Life Sciences Commons^™

Modeling And Analysis Of Electric Signal In Neurons, Kevin J. Roberts

All Graduate Reports and Creative Projects, Fall 2023 to Present

Neurons in humans and other species transmit information by sending electric signals via axons. This process relies on the generation and propagation of action potentials—rapid changes in the membrane potential of the axon. Understanding the mechanisms of action potentials, including how they are generated and influenced by the axon geometry and material parameters, is crucial for gaining insight into neurological diseases such as Alzheimer’s and Multiple Sclerosis (diseases highly correlated to demyelination). In this work, we review and summarize mathematical models for signal transmission–including the classical Hodgkin-Huxley model, the Single Cable (SC) model, and the Double Cable (DC) model. We …

A Persistent Homology Framework For Scrna-Seq: Assessing Clustering Robustness And Quantifying Preprocessing And Integration Effects On Topological Features., Jonah Daneshmand

Electronic Theses and Dissertations

As single-cell RNA sequencing (scRNA-seq) data expands, robust methods for integrating diverse datasets are critical. This dissertation applies Persistent Homology (PH), a technique from Topological Data Analysis (TDA), to a collection of scRNA-seq datasets spanning eight tissue types to quantify how data integration affects topological features and biological interpretability. We assessed global topological structure using Betti curves, Euler characteristics, and persistence landscapes across raw, normalized, and integrated data representations. Our analysis revealed a performance inversion: while conventional methods excelled on unintegrated data, high-granularity topological methods, particularly those sensitive to global data structure, became superior after integration. This suggests a synergy …

The Autonomic And Arrhythmogenic Effects Of Gestational E-Cigarette Exposure., Brittany Rachelle Reynolds

Electronic Theses and Dissertations

Introduction. E-cigarettes (e-cigs) have been shown to be pro-arrhythmic in both human and male rodent studies; however, little is known about how e-cig use impacts patients with a predisposed heightened risk for arrhythmias, including pregnant women. Both pregnancy and e-cig use have independently been shown to increase heart rate, diminish heart rate variability, and increase ventricular premature beats, which is suspected to be due to sympathetic dominance. Importantly, β-blockers have been shown to reduce sympathetic activity, reduce heart rate, increase HRV, and reduce arrhythmias. Thus, the use of β-blockers may help prevent adverse health effects driven by sympathetic dominance from …

Ground-Based Evaluation Of The Utah Reusable Root Module: Summary Of Three Crop Cycles With Mizuna, Tomato, And Lettuce, Claudia Garrido-Ruiz, Juan D. González-Teruel, Chihiro Dixon, Sarah Schreck, Bruce Bugbee, Scott B. Jones

NASA

The Utah Reusable Root Module (URRM) is a zero-discharge plant-growth system designed for microgravity. We evaluated its performance across four consecutive ground-based crop cycles with mizuna (Brassica rapa var. nipposinica), dwarf ‘Rejina Red’ tomato (Solanum lycopersicum), and ‘Outredgeous’ lettuce (Lactuca sativa). Five root modules (RMs) used distinct top-cover/containment designs with peatmoss medium. Growth conditions were 23–28 ^°C, 16/8 h photoperiod, PPFD ≈ 800 µmol m^⁻² s^⁻¹, RH ~ 50– 60%, and air velocity ~ 0.8 m s^⁻¹. Redundant moisture sensing (upper CS650, lower TEROS ONE) enabled accurate water-use accounting; slopes …

Impact Of Thermodynamic Factors And Intrinsic Properties On Crystallization Behavior And Physical Properties Of Edible Fats, Nabila Anjum

All Graduate Theses and Dissertations, Fall 2023 to Present

Crystallization behavior of three edible fats: interesterified soybean oil (IESBO), interesterified palm olein (IEPO), and fully hydrogenated palm kernel oil (FHPKO) were explored to understand how this process is affected by different factors. The study focused on how the chemical composition of these fats affects their behavior like how much time they require to be crystallized at a certain temperature. By using different scientific methods, how quickly each fat began to crystallize and how much energy it took to start the process was measured. Among the methods used, Gompertz equation, a mathematical model, gave the most consistent and reliable results …

