Life Sciences Commons^™

Pressure Field Estimation From 2d-Piv Measurements: A Case Study Of Fish Suction-Feeding, Jensine C. Coggin, Duvall Dickerson-Evans, Erin E. Hackett, Roi Gurka

Physics and Engineering Science

Particle image velocimetry (PIV) flow measurements are common practice in laboratory settings in a wide variety of fields involving fluid dynamics, including biology, physics, engineering, and medicine. Dynamic fluid pressure is a notoriously difficult property to measure non-intrusively, yet its variation is a driving flow force and critical to model correctly. Techniques have been developed to estimate the pressure from velocity and velocity gradient measurements. Here, we highlight a novel application of boundary conditions when applying such pressure estimation techniques based on two-dimensional PIV data; the novel method is especially relevant to problems with complex boundary conditions. As such, it …

Parameter Identification Of A Pi Controller For A Wind Energy Conversion System Based On Dfig, Mariam Hesham, Dina S. M. Osheba, Mahmoud M. Khater

Mansoura Engineering Journal

In this work, three methods are proposed to identify parameters of PI controllers used for wind energy conversion systems based on DFIG. Mathematical model of generator and grid side system is depicted. Three tuning methods; bode-plot, pole-placement, and MATLAB tuner are used for grid side and rotor side converter controllers’ design. Wind turbine system with PI controller parameters obtained using the mentioned method is investigated via MATLAB/SIMULINK under three different scenarios. The wind system is subjected to step wind speed change, random wind speed, and sever symmetrical voltage dip in the grid. The handled comparison illustrates that the pole-placement tuning …

Composite Flours For Sustainable Food Systems: Integrating Nutritional, Environmental, And Climate Resilience Strategies, Rashmi H. Poojara, Soumya P S, Alvina Rose, Niva Somarajan

Journal of Environmental Science and Sustainable Development

Composite flour blends prepared from cereals, millets, tubers, legumes, and vegetables have gained increasing attention due to their potential to enhance nutritional quality, improve functional properties, and support sustainable food systems. Previous studies have largely focused on individual nutritional or functional attributes, with limited integration of environmental and health perspectives. This review aimed to systematically analyze how composite flours simultaneously influence nutritional quality, functional performance, health relevance, and environmental sustainability within a unified analytical framework. A systematic literature review was conducted following PRISMA guidelines. Peer-reviewed studies published between 2014 and 2025 were retrieved from PubMed, Scopus, Web of Science, and …

Mechanical Improvements And Control Implementation On A Biomimetic Quadruped Model, Matthew Jack Lutz

Dissertations and Theses

Robotic development started billions of years after earth first began biological prototyping. While the evolutionary process in animals is quite different from robotic prototyping, it still remains no surprise that animals remain more agile, more efficient, and more adaptable than even the most advanced engineered robots to date, simply due to the sheer length of their improvement process. While bridging this improvement gap between deficits in robots and the abilities of animals is difficult, a specific subfield of robotics engineering has attempted to do so using biomimetic robotics. At Portland State, the Agile and Adaptive Robotics Lab (AARL) studies these …

Context Matching Is Not Reasoning When Performing Generalized Clinical Evaluation Of Generative Language Models, Andrew Wen, Qiuhao Lu, Yu-Neng Chuang, Guanchu Wang, Jiayi Yuan, Jiamu Zhang, Liwei Wang, Sunyang Fu, Kurt D Miller, Heling Jia, Steven D Bedrick, William R Hersh, Kirk E Roberts, Xia Hu, Hongfang Liu

Faculty, Staff and Student Publications

Current discussion surrounding the clinical capabilities of generative language models(GLMs) predominantly centers around multiple-choice question-answer(MCQA) benchmarks derived from clinical licensing examinations. While accepted for human examinees, characteristics unique to GLMs bring into question the validity of such benchmarks. Here, we validate five benchmarks using eight GLMs, ablating for parameter size and reasoning capabilities, validating via prompt permutation three key assumptions that underpin the generalizability of MCQA-based assessments: that knowledge is applied, not memorized, that semantic consistency will lead to consistent answers, and that situations with no answers can be recognized. While large models are more resilient to our perturbations compared …

Folding Architecture “Origami Art-Inspired” Applicability To Sustainable Architecture- Biomuseo As A Case Study, Vitta A. Ibrahim

