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Articles 151 - 165 of 165
Full-Text Articles in Biochemistry
Electron Capture Properties Of Halogenated Amine Derivatives / By Donald D. Clarke, Sherwin Wilk, And Stanley E. Gitlow, Donald Dudley Clarke Phd, Sherwin Wilk, Stanley E. Gitlow
Electron Capture Properties Of Halogenated Amine Derivatives / By Donald D. Clarke, Sherwin Wilk, And Stanley E. Gitlow, Donald Dudley Clarke Phd, Sherwin Wilk, Stanley E. Gitlow
Chemistry Faculty Publications
The use of gas-liquid chromatography (G.L.C.) for the analysis of amines of biological interest is currently under investigation in our laboratory. An intensive study of the chromatographic properties of a number of derivatives was presented by VandenHeuvel et al. (1), and this laboratory in a short communication reported on the possible use of heptafluorobutyrylated amine derivatives (2). As was noted in this early communication, sensitivity considerations must maintain priority in any proposed assay because of the extremely small quantities of these compounds present in biological fluids. For this reason, we have chosen to employ the electron capture detector (3). Trifluoroacetyl …
A Quantitative Assay For Vanillylmandelic Acid (Vma) By Gas-Liquid Chromatography / Sherwin Wilk From The Department Of Medicine, Th Emount Sinai Hospital, New York, New York And The Department Of Chemistry, Fordham University, New York, N.Y. Stanley E. Gitlow And Milton Mendlowitz From The Department Of Medicine, The Mount Sinai Hospital, New York, New York Morton J. Franklin And Herman E. Carr From The Department Of Psychiatry, Boston University, School Of Medicine, Boston, Massachusetts And Donald D. Clarke From The Department Of Chemistry, Fordham University, New York, New York, Sherwin Wilk, Stanley E. Gitlow, Milton Mendlowitz, Donald Dudley Clarke Phd
A Quantitative Assay For Vanillylmandelic Acid (Vma) By Gas-Liquid Chromatography / Sherwin Wilk From The Department Of Medicine, Th Emount Sinai Hospital, New York, New York And The Department Of Chemistry, Fordham University, New York, N.Y. Stanley E. Gitlow And Milton Mendlowitz From The Department Of Medicine, The Mount Sinai Hospital, New York, New York Morton J. Franklin And Herman E. Carr From The Department Of Psychiatry, Boston University, School Of Medicine, Boston, Massachusetts And Donald D. Clarke From The Department Of Chemistry, Fordham University, New York, New York, Sherwin Wilk, Stanley E. Gitlow, Milton Mendlowitz, Donald Dudley Clarke Phd
Chemistry Faculty Publications
Until the discovery of the major product of catecholamine n1etabolism, vanillylmandelic acid (VMA), by Annstrong in 1957 (1), biochemical studies of epinephrine and norepinephrine metabolism were dependent upon determination of the small quantities of these materials excreted unchanged in the urine. The methods designed to measure VMA have proved adequate to detect the gross abnormalities in metabolism usually associated with catecholamine-producing tumors (2-7), but more exact procedures are required for quantitative metabolic studies. Present spectrophotometric and electrophoretic methods are nonspecific in that they yield values for VMA that are higher than those obtained by chromatographic and isotope dilution techniques (5). …
Acid Hydrolysis Of 3-Phenylsydnone-2-N15 / Joanne Staley And Donald D. Clarke Chemistry Department, Fordham University, Bronx, New York, Joanne Staley, Donald Dudley Clarke Phd
Acid Hydrolysis Of 3-Phenylsydnone-2-N15 / Joanne Staley And Donald D. Clarke Chemistry Department, Fordham University, Bronx, New York, Joanne Staley, Donald Dudley Clarke Phd
Chemistry Faculty Publications
When N -phenylsydnone is hydrolyzed by acid, an internal oxidation- reduction reaction takes place with the formation of phenylhydrazine, formic acid, and carbon dioxide. The mechanism shown below was suggested for this reaction by Baker and Ollis. Aside from the nature of the end products of this hydrolysis, the strongest evidence cited by Baker and Ollis in support of their mechanism is the paper by Kenner and Mackay who reported the isolation of a-acylhydrazines when the hydrolysis was carried out in benzene with stoichiometric quantities of water and hydrochloric acid. However, Kenner and Mackay gave no experimental evidence to support …
