Animal Sciences Commons^™

Differences In Susceptibility To Sars-Cov-2 Infection Among Transgenic Hace2-Hamster Founder Lines, Scott A. Gibson, Yanan Liu, Rong Li, Brett L. Hurst, Zhiqiang Fan, Venkatraman Siddharthan, Deanna P. Larson, Ashley Y. Sheesley, Rebekah Stewart, Madelyn Kunzler, Irina A. Polejaeva, Arnaud J. Van Wettere, Stefan Moisyadi, John D. Morrey, E. Bart Tarbet, Zhongde Wang

Animal, Dairy, and Veterinary Science Faculty Publications

Animal models that are susceptible to SARS-CoV-2 infection and develop clinical signs like human COVID-19 are desired to understand viral pathogenesis and develop effective medical countermeasures. The golden Syrian hamster is important for the study of SARS-CoV-2 since hamsters are naturally susceptible to SARS-CoV-2. However, infected hamsters show only limited clinical disease and resolve infection quickly. In this study, we describe development of human angiotensin-converting enzyme 2 (hACE2) transgenic hamsters as a model for COVID-19. During development of the model for SARS-CoV-2, we observed that different hACE2 transgenic hamster founder lines varied in their susceptibility to SARS-CoV-2 lethal infection. The …

A Retrospective Analysis Of Sheep Generated By Somatic Cell Nuclear Transfer, Ying Liu, Rusty Stott, Misha Regouski, Zhiqiang Fan, Iuri Viotti Perisse, Tayler Patrick, Jacob Keim, Qinggang Meng, Irina A. Polejaeva

Animal, Dairy, and Veterinary Science Faculty Publications

Somatic cell nuclear transfer (SCNT) is one of the primary methods for production of genetically engineered sheep, which allows for gene editing or transgene introduction in somatic cells. The use of SCNT eliminates the risk of genetic mosaicism in embryos and animals that is commonly observed after zygote micromanipulations. This retrospective analysis of SCNT in sheep performed at Utah State University, spanning from 2016 to 2021, examined parameters that may impact pregnancy and full-term development, including donor oocytes (donor age), donor cell lines, SCNT parameters (time of oocyte activation following SCNT, number of transferred embryos, in vitro maturation and culture …

The Impact Of Estradiol And/Or Trenbolone Acetate On The Metabolome And Skeletal Muscle Metabolism Of Beef Cattle, Kara J. Thornton-Kurth

Funded Research Records

No abstract provided.

Effect Of Cytoplasmic Polyadenylation Element Protein Overexpression On The Development Of Bovine Cloned Embryos, Ying Liu

Funded Research Records

No abstract provided.

Rethinking Pregnancy Recognition In Ruminants: Pregnancy Recognition In Ewes Lacking Interferon-Tau Signaling, Chris Davies

Funded Research Records

No abstract provided.

Animal Breeding-Rcn: Farm Animal Genomics Collective, Noelle E. Cockett

Funded Research Records

No abstract provided.

Novel Hamster Models Of Chikungunya Viral Arthritis, Tian Wang, Zhongde Wang

Funded Research Records

No abstract provided.

Using Growth Implants In Bos Indicus Cattle Compared To Bos Taurus Cattle, Reganne K. Briggs, Caleb C. Reichhardt, Kara Thornton-Kurth, Matthew Garcia, Laura Motsinger

All Current Publications

A recent study at Utah State University compared production response to anabolic implant protocols of Santa Gertrudis-sired and Angus-sired steers. Feedlot performance, carcass characteristics, and economic analyses were completed to determine how implants affect Bos indicus-influenced animals. This fact sheet reviews the research findings and suggested benefits, such as increased efficiency and yield of steers.