Environmental Identities Of College Students Reveal Potential Conflicts And Common Ground For Wildlife Conservation, Richard Von Furstenberg, Lincoln R. Larson, M. Nils Peterson, Kangjae Jerry Lee, Victoria R. Vayer, Kathryn Stevenson, Stacy A.C. Nelson, Jeremy Bruskotter, Adam A. Ahlers, Christine Anhalt-Depies, Taniya Bethke, Chris Chizinski, Brian Clark, Kiley M.D. Fryman, Ashley A. Dayer, Benjamin Ghasemi, Larry Gigliotti, Alan Graefe, Samuel J. Keith, Matt Kelly, Gerard Kyle, Elizabeth Metcalf, Wayde Morse, Mark D. Needham, Neelam C. Poudyal, Michael Quartuch, Shari L. Rodriguez, Chelsie Romulo, Ryan L. Sharp, William Siemer, Matt Springer

Michigan Tech Publications

“Conservationist” and “environmentalist” are two prominent environmental social identities often perceived as conflicting, particularly on wedge issues like hunting. While these groups may hold differing philosophies, their beliefs could overlap, revealing opportunities for collaboration in conservation. We examined environmental identities among U.S. college students across 22 states (n = 17,203) from 2018 to 2020, assessing identity, wildlife values, and positions on polarizing issues. Students were classified into four groups: conservationists (8 %), environmentalists (9 %), pluralists (59 %) who expressed both identities, and eco-agnostics (24 %) who expressed neither. Environmentalists, the most diverse group demographically, exhibited mutualistic wildlife value orientations, …

Impacts Of Including Sprouted Barley In The Diet Of Beef Cattle On Production, Ruminal Health, And Meat Quality, Zachary C. Crump

All Graduate Theses and Dissertations, Fall 2023 to Present

Beef producers in the United States are working to meet rising global demand for animal protein while facing major challenges such as drought, climate uncertainty, and rapid urbanization. These issues make it difficult to produce consistent and dependable feed, pushing producers to explore new ways to grow feed using fewer natural resources. Vertical farming systems are one option that can grow sprouted cereal grains indoors throughout the year while using decreased land and water than traditional agriculture. Sprouted barley grows within six to seven days and may serve as a nutrient dense alternative feed source for cattle at several stages …

Dynamics, Predictability And Impacts Of Multi-Year La Niña Event, Nahid A. Hasan

All Graduate Theses and Dissertations, Fall 2023 to Present

This dissertation investigates the dynamics, predictability, and impacts of multi-year La Niña events. Multi-year La Niña events are referred to as extended periods of unusually cooler tropical Pacific that persist for two or more consecutive winters. These prolonged events can increase the risk of natural hazards such as droughts, floods, and heatwaves in the western US and around the world. Despite their worldwide significance, questions remain about the mechanisms driving their initiation, their predictability, and regional hydroclimate impacts.

The first chapter of the dissertation introduces what scientists currently believe causes them, and how well different types of climate models can …

Examing Fear Conditioning/Extinction And The Role Of The Amygdala In Human Neuroimaging., Olivia Cook

Electronic Theses and Dissertations

Fear plays a crucial role in survival but can lead to psychological disorders when dysregulated. Fears can be innate due to evolutionary relevance or learned through associative processes, where predictive accuracy of threat is pivotal. Disruptions in fear neurocircuitry contribute to anxiety disorders, characterized by heightened activation and impaired learning. Fear conditioning and extinction paradigms based on classical Pavlovian conditioning have been used to study mechanisms underlying fear learning. Using this experimental model, fear networks in rodents have been described in detail with clear distinction between conditioning and extinction neural functioning. Yet, there is no consensus on the neurobiological processes …

