Mokhtar, Mohamed Azab, Nader Shehata, Mohamed Rizk Jul 2016

System-Aware Smart Network Management For Nano-Enriched Water Quality Monitoring, Bassem Mokhtar, Mohamed Azab, Nader Shehata, Mohamed Rizk

Biology Faculty Publications

This paper presents a comprehensive water quality monitoring system that employs a smart network management, nano-enriched sensing framework, and intelligent and efficient data analysis and forwarding protocols for smart and system-aware decision making. The presented system comprises two main subsystems, a data sensing and forwarding subsystem (DSFS), and Operation Management Subsystem (OMS). The OMS operates based on real-time learned patterns and rules of system operations projected from the DSFS to manage the entire network of sensors. The main tasks of OMS are to enable real-time data visualization, managed system control, and secure system operation. The DSFS employs a Hybrid Intelligence …


Pheromone Lure And Trap Color Affects Bycatch In Agricultural Landscapes Of Utah, Lori R. Spears, Chris Looney, Harold Ikerd, Jonathan B. Koch, Terry L. Griswold, James P. Strange, Ricardo A. Ramirez Jul 2016

Pheromone Lure And Trap Color Affects Bycatch In Agricultural Landscapes Of Utah, Lori R. Spears, Chris Looney, Harold Ikerd, Jonathan B. Koch, Terry L. Griswold, James P. Strange, Ricardo A. Ramirez

Biology Faculty Publications

Aerial traps, using combinations of color and attractive lures, are a critical tool for detecting and managing insect pest populations. Yet, despite improvements in trap efficacy, collection of nontarget species (“bycatch”) plagues many insect pest surveys. Bycatch can influence survey effectiveness by reducing the available space for target species and increasing trap screening time, especially in areas where thousands of insects are captured as bycatch in a given season. Additionally, bycatch may negatively impact local nontarget insect populations, including beneficial predators and pollinators. Here, we tested the effect of pheromone lures on bycatch rates of Coccinellidae (Coleoptera), Apoidea (Hymenoptera), and …


Influence Of Free Water Availability On A Desert Carnivore And Herbivore, Bryan M. Kluever, Eric M. Gese, Stephen Dempsey Jul 2016

Influence Of Free Water Availability On A Desert Carnivore And Herbivore, Bryan M. Kluever, Eric M. Gese, Stephen Dempsey

Wildland Resources Faculty Publications

Anthropogenic manipulation of finite resources on the landscape to benefit individual species or communities is commonly employed by conservation and management agencies. One such action in arid regions is the construction and maintenance of water developments (i.e., wildlife guzzlers) adding free water on the landscape to buttress local populations, influence animal movements, or affect distributions of certain species of interest. Despite their prevalence, the utility of wildlife guzzlers remains largely untested. We employed a before–after control-impact (BACI) design over a 4-year period on the US Army Dugway Proving Ground, Utah, USA, to determine whether water availability at wildlife guzzlers influenced …


Collybolide Is A Novel Biased Agonist Of Κ-Opioid Receptors With Potent Antipruritic Activity, Achla Gupta, Ivone Gomes, Erin N. Bobeck, Amanda K. Fakira, Nicholas P. Massaro, Indrajeet Sharma, Adrien Cavé, Heidi E. Hamm, Joseph Parello, Lakshmi A. Devi May 2016

Collybolide Is A Novel Biased Agonist Of Κ-Opioid Receptors With Potent Antipruritic Activity, Achla Gupta, Ivone Gomes, Erin N. Bobeck, Amanda K. Fakira, Nicholas P. Massaro, Indrajeet Sharma, Adrien Cavé, Heidi E. Hamm, Joseph Parello, Lakshmi A. Devi

Biology Faculty Publications

Among the opioid receptors, the κ-opioid receptor (κOR) has been gaining considerable attention as a potential therapeutic target for the treatment of complex CNS disorders including depression, visceral pain, and cocaine addiction. With an interest in discovering novel ligands targeting κOR, we searched natural products for unusual scaffolds and identified collybolide (Colly), a nonnitrogenous sesquiterpene from the mushroom Collybia maculata. This compound has a furyl-δ-lactone core similar to that of Salvinorin A (Sal A), another natural product from the plant Salvia divinorum. Characterization of the molecular pharmacological properties reveals that Colly, like Sal A, is a highly potent and selective …


Stoichiometry Of Microbial Carbon Useefficiency In Soils, R. L. Sinsabaugh, B. L. Turner, J. M. Talbot, Bonnie G. Waring, J. S. Powers, C. R. Kuske, D. L. Moorhead, Shah J. Follstad May 2016

Stoichiometry Of Microbial Carbon Useefficiency In Soils, R. L. Sinsabaugh, B. L. Turner, J. M. Talbot, Bonnie G. Waring, J. S. Powers, C. R. Kuske, D. L. Moorhead, Shah J. Follstad

Biology Faculty Publications

The carbon use efficiency (CUE) of microbial communities partitions the flow of C from primary producers to the atmosphere, decomposer food webs, and soil C stores. CUE, usually defined as the ratio of growth to assimilation, is a critical parameter in ecosystem models, but is seldom measured directly in soils because of the methodological difficulty of measuring in situ rates of microbial growth and respiration. Alternatively, CUE can be estimated indirectly from the elemental stoichiometry of organic matter and microbial biomass, and the ratios of C to nutrient-acquiring ecoenzymatic activities. We used this approach to estimate and compare microbial CUE …


Beyond The Urban Stream Syndrome: Organic Matter Budget For Diagnostics And Restoration Of An Impaired Urban River, Dave M. Epstein, Julia E. Kelso, Michelle A. Baker May 2016

Beyond The Urban Stream Syndrome: Organic Matter Budget For Diagnostics And Restoration Of An Impaired Urban River, Dave M. Epstein, Julia E. Kelso, Michelle A. Baker

Biology Faculty Publications

In response to water quality standard violations linked to excessive organic matter (OM) and a lack of sampling data informing the Total Maximum Daily Load (TMDL), an organic matter budget was created to quantify and identify sources of OM in the lower Jordan River (Salt Lake City, UT). By sampling dissolved, fine and coarse particulate OM, as well as measuring ecosystem metabolism at seven different sites, the researchers aimed to identify the origin of excess OM, and understand pathways by which different size classes of the OM pool are generated. The dissolved fraction (DOM; 94 %) was found to be …