Mansoura Engineering Journal

The growing need for sustainable architectural solutions in the contemporary era underscores the necessity for interactive architectural applications that can adapt to changing requirements. In architecture, folding systems refer to three-dimensional, foldable structural forms that create unique spatial configurations and possess a wide range of capabilities. Drawing inspiration from origami techniques, this study emphasizes the role of folding systems in generating innovative spatial designs. The research problem arises from the fact that the built environment is a significant contributor to greenhouse gas emissions and energy consumption, necessitating the implementation of smart solutions. The goal of this study is to identify …

Investigation Of Regulated Cell Death (Rcd) Modalities Induced By Copper(Ii), Manganese(Ii) And Silver(I) Complexes Containing Bridging Dicarboxylate And 1,10-Phenanthroline Ligands, Ella O'Sullivan

Doctoral

With the increasing global cancer burden in recent years, there is an urgency to develop novel chemotherapeutic agents. Transition metal complexes represent an attractive class of candidates, owing to their unique electronic and stereochemical properties, as well as their capacity for ligand exchange, redox activity, and catalytic reactivity. These characteristics enable cellular signalling mechanisms that lead to tumour cell cytotoxicity via regulated cell death (RCD) mechanisms. The conventional RCD mechanisms of apoptosis and autophagy are attractive targets for the development of novel complexes because tumour cells evade apoptosis but use autophagy as a survival mechanism when under stress. Therefore, novel …

(R2150) Impact Of Specialist Predator Harvesting On The Stability Of A Three-Species Food Chain Model With A Generalist Predator, S. Ganga, S. Vijaya

Applications and Applied Mathematics: An International Journal (AAM)

In this study, the stability of a three-species food chain model comprising a prey, an intermediate specialist predator, and a top predator exhibiting generalist behavior is examined, with harvesting applied to the intermediate predator. The main objective is to investigate how variations in the harvesting rate influence system stability and the coexistence of all three species. The positivity, boundedness, and equilibrium points of the model are analyzed to ensure biological feasibility. The equilibrium point involving the prey and the top predator satisfies the criteria for both local and global asymptotic stability. The coexistence equilibrium point attains local asymptotic stability based …

Comparative Transcriptomics Reveals Novel And Differential Long-Noncoding Rna Responses Underlying Interferon-Mediated Antiviral Regulation In Porcine Alveolar Macrophages, Jiuyi Li, Oluwaseun Adeyemi, Laura C. Miller, Yongming Sang

Food and Animal Sciences Faculty Research

Porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to the global swine industry. Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of antiviral immunity, but their roles in porcine alveolar macrophages (PAMs)—the primary target of PRRSV—remain poorly characterized. This study presents a genome-wide analysis of lncRNA expression in PAMs stimulated with a PRRS modified live virus (MLV) vaccine and two type I interferons, IFN-α1 and IFN-ω5. Whole-transcriptome sequencing identified over 2000 differentially expressed lncRNAs, with IFN-ω5 inducing the most extensive transcriptional reprogramming. Weighted gene co-expression network analysis (WGCNA) revealed interferon-specific lncRNA-mRNA modules, and functional enrichment showed …

Seroprevalence And Risk Determinants Of Toxoplasma Gondii Infection In Pregnant Women In Pakistan: A Cross-Sectional Study, Tajul Haram, Kamran Khan

Journal of Bioresource Management

Toxoplasma gondii is a globally important zoonotic parasite, and maternal infection during pregnancy may cause miscarriage, congenital anomalies, or severe neonatal complications. This cross-sectional study was conducted among 367 pregnant women attending hospitals in District Dir Upper, Khyber Pakhtunkhwa, Pakistan, to evaluate the seroprevalence of T. gondii and associated risk factors. Blood samples were analyzed using Immunochromatographic Test (ICT) for initial screening, and positive cases were confirmed by Enzyme-Linked Immunosorbent Assay (ELISA). Overall, 34.6 % (127/367) of women tested positive. While no significant differences were observed across age groups, gestational trimesters, or abortion history, higher prevalence was noted in women …

Isolation And Molecular Characterization Of Shiga Toxin Producing Genes Stx1and Stx2 From The Captive Migratory Birds Of Lahore, Romana Zulfiqar, Hamid Ullah, Bushra Nisar Khan, Muhammad Habib Ur Rehman, Hoor Ul Ain, Alishba Zaheer, Samrah Hussain, Aazba Naeem

