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Articles 61 - 90 of 395
Full-Text Articles in Biology
Mathematical Analysis Of C Elegans Population Dynamics, Erik Bergstrom
Mathematical Analysis Of C Elegans Population Dynamics, Erik Bergstrom
Undergraduate Research Conference at Missouri S&T
Understanding how populations fluctuate is important for understanding how evolutionary pressures have shaped the life histories of species, such as reproductive patterns and aging. A laboratory ecosystem consisting of Caenorhabditis elegans and Escherichia coli and wormPOP, a simulation of this laboratory ecosystem, developed by Scharf and colleagues (Scharf et al., 2022) provides an opportunity to better understand population dynamics by tracking individual simulated worms and computing the emergent population dynamics. However, the output data consist of curves with peaks and troughs that are challenging to analyze and that were hypothesized to fit the mathematical definition of chaotic behavior. This project …
Evaluation Of Phosphorus Uptake Within Aquatic Plants For The Use Of Nutrient Removal, Grace Willbanks
Evaluation Of Phosphorus Uptake Within Aquatic Plants For The Use Of Nutrient Removal, Grace Willbanks
Undergraduate Research Conference at Missouri S&T
Stormwater runoff from urban areas can lead to excess nutrients, such as phosphorus or nitrogen, in our waterways. These waste nutrients can lead to overgrowth of algae and plants, deoxygenation of ponds and streams, and death of the aquatic life in these important ecosystems. Currently, floating treatment wetlands are being used to combat these excess nutrients, combining a floating element with an absorptive media, either man-made or natural aquatic plants, into a model to float on an impacted lake. In this research project, multiple small-scale microcosm level experiments were run with different native aquatic plants to test their uptake ability …
Wild Worms Vs. Lab Worms In A Laboratory Ecosystem, Alexis Winner
Wild Worms Vs. Lab Worms In A Laboratory Ecosystem, Alexis Winner
Undergraduate Research Conference at Missouri S&T
The model organism Caenorhabditis elegans lives artificially in labs since the 1970s. The question at hand is how well adapted the so-called wild-type strain is to these lab conditions. We developed a laboratory ecosystem based on wild type C. elegans and E. coli as food resource to investigate the impact of mutations that affect life history traits. In this project, we explore whether the observed population dynamics reflect wild C. elegans populations. In more detail, we compare the population dynamics of wild type worms and worms collected recently in different parts of the world.
Simulating Inter-Species Competition In C. Elegans, Kevin Lai
Simulating Inter-Species Competition In C. Elegans, Kevin Lai
Undergraduate Research Conference at Missouri S&T
In biological research, understanding the life cycles of Caenorhabditis elegans (C. elegans) is pivotal for insights into developmental biology, genetics, and population dynamics. Our project builds on Worm-Pop, a Python-based multi-agent simulation of Caenorhabditis elegans (C. elegans) , to enhance its capabilities in simulating survival strategies, reproductive success, and genetic drift. The current model simulates a uniform population without inter-agent interactions. I plan to introduce multiple species of worms into the simulation to study competitive dynamics and determine which variants are most successful under various conditions. Pheromones significantly influence C. elegans behavior, affecting mating, foraging, and social interactions. To address …
Insect Collection Methods At Fort Leonard Wood, Sage Wood, Miranda Ragland, Robin M. Verble
Insect Collection Methods At Fort Leonard Wood, Sage Wood, Miranda Ragland, Robin M. Verble
Undergraduate Research Conference at Missouri S&T
This project is part of a larger survey examining the terrestrial insect diversity at Fort Leonard Wood in summers 2021 and 2022. The data analyzed in this poster includes specimens collected during the 2022 collection period. This project attempts to elucidate the most effective method of insect collection at Fort Leonard Wood, as well as any hotspots of insect presence or diversity on the base. Specimens were collected using hand and net collection, Lindgren funnel trapping, leaf litter sampling, and three colors of pan trapping (blue, yellow, white). Specimens were processed in the lab, pinned, sorted, and identified. Preliminary analysis …
Effect Of Morphology As A Function Of The K-Index On The Drug Loading And Release Profiles In Polyurea And Poly(Isocyanurate-Urethane) Aerogels, Kamden J. George, Stephen Y. Owusu, Chariklia Sotiriou-Leventis
