Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (26)
- Neuroscience and Neurobiology (26)
- Medical Sciences (23)
- Biochemical Phenomena, Metabolism, and Nutrition (22)
- Anatomy (20)
-
- Molecular and Cellular Neuroscience (20)
- Nervous System (20)
- Systems Neuroscience (20)
- Behavioral Neurobiology (19)
- Physiology (18)
- Systems and Integrative Physiology (18)
- Physical Sciences and Mathematics (15)
- Endocrinology (14)
- Biology (13)
- Chemistry (10)
- Molecular Biology (10)
- Microbiology (5)
- Cell and Developmental Biology (4)
- Virology (4)
- Cell Biology (3)
- Environmental Sciences (3)
- Immunology and Infectious Disease (3)
- Arts and Humanities (2)
- Bioinformatics (2)
- Biophysics (2)
- Computer Sciences (2)
- Diseases (2)
- Keyword
-
- Hypothalamus (8)
- Chaperonin (5)
- 2-deoxyglucose (4)
- Catecholamine (4)
- Stress (4)
-
- Trypanosoma cruzi (4)
- Chagas disease (3)
- Circadian (3)
- Hsp60 (3)
- Metabolism (3)
- Bioenergetics (2)
- Chemistry and Biochemistry (2)
- Corticotropin-releasing hormone (2)
- Cruzain (2)
- Cryo-EM (2)
- Cyclic AMP (2)
- Dopamine (2)
- ESAT-6 (2)
- Eating (2)
- Enzyme (2)
- Glucoprivation (2)
- Hsp27 (2)
- Hsp90 (2)
- Hyopothalamus (2)
- Hypoglycemia (2)
- Infection (2)
- Insulin (2)
- Mycobacterium tuberculosis (2)
- Neuroanatomy (2)
- Neuroendocrinology (2)
- Publication Year
- Publication
- Publication Type
Articles 61 - 86 of 86
Full-Text Articles in Biochemistry
Identification And Characterization Of Fkbp52-Specific Inhibitors For The Treatment Of Prostate Cancer, Johanny Tonos De Leon
Identification And Characterization Of Fkbp52-Specific Inhibitors For The Treatment Of Prostate Cancer, Johanny Tonos De Leon
Open Access Theses & Dissertations
Steroid hormone receptors require the ordered assembly of various chaperone and cochaperone proteins in order to reach a functional state. The final stage in the receptor maturation process requires the formation of a mutimeric complex consisting of Hsp90 dimer, p23, and one of several large immunophilins. Studies conducted previously demonstrated that the large immunophilin FKBP52 acts to potentiate glucocorticoid, androgen, and progesterone receptor signaling pathways. The aim of these studies was to identify and characterize FKBP52-specific inhibitors that would not only serve as tools for the pharmacological analysis of FKBP52-receptor interactions, but may also lead to novel drugs with significant …
Ganglioside-Cytokine Interaction In The Induction Of Primary Brain Cell Death, John Charles Gorbet
Ganglioside-Cytokine Interaction In The Induction Of Primary Brain Cell Death, John Charles Gorbet
Open Access Theses & Dissertations
Gangliosides have been implicated in multiple pathologies affecting the central nervous system (CNS) and recent research has implicated them in playing an active role in the pathogenesis of multiple sclerosis. Empirical studies and theoretical considerations have suggested the possibility of interactions between gangliosides, like GD3, and pro-inflammatory cytokines present in the nervous system. This study sought to investigate the possibility that either individual gangliosides acting alone or complexed with other species interact with the known immune response factor TNF&alpha to initiate or facilitate cell death in the CNS. I examined the cellular viability and gene expression in primary brain cell …
Computer Aided Drug Design Methods & Quantitative Structure-Activity/Property Relationships, Suman Sirimulla
Computer Aided Drug Design Methods & Quantitative Structure-Activity/Property Relationships, Suman Sirimulla
Open Access Theses & Dissertations
The first part of dissertation consists of development of a QSAR model for 229 mutagenic aromatic amines and a QSPR model of partial molar volumes of amino acids. A common procedure for QSAR analysis consist of data selection (generally sets of homologous series of compounds and their corresponding biological activities), tabulation of trial physicochemical or molecular structural descriptors, followed by a multilinear statistical analysis to derive a statistically valid QSAR correlation of the activity data making use of a subset of the trial descriptors. A final important step is cross-validation to assess the putative predictive (rather than just correlative) capabilities …
Phosphorylation Of The Glycine Transporter 1, Javier Vargas Medrano
Phosphorylation Of The Glycine Transporter 1, Javier Vargas Medrano
Open Access Theses & Dissertations
The extracellular levels of the neurotransmitter glycine in the brain are tightly regulated by the high-affinity glycine transporter 1 (GlyT1) and the clearance of glycine depends on its rate of transport and the levels of cell surface GlyT1. Over the past years, it has been shown that PKC activation diminishes the activity and promoted phosphorylation of several neurotransmitter transporters including the dopamine, serotonin and norepinephrine transporters however, its role is unknown for the glycine transporter. To get insights into the role of PKC activation on GlyT1 regulation, we used three N-terminus GlyT1 isoforms stably expressed in porcine aortic endothelial (PAE) …
Structural Investigation Of Atp-Utilizing Enzymes: Structures Involved In H+ Homeostasis And The Proliferation Of Hormone-Dependent Cancers, Zacariah Louis Hildenbrand
Structural Investigation Of Atp-Utilizing Enzymes: Structures Involved In H+ Homeostasis And The Proliferation Of Hormone-Dependent Cancers, Zacariah Louis Hildenbrand
Open Access Theses & Dissertations
ATP is a multifunctional nucleotide considered to be the "molecular unit of currency" of intracellular energy transfer. ATP is utilized ubiquitously for the transport of chemical energy within the cell in addition to acting as a substrate in the regulation of many metabolic and signaling transduction pathways such as kinase-mediated signaling cascades. Interestingly, the functional mechanisms of many enzymes require the binding of ATP to trigger key structural and conformational changes that ultimately result in enzyme-directed catalysis. Two of the most omnipresent ATPases within the cell include the V-ATPase rotary proton pump and the Hsp90 protein-folding chaperone. Structural and biochemical …
Nerve, Muscle, Blood, Toil, Tears, And Sweat: England’S Pioneering Biophysicist, Soldier, And Statesman, Arshad Khan
Nerve, Muscle, Blood, Toil, Tears, And Sweat: England’S Pioneering Biophysicist, Soldier, And Statesman, Arshad Khan
Selected Works Temporary Series
No abstract provided.