Journal of Bioresource Management

A total of 240 cloacal and fecal swabs were collected from 25 avian species, including ducks, swans, geese, pheasants, guinea fowl, parrots, cranes, and crows. Samples were cultured on Sorbitol MacConkey Agar, and presumptive Escherichia coli isolates were confirmed using morphological, biochemical, and molecular methods. Shiga toxin–producing E. coli (STEC) was identified through PCR detection of stx1 and stx2 genes, followed by sequencing. Antibiotic susceptibility testing was performed using the Kirby–Bauer disc diffusion method against streptomycin, ceftriaxone, ciprofloxacin, azithromycin, and tetracycline. Only four STEC isolates were recovered, resulting in an overall prevalence of 1.66 % (4/240). Positive cases were detected …

The Assessment Of Soil Physico-Chemistry And Uptake Of Heavy Metals In Lumbricus Terrestris, Shahzad Anjum, Sidra Kanwal, Rana Manzoor Ahmad, Abdul Majid Khan, Muhammad Imran

Journal of Bioresource Management

Earthworms are considered ecosystem engineers, playing an essential role in soil fertility. Heavy metals are supposed to remain linked to soil for a very long time and can bio-accumulate swiftly in soil microbes, posing a severe threat to the environment. The current study was designed to investigate the bio-accumulation of heavy metals in Lumbricus terrestris and the impact of soil pH and texture on earthworm morphology and densities near industrial areas of the district of Okara, Punjab, Pakistan. The samples were collected from the locations of different industries using the quadrate method and analyzed for heavy metal accumulation by using …

Psychological Responses To Interval And Continuous Exercise In People Living With Hiv: A Single-Blind, Counterbalanced, Crossover Study., Phelipe Wilde, Victor S. De Queiros, Jason R. Jaggers, Angelo Sabag, Julio M. Alves, Elaine Fernandes, Robert F.C. Rocha, Paulo F. De Almeida-Neto, Ronaldo Vagner Thomatieli-Santos, Paulo Moreira Silva Dantas

Faculty and Staff Scholarship

Abstract
Aim: This study compared acute psychological responses to a single session of low-volume high-intensity interval exercise (HIIE-LV), high-volume highintensity interval exercise (HIIE-HV), and moderate-intensity continuous exercise (MICE) in people living with HIV, and healthy controls using a randomized, counterbalanced crossover design. Methods: The participants (people living with HIV, and healthy controls) completed three exercise sessions in randomized order: HIIE-HV (4  4 min at 80% of maximal power output [Wmax]), HIIE-LV (10  60 s at 90% Wmax), and MICE (30 min at 60% Wmax). Psychological outcomes included affective response assessed by the Feeling Scale, exercise enjoyment and future exercise intention …

The Impact Of Targeting Traf2 And Nck-Interacting Protein Kinase On Antitumor Effect And Tumor Immune Environment In C-Myc-High Sclc, Azusa Tanimoto, Kavya Ramkumar, C Allison Stewart, Bingnan Zhang, Kyle Concannon, Robert J Cardnell, Li Shen, Qi Wang, Jing Wang, Carl M Gay, Lauren Averett Byers

Faculty, Staff and Student Publications

Introduction: Wnt/β-catenin signaling pathway activation contributes to tumorigenesis and chemo-resistance in SCLC, yet clinical attempts to target this pathway have been unsuccessful. TRAF2 and NCK-interacting protein kinase (TNIK), an essential nuclear activator of Wnt/β-catenin target genes, has not yet been validated as a viable therapeutic target in SCLC. Here, we validated that TNIK inhibition is a promising approach for personalized anticancer therapy in SCLC.

Methods: We correlated the IC50 values of a TNIK inhibitor, NCB-0846, with proteomic profiling (reverse phase protein array) data across 28 SCLC cell lines. Cytokine array analysis was performed to quantify changes in 105 cytokines after …

Detection Of The Linac Jaw Face Angle Misalignment Using High Energy Electron Beam Symmetry, Song Gao, Andres Cibrian, Jared Ohrt, Peter Balter

Faculty, Staff and Student Publications

Purpose: To demonstrate the usage of a high energy electron beam symmetry measured at different collimator angles to detect jaws face angle misalignments on Varian TrueBeam linear accelerators (linac) during acceptance and commissioning processes.