Distinct Clinicogenomic Features And Immunotherapy Associations In Pulmonary Sarcomatoid Carcinoma: A Multicenter Retrospective Study, Lingzhi Hong, Alessandro Di Federico, Bolun Liu, Alissa J Cooper, Joao V Alessi, Phoebe Clark, Waree Rinsurongkawong, Chingyi Young, Hui Li, Kang Qin, Muhammad Aminu, Valentina Santo, Yasir Elamin, Boris Sepesi, Jeff Lewis, Don L Gibbons, Ara A Vaporciyan, J Jack Lee, Xiuning Le, Jia Wu, Sinchita Roy-Chowdhuri, Mark J Routbort, P Andrew Futreal, John V Heymach, Mark M Awad, Adam J Schoenfeld, Jianjun Zhang, Biagio Ricciuti, Lei Deng, Natalie I Vokes

Faculty, Staff and Student Publications

Introduction: Pulmonary sarcomatoid carcinoma (PSC) is a rare NSCLC subtype with poor prognosis. Outcomes to immune checkpoint inhibitors (ICIs) and genomic features in PSC remain underexplored compared with other NSCLC subtypes.

Methods: Patients from three institutions and the National Cancer Database (NCDB) with metastatic NSCLC treated with ICI alone or with chemotherapy were identified. Clinicogenomics and treatment outcomes were compared across PSC, lung adenocarcinoma (LUAD), and lung squamous cell carcinoma (LUSC).

Results: We analyzed 4841 patients including 165 PSC cases treated with ICI-based therapy from three institutions and 201 PSC from NCDB. In MDACC, 65 (4.3%) were PSC, 1138 (75.1%) …

Artificial Intelligence Biomarker Detects High-Risk Childhood Asthma Subgroup For Respiratory Infections And Exacerbations, Young J Juhn, Chung-Il Wi, Euijung Ryu, Katherine S King, Sunghwan Sohn, Elham Sagheb, Greg Jenkins, David Watson, Miguel A Park, Sergio E Chiarella, Hirohito Kita, Mir Ali, W Charles Huskins, Elizabeth H Ristagno, Imad Absah, Charles Grose, Kathy Ihrke, Elizabeth A Krusemark, Thanai Pongdee, Björn Nordlund, Carla M Davis, Robert J Pignolo, Hongfang Liu

Faculty, Staff and Student Publications

Background: Asthma is associated with an increased risk of acute respiratory infections (ARI). Little is known about whether natural language processing (NLP)-powered digital biomarkers can identify a high-risk asthma subgroup for ARI during early childhood.

Objective: We assessed whether a digital biomarker could identify a high-risk subgroup of childhood asthma for ARI.

Methods: We applied validated NLP algorithms for Predetermined Asthma Criteria (NLP-PAC) and Asthma Predictive Index (NLP-API) to electronic health records of the 1997-2016 Mayo Clinic Birth Cohort. We categorized the cohort into 4 subgroups: both criteria positive (NLP-PAC+/NLP-API+), PAC positive only (NLP-PAC+), API positive only (NLP-API+), and both …

Genetic Identification Of A Rapidly-Adapting Low-Threshold Mechanoreceptor Innervating Fungiform Papillae., Thomas Alexander Myers Ii

Electronic Theses and Dissertations

Mechanosensory innervation of the oral cavity enables us to detect the texture and location of the foods we consume. Our goal was to find a genetic identifier for a mechanoreceptive subtype. Toward this goal, we examined neurons expressing the neurotrophin receptor TrkC, parvalbumin (Pvalb), and the glutamate transporter Vglut3. Because different papilla types contribute to food detection in different ways, we examined the innervation patterns of these neuron subtypes. We found that Pvalb+ and Vglut3+ neurons were fungiform papilla specific, where TrkC innervated both papilla types. We examined the anatomy of the three genetic populations, finding that the Pvalb+ neurons …

Further Characterization Of The Fungal Effector Mvlg-01732 In Planta And Heterologous Expression Of Fungal Effectors In Different Smut Fungi., Joseph Paul Ham

Electronic Theses and Dissertations

Host-pathogen interactions in smut fungi are characterized by effector proteins and their role in infection. The goal of this work is to better understand these interactions by further characterizing an effector from Microbotryum lychnidis-dioicae and heterologously expressing this and other effectors in heterologous species to see if the range of these effectors can play a role in pathogenicity when expressed in distantly and closely related fungal species. These effectors have been attuned over time to their host plant but have homologous interactors in other plant species. In this study, Microbotryum lychnidis-dioicae, Sporisorium reilianum, and Ustilago maydis, were all used …

