Life Sciences Commons^™

Pathological Drivers Of Coral Diseases Across The Arabian Peninsula, Thierry M. Work, Greta S. Aeby, David Abrego, Jessica Bouwmeester, Emily Howells, Pedro Range, Maren Ziegler, Thor Jensen, Amanda Shore, Grace Vaughan, John A. Burt, Christian R. Voolstra, Radhouan Ben-Hamadou

All Works

Increasing trends of coral mortality are a challenge to coral reef management worldwide, and a need exists to identify the causes and pathways involved. Pathology is useful to help decipher potential causes of mortality in animals, because it illuminates agents associated with lesions and gives insights on the nature of how a host responds to said agents. To better understand the nature of threats facing corals in the Arabian Peninsula, we performed gross and microscopic pathology on corals from Saudi Arabia, Qatar, and the United Arab Emirates. Among 321 coral fragments examined from 21 genera, tissue loss was the most …

Using Artificial Intelligence Applications In Humanizing Temporary Buildings For Workers, Developing Design Standards And Involving Users, Anas Almahmoud, Hatem El Shafie

Mansoura Engineering Journal

This research focuses on artificial intelligence (AI) and its tools for assisting in architectural design and decision-making. It identifies modern AI applications for use in research and design processes, aiming to raise awareness among architects and consulting firms. This is the primary objective of the research. The study also analyzes a mobile temporary worker cabin complex in Riyadh, specifically the metro project, as a case study. The goal is to address its architectural program, improve its design, identifies the necessary design criteria and make it more humane. The core research problem lies in testing the effectiveness of using AI tools …

Explainable Ai For Liver Transplant Survival Prediction: Integrating Immunological Mismatch Features, Sourab Shaik

Honors Projects

Liver Transplantations are crucial treatment for end-stage liver disease. However, a persistent deficit of donor organs necessitates maximizing the utility of each available graft to minimize failure rates. We evaluated whether donor–recipient molecular immunogenicity metrics - Electrostatic and Hydrophobic Mismatch Scores (HMS/EMS) and eplet-based counts - improve post–liver-transplant survival prediction. The analytic cohort comprised adult, first time, single-organ deceased-donor transplants drawn from Scientific Registry of Transplant Recipients; follow-up was truncated at five years, and the endpoint was all-cause graft failure (earliest of graft failure or death; otherwise, censored). HLA variables were derived via high- resolution conversion and molecular mismatch computations …

Effects Of Ghost Energy Drink On Muscle Strength, Psychomotor Vigilance, And Mood., Jason M. Curtis, Jose J. Rojas, Flavia F. Pereira, Cassandra Evans, Elizabeth Espocito, Alyana Andal Andal, Gavin Poulshock, Hena Thakkar, Taila De Castro, Alexandra Jimenez, Antonio Cristanti, Antonella V. Schwarz, Juan Carlos Santana, Jose Antonio

Journal for Sports Neuroscience

Abstract

Background: This study aimed to evaluate the effects of a commercially available energy drink (Ghost®) compared to a caffeine-matched control on measures of mental and physical performance.

Methods: In a randomized, double-blind design, 62 participants were assigned to receive either the energy drink (Ghost®) or a caffeine-matched control (200 mg caffeine). Assessments were conducted at baseline and approximately 45 minutes post-ingestion, including the Psychomotor Vigilance Test (PVT), CNS Tap Test, handgrip strength, and the Profile of Mood States (POMS).

Results: Participant demographics are presented in Table 1. No significant between-group differences were observed for any performance measures. Both groups …

Hogfish (Lachnolaimus Maximus) Neurocranium, Nate B. Nutting-Hartman, Naya H. Mondrosch, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

The Triangular Interaction Between Dietary Polyphenols, Gut Microbiota, And Metabolic Syndrome, Emily Bayliss

Senior Honors Theses

Type 2 diabetes mellitus (T2DM) is a growing global health concern characterized by peripheral insulin resistance as well as impaired insulin secretion from pancreatic β-cells. Emerging evidence suggests that the gut microbiome, specifically gut dysbiosis, an imbalance in the gut microbiome, is a critical modulator of the pathophysiology of T2DM. Dietary polyphenols, a diverse group of bioactive compounds that are abundant in plant-based foods, have recently gained attention for their potential to attenuate metabolic disorders through their antioxidant and anti-inflammatory properties as well as through modulating the composition and activity of gut microbes, thereby attenuating dysbiosis. However, the diabetic state …