Methods: During the linac acceptance, all beams were steered to a symmetric shape with the gantry and collimator at 0°. We noted that the symmetries of higher energies electrons (e.g., 16 MeV, 20 MeV) changed over 2% when measured with the collimator at 90° and/or 270° for two linacs commissioned within 5-months of each other. Misaligned applicators were ruled out as the cause of this issue. …

Anti-Saccade Error Rates Are Associated With Somatic Depressive Symptoms In Cocaine Use Disorder, Constanza De Dios, Heather E Webber, Margaret C Wardle, Jin H Yoon, Michelle A Patriquin, Jessica N Vincent, Joy M Schmitz, Scott D Lane

Faculty, Staff and Student Publications

Background: Inhibitory control deficits are associated with cocaine use disorder (CUD) development and maintenance. Additionally, drug use and inhibitory control can be negatively affected by depressive symptoms, including somatic factors like sleep disturbance and fatigue.

Aim: The current study assessed the relationship between inhibitory control and depressive symptoms among individuals initiating CUD treatment. We examined associations among anti-saccade response inhibition performance, total scores on the Beck Depression Inventory-II (BDI-II), and individual BDI-II items.

Methods: N = 101 patients enrolled in a clinical trial for CUD completed drug-specific anti-saccade and depression (BDI-II) measures prior to treatment. Generalized linear models tested the …

New Geographic Distributional Records For Fishes From The Black River At Black Rock, Lawrence County, Arkansas, C. T. Mcallister, H. W. Robison

Journal of the Arkansas Academy of Science

During February and/or March 2020-2025, various fishes were collected with a modified minnow trap and hoop nets from the White River drainage of the Black River at Black Rock, Lawrence County, Arkansas. A total of 35 species within 11 families were collected and the following taxa represent new distributional records: Acipenseridae: Lake Sturgeon (Acipenser fulvescens); Polydontidae: Paddlefish, Polyodon spathula; Catostomidae: Quillback (Carpiodes cyprinus), Highfin Carpsucker (Carpiodes velifer), Blue Sucker (Cycleptus elongatus), Northern Hogsucker (Hypentelium nigricans); Leuciscidae: Creek Chub (Semotilus atromaculatus). The most significant discoveries were the collection …

Microtubule Self-Organization With Active And Passive Crosslinkers, Prashali Chauhan

Dissertations - ALL

Humans have always been trying to unravel principles that guide how things around us function, all the way from galactic ovements to basic building blocks of matter. The physical and chemical properties of ‘biological’ systems govern processes all the way from molecular interactions of proteins to the form and function of individual living organisms. In this work, I focus on the proteins which help give shape and structure to the smallest building block of life, the cell and associated mechanisms of building fundamental cellular architectures, like the mitotic spindle. Mitosis takes place by microtubules aligning themselves in anti-parallel fashion with …

Enterobacteriaceae Contamination In Locally Packaged Roasted Cashew Kernels From The Coast And Morogoro Regions, Tanzania, Douglas Mushi, Silvia Francis Materu

Tanzania Journal of Science

The increased sales of locally packaged roasted cashew kernels (RCK) in Tanzania reflect growing consumer demand for healthy, convenient snacks. Despite this popularity and frequently reported cases of gastrointestinal illness, the microbial safety of these plastic- bagged products is not well-documented, posing a potential public health concern. To address this, a study was performed to evaluate packaging hygiene, package integrity, and microbial contamination of randomly selected packages of RCK (small: n=99; medium: n=87; large: n=118) from vendors in Coast and Morogoro regions, Tanzania. Package integrity was assessed using a vacuum decay leak tester while microbial contamination on surfaces including RCK, …

Molecular Evidence For Presence Of Manihot Esculenta Associated Virus 1: Cg-Nmb And/Or Cg-Kah Isolates In Coast, Tanzania: A Threat To Cassava Production, Herieth R. Mero

Tanzania Journal of Science

Genetic diversity of Manihot esculenta associated virus type 1 (MEaV-1) species suspected to cause the most destructive Brown Streak of Cassava (CBSD) in Tanzania, has remained elusive since the year 2020 when MY-6mb-4 virus isolate was first identified in Chambezi, Coast region. In this study, two additional isolates (CG-Nmb and CG-Kah) of the MEaV-1 species were characterized in the same area after screening leaf samples collected from 292 Kiroba, 12 Albert and 22 Kikombe varieties of cassava using a Reverse Transcription Polymerase Chain Reaction (RT- PCR) assay. One half of the leaf samples collected from each of the three varieties …

Enhancing Topical Delivery Of N-Acetylcysteine And Collagen Via A Novel Electrospun Collagen/Pmma Nanofibrous Mats As Facial Mask Development: Nanofibers Optimization And In Vitro Experiments, Samar A. Salim, Galala University, King Faisal University, Badr University, National Research Centre, City Of Scientific Research And Technological Applications (Srta-City),, Badr University