Nerve, Muscle, Blood, Toil, Tears, And Sweat: England’S Pioneering Biophysicist, Soldier, And Statesman, Khan
Departmental Papers (Biology)
No abstract provided.
The Role Of Protein Disulfide Isomerase (Pdi) In Oxidative Folding, Veronica Gonzalez
The Role Of Protein Disulfide Isomerase (Pdi) In Oxidative Folding, Veronica Gonzalez
Open Access Theses & Dissertations
Protein Disulfide Isomerase is a highly evolved oxidoreductase enzyme that has the capability of oxidizing, reducing, and isomerizing disulfides in substrate. PDI is organized into several domains denoted a, b, b', a' and c. These domains are believed to have different functions but all must be present for full PDI activity. In this manuscript we recorded the ability of PDI b' to catalyze oxidative folding in fully reduced RNase A. We also examined competition between thiol-disulfide shuffling and conformational folding by PDI. This competition creates a rough effect of a highly efficient enzyme in two different substrates: RNase A and …
A Role For The Forebrain In Mediating Time-Of-Day Differences In Glucocorticoid Counterregulatory Responses To Hypoglycemia In Rats, Lori Gorton, Arshad Khan, Maryann Bohland, Graciela Sanchez-Watts, Casey Donovan, Alan Watts
A Role For The Forebrain In Mediating Time-Of-Day Differences In Glucocorticoid Counterregulatory Responses To Hypoglycemia In Rats, Lori Gorton, Arshad Khan, Maryann Bohland, Graciela Sanchez-Watts, Casey Donovan, Alan Watts
Selected Works Temporary Series
No abstract provided.
A Role For The Forebrain In Mediating Time-Of-Day Differences In Glucocorticoid Counterregulatory Responses To Hypoglycemia In Rats, Gorton, Arshad Khan, Maryann Bohland, Graciela Sanchez-Watts, Casey Donovan, Alan Watts
A Role For The Forebrain In Mediating Time-Of-Day Differences In Glucocorticoid Counterregulatory Responses To Hypoglycemia In Rats, Gorton, Arshad Khan, Maryann Bohland, Graciela Sanchez-Watts, Casey Donovan, Alan Watts
Departmental Papers (Biology)
No abstract provided.
Catecholaminergic Control Of Mitogen-Activated Protein Kinase Signaling In Paraventricular Neuroendocrine Neurons In Vivo And In Vitro: A Proposed Role During Glycemic Challenges, Arshad Khan, Todd Ponzio, Graciela Sanchez-Watts, B. Stanley, Glenn Hatton, Alan Watts
Catecholaminergic Control Of Mitogen-Activated Protein Kinase Signaling In Paraventricular Neuroendocrine Neurons In Vivo And In Vitro: A Proposed Role During Glycemic Challenges, Arshad Khan, Todd Ponzio, Graciela Sanchez-Watts, B. Stanley, Glenn Hatton, Alan Watts
Selected Works Temporary Series
No abstract provided.
Catecholaminergic Control Of Mitogen-Activated Protein Kinase Signaling In Paraventricular Neuroendocrine Neurons In Vivo And In Vitro: A Proposed Role During Glycemic Challenges, Khan, Todd Ponzio, Graciela Sanchez-Watts, B. Stanley, Glenn Hatton, Alan Watts
Catecholaminergic Control Of Mitogen-Activated Protein Kinase Signaling In Paraventricular Neuroendocrine Neurons In Vivo And In Vitro: A Proposed Role During Glycemic Challenges, Khan, Todd Ponzio, Graciela Sanchez-Watts, B. Stanley, Glenn Hatton, Alan Watts
Departmental Papers (Biology)
No abstract provided.