Quantitative Aspects Of Co2 Fixation In Mammalian Brain In Vivo / H. Waelsch, S. Berl, C.A. Rossi, D. D. Clarke, And D. P. Purpura New York State Psychiatric Institute And Departments Of Biochemistry And Neurological Surgery, College Of Physicians And Surgeons, Columbia University, New York, N.Y., Heinrich Waelsch, Soll Berl, C. A. Rossi, Donald Dudley Clarke Phd
Quantitative Aspects Of Co2 Fixation In Mammalian Brain In Vivo / H. Waelsch, S. Berl, C.A. Rossi, D. D. Clarke, And D. P. Purpura New York State Psychiatric Institute And Departments Of Biochemistry And Neurological Surgery, College Of Physicians And Surgeons, Columbia University, New York, N.Y., Heinrich Waelsch, Soll Berl, C. A. Rossi, Donald Dudley Clarke Phd
Chemistry Faculty Publications
The rate of fixation of carbon dioxide in vivo into aspartate, glutamate, oxoglutarate, and glutamine of cerebral cortex and liver in the absence and presence of elevated concentrations of tissue ammonia was studied. The specific activities of the isolated metabolites were related to the specific activity of the tissue CO2. It was attempted to obtain an approximate steady state level of tissue 14CO2 by maintaining a constant isotope concentration in the venous and arterial blood through continuous intravenous administration of NaH14CO3. 1. In the absence of ammonia, aspartic acid achieved the highest specific activity in both brain and liver; the …
Radicinin: Revision Of Its Structure Obtained From Nmr Measurements / D. D. Clarke F. F. Nord N. S. Bhacca Laboratory Of Organic Chemistry And Enzymology Fordham University Bronx 58, New York Spectroscopy Applications Laboratory Varian Associates Palo Alto, California, Donald Dudley Clarke Phd, Friedrich F. Nord, N. S. Bhacca
Radicinin: Revision Of Its Structure Obtained From Nmr Measurements / D. D. Clarke F. F. Nord N. S. Bhacca Laboratory Of Organic Chemistry And Enzymology Fordham University Bronx 58, New York Spectroscopy Applications Laboratory Varian Associates Palo Alto, California, Donald Dudley Clarke Phd, Friedrich F. Nord, N. S. Bhacca
Chemistry Faculty Publications
Radicinin, a metabolite of the formula C12H1205 was isolated from the carrot plant pathogen Stemphylium Tadicinum and described in earlier communications. Hansen isolated a metabolite from S. radicinum that inhibited the growth of Lepidium sativum and named it stemphylone. From the physical and chemical properties described for stemphylone it would appear to be identical with radicinin
Carbon Dioxide Fixation In The Brain / Soll Berl, Genkichiro Takagaki, Donald D Clarke, And Heinrich Waelsch From The New York Psychiatric Institute And The Colleg Eof Physicians And Surgeons, Columbia University, New York, New York, Soll Berl, Genkichiro Takagaki, Donald Dudley Clarke Phd, Heinrich Waelsch
Carbon Dioxide Fixation In The Brain / Soll Berl, Genkichiro Takagaki, Donald D Clarke, And Heinrich Waelsch From The New York Psychiatric Institute And The Colleg Eof Physicians And Surgeons, Columbia University, New York, New York, Soll Berl, Genkichiro Takagaki, Donald Dudley Clarke Phd, Heinrich Waelsch
Chemistry Faculty Publications
Carbon dioxide fixation in brain was studied in cats to which NaHC14O3, with and without ammonia, was administered by intracarotid infusion. Glutamic and aspartic acids, glutamine, glutathione, and γ-aminobutyric acid were isolated from blood, brain, and liver, and their specific activities were determined. The data indicate a significant incorporation of CO2 into the amino acids of the cerebral cortex, presumably by way of the citric acid cycle. Without simultaneous ammonia infusion, the specific activity of aspartic acid is 3 times that of glutamine, whereas in the presence of ammonia the ratios of specific activity of both compounds are closer to …
Amine Incorporation Into Insulin As Catalyzed By Transglutaminase / M. J. Mycek, D. D. Clarke, A. Neidle And H. Waelsch From The Department Of Biochemistry, College Of Physicians And Surgeons, Columbia University, New York, And The New York State Psychiatric Institute, New York, New York, M. J. Mycek, Donald Dudley Clarke Phd, A. Neidle, Heinrich Waelsch
Amine Incorporation Into Insulin As Catalyzed By Transglutaminase / M. J. Mycek, D. D. Clarke, A. Neidle And H. Waelsch From The Department Of Biochemistry, College Of Physicians And Surgeons, Columbia University, New York, And The New York State Psychiatric Institute, New York, New York, M. J. Mycek, Donald Dudley Clarke Phd, A. Neidle, Heinrich Waelsch
Chemistry Faculty Publications
No abstract provided.
