Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (3)
- University of Connecticut (3)
- University of Kentucky (3)
- City University of New York (CUNY) (2)
- Ouachita Baptist University (2)
-
- Technological University Dublin (2)
- Virginia Commonwealth University (2)
- Western Kentucky University (2)
- Western University (2)
- Old Dominion University (1)
- Purdue University (1)
- Rowan University (1)
- Seton Hall University (1)
- University of Arkansas, Fayetteville (1)
- University of Denver (1)
- University of Mississippi (1)
- University of Montana (1)
- University of Nebraska Medical Center (1)
- University of Nevada, Las Vegas (1)
- University of Rhode Island (1)
- Wayne State University (1)
- Publication Year
- Publication
-
- Dissertations & Theses (Open Access) (3)
- Honors Theses (3)
- Articles (2)
- Dissertations, Theses, and Capstone Projects (2)
- Electronic Thesis and Dissertation Repository (2)
-
- Honors Scholar Theses (2)
- Mahurin Honors College Capstone Experience/Thesis Projects (2)
- Theses and Dissertations (2)
- Center for Environmental and Systems Biochemistry Faculty Publications (1)
- Electronic Theses and Dissertations (1)
- Graduate Theses and Dissertations (1)
- McNair Poster Presentations (1)
- Rowan-Virtua School of Osteopathic Medicine Faculty Scholarship (1)
- Senior Honors Projects (1)
- Seton Hall University Dissertations and Theses (ETDs) (1)
- The Summer Undergraduate Research Fellowship (SURF) Symposium (1)
- Theses & Dissertations (1)
- Theses and Dissertations in Biomedical Sciences (1)
- Theses and Dissertations--Chemistry (1)
- Undergraduate Theses, Professional Papers, and Capstone Artifacts (1)
- University Scholar Projects (1)
- University of Kentucky Doctoral Dissertations (1)
- Wayne State University Theses (1)
- Publication Type
Articles 31 - 33 of 33
Full-Text Articles in Biochemistry
Loss Of Bloom Syndrome Protein Causes Destabilization Of Genomic Architecture And Is Complemented By Ectopic Expression Of Escherichia Coli Recg In Human Cells, Michael Wayne Killen
Loss Of Bloom Syndrome Protein Causes Destabilization Of Genomic Architecture And Is Complemented By Ectopic Expression Of Escherichia Coli Recg In Human Cells, Michael Wayne Killen
University of Kentucky Doctoral Dissertations
Genomic instability driven by non-allelic homologous recombination (NAHR) provides a realistic mechanism that could account for the numerous chromosomal abnormalities that are hallmarks of cancer. We recently demonstrated that this type of instability could be assayed by analyzing the copy number variation of the human ribosomal RNA gene clusters (rDNA). Further, we found that gene cluster instability (GCI) was present in greater than 50% of the human cancer samples that were tested. Here, data is presented that confirms this phenomenon in the human GAGE gene cluster of those cancer patients. This adds credence to the hypothesis that NAHR could be …
Treg Depletion Inhibits Efficacy Of Cancer Immunotherapy: Implications For Clinical Trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, Maria Castro
Treg Depletion Inhibits Efficacy Of Cancer Immunotherapy: Implications For Clinical Trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, Maria Castro
Articles
BACKGROUND: Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Clinical trials that combine Treg depletion with tumor vaccination are underway to determine whether transient Treg depletion can enhance anti-tumor immune responses and improve long term survival in cancer patients. FINDINGS: Using a syngeneic intracrabial glioblastoma (GBM) mouse model we show that systemic depletion of Tregs 15 days after tumor implantation using PC61 resulted in a decrease in Tregs …
The Role Of Small Peptides In Cancer Physiology And Chemotherapy, Bao-Ling Tsay
The Role Of Small Peptides In Cancer Physiology And Chemotherapy, Bao-Ling Tsay
Theses and Dissertations in Biomedical Sciences
The targeting of proven anticancer drugs specifically to cancer cells would provide a unique opportunity to restrict neoplasms without damaging the cancer patient. The present research utilizes the phenomenon of illicit transport, i.e. the coupling of normally impermeant metabolites to permeant metabolites, in targeting the drug melphalan to mouse Ehrlich ascites tumor cells. The dipeptide beta-alanyl-melphalan was synthesized and tested in vitro for toxicity towards mouse Ehrlich ascites tumor cells, mouse liver cells, and mouse 3T3 embryonic cells. The parent compound, melphalan, was used as a control treatment. In addition, both melphalan and beta-alanyl-melphalan were utilized in in vivo chemotherapeutic …