Edna Surveys For The Critically Endangered Caribbean Staghorn Coral, Acropora Cervicornis (Lamarck, 1816), Pari Elaine Cribbins

All HCAS Student Capstones, Theses, and Dissertations

Historically, Acropora cervicornis was a dominant coral on Caribbean reef systems, but an outbreak of white band disease in the late 1970s marked the beginning of devastating, multi-decadal population declines that led to the coral being listed as “critically endangered” on the IUCN Red List in 2022. Today, after a record-setting marine heat wave in 2023 triggered a mass bleaching event on Florida’s Coral Reef (FCR), A. cervicornis is considered functionally extinct on the FCR. While individuals of A. cervicornis do remain on the FCR, the small population size of the coral makes in situ surveys difficult. However, surveys using …

Single Compost Application Benefits For Organic Dryland Wheat Production, Shikha Sharma, Matt Yost, Earl Creech, Jennifer R. Reeve, Astrid R. Jacobson, Idowu Ademola Atoloye

All Current Publications

This research highlights the long-term value of compost in dryland wheat systems, where water scarcity and declining soil fertility limit productivity. A single, high-rate compost application (22 tons per acre) can improve soil moisture content, organic carbon content, aggregate stability, and microbial activity. All these benefits contributed to higher and more stable wheat yields, even more than two decades after application. These changes help to make the compost-treated wheat more resilient during dry years. While composting incurs a high upfront cost, its long-term benefits can significantly reduce the need for repeated fertilizer or soil amendments, offering cost and labor savings …

Hif-2-Dependent Regulation Of Pthrp And Paraneoplastic Hypercalcemia In Aggressive Clear-Cell Renal Cell Carcinoma, Arijit Mal, Bingqing Xie, Zane Gray, Charlotte Small, Susmita G Ramanand, Yunpeng Gao, Vanina Toffessi Tcheuyap, Sashi Debnath, Alana Christie, Jeffrey Miyata, Brooklyn Jackson, Hua Zhong, Boning Gao, Jay Lohrey, Naim M Maalouf, Sangeetha M Reddy, John D Minna, Ivan Pedrosa, Xiankai Sun, Ram S Mani, Payal Kapur, James Brugarolas

Faculty, Staff and Student Publications

Renal cell carcinoma (RCC) patients with hypercalcemia (HC) have worse outcomes. HC often involves PTHrP, and the role of HIF-2 is incompletely understood. Leveraging RCC tumorgraft (TG) models of HC, which were characterized by tumor cell autonomous inflamatory/immune signatures, we show that HIF-2 inhibition with PT2399 frequently normalized calcium, downregulated circulating PTHrP and reduced HIF-2 binding to the PTHLH (PTHrP) promoter. Likely contributing to the selective induction of PTHrP in a subset of HIF-2-dependent tumors, the PTHLH locus was generally more accessible in TG(HC). However, PTHLH chromatin accessibility was grossly unaffected by PT2399, unlike elsewhere (including EPO locus in a …

Characterizing Circulating Rare Cells In Peripheral Blood For Detecting And Monitoring Multiple Myeloma And Precursor States, Stephanie N Shishido, Jeremy Mason, Mohamed Kamal, Sonia Maryam Setayesh, Amishi U Vora, David Berrios, Luz Yurany Moreno Rueda, Krina Patel, Elisabet E Manasanch, Robert Z Orlowski, Peter Kuhn

Faculty, Staff and Student Publications

Multiple myeloma (MM) arises from abnormal plasma cells (PCs) progressing from precursor states, including monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Understanding this transition and progression to overt MM requires improved non-invasive strategies. We employed a liquid biopsy approach to detect and characterize circulating PCs across disease states in 68 patients (MGUS = 11, SMM = 21, NDMM = 19, RRMM = 17) using multi-channel immunofluorescence staining and machine learning-assisted rare event detection. PCs were identified by CD138 and B-cell maturation antigen (BCMA) expressions, with distinct phenotypic subpopulations stratifying disease states. The D | CD138 | …