Effect Of Morphology As A Function Of The K-Index On The Drug Loading And Release Profiles In Polyurea And Poly(Isocyanurate-Urethane) Aerogels, Kamden J. George, Stephen Y. Owusu, Chariklia Sotiriou-Leventis
Undergraduate Research Conference at Missouri S&T
This study explores the potential to predict the drug loading and release profiles of aerogels based on their morphologies: a milestone in drug delivery research which can help save time and cost invested in formulating new aerogel drug carriers and cut-down evaluation of the drug delivery capabilities of aerogels to a few experimental runs. Polyurea (PUA) and poly (isocyanurate-urethane) (PIR-PUR) aerogels were used as model systems while 5-fluorouracil (5-FU) and paracetamol (PM) were used as model drugs. These model systems were chosen because they can be synthesized into different morphologies identified by the so-called K-index (contact angle:porosity). The model drugs …
Cytokinesis And Dbf2, Katharine Gray, Katie Shannon
Cytokinesis And Dbf2, Katharine Gray, Katie Shannon
Undergraduate Research Conference at Missouri S&T
During cell division, the cytoplasm must be divided between the parent and daughter cell. The Mitotic Exit Network (MEN) is a signaling pathway that allows a dividing cell to exit mitosis and complete cytokinesis. Obf2 is a MEN protein kinase in yeast, which provides a simplified model for studying this conserved pathway. By regulating Dbf2s' activity through phosphorylation mutants, its effect on cytokinesis can be studied. Cells were viewed under a microscope, to visualize division errors. Yeast cells that fail to complete cytokinesis will form chains, as the budding daughter cells fail to separate from their parents. Chains of 3 …
Dynamics Of Laboratory Nematode Populations, Erik Bergstrom, Andrea Scharf
Dynamics Of Laboratory Nematode Populations, Erik Bergstrom, Andrea Scharf
Undergraduate Research Conference at Missouri S&T
Understanding how populations fluctuate is important for understanding how evolutionary pressures have shaped the life histories of species, such as reproductive patterns and aging. A laboratory ecosystem consisting of Caenorhabditis elegans and Escherichia coli and wormPOP, a simulation of this laboratory ecosystem, developed by Scharf and colleagues (Scharf et al., 2022) provides an opportunity to better understand population dynamics by tracking individual simulated worms and computing the emergent population dynamics. However, the output data consist of curves with peaks and troughs that are challenging to analyze and that were hypothesized to fit the mathematical definition of chaotic behavior. This project …
Are Pheromones Necessary To Survive?, Galayna Baur
Are Pheromones Necessary To Survive?, Galayna Baur
Undergraduate Research Conference at Missouri S&T
Caenorhabditis elegans (C.elegans) is a species of nematodes widely found on rotting plant material due to the presence of their primary food source, bacteria. These animals utilize pheromones for communication to signal larval stages to enter the dauer phase-a survival strategy enabling them to withstand periods of minimal to no food availability, thereby regulating their population size. This study investigates the role of pheromone signaling in population dynamics and survival strategies of C. elegans using a population dynamics experiment. We employ two strains: N2, a laboratory strain with intact pheromone signaling, and a mutant strain lacking the ability to signal …
Stream Fungal Biodiversity And Leaf Decomposition, Vale Miller
Stream Fungal Biodiversity And Leaf Decomposition, Vale Miller
Undergraduate Research Conference at Missouri S&T
CURRENTLY ONGOING PROJECT We are investigating the possible impact of aquatic fungi biodiversity on leaf litter decomposition and respiration. Four different species of aquatic fungi were placed into flasks with leaf cores (A, B, C, and D), one with no fungi as a control, and one with all four species in equal amounts (ABCD). So far, there seems to be little to no effect on respiration between the species and similar results in the flasks with all four species. Based on this information, biodiversity has yet to show a significant impact in leaf respiration and little to no effect on …
Xenobiotic-Lnduced Developmental Neuropathology, Lindsay Schneider
Xenobiotic-Lnduced Developmental Neuropathology, Lindsay Schneider
Undergraduate Research Conference at Missouri S&T
As new drugs and pollutants are introduced, a larger subset of people are exposed. The question that arises is whether exposure of a pregnant woman to drugs/pollutants will have negative effects on the neurobiology of her unborn child. We are establishing a screen to test the effects of drugs and pollutants on the developmental neuropathology of the model organism, Caenorhabditis elegans. The roundworm has 302 neurons that are structurally similar to human neurons, and defects in single neurons can be detected by impairment in their neural behaviors such as chemotaxis towards an attractant. Using a chemotaxis assay, we can investigate …
