Life Sciences Commons^™

Predicting Human Drug Toxicity And Safety Via Animal Tests: Can Any One Species Predict Drug Toxicity In Any Other, And Do Monkeys Help?, Jarrod Bailey, Michelle Thew, Michael Balls

Laboratory Experiments Collection

Animals are still widely used in drug development and safety tests, despite evidence for their lack of predictive value. In this regard, we recently showed, by producing Likelihood Ratios (LRs) for an extensive data set of over 3,000 drugs with both animal and human data, that the absence of toxicity in animals provides little or virtually no evidential weight that adverse drug reactions will also be absent in humans. While our analyses suggest that the presence of toxicity in one species may sometimes add evidential weight for risk of toxicity in another, the LRs are extremely inconsistent, varying substantially for …

Beyond Pain—Controlling Suffering In Laboratory Animals, Bernard E. Rollin

Experimental Research and Animal Welfare Collection

No abstract provided.

Gopher Intrusion In Cropping Systems, Kenneth Romero, Paul Cardinalli

Agricultural Education and Communication

The purpose of this project was to determine if no till vs. till on gopher populations was more beneficial. Which is more efficient at controlling gophers and explain the damage they can cause and the diseases they can potentially vector. What are the different options of pest managements that have to be used when dealing with a gopher infestation in a tilled field vs. a no-tilled field.

Resource Partitioning Along Multiple Niche Axes Drives Functional Diversity In Parrotfishes On Caribbean Coral Reefs, Thomas C. Adam, Megan Kelley, Benjamin I. Ruttenberg, Deron E. Burkepile

Biological Sciences

The recent loss of key consumers to exploitation and habitat degradation has significantly altered community dynamics and ecosystem function across many ecosystems worldwide. Predicting the impacts of consumer losses requires knowing the level of functional diversity that exists within a consumer assemblage. In this study, we document functional diversity among nine species of parrotfishes on Caribbean coral reefs. Parrotfishes are key herbivores that facilitate the maintenance and recovery of coral-dominated reefs by controlling algae and provisioning space for the recruitment of corals. We observed large functional differences among two genera of parrotfishes that were driven by differences in diet. Fishes …

Research Notes Lower Prairie Creek Project Redwood National Park, Susie Van Kirk

Susie Van Kirk Papers

Project Description: to conduct Phase 1 of a narrative history project for the Lower Prairie Creek Watershed, funded by Save the Redwoods League. Phase1 of this project will be to compile reference materials, sources, conduct scoping with NPS staff and other local stakeholders to develop historical research themes that will be needed for a future narrative history of the Lower Prairie Creek Watershed. It will result in a detailed chapter outline to be submitted to NPS.

Using Precision Agriculture Field Data To Evaluate Combine Harvesting Efficiency, Justin Carroll

Agricultural Education, Communications and Technology Undergraduate Honors Theses

Soybean crops must be harvested during a limited time period using expensive combines and associated equipment. Maximizing combine field efficiency, the ratio of the actual harvesting capacity to theoretical harvesting capacity, is an important objective of machinery managers. Spatial and temporal yield data from a 2012 CaseIH 8120 Axial-Flow combine equipped with a 30-foot MacDon D-65 Draper header and the Case-IH Advanced Farming System (AFS) yield monitoring system were used to examine field efficiency when harvesting soybean in three Arkansas Delta irrigated soybean fields during the 2015 season. Time efficiencies (TE) in the three fields ranged from 72.9 to 85.8% …

The Nuts & Bolts For School Administrators: Legislation, Guidance & Best Practices, Kevin Lorson, Ryan Eldridge

School of Health and Exercise Sciences Faculty Publications

No abstract provided.

Sports Broadcasting News Analysis [Career Paper], Jefferson Sanders

Undergraduate Research Award

No abstract provided.

How To Start A Movement: Ted Talk Annotated Resource List, Daulton Cowan

Undergraduate Research Award

No abstract provided.

Cretonthophilus Tuberculatus , A Remarkable New Genus And Species Of Hister Beetle (Coleoptera: Histeridae) From Cretaceous Burmese Amber, Michael S. Caterino, Karin Wolf-Schwenninger, Gunter Bechly

Publications

The early history of the beetle family Histeridae is still very obscure. In part this results from difficulty resolving phylogenetic relationships at deeper levels (Caterino & Vogler, 2002; McKenna et al., 2015a). But it is also partly a result of a sparse and poorly documented fossil record (Chatzimanolis et al., 2006). Here we describe a new genus and species of fossil histerid from Burmese amber (~99 mya), which helps to address both of these problems. Although histerid fossils have been reported from a variety of fossil localities and strata, relatively few have been adequately described. Until recently, the earliest described …

Declining Incidence Of Stroke And Dementia: Coincidence Or Prevention Opportunity?, Luciano A. Sposato, Moira K. Kapral, Jiming Fang, Sudeep S. Gill, Daniel G. Hackam, Lauren E. Cipriano, Vladimir Hachinski

Anatomy and Cell Biology Publications

No abstract provided.