El Poder Del Bilingüismo Y La Ciencia, Isabella Winslow

World Languages and Cultures

This project is an explanation of the importance of bilingualism, science, and our responsibility as humans within this environment. As living beings on this planet, we have a responsibility to respect and protect it. Over the course of the last several hundred years, we humans have made countless advancements. We have created unimaginable technology and discovered incredible resources produced by the land. However, in the process of doing so, we have damaged and continue to damage our environment. Reefs in the ocean have been bleached by increases in acidity, thousand year old glaciers have melted, forests have been destroyed by …

The Nebraska Bird Review (December 2025) 93(4), Whole Issue

Nebraska Bird Review

Changes to The Nebraska Bird Review, by Janis Paseka

Fall Field Report, August–November 2025, by W. Ross Silcock

First definitive records of Hermit Thrush and Wilson’s Warbler subspecies for Nebraska, by Stephen J. Brenner and Joel G. Jorgensen

Ogallala Fall Field Days, Sept. 26–28, 2025

Index to Volume 93

Subscription and Organization Information

Index To Volume 93

Nebraska Bird Review

Adams, Morgan
Aguiar: Maritza, Stephanie
Albright, Don
Alexander: Jeff, Jan
Aliferis, Taylor
Allard, Savannah
Allen, Edward
Allison, Betty
Altman, Dakota
Alvarado, A. H.
Ammon, E. M.
Anandan, Sampath Kumar
Andersen, Brett
Anderson: Ann, Chris, Will
Andrews, Ryan
Anhinga
Ani, Groove-billed
Annunziata, Laura
Armstrong, Nancy
Augustine, Jackie
Aurilio, James
Avocet, American

. . .

Zagst: Fred, Kay
Zeillemaker, Fred
Zemaitis, William
Zicafoose, Kirby
Zonotrichia leucophrys: gambelii, leucophrys, oriantha

First Definitive Records Of Hermit Thrush And Wilson’S Warbler Subspecies For Nebraska, Stephen J. Brenner, Joel G. Jorgensen

Nebraska Bird Review

During the fall of 2025, we initiated a pilot migratory bird-banding project in the Nebraska Panhandle. While the project’s goals included examining species composition, volume, and body condition of migratory birds at the western edge of the state compared to the eastern edge of the state, we also used this project to document the occurrence of subspecies and species which are very challenging or impossible to identify through field observation. Here, we report on the first definitive records of two subspecies in Nebraska.

On 16 September 2025, SJB banded an adult male Wilson’s Warbler (Cardellina pusilla) that was …

Fall Field Report, August–November 2025, W. Ross Silcock

Nebraska Bird Review

As in previous fall seasons, by far the most modifications to BONO came from late departure dates; around 87 species were included, no fewer than 13 of these setting record late dates, notably Eastern Whip-poor-will, Mountain Plover, Brown Thrasher (north), Henslow’s Sparrow (flight call only), and Orchard Oriole.

Although this is a Fall Seasonal Report, noted or suggested breeding activity is of interest. Exciting were the 2nd and 3rd presumed breeding records of Black-chinned Hummingbird and, in Dodge Co, the 5th record of breeding by Black-bellied Whistling-Duck. Perhaps the strangest west to east occurrence was a Golden Eagle adventure in …

Changes To The Nebraska Bird Review, Janis Paseka

Nebraska Bird Review

As of this issue, The Nebraska Bird Review has been in existence for 93 years, looking very much now as it did when it began in 1933. However, due to the increasing costs of printing and postage, there will be some changes in its future. Our newsletter, The Burrowing Owl, is already provided online to our members, in a user-friendly and informative form. Future issues of The Nebraska Bird Review will also utilize a digital format to offer a more timely and colorful publication.