Inhibition Of Clostridioides Difficile-Specific Dna Adenine Methyltransferase Cama By Analogs Of S‑Adenosyl‑L‑Methionine, Jujun Zhou, Youchao Deng, Dan Yu, Taraneh Hajian, Masoud Vedadi, Xing Zhang, Robert M Blumenthal, Rong Huang, Xiaodong Cheng

Faculty, Staff and Student Publications

Epigenetically targeted therapies, especially those inhibiting S-adenosyl-l-methionine (SAM)-dependent methylations of DNA, mRNA, and histones, have advanced rapidly in cancer treatment. However, these therapies remain underexplored for antibiotic development, despite the growing threat of antimicrobial resistance. Here, we screened a focused library of SAM analogs against the DNA adenine methyltransferase CamA specific to the enteric pathogen Clostridioides difficile. At the same time, we examined six other adenine methyltransferases, including two bacterial DNA methyltransferases and four human RNA methyltransferases having distinct RNA substrates. Compound 113 selectively inhibited CamA (IC50 = 0.15 μM). In addition, compound 67 inhibited Caulobacter crescentus CcrM …

Longitudinal Pharmacokinetic And Safety Studies Of An Antibody-Erythropoietin Fusion Protein For Alzheimer's Disease, Rudy Chang, Devaraj Venkatapura Chandrashekar, G. Chuli Roules, Nataraj Jagadeesan, Emi Iwasaki, Adenike Oyegbesan, Hayk Davtyan, Rachita K. Sumbria

Pharmacy Faculty Articles and Research

Erythropoietin (EPO) shows promise for Alzheimer's disease (AD) but has poor brain penetration, necessitating high doses that cause hematopoietic side effects. To improve brain delivery, EPO was fused to a transferrin receptor monoclonal antibody (TfRMAb), and this study evaluated the pharmacokinetics (PK), safety, and efficacy of repeated TfRMAb-EPO dosing in mice to further its preclinical development. C57BL/6J male mice (10 weeks old, n = 4–5/dose) received subcutaneous (SQ) low (1 mg/kg), mid (3 and 6 mg/kg), or high (20 mg/kg) TfRMAb-EPO doses for 4 weeks. The 1 mg/kg dose showed no adverse effects and resulted in sustained brain and plasma …

Multi-Omic Profiling Provides Insights Into The Heterogeneity, Microenvironmental Features, And Biomarker Landscape Of Small-Cell Lung Cancer, Mingchao Xie, Miljenka Vuko, Shashank Saran, Siyu Liu, Andrew G Chambers, Hana Baakza, Helen K Angell, Felicia Ng, Carl M Gay, Robert J Cardnell, Felix J Segerer, Alma Andoni, Jaime Rodriguez-Canales, Paul M Waring, Markus Schick, J Carl Barrett, Lauren A Byers, Giulia Fabbri

Faculty, Staff and Student Publications

Background: Greater understanding of differential therapeutic sensitivity, specifically to immunotherapy, in small-cell lung cancer (SCLC) is required.

Methods: We explored SCLC heterogeneity through integrated molecular characterization of tumor tissue samples from 159 treatment-naive patients, utilizing genetic, epigenetic, transcriptional, and proteomic profiling, immunohistochemistry staining for multiple biologically relevant markers including transcriptional subtype-defining proteins, and spatial immune profiling using multiplex immunofluorescence.

Results: Multi-omics analysis confirmed high heterogeneity across/within neuroendocrine and non-neuroendocrine subtypes. Methylomics analysis identified four methylome clusters that may enhance subtype prediction, prognosis, and longitudinal monitoring of subtype evolution. Immunohistochemistry analysis showed high MHC-I expression in non-neuroendocrine subtypes, which have greatest …

The Impact Of Infrastructure Construction And Remodeling Of Cities On Its People' Quality Of Life Miraj District-(Madi-Cairo) As A Geological Heritage Area, Ahmed M.E. Hammad

Mansoura Engineering Journal

Rapid urbanization is increasing globally, the urbanization rate expected to rise to more than 66% by 2050. (According to UN estimates) the increasing rates of urbanization in the world means adding 2.5 billion people to the urban population within a short period. Which necessitates increasing the traffic axes and the rest of the networks in terms of lengths and widths within the existing cities, and with the presence of the population during these works - despite their inevitability - the quality of their urban life is affected socially, naturally and economically. the research monitors these effects and the extent of …