Activation In Neural Networks Controlling Ingestive Behaviors: What Does It Mean, And How Do We Map And Measure It?, Alan Watts, Arshad Khan, Graciela Sanchez-Watts, Dawna Salter, Christina Neuner
Activation In Neural Networks Controlling Ingestive Behaviors: What Does It Mean, And How Do We Map And Measure It?, Alan Watts, Arshad Khan, Graciela Sanchez-Watts, Dawna Salter, Christina Neuner
Selected Works Temporary Series
No abstract provided.
Activation In Neural Networks Controlling Ingestive Behaviors: What Does It Mean, And How Do We Map And Measure It?, Watts, Arshad Khan, Graciela Sanchez-Watts, Dawna Salter, Christina Neuner
Activation In Neural Networks Controlling Ingestive Behaviors: What Does It Mean, And How Do We Map And Measure It?, Watts, Arshad Khan, Graciela Sanchez-Watts, Dawna Salter, Christina Neuner
Departmental Papers (Biology)
No abstract provided.
Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Arshad Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley
Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Arshad Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley
Selected Works Temporary Series
No abstract provided.
Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley
Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley
Departmental Papers (Biology)
No abstract provided.
Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Arshad Khan, Alan Watts
Selected Works Temporary Series
No abstract provided.
Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Khan, Alan Watts
Departmental Papers (Biology)
No abstract provided.
N-Methyl-D-Aspartate Receptor Subunit Nr2b Is Widely Expressed Throughout The Rat Diencephalon: An Immunohistochemical Study, Arshad Khan, B. Stanley, Lisa Bozzetti, Christina Chin, Cyndi Stivers, Margarita Curras-Collazo
N-Methyl-D-Aspartate Receptor Subunit Nr2b Is Widely Expressed Throughout The Rat Diencephalon: An Immunohistochemical Study, Arshad Khan, B. Stanley, Lisa Bozzetti, Christina Chin, Cyndi Stivers, Margarita Curras-Collazo
Selected Works Temporary Series
No abstract provided.
N-Methyl-D-Aspartate Receptor Subunit Nr2b Is Widely Expressed Throughout The Rat Diencephalon: An Immunohistochemical Study, Khan, B. Stanley, Lisa Bozzetti, Christina Chin, Cyndi Stivers, Margarita Curras-Collazo
N-Methyl-D-Aspartate Receptor Subunit Nr2b Is Widely Expressed Throughout The Rat Diencephalon: An Immunohistochemical Study, Khan, B. Stanley, Lisa Bozzetti, Christina Chin, Cyndi Stivers, Margarita Curras-Collazo
Departmental Papers (Biology)
No abstract provided.
Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Arshad Khan, Margarita Curras, Jennifer Dao, Faizi Jamal, Rishi Goel, Elizabeth Gillard, Stefany Wolfsohn, B. Stanley
Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Arshad Khan, Margarita Curras, Jennifer Dao, Faizi Jamal, Rishi Goel, Elizabeth Gillard, Stefany Wolfsohn, B. Stanley
Selected Works Temporary Series
No abstract provided.
Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Khan, Margarita Curras, Jennifer Dao, Faizi Jamal, Rishi Goel, Elizabeth Gillard, Stefany Wolfsohn, B. Stanley
Lateral Hypothalamic Nmda Receptor Subunits Nr2a And/Or Nr2b Mediate Eating: Immunochemical/Behavioral Evidence, Khan, Margarita Curras, Jennifer Dao, Faizi Jamal, Rishi Goel, Elizabeth Gillard, Stefany Wolfsohn, B. Stanley
Departmental Papers (Biology)
No abstract provided.
The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Elizabeth Gillard, Arshad Khan, Rickinder Grewal, Bara Mouradi, Stefany Wolfsohn, B. Stanley
The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Elizabeth Gillard, Arshad Khan, Rickinder Grewal, Bara Mouradi, Stefany Wolfsohn, B. Stanley
Selected Works Temporary Series
No abstract provided.
The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Gillard, Arshad Khan, Rickinder Grewal, Bara Mouradi, Stefany Wolfsohn, B. Stanley
The Second Messenger Camp Elicits Eating By An Anatomically Specific Action In The Perifornical Hypothalamus, Gillard, Arshad Khan, Rickinder Grewal, Bara Mouradi, Stefany Wolfsohn, B. Stanley
Departmental Papers (Biology)
No abstract provided.
Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Elizabeth Gillard, Arshad Khan, Bara Mouradi, Omkar Nalamwar, B. Stanley
Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Elizabeth Gillard, Arshad Khan, Bara Mouradi, Omkar Nalamwar, B. Stanley
Selected Works Temporary Series
No abstract provided.
Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Gillard, Arshad Khan, Bara Mouradi, Omkar Nalamwar, B. Stanley
Eating Induced By Perifornical Camp Is Behaviorally Selective And Involves Protein Kinase Activity, Gillard, Arshad Khan, Bara Mouradi, Omkar Nalamwar, B. Stanley
Departmental Papers (Biology)
No abstract provided.