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Articles 1 - 7 of 7
Full-Text Articles in Dairy Science
Identification Of Snps Located On Bta 6 And Bta 20 Significantly Associated With Bovine Respiratory Disease In Crossbred Cattle, S. L. Miller, S. Mizell, R. Walker, T. Page, Matthew D. Garcia
Identification Of Snps Located On Bta 6 And Bta 20 Significantly Associated With Bovine Respiratory Disease In Crossbred Cattle, S. L. Miller, S. Mizell, R. Walker, T. Page, Matthew D. Garcia
Animal, Dairy, and Veterinary Science Faculty Publications
The objective of the present study was to evaluate single nucleotide polymorphisms (SNPs) located in two quantitative trait locus (QTL) regions (BTA 6 and BTA 20) that are associated with bovine respiratory disease (BRD). A population of 323 crossbred steers sired by five purebred sire breeds during 2010-2013 (Angus, Braford, Braunvieh, Charolais, and Simmental) were evaluated for BRD susceptibility during the finishing process at a commercial feedlot. A total of 21 animals representing all sire breeds were affected with BRD at some time during the finishing process over the 4-year period. Although multiple sire breeds were evaluated in the present …
A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection By Specifically Targeting Ns4b Protein, Fang Guo, Shuo Wu, Justin Julander, Julia Ma, Xuexiang Zhang, John Kulp, Andrea Cuconati, Timothy M. Block, Yanming Du, Ju-Tao Guo, Jinhong Chang
A Novel Benzodiazepine Compound Inhibits Yellow Fever Virus Infection By Specifically Targeting Ns4b Protein, Fang Guo, Shuo Wu, Justin Julander, Julia Ma, Xuexiang Zhang, John Kulp, Andrea Cuconati, Timothy M. Block, Yanming Du, Ju-Tao Guo, Jinhong Chang
Animal, Dairy, and Veterinary Science Faculty Publications
Although a highly effective vaccine is available, the number of yellow fever cases has increased over the past 2 decades, which highlights the pressing need for antiviral therapeutics. In a high-throughput screening campaign, we identified an acetic acid benzodiazepine (BDAA) compound which potently inhibits yellow fever virus (YFV). Interestingly, while treatment of YFV-infected cultures with 2 MBDAA reduced the virion production by greater than 2 logs, the compound was not active against 21 other viruses from 14 different viral families. Selection and genetic analysis of drug-resistant viruses revealed that replacement of the proline at amino acid 219 (P219) of the …
Large Animal Genetic Engineering Summit 2016 Proceedings, Utah State University
Large Animal Genetic Engineering Summit 2016 Proceedings, Utah State University
Animal, Dairy, and Veterinary Science Faculty Publications
It is our great pleasure to welcome you to the first Large Animal Genetic Engineering (LAGE) Summit. Our objectives for the summit are twofold: 1) to provide an update on new approaches to the genetic modification of large animal species for development of better animal models for biomedical research, biomanufacturing, and improved agricultural production; and 2) to provide a forum for discussions on funding mechanisms and regulations effecting development of genetically engineered large animals. Our first summit is being held in Bethesda, Maryland, to facilitate participation by representatives from various federal agencies who either fund or regulate the production of …
Complete Genome Sequences Of Three Historically Important, Spatiotemporally Distinct, And Genetically Divergent Strains Of Zika Virus: Mr-766, P6-740, And Prvabc-59, Sangim Yun, Byunghak Song, Jordan C. Frank, Justin G. Julander, Irina A. Polejaeva, Christopher J. Davies, Kenneth L. White, Youngmin Lee
Complete Genome Sequences Of Three Historically Important, Spatiotemporally Distinct, And Genetically Divergent Strains Of Zika Virus: Mr-766, P6-740, And Prvabc-59, Sangim Yun, Byunghak Song, Jordan C. Frank, Justin G. Julander, Irina A. Polejaeva, Christopher J. Davies, Kenneth L. White, Youngmin Lee
Animal, Dairy, and Veterinary Science Faculty Publications
Here, we report the 10,807-nucleotide-long consensus RNA genome sequences of three spatiotemporally distinct and genetically divergent Zika virus strains, with the functionality of their genomic sequences substantiated by reverse genetics: MR-766 (African lineage, Uganda, 1947), P6-740 (Asian lineage, Malaysia, 1966), and PRVABC-59 (Asian lineage-derived American strain, Puerto Rico, 2015).
