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Full-Text Articles in Biochemistry
Strategies For The Modulation Of Protease Activated Receptors (Pars), Disha M. Gandhi
Strategies For The Modulation Of Protease Activated Receptors (Pars), Disha M. Gandhi
Dissertations (1934 -)
Protease-activated receptors (PARs) are class A G protein-coupled receptors (GPCRs) with 4 subtypes (PAR 1 – 4) and with a unique mode of action. PARs are cleaved by extracellular proteases at the N-terminus, creating a new tethered ligand that activates the receptor and transduces biological signals into the cell. PARs have been implicated in various productive and pathological signals, including those related to thrombosis, inflammation, reperfusion injury, and cancer cell metastasis. Despite the fact that PARs are attractive as drug targets, their intramolecular mode of activation makes it challenging to modulate them with drugs in a selective manner, and only …
Dynamics And Interactions Of Membrane Proteins, Azamat Galiakhmetov
Dynamics And Interactions Of Membrane Proteins, Azamat Galiakhmetov
Dissertations (1934 -)
Membrane proteins are members of the class of proteins that perform their functions while being associated with a lipid bilayer. In the cell, they serve as transporters, receptors, anchors and enzymes. The domain organisation of these proteins suggests importance of lipid membrane and protein-lipid interactions for protein function. The requirement of a membrane mimic and the level of its resemblance to a native one for protein investigation makes the studies of membrane proteins a challenging project. My research work is focusing on the biophysical and biochemical studies of membrane proteins. This dissertation outlines two separate projects, each with their own …