Development Of A Method For Using Effective Elements For The Storage Of Electrical Energy, Jasur M. Melibaev, Nasiba U. Abduraimova, Sardor S. Abriev, Yulbarskhon N. Mansurov

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the work is to find ways to use cryotic metals that also provide added value to the economy, using the example of tantalum and zirconium. Among the critical metals, there are those that are rarely found in the Earth’s crust but possess unique properties. These include tantalum and zirconium. While zirconium finds industrial applications, tantalum is still rarely used – its main application in capacitors for producing phones, computers, and automotive electronics. A small amount of tantalum is used to make hard alloy elements. Analysis showed that between zirconium and tantalum, there is a mixture of two …

Tactile And Photoelectric Sensing For Leveling Berms In Peach Tree Rows, Shubham Singh, A. Bulent Koc, Guido Schnabel, Juan Carlos Melgar, Michael Vassalos, Jasanmol Singh

Open Access Publishing Fund

Planting peach trees shallow on berms is a short-term Armillaria root rot management strategy to facilitate root collar excavation for about two years after planting. Leveling of berms between trees planted in rows helps improve worker and machine mobility during orchard operations and reduces soil erosion caused by adjacent furrows on either side of the berm. The berm leveling mechanism in a prior study used tractor operator input to avoid trees during field operations. This research aimed to automate the actuation of the berm leveling machine around peach trees and to evaluate the effectiveness of a finger weeder attachment in …

Development And Evaluation Of Rhizoqol, A Quality-Of-Life Caregiver-Reported Survey For Rhizomelic Chondrodysplasia Punctata, A Rare Peroxisomal Disorder, Mousumi Bose, Tahra C. Anglade, Chelsea I. Donlon, Adrian L. Kerrihard, Hila F. Berger, Ariel S. Berkowitz, Shawn A. Ritchie, Tara M. Smith

Department of Nutrition and Food Studies Scholarship and Creative Works

Background: Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic disorder characterized by symptoms such as respiratory dysfunction, seizures, orthopedic issues, and neurodevelopmental delay. Potential therapeutics for RCDP warrant the development of clinical outcome assessments to assess the efficacy of treatment and the well-being of patients. Our study aimed to develop a valid quality-of-life (QOL) caregiver-reported survey instrument, RhizoQOL, to be used as a supportive endpoint in RCDP clinical trials. Methods: Development of the RhizoQOL survey tool included three RCDP caregiver focus groups to elicit concepts to serve as potential domains in a QOL survey instrument for RCDP, pilot survey development …

Using Insecticidal Compounds To Elucidate The Potential Role Of Neurotransmitters In Lepidoptera Pupal Ecdysis, Niranjana Krishnan, Cassandra Gorman, Jillian Stewart, Steven Bradbury, Russell Jurenka

Biological Sciences Faculty Research & Creative Works

Previously, we reported final-instar lepidopteran larvae exposed to low doses of imidacloprid, clothianidin, and thiamethoxam had arrest in pupal ecdysis, which is a novel adverse outcome for neonicotinoid insecticides. Since neonicotinoids disrupt acetylcholine signaling, we hypothesized that the excitatory neurotransmitter acetylcholine plays a critical role in regulation of pupal ecdysis, likely by modulating the release of peptides from crustacean cardioactive peptide (CCAP) neurons. In this paper, using two lepidopteran species, we undertook studies with five additional nicotinic acetylcholine receptor (nAChR) agonists and three muscarinic acetylcholine receptor (mAChR) agonists to hypothesize the putative nAChR subunits that mediate pupal ecdysis. We also …

Applicability Of Syntropic Agriculture To A Semi-Arid Continental Climate: Alentejo To New Mexico, Arielle Nathan, Joana Dionisio Msc, João Serra, Joseph Lanning, Cátia Magro Dr.