This is the final issue for which Ross Silcock will be compiler of the seasonal …

Wacsaw: An Adaptive, Statistical Method To Classify Movement Into Sleep And Wakefulness States, Austin Vandegriffe, V. A. Samaranayake, Matthew S. Thimgan

Mathematics and Statistics Faculty Research & Creative Works

Wearable actimeters can improve our understanding of sleep in the natural environments. Current algorithms may produce inaccuracies in specific individuals and circumstances, such as quiet wakefulness. New hardware allows data collection at higher frequencies enabling sophisticated analytical methods. We have developed a novel statistical algorithm, the Wasserstein Algorithm for Classifying Sleep and Wakefulness (WACSAW), to identify behavioral states from recordings of everyday movement. WACSAW employs optimal transport techniques to identify segments with differing activity variability. Functions characterizing the segments' movement distributions were clustered into two groups using a k-nearest neighbors and labeled as sleep or wake based on their proximity …

Effect Of Successive Subculturing On Virulence, Growth, And Germination Of Fungus Metarhizium Rileyi For Biological Control Of Fall Armyworm, Joanna Marie E. Valeros, Trisha Anne P. Garcia, Noel G. Sabino, Marcela M. Navasero, Melissa P. Montecalvo

The Philippine Agricultural Scientist

This study explored the impact of successive subcultures of Metarhizium rileyi (Farl.) Kepler, S.A. Rehner & Humber on its cultural traits, spore germination, and virulence against fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), a key pest in agricultural systems. The mass production of infective propagules is essential for effective biological control. Notable changes were observed in the texture and mycelial appearance of the fungus across subcultures. Initially, the fungus exhibited a powdery texture up to the 6th subculture. However, the fungal growth became fluffy and cottony by the 8th and 10th subcultures. Additionally, sporulation rates (7.05 × 10^{8 …}

Evaluation Of Food-Safe Silicone Rubber Containment For Seedling Emergence, Yield, And Reusability, Claudia Garrido-Ruiz, Juan D. González-Teruel, Bruce Bugbee, Scott B. Jones

NASA

Flexible containment materials are essential for repeated planting cycles in the Utah Reusable Root Module (URRM), a zero-discharge system developed for space-based crop production. In previous trials, a vinyl top cover provided effective evaporative control and media retention but could not meet flight certification. To identify a suitable alternative, this study evaluated food-safe, flight-qualifiable silicone rubber sheets as an impermeable top cover for a wedge-based seeding system. The silicone rubber was tested at three thicknesses (1/32", 2/32", and 3/32") in combination with three linear fringe lengths (1.0", 1.5", and 2.0") and two fringe widths (0.25" and 0.5") and compared with …

Understanding Landowner Perceptions: Enhancing Conservation Easement Adoption In Missouri's Priority Landscapes, Mckenna N. Thompson, Jennah I. Klein, Robin M. Rotman, Sonja A. Wilhelm Stanis, Gus C. Raeker, Michele D. Baumer

Faculty Publications

Conservation of private lands is essential for protecting open space, supporting ecosystems and species, preserving resources, and facilitating outdoor recreation. One tool for private land conservation is a conservation easement – a voluntary legal agreement where a landowner surrenders certain rights to use or develop their property. This study explores landowner perceptions of perpetual conservation easements in areas of high conservation value in Missouri, focusing on landowners without existing easements. Through interviews, four themes emerge containing both motivations and constraints: prior knowledge, land protection, regulations, and finance. Many landowners were unfamiliar with conservation easements or had misconceptions or misunderstandings. The …

Defining The Causal Contribution Of The Gut Microbiota To Cardiomyopathy Pathogenesis As A Basis For Developing Microbiome-Targeted Therapies, Xu Shi

Department of Food Science and Technology: Dissertations, Theses, and Student Research

Heart failure (HF) is a leading cause of morbidity and mortality worldwide, placing substantial clinical and economic burdens on society. Although advances in therapy have improved patient outcomes, the biological mechanisms that drive HF onset and progression remain incompletely understood. Increasing evidence suggests that the gut microbiota, the trillions of microorganisms residing in the gastrointestinal tract, plays a key role in some forms of heart disease, especially cardiovascular disease. Moreover, gut microbial dysbiosis has been associated with systemic inflammation, metabolic imbalance, and immune dysregulation, all of which contribute to the pathophysiology of HF. Cardiomyopathy, a primary disorder of the heart …