An Enzymically Catalyzed Incorporation Of Amines Into Proteins / Nirmal K. Sarkar Donald D. Clarke Heinrich Waelsch Department Of Biochemistry, College Of Physicians And Surgeons, Columbia University, New York, And The New York Psychiatric Institute, New York, N.Y. (U.S.A.), Nirmal K. Sarkar, Donald Dudley Clarke Phd, Heinrich Waelsch
An Enzymically Catalyzed Incorporation Of Amines Into Proteins / Nirmal K. Sarkar Donald D. Clarke Heinrich Waelsch Department Of Biochemistry, College Of Physicians And Surgeons, Columbia University, New York, And The New York Psychiatric Institute, New York, N.Y. (U.S.A.), Nirmal K. Sarkar, Donald Dudley Clarke Phd, Heinrich Waelsch
Chemistry Faculty Publications
In experiments reported some years ago the enzyme-catalyzed exchange of the amide group of glutamine and asparagine with 15N ammonia was demonstrated but an exchange of the amide groups of protein bound dicarboxylic amino acids could not be explored owing to the unfavorable experimental conditions1 . Recently the problem of the metabolism of protein-amide groups was approached again with the aid of 14C-labeled amines, such as ethanolamine or cadaverine. Soluble protein fractions obtained from sucrose homogenates (o.2sM) of the livers of guinea pigs, rats, mice, and rabbits by centrifugation at roo,ooo X g were incubated in the presence of Ca++ …
Synthesis Of Phosphatidyl Peptides I. O-(Distearoyl-L-A-Glycerylphosphoryl)-L-Serylglycylglycine / By Erich Baer, Jonas Maurukas, And Donald D. Clarke (From The Banting And Best Department Of Medical Research, University Of Toronto, Toronto, Canada), Erich Baer, Jonas Maurukas, Donald Dudley Clarke Phd
Synthesis Of Phosphatidyl Peptides I. O-(Distearoyl-L-A-Glycerylphosphoryl)-L-Serylglycylglycine / By Erich Baer, Jonas Maurukas, And Donald D. Clarke (From The Banting And Best Department Of Medical Research, University Of Toronto, Toronto, Canada), Erich Baer, Jonas Maurukas, Donald Dudley Clarke Phd
Chemistry Faculty Publications
The synthesis of a phosphatidyl tripeptide has been accomplished. It was prepared by (a) phosphorylation of D-α,β-distearin with phenylphosphoryl dichloride and pyridine, (b) esterification of the resulting distearoylL- α-glycerylphenylphosphoryl chloride with N-carbobenzoxy-L-serylglycylglycine benzyl ester in the presence of lutidine, and (c) removal of the protective groups by catalytic hydrogenolysis. The O-( distearoyl-L-α-glycerylphosphoryl)- L-serylglycylglycine was obtained in an over-all yield of 12 per cent. The synthesis of N-carbobenzoxy-L-serylglycylglycine benzyl ester, for which two procedures have been reported, has been simplified considerably by condensing N -carbobenzoxy-L-serine with glycylglycine benzyl ester by means of N ,N' -dicyclohexylcarbodiimide. The phosphatidyl tripeptide is cleaved by …
Metabolic Activity Of Protein Amide Groups, Donald Dudley Clarke Phd, Amos Neidle, Nirmal K. Sarkar, Heinrich Waelsch
Metabolic Activity Of Protein Amide Groups, Donald Dudley Clarke Phd, Amos Neidle, Nirmal K. Sarkar, Heinrich Waelsch
Chemistry Faculty Publications
No abstract provided.