Effects Of Revegetation Approaches On Wetland Plant Community Reassembly Under Hydrologic Extremes, Maddie Houde, Karin Kettenring

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Active revegetation is often necessary to recover native plant communities in disturbed or degraded wetlands. However, active revegetation has been pursued less in wetlands than other ecosystems and thus, there are few established best practices to guide implementation. Additionally, wetland revegetation is challenging due to dynamic hydrology becoming more extreme and high invasive plant propagule pressure that can limit native plant recruitment and favor invasive plant dominance. In this study, we tested the efficacy of varied revegetation approaches on native plant reassembly and invasion resistance in semi-arid wetlands subject to seasonal hydrologic fluctuations. In a Great Salt Lake wetland in …

Preventing And Managing Equine Gastric Ulcer Syndrome, Kylie Bell, Karl Hoopes

All Current Publications

Current industry trends regarding equine management practices largely contribute to the development of equine gastric ulcer syndrome (EGUS). Research on effective medical management exists; however, we lack studies on the efficacy of equine-welfare-minded solutions. This fact sheet reviews current literature, including diagnosing, treating, and preventing EGUS. It also provides a general overview of the natural equine, promoting a greater understanding of the connection between strategies to prevent and manage EGUS.

Dietary Milk Phospholipids Increase Body Fat And Modulate Gut Permeability, Systemic Inflammation, And Lipid Metabolism In Mice, Albert Lihong Zhou, Robert E. Ward

Nutrition, Dietetics, and Food Sciences Faculty Publications

The study aimed at how dietary milk polar lipids affect gut permeability, systemic inflammation, and lipid metabolism during diet-induced obesity (DIO). C57BL/6J mice (n = 6x3) were fed diets with 34% fat as energy for 15 weeks: (1) modified AIN-93G diet (CO); (2) CO with milk gangliosides (GG); (3) CO with milk phospholipids (MPL). Gut permeability was assessed by FITC-dextran and sugar absorption tests. Intestinal tight junction proteins were evaluated by Western blot. Plasma cytokines were measured by immunoassay. Body composition was assessed by magnetic resonance imaging. Tissue lipid profiles were obtained by thin layer chromatography. Hepatic expression of genes …

Managing Equine Metabolic Syndrome, Abigail Meldrum, Karl Hoopes

All Current Publications

Equine metabolic syndrome (EMS) is a relatively new disease that we are still learning about. There are many things to investigate when dealing with a new disease: causes, predispositions, symptoms, secondary issues, treatments, and prevention. Because changing the animal's feed regimen is currently the most effective and well-known way to manage EMS, this fact sheet focuses primarily on how diet can impact affected horses. As a newer syndrome, it is vital to learn as much as possible about it to understand, treat, and prevent this disease.

Balancing The Scales: Evaluating Variables Of Greatest Impact To Profit Margins When Finishing Cattle, Ryan Bake

All Graduate Reports and Creative Projects, Fall 2023 to Present

This study examines the risk associated with finishing cattle in a feedlot, specifically in the context of historically high cattle prices and quality grade grid marketing systems that have not adjusted to these elevated prices. The analysis also looks at performance factors that drive profitability differences in pens of cattle in a commercial feedlot, and how market factors also impact profitability. Regression analysis determines the significance of performance variables such as days on feed, average daily gain, feed conversion rates, and carcass characteristics on pen profitability. The impact of cattle breeding and pre-feedlot management of the cattle are also considered …

California Condor Feeding Habitat, Vigilance, And Competition With Avian Scavengers In Southern Utah, Usa, Alex Blanche

All Graduate Theses and Dissertations, Fall 2023 to Present

Independent foraging is needed for the reintroduction of a species to be successful, but it can cause cascades in interconnected ecological communities. California condors (Gymnogyps californianus) were reintroduced to the Colorado Plateau in 1996, and the population has continued to grow with yearly releases of captive individuals. However, little is known about foraging behavior of condors and their potential competitors. Carrion is a risky food source, and there is a tradeoff between vigilance and feeding. Altering behavior can maximize caloric intake while minimizing risk. Here, I investigate habitat selection, vigilance, and interspecific interactions among condors, golden eagles ( …

Effects Of Winter Ticks (Dermacentor Albipictus) On The Reproduction Of Utah Moose (Alces Alces Shirasi), Samuel D. Robertson

All Graduate Theses and Dissertations, Fall 2023 to Present

Moose (Alces alces) are the largest and only solitary members of the deer family. The species can be found across many northern regions around the world. Moose are considered to have high intrinsic, recreational and ecological value. In recent years, there have been concerns about declining moose populations in portions of the species circumpolar range. Moose in Utah (Alces alces shirasi) belong to the Shiras subspecies, which is the smallest of the four subspecies found in North America. Utah moose are the southernmost naturally occurring moose population in the world. The Utah Division of Wildlife Resources …