Bioaerosol Size As A Potential Determinant Of Airborne E. Coli Viability Under Ultraviolet Germicidal Irradiation And Ozone Disinfection, Weixing Hao, Yue-Wern Huang, Yang Wang
Bioaerosol Size As A Potential Determinant Of Airborne E. Coli Viability Under Ultraviolet Germicidal Irradiation And Ozone Disinfection, Weixing Hao, Yue-Wern Huang, Yang Wang
Biological Sciences Faculty Research & Creative Works
Ultraviolet germicidal irradiation (UVGI) and ozone disinfection are crucial methods for mitigating the airborne transmission of pathogenic microorganisms in high-risk settings, particularly with the emergence of respiratory viral pathogens such as SARS-CoV-2 and avian influenza viruses. This study quantitatively investigates the influence of UVGI and ozone on the viability of E. coli in bioaerosols, with a particular focus on how E. coli viability depends on the size of the bioaerosols, a critical factor that determines deposition patterns within the human respiratory system and the evolution of bioaerosols in indoor environments. This study used a controlled small-scale laboratory chamber where E. …
Homodimeric Granzyme A Opsonizes Mycobacterium Tuberculosis And Inhibits Its Intracellular Growth In Human Monocytes Via Toll-Like Receptor 4 And Cd14, Valerio Rasi, Kathleen R. Phelps, Keegan R. Paulson, Christopher S. Eickhoff, Mathivanan Chinnaraj, Nicola Pozzi, Marco Di Gioia, Ivan Zanoni, Shubha Shakya, Haley L. Carlson, David A. Ford, Grant R. Kolar, Daniel F. Hoft
Homodimeric Granzyme A Opsonizes Mycobacterium Tuberculosis And Inhibits Its Intracellular Growth In Human Monocytes Via Toll-Like Receptor 4 And Cd14, Valerio Rasi, Kathleen R. Phelps, Keegan R. Paulson, Christopher S. Eickhoff, Mathivanan Chinnaraj, Nicola Pozzi, Marco Di Gioia, Ivan Zanoni, Shubha Shakya, Haley L. Carlson, David A. Ford, Grant R. Kolar, Daniel F. Hoft
Biological Sciences Faculty Research & Creative Works
Mycobacterium tuberculosis (Mtb)-specific γ9δ2 T cells secrete granzyme A (GzmA) protective against intracellular Mtb growth. However, GzmA-enzymatic activity is unnecessary for pathogen inhibition, and the mechanisms of GzmA-mediated protection remain unknown. We show that GzmA homodimerization is essential for opsonization of mycobacteria, altered uptake into human monocytes, and subsequent pathogen clearance within the phagolysosome. Although monomeric and homodimeric GzmA bind mycobacteria, only homodimers also bind cluster of differentiation 14 (CD14) and Toll-like receptor 4 (TLR4). Without access to surface-expressed CD14 and TLR4, GzmA fails to inhibit intracellular Mtb. Upregulation of Rab11FIP1 was associated with inhibitory activity. Furthermore, GzmA colocalized with …
Wearable Mxene-Graphene Sensing Of Influenza And Sars-Cov-2 Virus In Air And Breath: From Lab To Clinic, Yanxiao Li, Zhekun Peng, Jiaoli Li, Congjie Wei, Shangbin Liu, Weixing Hao, Huanyu Cheng, Casey Burton, Yang Wang, Yue-Wern Huang, Chang Soo Kim, Fang Yao Stephen Hou, Donghyun (Bill) Kim, Chenglin Wu
Wearable Mxene-Graphene Sensing Of Influenza And Sars-Cov-2 Virus In Air And Breath: From Lab To Clinic, Yanxiao Li, Zhekun Peng, Jiaoli Li, Congjie Wei, Shangbin Liu, Weixing Hao, Huanyu Cheng, Casey Burton, Yang Wang, Yue-Wern Huang, Chang Soo Kim, Fang Yao Stephen Hou, Donghyun (Bill) Kim, Chenglin Wu
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
The rapidly expanding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants demand a continuous monitoring method through portable and wearable devices. Utilizing the rich surface chemistry and high chemical-to-electrical signal conversion of 2D MXene-graphene heterostructure thin films, a field-effect-transistor (FET) sensor, which has a flexible substrate to be assembled onto the mask and combines with a Bluetooth system for wireless transmission is developed, to detect the influenza and SARS-CoV-2 viruses in air and breath. At first, the developed sensors are examined in the laboratory through direct contact with sensing targets in solution form. The results show a low …
Entomologists Require Ethical Guidance For Compassionate Management Of Delusional Parasitosis Cases, Kathleen Murphy-Hollies, Michael Skvarla, Robin M. Verble
Entomologists Require Ethical Guidance For Compassionate Management Of Delusional Parasitosis Cases, Kathleen Murphy-Hollies, Michael Skvarla, Robin M. Verble
Biological Sciences Faculty Research & Creative Works
No abstract provided.