L-Serylglycylglycine / By Erich Baer, Jonas Maurukas, And Donald D. Clarke, Erich Baer, Jonas Maurukas, Donald Dudley Clarke Phd
L-Serylglycylglycine / By Erich Baer, Jonas Maurukas, And Donald D. Clarke, Erich Baer, Jonas Maurukas, Donald Dudley Clarke Phd
Chemistry Faculty Publications
A synthesis of the hitherto unreported L-serylglycylglycine by two different methods is described. N-carbobenzoxy L-serylglycylglycine benzyl ester, an intermediate in the preparation of the tripeptide, was found to be a suitable derivative in the synthesis of L-α-phosphatidyl L-serylglycylglycine
Radicinin: A Metabolite From Stemphylium Radicinum. I. Chemistry And Action / D. D. Clarke And F. F. Nord From The Department Of Organic Chemistry And Enzymology, Fordham University, New York, New York, Donald Dudley Clarke Phd, Friedrich F. Nord
Radicinin: A Metabolite From Stemphylium Radicinum. I. Chemistry And Action / D. D. Clarke And F. F. Nord From The Department Of Organic Chemistry And Enzymology, Fordham University, New York, New York, Donald Dudley Clarke Phd, Friedrich F. Nord
Chemistry Faculty Publications
The conditions for the growth of Sterad and isolation of radicinin are described. The formula C12H1205 wasas established for this compound by preparation and analyses of several derivatives. Degradation and spectrophotometric studies were employed to establish the molecular formula. Studies on the mode of action of radicinin revealed that it caused an increase in the rate of dehydrogenation of isopropyl alcohol by FIB, but that it had no effect on the quantity or degree of desaturation of the fat synthesized by FIB
Radicinin: A Metabolite From Stemphylium Radicinum. Ii. On The Mechanism Of Its Biosynthesis / D. D. Clarke And F. F. Nord From The Department Of Organic Chemistry And Enzymology, Fordham University, New York, New York, Donald Dudley Clarke Phd, Friedrich F. Nord
Radicinin: A Metabolite From Stemphylium Radicinum. Ii. On The Mechanism Of Its Biosynthesis / D. D. Clarke And F. F. Nord From The Department Of Organic Chemistry And Enzymology, Fordham University, New York, New York, Donald Dudley Clarke Phd, Friedrich F. Nord
Chemistry Faculty Publications
After studying the effect of various substrates and also of certain enzyme inhibitors on the rate of formation of radicinin by Sterad, it is suggested that the carbohydrate molecule is utilized intact in the biosynthesis of radicinin
Ultraviolet Absorption Spectra Of Derivatives Of 2,3,5- And 2,4,5-Trihydroxyacetophenone / By D. D. Clarke And F. F. Nord, Donald Dudley Clarke Phd, Friedrich F. Nord
Ultraviolet Absorption Spectra Of Derivatives Of 2,3,5- And 2,4,5-Trihydroxyacetophenone / By D. D. Clarke And F. F. Nord, Donald Dudley Clarke Phd, Friedrich F. Nord
Chemistry Faculty Publications
No abstract provided.
Radicinin: A New Pigment From Stemphylium Radicinum / D. D. Clarke F. F. Nord Department Of Organic Chemistry And Enzymology, Fordham University, New York 58, New York, Donald Dudley Clarke Phd, Friedrich F. Nord
Radicinin: A New Pigment From Stemphylium Radicinum / D. D. Clarke F. F. Nord Department Of Organic Chemistry And Enzymology, Fordham University, New York 58, New York, Donald Dudley Clarke Phd, Friedrich F. Nord
Chemistry Faculty Publications
No abstract provided.