Comparative Morphology And Development Of The Trigeminally Innervated Infrared-Imaging System In Boas And Pythons, Helen Bond Plylar

All Graduate Theses and Dissertations, Fall 2023 to Present

Boas and pythons use specialized sense organs called pit organs to detect radiant heat. Pit organs in these lineages occur in paired arrays along the upper and lower jaws and are served by the trigeminal nerve (the fifth cranial nerve and one of the largest). Information from the pit organs travels via branches of the trigeminal to the brain and ultimately is processed in the optic tectum, along with information from the visual system. That means these snakes effectively “see” heat. While studies of the pitviper infrared-imaging system are numerous, very few studies of this system in pythons or boas …

Effects Of Premortem Stress On Protein Expression, Steak Color, Oxidation, And Myofibrillar Fragmentation Index In The Longissimus Lumborum, Reganne K. Briggs, Jerrad F. Legako, Paul R. Broadway, Jeff A. Carroll, Nicole C. Burdick Sanchez, Nikole E. Ineck, Zachary K. Smith, Ranjith Ramanathan, Kara J. Thornton

Animal, Dairy, and Veterinary Science Faculty Publications

No abstract provided.

Expression And Secretion Of Sparc, Fgf-21 And Dcn In Bovine Muscle Cells: Effects Of Age And Differentiation, Katie A. Shira, Kara J. Thornton, Brenda M. Murdoch, Gabrielle M. Becker, Gwinyai E. Chibisa, Gordon K. Murdoch

Animal, Dairy, and Veterinary Science Faculty Publications

Skeletal muscle growth is an economically important trait in the cattle industry. Secreted muscle-derived proteins, referred to as myokines, have important roles in regulating the growth, metabolism, and health of skeletal muscle in human and biomedical research models. Accumulating evidence supports the importance of myokines in skeletal muscle and whole-body health, though little is known about the potential presence and functional significance of these proteins in cattle. This study evaluates and confirms that secreted proteins acidic and rich in cysteine (SPARC), fibroblast growth factor 21 (FGF-21), myostatin (MSTN), and decorin (DCN) are …

Evaluating 45 Years Of Collaborative Range Livestock Education, Melanie Heaton, Andrew Brischke, Ben Scow

Outcomes and Impact Quarterly

The Arizona/Utah Range Livestock Workshop & Tour builds cooperation and understanding between public land grazing permittees and federal agency personnel through science-based education. The workshop provides information on livestock production practices and addresses controversial grazing issues in a non-confrontational environment. Topics range from animal handling, vaccination, and health to solar development, partnering with public land agencies, and recreation effects.

Comparison Of Sheep And Goats To The Acute Toxic Effects Of Foothill Death Camas, Kevin D. Welch, Stephen T. Lee, Clint A. Stonecipher, Dale R. Gardner, Daniel Cook

Poisonous Plant Research (PPR)

Death camas (Zigadenus spp) is a perennial forb found throughout the western United States, which is known to kill both sheep and cattle. In a previous study, goats appeared to be somewhat resistant to the adverse effects of death camas. Therefore, the objective of this study was to directly compare the susceptibility of goats and sheep to the acute toxic effects of death camas. Sheep and goats were dosed at 0.5, 1.0, 2.0, 4.0, and 6.0 g death camas per kg BW. The data presented in this manuscript suggest that goats are more susceptible to death camas than sheep. …

Toxicosis From Range Lupine Ingestion In A Research Herd Of Rafter 7 Merino Sheep, Benjamin J. Weigler, Walter F. Mandeville Iii, Scott Huber, Gary Mccuin, Fabrizio Caragena, Daniel D. Cook, Stephen T. Lee, Chris A. Pritsos

Poisonous Plant Research (PPR)

An outbreak of lupine alkaloid neurotoxicosis and death occurred in sheep grazed on rangeland areas of the Nevada Great Basin during the summer of 2023. Overall, 97 sheep died despite veterinary supportive care. Lupinus argenteus var. utahensis was implicated as the causative plant with high levels of lupanine (11.5 µg/mg) and spartiene (13.7 µg/mg) in collected and archived samples. Previous reports of sheep deaths due to lupine ingestion have not been recorded in this region. An increased abundance of the number plants producing seed pods having a high alkaloid content may have been associated with abnormally elevated levels of precipitation …