Journal of Critical Global Issues

Conventional industrial agriculture has detrimental effects on the environment including pollution and overconsumption of water, soil degradation, and biodiversity reduction. An environmentally sustainable future of food production requires alternative methods that limit negative environmental consequences. Syntropic Agriculture (SA) is a promising farming alternative especially for arid systems at risk of desertification. New Mexico, USA, is a semi-arid continental climate in a prolonged period of drought and predicted to experience worsening agricultural conditions including desertification, wildfire intensification, and exacerbated water scarcity. The Alentejo region of Portugal has a Mediterranean climate with similar agricultural challenges. The agroecological transition project, Terra Sintrópica, located …

Fisheries Research Report No. 362: Characterising Essential Benthic Habitats And Environmental Drivers Of Fishery Recruitment In The Exmouth Gulf Prawn Managed Fishery, Scott Evans, Nick Konzewitsch, Rachel Marks, Renae Hovey, Gary A. Kendrick, Lynda M. Bellchambers

Fisheries Research Reports

Fisheries management relies on the development and evolution of effective assessment and monitoring techniques that are applicable in a range of fishery contexts (Fletcher et al., 2016; L. M. Robinson et al., 2021). The assessment of fish habitats and environmental drivers that influence recruitment is central to sustainable fisheries management (de Lestang et al., 2010; Galindo-Cortes et al., 2010; Gao & Wang, 2021). Western Australia conducts robust fishery-specific monitoring and assessment programs to ensure the sustainable use of its aquatic resources (Newman et al., 2023). However, few long-term datasets exist that directly monitor critical fish habitats and environmental conditions that …

Exploring Retention And Satisfaction Among Arkansas County-Level Cooperative Extension Employees: A Job Embeddedness Perspective, Rebecca M. Simon

Graduate Theses and Dissertations

Abstract This quantitative study investigated the retention of county-level employees within the Arkansas Cooperative Extension Service (CES) using Job Embeddedness Theory (JET) as the theoretical framework. The research aimed to describe levels of job embeddedness, job satisfaction, and intent to stay, and to examine the relationships among these variables. A census of 328 CES employees was conducted, yielding a 53% response rate. Data were collected through a validated online survey and analyzed using descriptive statistics, correlation analysis, and multiple regression. Results indicated high scores in organizational fit and sacrifice dimensions, while links to organization and community were comparatively lower. Age …

The Power Of Core Memories In Financial Education For Gen Alpha Children, Karen Richel

Journal of Human Sciences and Extension

Financial education plays a critical role in shaping lifelong financial behaviors and decision-making skills. To create a lasting impact, it is essential to establish core memories associated with money management from an early age. This article explores the significance of these foundational experiences and their role in financial education for Gen Alpha children.

A series of eight immersive financial education events was developed to meet state and national standards for students in pre-kindergarten through sixth grade. These events employ play-based and object-based learning approaches, immersing students in engaging, age-appropriate activities that incorporate real-world scenarios. By creating a fun and memorable …

Enhancing Youth Learning Outcomes Of Travel Programs Through Storytelling, Gary Ellis, Parisa Paymard, Dottie Goebel, Darlene Locke, William F. Zanolini, Emily Catalan, Kelley Ranly

Journal of Human Sciences and Extension

We conducted two studies to evaluate strategies that Extension educators may use to enrich youth travel program experiences. Study 1 evaluated the effects of telling stories about attractions before site visits on youth experiences and learning outcomes on site. Seventeen youth in a 4-H program designed to promote cultural understanding visited eight attractions in Costa Rica. The evening before visiting three sites, youth were told a fictional or cross-fictional story about the sites. The stories elicited imaginary travel to the site (narrative transportation). After visiting the sites, the youth reported the extent to which they felt like they were in …

Food Access And Food Insecurity Among Early Childhood Educators And Staff Prior To And During The Covid-19 Pandemic: A Mixed Methods Pilot Study, Rahel Mathews, Leah Pylate, Will Davis, Elizabeth Thorne, Jamila Taylor, Shecoya White, Bennett Pope, Emma Bryant

Journal of Human Sciences and Extension

Emerging research indicates that 40% of early childhood education (ECE) workers experience food insecurity. The purpose of this study was to describe the food insecurity and food access of Head Start teachers and staff in Mississippi before the COVID-19 pandemic and to understand how COVID-19 affected food access. A mixed-methods design was employed using cross-sectional surveys, at two different time points, and three focus groups. Three Head Start centers from the Mississippi Coast participated. Approximately 52% of teacher and staff respondents experienced food insecurity before COVID-19; during the pandemic, their level of food insecurity worsened from low to very low …