Comparison Of Energy Budget Of Cockroach Nymph (Hemimetabolous) And Hornworm (Holometabolous) Under Food Restriction, Charles J. Green, Chen Hou
Comparison Of Energy Budget Of Cockroach Nymph (Hemimetabolous) And Hornworm (Holometabolous) Under Food Restriction, Charles J. Green, Chen Hou
Biological Sciences Faculty Research & Creative Works
Animals with different life histories budget their intake energy differently when food availability is low. It has been shown previously that hornworm (larva of Manduca sexta), a holometabolous insect species with a short development stage, prioritizes growth at the price of metabolism under food restriction, but it is unclear how hemimetabolous insect species with a relatively long development period budget their intake energy under food scarcity. Here, we use orange head cockroaches (Eublaberus posticus) to investigate this question. We found that for both species under food restriction, rates of metabolism and growth were suppressed, but the degree of reduction was …
Borate-Based Bioactive Glasses Properties: Clinical And Biomedical Applications, Sarah Fakher, David J. Westenberg
Borate-Based Bioactive Glasses Properties: Clinical And Biomedical Applications, Sarah Fakher, David J. Westenberg
Biological Sciences Faculty Research & Creative Works
Borate bioactive glasses (BBGs) constitute the recently produced bioactive glasses (BGs) in the domain of bioactive materials, offering enhanced functionalities over conventional silicate and phosphate BGs. This advancement is primarily characterized by BBGs' rapid yet controllable degradation rates, superior bioactivity, and the ability to swiftly form a hydroxyapatite layer (HAP) upon interaction with physiological fluids. A distinguishing feature of BBGs lies in their customizability; doping with therapeutic metal ions tailors their bioactivity towards specific physiological responses, including promoting angiogenesis, antibacterial activity, and osteogenesis. This versatility of BBGs' applications extends to bone regeneration, wound healing, drug delivery systems, and potentially nerve …
Advanced Detection Of Sars-Cov-2 And Omicron Variants Via Mxene-Graphene Hybrid Biosensors Utilizing Nucleic Acid Probes, Jiaoli Li, Yuwei Zhang, Congjie Wei, Yanxiao Li, Zhekun Peng, Hsin Yin Chuang, Logan Pearce, Adrianus Boon, Yue-Wern Huang, Dong Hyun Kim, Risheng Wang, Chenglin Wu
Advanced Detection Of Sars-Cov-2 And Omicron Variants Via Mxene-Graphene Hybrid Biosensors Utilizing Nucleic Acid Probes, Jiaoli Li, Yuwei Zhang, Congjie Wei, Yanxiao Li, Zhekun Peng, Hsin Yin Chuang, Logan Pearce, Adrianus Boon, Yue-Wern Huang, Dong Hyun Kim, Risheng Wang, Chenglin Wu
Biological Sciences Faculty Research & Creative Works
Low-cost biosensors that can rapidly and widely detect viruses are critical for faster diagnosis and treatment decision-making, especially for infections. The commonly used field-effect transistor is sensitive to the biomarker's detection but struggles with precise detection, particularly of nontargets such as ions and proteins. To overcome this limitation, we developed a field-effect transistor biosensor design based on MXene-graphene materials to increase the accuracy and sensitivity of virus detection. Based on the hybridization process between two complementary DNA strands, single-stranded nucleic acids were immobilized on the sensing surface via 3-aminopropyltriethoxysilane and glutaraldehyde to capture the nucleic acids of the target virus. …
A Review Of Dielectric Barrier Discharge Cold Atmospheric Plasma For Surface Sterilization And Decontamination, Kolawole Adesina, Ta Chun Lin, Yue-Wern Huang, Marek Locmelis, Daoru Frank Han
A Review Of Dielectric Barrier Discharge Cold Atmospheric Plasma For Surface Sterilization And Decontamination, Kolawole Adesina, Ta Chun Lin, Yue-Wern Huang, Marek Locmelis, Daoru Frank Han
Biological Sciences Faculty Research & Creative Works