Nanotechnology Research Centre

This study endeavours to craft a potent topical facial mask using electrospun nanofibers. The nanofibers were carefully fabricated based on loading of N-acetylcysteine (NAC) onto electrospun marine collagen (MC), and poly (methyl methacrylate) (PMMA) nanofibers. Through precise adjustments of electrospinning parameters, a uniform array of nanoscale fibres with a smooth surface was achieved. The morphology and chemical structure configuration of nanofibers (NFs) were examined using SEM, FTIR, and XRD analyses. Furthermore, the cytotoxic impact was assessed on a human normal fibroblast cell line (BJ1), while protein levels were gauged using the Bradford dye-binding assay (Coomassie assay). Also, the antioxidant potential …

Exploring Bacterial Diversity In Seagrass Meadow Of Thalassia Hemprichii And Syringodium Isoetifolium From Tanzania’S Coast, Lucy D. Mbusi, Thomas J. Lyimo, Sylvester L. Lyantagaye

Tanzania Journal of Science

Seagrasses are highly productive coastal ecosystems that harbor diverse bacterial communities, including both culturable and unculturable taxa. These bacteria play vital roles in ecological, biogeochemical, and biotechnological processes. In this study, a metagenomic approach using Pacific Biosciences next-generation sequencing was employed to investigate bacterial diversity associated with Thalassia hemprichii and Syringodium isoetifolium collected from the Mjimwema coast, Dar es Salaam, Tanzania. Results revealed that T. hemprichii supported greater bacterial species diversity (117 OTUs) compared to S. isoetifolium (109 OTUs). Among plant compartments, roots harbored the highest diversity, followed by rhizosphere sediment and leaves. The phylum Proteobacteria dominated across all samples …

Green Ai-Enhanced Deep Learning Model For Breast Cancer Detection And Classification In Mammography Images: Bc-Net-512, Nesma Abd El-Mawla, Mohamed A. Berbar, Nawal A. El-Fishawy, Mohamed A. El-Rashidy

Mansoura Engineering Journal

This study champions a sustainable approach for developing a Deep Learning (DL) model for medical image analysis, specifically focusing on breast cancer (BC) detection in mammograms. By prioritizing low-computing algorithms to achieve high diagnostic accuracy while minimizing the model's environmental footprint, that aligns with the principles of Green AI. In this paper, an innovative architecture called BC-Net-512 was constructed for the classification of BC mammography. It is composed of lightweight Convolutional Neural Network (CNN) blocks for texture, density, and structure feature extraction and detection, a thin, fully connected layer for learning complex patterns and correlations in the extracted features, and …

Hepatocyte-Specific Lrp1 Silencing Exacerbates Brain Amyloidosis Without Compensatory Ldl Receptor Family Involvement, Brian Carson, Josephine Chu, Devaraj V. Chandrashekar, Jerome Garcia, Rachita K. Sumbria, Derick Han

Pharmacy Faculty Articles and Research

Background

LDL receptor related protein 1 (LRP1) is a major hepatic receptor involved in lipoprotein metabolism, protease degradation, transmembrane receptor modulation, and clearance of excess protein, such as Aβ. Decreased expression of LRP1 due to liver injury can impair receptor-mediated clearance, increasing Aβ availability in the periphery. We investigated the effects of hepato-specific silencing of LRP1 on Aβ deposition in the brain. Additionally, other LDL family members (LRP5, LRP6, and LDLR) that may participate in Aβ clearance were monitored in the liver to ensure non-compensatory effects of LRP1 silencing.

Method

4-month-old male double transgenic (APP/PS1) AD mice were injected with …

Cd177+ Neutrophils: New Drivers Of Liver Regeneration, Yankai Wen, Cynthia Ju

Faculty, Staff and Student Publications

No abstract provided.