Teaching Leadership In The Context Of Crisis: Connecting Organizational Leadership And Crisis Competencies In A Faculty Leadership Education Program, Caitlin Lunzmann, Nicole Lamee Perez Stedman, Matthew Sowcik

Journal of Human Sciences and Extension

This research focused on enhancing leadership instruction in colleges of agriculture. A multi-institutional research team initiated a program to teach agricultural and natural resource faculty how to create leadership-oriented case studies for undergraduates. Forty faculty members participated in an online training academy centered on Bolman and Deal’s Organizational Frames and case study writing. Following the academy, these faculty members participated in field experiences in the southeastern U.S. to gather data on natural disasters, which they used to write case studies about leadership in agriculture. Though the program focused on organizational leadership, it also discussed leadership in the context of natural …

Exploring The Educational Needs Of Family Caregivers For Patients With Dementia, Karen L. Franck, Janet Fox, Ann A. Berry, Kristen Johnson, Jessica Taylor, Matt Devereaux

Journal of Human Sciences and Extension

Family members who care for patients diagnosed with Alzheimer’s and dementia often face significant stressors and challenges that impact their quality of life. As part of a project to develop Extension educational materials and resources specifically for family caregivers, we conducted an online needs assessment survey with 196 adults in the U.S. Participants identified doctors, the internet, and caregiver support groups as top sources of information about dementia. They were interested in strategies to help them manage stress, address patient behavioral issues, and access locally available resources. Furthermore, they were interested in attending educational programs with other caregivers. These findings …

Increase In Area Burned And Wildfire Frequency In Utah By 2050, James A. Lutz, Joseph D. Birch

Wildland Resources Faculty Publications

By 2050 nearly all landscapes in Utah (Fig. 1) will experience increases in area burned and fire frequency. However, these increases will not be equal across all vegetation (Fig. 2). Forests and Wildland Urban Interface (WUI) will likely experience the largest increases and expected to burn at higher severity than non-forest systems.

The Price Of Priorities: How Human Choices Fuel Climate And Ecological Decline, Keisha Hickman

Biological Sciences Undergraduate Honors Theses

This thesis examines the ways in which human priorities and behaviors contribute to the escalating climate crisis and ecological systems. We will first analyze the role of social media in shaping public discourse on climate change and critically evaluate the priorities of institutions that have the means to assist in wildlife conservation. Both speak to the current behaviors of humankind prioritizing their own entertainment over meaningful efforts to mitigate climate change and preserve biodiversity. We will then shift to exploring the profound impact of human population growth and its associated activities on other species and ecosystems. Finally, the thesis will …

Assessing Response Diversity Of Spawning Conditions For Native Trout Among Streams To Interannual Changes In Snowpack, Autumn Kaye Zierenberg

Undergraduate Honors Capstone Projects

Stream habitat suitability for fish is controlled by physical, chemical and biological conditions impacted by interannual changes in climate. Intermittent streams are particularly sensitive to climatic variation and have long been overlooked as potential spawning habitats for fish and other riverine species. Spawning suitability in stream habitats is strongly influenced by connectivity to perennial habitats, the duration of surface flows and water temperatures, each of which are driven by annual snowpack and discharge conditions. Here, we examine how the spawning habitat suitability in different tributaries within a single river basin respond to changes in annual snowpack conditions. Specifically, we examined …

Modeling And Analysis Of Electric Signal In Neurons, Kevin J. Roberts

All Graduate Reports and Creative Projects, Fall 2023 to Present

Neurons in humans and other species transmit information by sending electric signals via axons. This process relies on the generation and propagation of action potentials—rapid changes in the membrane potential of the axon. Understanding the mechanisms of action potentials, including how they are generated and influenced by the axon geometry and material parameters, is crucial for gaining insight into neurological diseases such as Alzheimer’s and Multiple Sclerosis (diseases highly correlated to demyelination). In this work, we review and summarize mathematical models for signal transmission–including the classical Hodgkin-Huxley model, the Single Cable (SC) model, and the Double Cable (DC) model. We …