Numerous investigations have shown that non-equilibrium discharges at atmospheric pressure, also known as "cold atmospheric plasma" (CAP) are efficient to remove biological contaminants from surfaces of a variety of materials. Recently, CAP has quickly advanced as a technique for microbial cleaning, wound healing, and cancer therapy due to the chemical and biologically active radicals it produces, known collectively as reactive oxygen and nitrogen species (RONS). This article reviews studies pertaining to one of the atmospheric plasma sources known as Dielectric Barrier Discharge (DBD) which has been widely used to treat materials with microbes for sterilization, disinfection, and decontamination purposes. To …
Bioprinting With Adipose Stem Cells And Hydrogel Modified With Bioactive Glass, Krishna C.R. Kolan, Apurv Saxena, Bradley A. Bromet, Lesa B. Steen, August T. Bindbeutel, Julie A. Semon, Delbert E. Day, Ming C. Leu
Bioprinting With Adipose Stem Cells And Hydrogel Modified With Bioactive Glass, Krishna C.R. Kolan, Apurv Saxena, Bradley A. Bromet, Lesa B. Steen, August T. Bindbeutel, Julie A. Semon, Delbert E. Day, Ming C. Leu
Biological Sciences Faculty Research & Creative Works
Bioprinting research is focused on utilizing growth factors and multiple cell types to create clinically relevant three-dimensional (3D) tissue models using hydrogels. Rheological and biological challenges are two main factors that limit the creation of extrudable bioactive hydrogels. In this study, we investigate incorporation of fast dissolving and bioactive borate glass in different weight to volume percentages (0.075 to 0.6%) to alginate-gelatin (1:1) hydrogel to improve rheological properties and enable bioprinting with bioactive glass. The addition of glass improved the stiffness of the hydrogel. Human adipose-derived mesenchymal stem cells (ASCs) were uniformly mixed in this bioink at 1 x 106 …
In Vitro Assessment Of The Anti-Biofilm Effectiveness Of Copper And Zinc Enhanced Borate Bioactive Glass Using Processed Microscopic Images, Sarah Fakher, David J. Westenberg
In Vitro Assessment Of The Anti-Biofilm Effectiveness Of Copper And Zinc Enhanced Borate Bioactive Glass Using Processed Microscopic Images, Sarah Fakher, David J. Westenberg
Biological Sciences Faculty Research & Creative Works
The escalating burden of nosocomial infections presents a formidable challenge to healthcare systems worldwide, leading to increased morbidity, prolonged hospital stays, and elevated healthcare costs. These infections are often resistant to conventional antibiotic therapies due to their association with biofilms which contribute to the persistence and resistance of pathogens. In addressing the challenge of biofilm-associated nosocomial infections, borate bioactive glasses (BBGs) have emerged as promising biomaterials. Doping these glasses with antimicrobial metals could potentially harness their antibacterial properties to prevent biofilm formation. This study undertakes a rigorous evaluation of the anti-biofilm efficacy of copper and zinc-doped BBGs by employing processed …
Effect Of Bioactive Borate Glass On Printability And Physical Properties Of Hydrogels, Fateme Fayyazbakhsh, Mehedi H. Tusar, Yue-Wern Huang, Ming C. Leu
Effect Of Bioactive Borate Glass On Printability And Physical Properties Of Hydrogels, Fateme Fayyazbakhsh, Mehedi H. Tusar, Yue-Wern Huang, Ming C. Leu
Mechanical and Aerospace Engineering Faculty Research & Creative Works
Hydrogels are a key component in bioinks and biomaterial inks for bioprinting due to their biocompatibility and printability at room temperature. The research described in the present paper contributes to the advancement of bioprinting by studying the effect of bioactive borate glass (BBG) incorporated into hydrogels on printability and physical properties. In this study, we fabricated 3D-printed hydrogel scaffolds using gelatin and alginate hydrogel mixture incorporated with various amounts of BBG, a bio ceramic rich in therapeutic ions including boron, calcium, copper, and zinc. We investigated the effect of incorporating BBG on the density, viscosity, physical interactions, chemical structure, and …