Cytokine-Supplemented Maturation Medium Enhances Cytoplasmic And Nuclear Maturation In Bovine Oocytes, Renata Blocher, Ying Liu, Tayler Patrick, Irina A. Polejaeva

Animal, Dairy, and Veterinary Science Faculty Publications

Bovine in vitro oocyte maturation (IVM) is an easy way to obtain oocytes for subsequent assisted reproductive techniques but is inefficient compared to in vivo maturation. Supplementation of three cytokines, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF1), or FLI, has increased oocyte maturation and embryo development in multiple species, but studies have not explored the oocyte differences caused by FLI IVM supplementation. This study aimed to assess important nuclear and cytoplasmic maturation events in high-quality oocytes. FLI-supplemented oocytes had a decreased GV (3.0% vs. 13.7%, p < 0.01) and increased telophase I incidence (34.6% vs. 17.6%, p < 0.05) after IVM, increased normal meiotic spindles (68.8% vs. 50.0%, p < 0.001), and an increased nuclear maturation rate (75.1% vs. 66.8%, p < 0.001). Moreover, in metaphase II oocytes, the percentage of FLI-treated oocytes with a diffuse mitochondrial distribution was higher (87.7% vs. 77.5%, p < 0.05) and with a cortical mitochondrial distribution was lower (11.6% vs. 17.4%, p < 0.05). Additionally, FLI-supplemented oocytes had more pattern I cortical granules (21.3% vs. 14.4%, p < 0.05). These data suggest that FLI supplementation in bovine in vitro maturation medium coordinates nuclear and cytoplasmic maturation to produce higher-quality oocytes.

Cattle Toxicity From Woolly Locoweed (Astragalus Mollissimus): A Case Study In Central New Mexico, Casey N. Spackman, Clint A. Stonecipher, Daniel Cook

Poisonous Plant Research (PPR)

Livestock toxicity resulting from poisonous plants poses a significant challenge for ranchers, particularly concerning locoweeds (Astragalus spp. or Oxytropis spp.). This study investigated a case of cattle poisoning in central New Mexico, where clinical signs were consistent with locoweed toxicity. Rangeland conditions were hot and dry following earlier spring rains, promoting advantageous environmental conditions for a locoweed outbreak. Analysis of Woolly locoweed (Astragalus mollissimus) and animal samples from the ranch confirmed the presence of swainsonine, a key toxin in locoweeds. It can be concluded that the likely cause of cattle losses was locoweed toxicity, highlighting the …

Influence Of Steroidal Implants And Zinc Sulfate Supplementation On Growth Performance, Trace Mineral Status, Circulating Metabolites, And Transcriptional Changes In Skeletal Muscle Of Feedlot Steers, Dathan T. Smerchek, Emma L. Rients, Amy M. Mclaughlin, Kara J. Thornton, Stephanie L. Hansen

Animal, Dairy, and Veterinary Science Faculty Publications

Angus-cross steers (n = 144; 362 kg ± 20.4) were used to determine the effect of Zn and steroidal implants on performance, trace mineral status, circulating metabolites, and transcriptional changes occurring in skeletal muscle. Steers (n = 6 per pen) were stratified by body weight (BW) in a 3 x 2 factorial. GrowSafe bunks recorded individual feed intake (steer as experimental unit; n = 24 per treatment). Dietary treatments (ZINC; eight pens per treatment) included supplemental Zn as ZnSO₄ at 1) 0 (analyzed 54 mg Zn/kg DM; Zn0); 2) 30 mg/kg DM ( …

Temporal And Spatial Influences On Fawn Summer Survival In Pronghorn Populations: Management Implications From Noninvasive Monitoring, Cole A. Bleke, Eric M. Gese, Juan J. Villalba, Shane B. Roberts, Susannah S. French

