Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- ALS/FTD (1)
- Alzheimer's disease (1)
- Biophysical Characterization (1)
- CCAAT-enhancer-binding protein β (C/EBPβ) (1)
- FMRP (1)
-
- FUS (1)
- Fragile X Syndrom (1)
- Gene Transcription (1)
- Hepatitis C Virus (1)
- Inflammation (1)
- Interleukin 1 beta (IL-1β) (1)
- MicroRNA (1)
- Neurodegeneration (1)
- Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) (1)
- Nucleic Acid (1)
- Protein (1)
- Protein–Protein Molecular Docking (1)
- RNA structure (1)
- SARS-CoV-2 (1)
- Spi1/PU.1 (1)
- T cell receptor activation (1)
- THP-1 Monocytic cell line (1)
- Toll-like Receptor 4 (TLR4) activation (1)
Articles 1 - 3 of 3
Full-Text Articles in Biochemistry
Rna Structure And Function: Biological Relevance In Neurodegenerative And Infectious Disease Pathogenesis, Joshua Imperatore
Rna Structure And Function: Biological Relevance In Neurodegenerative And Infectious Disease Pathogenesis, Joshua Imperatore
Electronic Theses and Dissertations
The studies outlined in this dissertation encompass a broad focus, relating to the pathogenesis of neurological disorders such as Alzheimer’s disease, fragile X syndrome, and amyotrophic lateral sclerosis, as well as a novel infectious disease, COVID-19. However, all four studies detailed within this dissertation contain similar elements, namely, the coordinated role of RNA structure and function in essential molecular mechanisms. The results of these investigations allow us to speculate on various disease- related mechanisms, including dysregulated microRNA processing pathways, nucleocytoplasmic shuttling via distinct RNA-protein interactions, and fine-tuned molecular switches controlling genomic dimerization and viral hijacking of host cellular microRNAs. Taken …
Transcription Regulation Of Human Il1b Gene In Monocytes And Lymphoid Cd4 T Cells, Sree H. Pulugulla
Transcription Regulation Of Human Il1b Gene In Monocytes And Lymphoid Cd4 T Cells, Sree H. Pulugulla
Electronic Theses and Dissertations
Cytokines are key regulators of the inflammatory response and play an important role in facilitating intercellular communication between various immune cell types. Interleukin‑1β (IL‑1β) is a potent pro-inflammatory cytokine that is required for robust initiation of innate immune response and subsequent development of adaptive immunity. IL-1β is first synthesized as an inactive cytoplasmic, non‑glycosylated, precursor molecule (proIL‑1β) by monocytes and macrophages in response to invading pathogenic microbes. The activation of caspase‑1 by inflammasomes cleaves proIL-1β into mature biologically active IL-1β that is released from cells via a non-classical, endoplasmic reticulum‑independent secretory pathway directly from the cytoplasm via Gasdermin D membrane …
Neuronal Gq Structures In Neurodegeneration, Damian S. Mcaninch
Neuronal Gq Structures In Neurodegeneration, Damian S. Mcaninch
Electronic Theses and Dissertations
This study investigates protein nucleic acid interactions between various proteins and G quadruplex (GQ) forming messenger RNAs (mRNAs) in human neurological disorders. GQ structures are formed in DNA/RNA, when four guanine residues form planar tetrads stabilized by Hoogsteen base pairing, that stack forming a GQ structure stabilized by potassium ions. These GQ structures are targeted by the arginine-glycine-glycine (RGG) repeat domain containing RNA-binding domain.
Three RGG domain containing RNA-binding proteins, all of which have been implicated in neurological disorders, and their interactions with GQ forming mRNAs, were investigated in this study: fused in sarcoma (FUS), fragile X mental retardation protein …