Upa-Mediated Polyamidoamine Dendrimer-Based Targeted Gene Delivery System On Triple-Negative Breast Cancer, Hsin-Yin Chuang
Upa-Mediated Polyamidoamine Dendrimer-Based Targeted Gene Delivery System On Triple-Negative Breast Cancer, Hsin-Yin Chuang
Masters Theses
"Around 15% of breast cancers are triple-negative breast cancer (TNBC), which is characterized by the absence of three common receptors—ER, PR, and HER2, and therefore do not respond to hormonal or anti-HER2 therapies. It is urgent to explore targeted therapeutic strategies for TNBC due to its poor prognosis and rare effective targeted therapy. In this study, we developed a polyamidoamine (PAMAM) dendrimer-based targeted gene delivery system—GDP-uPA, to utilize urokinase-type plasminogen activator (uPA) to target uPA receptor (uPAR), which is highly expressed in both TNBC cells and cancer-associated stromal cells. Our results of 1H NMR spectrum, TEM imaging, and MTT assay …
Development Of A Novel Bioink For Human Vascularized Organoids, Bradley Allen Bromet
Development Of A Novel Bioink For Human Vascularized Organoids, Bradley Allen Bromet
Masters Theses
"There is a need for a model to better mimic human physiology in the clinic, so the objective was to develop a novel bioink for a 3D tissue model to study human disease and development in a dynamic 3D environment. The results from each corresponding study helped in developing a novel bioink for use in a bio printed human vascularized organoid. The bioink composed of alginate with other natural hydrogels to function as extracellular matrix and with the addition of borophosphate bioactive glasses (BPBGs) to replace growth factors, can be used with multiple cell types to bio print the proposed …
Protein Turnover Rate And Life History As An Explanation Of The Extreme Difference In Cost Of Biosynthesis In Cockroach Nymphs And Painted Lady Butterfly Larva, Kyara Nicole Holloway
Protein Turnover Rate And Life History As An Explanation Of The Extreme Difference In Cost Of Biosynthesis In Cockroach Nymphs And Painted Lady Butterfly Larva, Kyara Nicole Holloway
Masters Theses
The cost of biosynthesis in painted lady caterpillars is far lower than that of a red runner cockroach. A promising explanation for this phenomenon is the protein turnover rate for the animal during biosynthesis and tissue maintenance. Previous research has shown that, per gram of body weight, the painted lady butterfly can synthesize a biomass using up to 15x less energy and resources than the cockroach, even under similar conditions. The resulting ratios, especially in respect to growth rate, show a wide disparity between species in such a manner that does support a protein synthesis and degradation rates as a …
Occupational And Environmental Factors Influencing Morale Of United States Federal Wildland Firefighters, Rachel M. Granberg, Ting Shen, Seth W. Pearson, Robin M. Verble
Occupational And Environmental Factors Influencing Morale Of United States Federal Wildland Firefighters, Rachel M. Granberg, Ting Shen, Seth W. Pearson, Robin M. Verble
Psychological Science Faculty Research & Creative Works
Background. Wildland firefighters have physically and psychologically demanding jobs that can result in social, economic and health-related stress. Previous studies have examined the physiological and physical effects of a career in wildland fire, but fewer studies have addressed psychological effects, and to date, none have directly analyzed the hiring and work experiences of wildland firefighters. Aims. We surveyed work experiences, health and well-being, and morale of wildland firefighters, explored factors that can improve recruitment and retention, and summarized broad patterns. Methods. We conducted a voluntary anonymous survey of 708 federal wildland firefighters via an online platform over 2 months in …
Mesenchymal Stem Cells In The Treatment Of Osteogenesis Imperfecta, Erica Lang, Julie A. Semon
Mesenchymal Stem Cells In The Treatment Of Osteogenesis Imperfecta, Erica Lang, Julie A. Semon