Trophoblast Major Histocompatibility Complex Class I Expression Is Associated With Immune-Mediated Rejection Of Bovine Fetuses Produced By Cloning, Heloisa M. Rutigliano, Aaron J. Thomas, Amanda Wilhelm, Benjamin R. Sessions, Brady A. Hicks, Donald H. Schlafer, Kenneth L. White, Christopher J. Davies
Trophoblast Major Histocompatibility Complex Class I Expression Is Associated With Immune-Mediated Rejection Of Bovine Fetuses Produced By Cloning, Heloisa M. Rutigliano, Aaron J. Thomas, Amanda Wilhelm, Benjamin R. Sessions, Brady A. Hicks, Donald H. Schlafer, Kenneth L. White, Christopher J. Davies
Animal, Dairy, and Veterinary Science Faculty Publications
Trophoblast cells from bovine somatic cell nuclear transfer (SCNT) conceptuses express major histocompatibility complex class I (MHC-I) proteins early in gestation, and this may be one cause of the significant first-trimester embryonic mortality observed in these pregnancies. MHC-I homozygous-compatible (n = 9), homozygous-incompatible (n = 8), and heterozygous-incompatible (n = 5) SCNT pregnancies were established. The control group consisted of eight pregnancies produced by artificial insemination. Uterine and placental samples were collected on Day 35 ± 1 of pregnancy, and expression of MHC-I, leukocyte markers, and cytokines were examined by immunohistochemistry. Trophoblast cells from all SCNT pregnancies expressed MHC-I, while …
Prevalence Of Bovine Viral Diarrhea Virus In Bovine Samples From The Intermountain West Of The U.S.A. - Comparison Between Age, Sex, Breed And Diagnostic Methods, David J. Wilson, T. J. Baldwin, E. J. Kelly, A. Van Wettere, G. Hullinger, J. Bunnell
Prevalence Of Bovine Viral Diarrhea Virus In Bovine Samples From The Intermountain West Of The U.S.A. - Comparison Between Age, Sex, Breed And Diagnostic Methods, David J. Wilson, T. J. Baldwin, E. J. Kelly, A. Van Wettere, G. Hullinger, J. Bunnell
Animal, Dairy, and Veterinary Science Faculty Publications
Prevalence of Bovine viral diarrhea virus (BVDV) (“detected” test results) among all bovine samples tested at the Utah Veterinary Diagnostic Laboratory from 2008 - 2013 was calculated, and results were compared by age, sex, or breed of the cattle and BVDV diagnostic test methods. Necropsies were tested for BVDV when lesions suggestive of infection were identified. Adults, juveniles and most calves were tested by antigen (Ag) capture ELISA, while fetuses and some calves were tested by real-time reverse transcriptase PCR. Cattle originated from Utah and surrounding states. Chi-square analyses were used to test for significant differences in BVDV prevalence between …
Histopathologic Evaluation Of Postmortem Autolytic Changes In Bluegill (Lepomis Macrohirus) And Crappie (Pomoxis Anularis) At Varied Time Intervals And Storage Temperatures, Jami George, Arnaud J. Van Wettere, Blayk B. Michaels, Debbi Crain, Gregory A. Lewbart
Histopathologic Evaluation Of Postmortem Autolytic Changes In Bluegill (Lepomis Macrohirus) And Crappie (Pomoxis Anularis) At Varied Time Intervals And Storage Temperatures, Jami George, Arnaud J. Van Wettere, Blayk B. Michaels, Debbi Crain, Gregory A. Lewbart
Animal, Dairy, and Veterinary Science Faculty Publications
Information is lacking on preserving fish carcasses to minimize postmortem autolysis artifacts when a necropsy cannot be performed immediately. The purpose of this study was to qualitatively identify and score histologic postmortem changes in two species of freshwater fish (bluegill - Lepomis macrochirus; crappie - Pomoxis annularis), at varied time intervals and storage temperatures, to assess the histologic quality of collected samples. A pooled sample of 36 mix sex individuals of healthy bluegill and crappie were euthanized, stored either at room temperature, refrigerated at 4 C, or frozen at 20, and then necropsied at 0, 4, 24, and 48 h …