Advancing Trypanosoma Cruzi N-Myristoyltransferase As A Drug Target For Chagas Disease Through In Silico Discovery And Biochemical Evaluation, Diana Citlali González García

Open Access Theses & Dissertations

Chagas disease remains one of the most persistent and neglected parasitic infections in the Americas, advancing silently through the intracellular replication of Trypanosoma cruzi amastigotes and the invasive spread of trypomastigotes. The survival of the parasite is critically reliant on protein N-myristoylation, a lipid modification catalyzed by N-myristoyltransferase (NMT). This dissertation aims to advance beyond prior studies by systematically investigating NMT inhibition across multiple biological levels, spanning from the characterization of the purified enzyme, through cellular infection models, to the global proteomic remodeling induced within the parasite, thereby evaluating TcNMT as a potential therapeutic vulnerability in T.cruzi.Recombinant TcNMT was expressed, …

Birds In Changing Landscapes: Community Diversity And Breeding Phenology, Lindsay Peria

Master's Theses

Humans are altering the environment in varied and widespread ways. Increasing urban and agricultural development causes changes to habitat and resource availability as well as changes to the sensory environment via light and noise pollution. Climate change also causes more extreme temperature anomalies, storms, and droughts that challenge birds in a multitude of ways. In this thesis, we assessed these impacts of these changes on a local and continental scale. In the first chapter, we assessed the impact of natural, anthropic, and structural characteristics of viticultural land on both taxonomic and structural avian diversity. Loss of habitat from agriculture is …

Associations Between Feed Efficiency And Feeding Behavior In Yearling Angus Bulls In A Competitive Environment, Amelia Katz

Master's Theses

Feed efficiency in beef cattle is a complex trait shaped by physiological, behavioral, and social factors that influence how animals access and utilize feed resources. This study examined feed efficiency classification and how it is influenced by feeding behavior, competitive interactions, and bunk approach patterns in yearling Angus bulls housed in a drylot over two years. Bulls were grouped into high and low feed efficiency categories using residual feed intake and feed conversion ratio within pen and year (n = 40 per year; n = 40 per treatment). Continuous electronic monitoring quantified feeder visitation, feeding duration, intake, and rate. A …

Factors Affecting Diet Selection In Sheep Fed Endophyte-Infected Toxic Fescue, Jordan Thomas

Animal Science Undergraduate Honors Theses

Tall fescue infected with endophyte‑producing fungi can induce fescue toxicosis in grazing ruminants, reducing performance and altering forage intake. Isoflavones—such as biochanin A, a major compound in red clover (Trifolium pratense)—have been proposed to mitigate these effects through improved palatability and vascular relaxation. This study examined whether inclusion of ground red clover (GRC)—either directly or combined with hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG)—affected voluntary diet selection in lambs offered toxic fescue.

Thirty‑two lambs were housed individually and assigned randomly to one of four diets: (1) toxic fescue silage (CONT), (2) silage + 5% GRC (RC5), (3) silage + 10% …

Behavioral Strategies And Neural Mechanisms Underlying Short-Range Navigation In Teleost Fish, Adelaide Sibeaux, Theresa Burt De Perera, Thomas Mueller, Ronen Segev

Department of Biology Faculty Scholarship and Creative Works

Studies of spatial cognition in teleosts have uncovered a remarkable array of behavioral strategies and neural mechanisms. While there is compelling evidence that short-range navigation in teleost fish is connected to the telencephalon, the rostral part of the forebrain, little is known about the telencephalic regions mediating this behavior. On the cellular level, several neuron types have been identified in specific regions of the telencephalon that respond to different aspects of the fish’s individual position within a given space. To comprehensively understand spatial representation in fish, we must bridge behavioral and neurophysiological studies. Here, we review the behavioral strategies used …

The Mayfly Newsletter, Donna Giberson

The Mayfly Newsletter

The Mayfly Newsletter is the official newsletter of the Permanent Committee of the International Conferences on Ephemeroptera.