Biological Sciences Faculty Research & Creative Works
Osteogenesis Imperfecta (OI) is a Disease Caused by Mutations in Different Genes Resulting in Mild, Severe, or Lethal Forms. with No Cure, Researchers Have Investigated the Use of Cell Therapy to Correct the Underlying Molecular Defects of OI. Mesenchymal Stem Cells (MSCs) Are of Particular Interest Because of their Differentiation Capacity, Immunomodulatory Effects, and their Ability to Migrate to Sites of Damage. MSCs Can Be Isolated from Different Sources, Expanded in Culture, and Have Been Shown to Be Safe in Numerous Clinical Applications. This Review Summarizes the Preclinical and Clinical Studies of MSCs in the Treatment of OI. Altogether, the …
Deepening Undergraduate Students’ Thinking About Central Dogma Through Problem-Based Learning, Katherine Alberta Sharp, Rebecca Mc Nall Krall, Jeffrey Chalfant
Deepening Undergraduate Students’ Thinking About Central Dogma Through Problem-Based Learning, Katherine Alberta Sharp, Rebecca Mc Nall Krall, Jeffrey Chalfant
Teacher Education and Certification Faculty Research & Creative Works
A Common Belief among Pre-Medical and Medical Students is that Biochemistry is Not Relevant to Practicing Medicine. the Problem-Based Approach of Case Studies Has Been Used in Medical Education to Scaffold the Application of Content to Clinical Cases, But Few Studies Report on a Similar Use in Undergraduate Biochemistry. Case Studies in Biochemistry and Related Disciplines Have Been Previously Reported as Increasing Learning Motivation and Supporting Depth of Knowledge. Additionally, Students Engaging in Case Studies Outperform Students in Traditional Instruction. the Objective of This Qualitative Case Study Was to Find How the Timing of a Medical Case Study within the …
Variable Rates Of Hybridization Among Contact Zones Between A Pair Of Topminnow Species, Fundulus Notatus And F. Olivaceus, David D. Duvernell, Naznin S. Remex, Jeffrey T. Miller, Jacob F. Schaefer
Variable Rates Of Hybridization Among Contact Zones Between A Pair Of Topminnow Species, Fundulus Notatus And F. Olivaceus, David D. Duvernell, Naznin S. Remex, Jeffrey T. Miller, Jacob F. Schaefer
Biological Sciences Faculty Research & Creative Works
Pairs of species that exhibit broadly overlapping distributions, and multiple geographically isolated contact zones, provide opportunities to investigate the mechanisms of reproductive isolation. Such naturally replicated systems have demonstrated that hybridization rates can vary substantially among populations, raising important questions about the genetic basis of reproductive isolation. The topminnows, Fundulus notatus and F. olivaceus, are reciprocally monophyletic, and co-occur in drainages throughout much of the central and southern United States. Hybridization rates vary substantially among populations in isolated drainage systems. We employed genome-wide sampling to investigate geographic variation in hybridization, and to assess the possible importance of chromosome fusions to …
Best Practices To Promote Field Science Safety, Kristen Yarincik, Anne Kelly, Terry Mcglynn, Robin M. Verble
Best Practices To Promote Field Science Safety, Kristen Yarincik, Anne Kelly, Terry Mcglynn, Robin M. Verble
Biological Sciences Faculty Research & Creative Works
Interventions are necessary to address the ongoing epidemic of sexual harassment and assault in field settings. An evidence-based approach to identifying specific interventions will be most effective at promoting the safety of scientists. We present the results of a workshop conducted by experts in field biology and the study of sexual harassment and assault that identified a comprehensive set of best practices for individuals and organizations. These recommendations are grounded in peer-reviewed scholarship and are separated into four topics: culture change, accountability, policy development, and reporting. The resulting report of the workshop recommends 44 practices, categorized by the resources required …