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Full-Text Articles in Structural Biology
Towards An Action Spectrum For Photoentrainment Of The Chlamydomonas Reinhardtii Circadian Clock, Christa Gaskill
Towards An Action Spectrum For Photoentrainment Of The Chlamydomonas Reinhardtii Circadian Clock, Christa Gaskill
Masters Theses & Specialist Projects
No abstract provided.
Capturing Hammerhead Ribozyme Structures In Action By Modulating General Base Catalysis, Young-In Chi, Monika Martick, Monica Lares, Rosalind Kim, William G. Scott, Sung-Hou Kim
Capturing Hammerhead Ribozyme Structures In Action By Modulating General Base Catalysis, Young-In Chi, Monika Martick, Monica Lares, Rosalind Kim, William G. Scott, Sung-Hou Kim
Center for Structural Biology Faculty Publications
We have obtained precatalytic (enzyme-substrate complex) and postcatalytic (enzyme-product complex) crystal structures of an active full-length hammerhead RNA that cleaves in the crystal. Using the natural satellite tobacco ringspot virus hammerhead RNA sequence, the self-cleavage reaction was modulated by substituting the general base of the ribozyme, G12, with A12, a purine variant with a much lower pKa that does not significantly perturb the ribozyme's atomic structure. The active, but slowly cleaving, ribozyme thus permitted isolation of enzyme-substrate and enzyme-product complexes without modifying the nucleophile or leaving group of the cleavage reaction, nor any other aspect of the substrate. The predissociation …
Detection Of Biomarkers By Mrs Requires Error Analysis, Jeffrey C. Hoch, Mark W. Maciejewski, Michael R. Gryk
Detection Of Biomarkers By Mrs Requires Error Analysis, Jeffrey C. Hoch, Mark W. Maciejewski, Michael R. Gryk
UCHC Articles - Research
Using MRS imaging and singular value decomposition (SVD), Manganas et al. (Science 318, 980,2007) reported a nuclear magnetic resonance diagnostic for neural progenitor cells. Characteristics of MRS experiments are known to be problematic for SVD-based methods. Absent detection using alternate methods of spectrum analysis or controls to quantify the false discovery rate, little significance can be attached to their result.
Biomechanical Modeling Of Forelimb Adduction In The Eastern Mole, Scalopusaquaticus, Mark Sandefur
Biomechanical Modeling Of Forelimb Adduction In The Eastern Mole, Scalopusaquaticus, Mark Sandefur
Mahurin Honors College Capstone Experience/Thesis Projects
The hypertrophied musculoskeletal system driving adduction of Sealopus aquatieus's forelimb supports the locomotion of these burrowing subterranean mammals. Due to the excessive bulk of the major muscles contributing to this action, it was thought that this particular species may represent a rare case of a mammalian species with a greatly enhanced force contribution from each muscle, correlating with a reduction in the potential for the forelimb to adduct at a high velocity. By assessing the lever ratios of five significant muscles contributing to forelimb adduction, combined with vector analyses for the angles of these muscles' insertions, a model was established …