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Articles 1 - 5 of 5
Full-Text Articles in Biophysics
Allosteric Inhibition Of A Stem Cell Rna-Binding Protein By An Intermediary Metabolite, Carina Clingman, Laura Deveau, Samantha Hay, Ryan Genga, Shivender Shandilya, Francesca Massi, Sean Ryder
Allosteric Inhibition Of A Stem Cell Rna-Binding Protein By An Intermediary Metabolite, Carina Clingman, Laura Deveau, Samantha Hay, Ryan Genga, Shivender Shandilya, Francesca Massi, Sean Ryder
Sean P. Ryder
Gene expression and metabolism are coupled at numerous levels. Cells must sense and respond to nutrients in their environment, and specialized cells must synthesize metabolic products required for their function. Pluripotent stem cells have the ability to differentiate into a wide variety of specialized cells. How metabolic state contributes to stem cell differentiation is not understood. In this study, we show that RNA-binding by the stem cell translation regulator Musashi-1 (MSI1) is allosterically inhibited by 18-22 carbon omega-9 monounsaturated fatty acids. The fatty acid binds to the N-terminal RNA Recognition Motif (RRM) and induces a conformational change that prevents RNA …
Three-Dimensional Confocal Microscopy Indentation Method For Hydrogel Elasticity Measurement, Donghee Lee, Md Mahmudur Rahman, You Zhou, Sangjin Ryu
Three-Dimensional Confocal Microscopy Indentation Method For Hydrogel Elasticity Measurement, Donghee Lee, Md Mahmudur Rahman, You Zhou, Sangjin Ryu
Md Mahmudur Rahman
No abstract provided.
Exploring The Role Of The Solvent In The Denaturation Of A Protein: A Molecular Dynamics Study Of The Dna Binding Domain Of The 434 Repressor, Celia Schiffer, Volker Dötsch, Kurt Wuthrich, Wilfred Van Gunsteren
Exploring The Role Of The Solvent In The Denaturation Of A Protein: A Molecular Dynamics Study Of The Dna Binding Domain Of The 434 Repressor, Celia Schiffer, Volker Dötsch, Kurt Wuthrich, Wilfred Van Gunsteren
Celia A. Schiffer
Molecular dynamics simulations of the DNA binding domain of 434 repressor are presented which aim at unraveling the role of solvent in protein denaturation. Four altered solvent models, each mimicking various possible aspects of the addition of a denaturant to the aqueous solvent, were used in the simulations to analyze their effects on the stability of the protein. The solvent was altered by selectively changing the Coulombic interaction between water and protein atoms and between different water molecules. The use of a modified solvent model has the advantage of mimicking the presence of denaturant without having denaturant molecules present in …
Pericellular Conditions Regulate Extent Of Cell-Mediated Compaction Of Collagen Gels, Mark Stevenson, Alisha Sarang-Sieminski, Claire Mcleod, Fitzroy Byfield, Victor Barocas, Ketih Gooch
Pericellular Conditions Regulate Extent Of Cell-Mediated Compaction Of Collagen Gels, Mark Stevenson, Alisha Sarang-Sieminski, Claire Mcleod, Fitzroy Byfield, Victor Barocas, Ketih Gooch
Alisha L. Sarang-Sieminski
Cell-mediated compaction of the extracellular matrix (ECM) plays a critical role in tissue engineering, woundhealing, embryonic development, and many disease states. The ECM is compacted as a result of cellular traction forces. Wehypothesize that a cell mechanically remodels the nearby ECM until some target conditions are obtained, and then the cell stopscompacting. A key feature of this hypothesis is that ECM compaction primarily occurs in the pericellular region and the propertiesof the ECM in the pericellular region govern cellular force generation. We developed a mathematical model to describe theamount of macroscopic compaction of cell-populated collagen gels in terms of the …
A Comparison Of Three Computer-Based Methods Used To Determine Emg Signal Amplitude, Doug Renshaw
A Comparison Of Three Computer-Based Methods Used To Determine Emg Signal Amplitude, Doug Renshaw
Doug Renshaw
No abstract provided.