Wildland Resources Student Research

Monitoring vital rates allows managers to estimate trends in growth rates of ungulate populations. However, connecting the influence of nutrition on ungulate demography is challenging. Noninvasive sampling offers a low-cost, low-effort alternative for measuring nutritional indices, allowing for an increased understanding of the mechanistic relationships between environmental factors, nutrition, and specific population vital rates. We examined the temporal influence of intrinsic and extrinsic factors on pronghorn (Antilocapra americana) fawn recruitment. We collected fresh fecal samples from adult female pronghorn in five subpopulations spanning three sampling periods associated with critical maternal life-history stages (late gestation, early lactation, breeding season) …

The Effects Of Ammonia On The Functionality Of Bovine Granulosa Cells, Micah Henrie

All Graduate Theses and Dissertations, Fall 2023 to Present

It is common practice in the livestock animal production industries to feed high levels of protein to maximize the yield of each animal in production. However, diets high in protein can cause decreased reproductive success within these animals. The causes behind this decrease are not fully understood. Increased dietary protein leads to increased levels of both ammonia and urea in the blood of the animal. These increased metabolite levels may be a possible explanation for the decline in reproductive success. The goal of this study is to identify how various levels of ammonia affect the function of bovine granulosa cells …

The Role Of Extracellular Vesicles In Immunomodulation During Bovine Pregnancy, Amber E. Thornton

All Graduate Theses and Dissertations, Fall 2023 to Present

During pregnancy, the maternal immune system must be altered to protect the partially non-self fetus from attack. Our previous studies show an inflammatory response in the uterus of cows carrying somatic cell nuclear transfer (SCNT), commonly known as cloned, pregnancies due to abnormalities in proteins expressed by placental trophoblast cells. Between 30 and 90 days the rate of pregnancy loss is 50-100% for SCNT compared to 2-10% for artificial insemination (AI) pregnancies. Abnormal communication between the maternal and fetal systems during placentation is a major cause of this loss. The trafficking of extracellular vesicles (EVs), membrane-bound cargo carriers, potentially represents …

Spatial Ecology Of Mule Deer Migrations From Grand Teton National Park And The Teton Range, Justin K. Schwabedissen

All Graduate Theses and Dissertations, Fall 2023 to Present

The Greater Yellowstone Ecosystem hosts several of the longest, fully intact ungulate migrations remaining in the continental United States. However, expanding development and an increasing human footprint continue to truncate migratory routes. While the endpoints are often a seasonal range on protected lands, these migration corridors frequently cross other jurisdictional boundaries, including large tracts of private or multiple-use lands, with varying levels of protection. Thus, it is critical resource managers understand the dynamics of migratory movements to define population-level corridors and prioritize appropriate conservation strategies. Mule deer in Wyoming have been documented traveling long distances between summer and winter ranges; …

How Variation In Activity Time And Duration At Water Sources Affects Feral Horse Vulnerability To Cougar Predation In Southern Nevada, Katelyn Davies

Undergraduate Honors Capstone Projects

Feral horses have become prominent in the Intermountain West. Approximately 43,000 horses are found in Nevada alone. With increasing numbers, they have become a large portion of ungulate biomass. Thus, it is important to understand their behavior, as they become integrated into western wildlife communities. However, little research has been conducted on the ecology of feral horses, and their relationships with native ungulates, carnivores, and local resources such as water.

To address these concerns, I outlined three objectives: (1) determine if horses changed their water visitation activity times in relation to temperature. As a primarily diurnal species, we were interested …

Cocoa Polyphenols Modulate The Fecal Microbiome In A Mouse Model Of Colitis, Independent Of Basal Diet And Colon Inflammation, Abby D. Benninghoff

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Chronic inflammation increases the risk of developing multiple chronic diseases, including cancer. The risk of developing colorectal cancer (CRC) specifically is increased in individuals who suffer from colitis, a characteristic of Inflammatory Bowel Disease (IBD). Diet is another risk factor for developing CRC, particularly an inflammation-promoting Western-type diet. Thus, supplementing a Western diet with functional foods containing anti-inflammatory polyphenols is a potential approach to decreasing CRC risk by reducing gut inflammation and altering gut microbiome profile. This study aimed to determine the effects of cocoa polyphenol (CP) supplementation on inflammation status and microbiome profile before, during, and after colitis when …