Intraventricular Iron Causes Severe Hydrocephalus – A Model Of Severe Neonatal Hydrocephalus, Kwang-Min Kim, Arokoruba Oboba Cheetham-West, Mohamed Rafiuddin Ahmed, Megan Phillips, Andrey V Malkovskiy, Venkata Raveendra Pothineni, Kyle D Brewer, Chirag B Patel, Jayakumar Rajadas, Kelly B Mahaney

Faculty, Staff and Student Publications

Background: Neonatal germinal matrix hemorrhage-intraventricular hemorrhage and subsequent post-hemorrhagic hydrocephalus (PHH) is a leading cause of neurologic morbidity and mortality in preterm infants. Preclinical models of PHH have implicated hemoglobin and iron-mediated cellular injury in the pathogenesis of PHH, but have typically demonstrated a phenotype characterized by mild to moderate ventriculomegaly – the equivalent of which may not even require intervention in the human condition. We sought to establish a preclinical model of severe IVH that recapitulates the severity of the hydrocephalus phenotype requiring neurosurgical intervention and to determine the causal blood degradation product resulting in severe hydrocephalus following preterm …

Effects Of Replacing Antibiotics With Bacillus-Based Probiotics In The Diet Of Lactating Sows On Reproductive Performance, Feed Intake, Serum Immunoglobulin Levels, Milk Production, Oxidative Stress Markers, Fecal Short-Chain Fatty Acids, And Piglet Growth Performance, Chutikan Srisang, Tip-Apa Akkhaphan, Preechaphon Taechamaeteekul, Junpen Suwimonteerabutr, Rafa Boonprakob, Suparlark Nuntawan Na Ayudhya Dr, Lea Hübertz Birch Hansen Dr, Padet Tummaruk

The Thai Journal of Veterinary Medicine

This clinical trial investigated the effects of adding a Bacillus-based probiotic to the lactation diet of sows (without in-feed antibiotics) on maternal and piglet outcomes. A total of 109 Landrace × Yorkshire sows (parity 1–7) were assigned to either a control group (n = 61) or a treatment group (n = 48) receiving Bacillus subtilis – 541 and Bacillus amyloliquefaciens – 516. Piglets in the treatment group also received the probiotics via creep feed from day 3 until weaning. Blood samples were collected within 12 h after farrowing to assess serum immunoglobulins (IgG, IgA, and IgM) and malondialdehyde (MDA) …

The Implementation Of Indoor Urban Gardening: A Microgreens Pilot Study In A University Setting, Kathryn Chang, Samantha Brink, Annette Gadegbeku

Transformative Medicine

Introduction: “Food deserts” are geographical areas that lack affordable full-service grocery stores and have higher densities of unhealthy or “fast food” options. These deserts not only exist in communities such as Philadelphia, but also on college campuses. One solution to creating access to fresh vegetables is urban farming, which refers to green areas (i.e. community gardens) that provide places for food to be grown by local residents. Microgreens Health Outreach Project (HOP), aimed to build and implement a small, indoor community garden cart within the Health Sciences Building (HSB) at Drexel University; the organization hoped that this cart would be …

Assessing Utah's Agricultural Producer And Small Processor Interest In Value-Added Food Production, Kynda R. Curtis, Makaylie Langford, Karin E. Allen, Ruby Ward

All Current Publications

In 2024, Utah State University researchers conducted a study of Utah agricultural producers and food processors interested in value-added food production. This fact sheet provides an overview of the study’s results on respondents’ operational details, including years in business, number of employees, and annual sales, as well as their interest in and rationale for expanding into value-added food production. It also discusses their current or planned timeframe for processing operation implementation, the types of products and markets involved, processing locations, and sales projections. Finally, it highlights the resources, tools, information, and services respondents identified as most useful for their processing …

Light-Induced Oslike1 Phosphorylation Enhances Rice Resistance Against Blast Disease, Jiangtao Liu, Lei Su, Wenya Wang, Jintao Wang, Weizhong Chen, Zhixiang Yang, Leiyun Yang, Gang Li, Xinyu Liu, Haifeng Zhang, Zhongqiang Qi, Yongfeng Liu, Yuqiang Liu, Ping Wang, Muxing Liu, Zhengguang Zhang

School of Graduate Studies Faculty Publications

Rice blast caused by Magnaporthe oryzae poses a major threat to world food supply. Conditions conducive to the disease include insufficient light. Our previous studies found that light-dependent phosphorylation of light-harvesting complex II protein (LHCB5) mediates rice immunity; however, the underlying mechanisms, in particular, the upstream regulators of LHCB5 phosphorylation, remain unknown. Here, we show that OsLIKE1 functions as a lectin receptor-like kinase (LecRLK) to play a critical role in rice resistance against M. oryzae. OsLIKE1 interacts with and phosphorylates LHCB5. In addition, we find two phosphorylation sites in the kinase domain of OsLIKE1 important for its auto-phosphorylation and phosphorylation …