Linking Energetics And Overwintering In Temperate Insects., Brent J Sinclair

Biology Publications

Overwintering insects cannot feed, and energy they take into winter must therefore fuel energy demands during autumn, overwintering, warm periods prior to resumption of development in spring, and subsequent activity. Insects primarily consume lipids during winter, but may also use carbohydrate and proteins as fuel. Because they are ectotherms, the metabolic rate of insects is temperature-dependent, and the curvilinear nature of the metabolic rate-temperature relationship means that warm temperatures are disproportionately important to overwinter energy use. This energy use may be reduced physiologically, by reducing the slope or elevation of the metabolic rate-temperature relationship, or because of threshold changes, such …

Methods And Considerations For The Analysis And Standardization Of Assessing Muscle Sympathetic Nerve Activity In Humans., Daniel W White, J Kevin Shoemaker, Peter B Raven

Kinesiology Publications

The technique of microneurography and the assessment of muscle sympathetic nerve activity (MSNA) are used in laboratories throughout the world. The variables used to describe MSNA, and the criteria by which these variables are quantified from the integrated neurogram, vary among studies and laboratories and, therefore, can become confusing to those starting to learn the technique. Therefore, the purpose of this educational review is to discuss guidelines and standards for the assessment of sympathetic nervous activity through the collection and analysis of MSNA. This review will reiterate common practices in the collection of MSNA, but will also introduce considerations for …

Research Notes Lower Prairie Creek Project, Susie Van Kirk

Susie Van Kirk Papers

No abstract provided.

Sagestep News, Winter 2015, No. 27, Sagestep

Newsletters

Seasonal newsletter of SageSTEP.

The Receptor For Activated C Kinase In Plant Signaling: Tale Of A Promiscuous Little Molecule, Tania Islas-Flores, Ahasanur Rahman, Hemayet Ullah, Marco Villanueva

Department of Biology Faculty Publications

Two decades after the first report of the plant homolog of the Receptor for Activated C Kinase 1 (RACK1) in cultured tobacco BY2 cells, a significant advancement has been made in the elucidation of its cellular and molecular role. The protein is now implicated in many biological functions including protein translation, multiple hormonal responses, developmental processes, pathogen infection resistance, environmental stress responses, and miRNA production. Such multiple functional roles are consistent with the scaffolding nature of the plant RACK1 protein. A significant advance was achieved when the β-propeller structure of the Arabidopsis RACK1A isoform was elucidated, thus revealing that its …

A Comparative Study Of Medicago Truncatula Transcriptomes As They Relate To Saponin Defenses Against Insect Pests, Audra Mae Rogers

Graduate Theses and Dissertations

Triterpene saponins are a class of defensive plant-derived compounds, which have a

variety of functions including antimicrobial, insecticidal, and nematicidal activities. This

research assessed the performance of the beet armyworm, Spodoptera exigua, following ad

libero feeding on Medicago truncatula accessions differing in specialized metabolite and

saponin profiles. Insect performance did not directly relate to the foliar saponin levels in the

accessions, which was measured using HPLC mass spectrometry. Accession ESP105 had the lowest foliar saponins overall, yet had similar levels of soyasaponins compared to the other accessions. Conversely, accessions A17, PRT178, and GRC43 had high foliar saponins with particularly high …

The Effects Of Meloidogyne Incognita And Heterodera Glycines On The Yield And Quality Of Edamame In Arkansas, Juliet Fultz

Graduate Theses and Dissertations

Edamame (Glycine max), also known as vegetable soybean, was introduced to the United States from Japan in 1890 and has been growing in popularity as a nutrient-rich, low-sugar snack in recent years. In 2012, the American Vegetable Soybean and Edamame, Inc. established the first domestic commercial processing plant in Mulberry, Arkansas and contracted local growers for production. Since the crop is harvested when seed are immature, management practices are different from those for traditional soybean. Plant-parasitic nematodes, particularly Meloidogyne incognita (southern root-knot) and Heterodera glycines (soybean cyst), are common in Arkansas and are pests of concern for edamame growers. Edamame …

Rice Blast Disease In The U.S. And Africa: Determination Of Pathogen Diversity And The Identification Of Resistance Genes For Disease Management, Felix Rotich

Graduate Theses and Dissertations

Rice blast caused by Magnaporthe oryzae (= Pyricularia oryzae) B. Couch, is a leading disease of rice. Magnaporthe oryzae exhibits a high degree of diversity. The diversity of isolates of M. oryzae from Africa and the U.S. were examined using vegetative compatibility and virulence phenotyping as well as determination of variation in the avirulence gene AVRPiz-t in isolates from Africa. Also, evaluation of blast resistance genes in the interspecific rice germplasm “New Rice for Africa” NERICA was done using F2 progeny of the cross of U.S. susceptible cultivar M204 and NERICA 12. The U.S. isolates were in three vegetative compatibility …

Investigation Of The Inherent Chemical, Structural, And Mechanical Attributes Of Bio-Engineered Composites Found In Nature: Alligator Gar’S Exoskeleton Fish Scales, Wayne Derald Hodo

Graduate Theses and Dissertations

The U.S. Army has determined a huge cost savings of up to 51% can be accomplished by reducing the gross vehicle weight, for their personnel carrier, by 33%. To cut cost, composite materials are needed. Man-made composites can have superior material properties (high-strength, high-fracture toughness, and lightweight), but they are prone to delamination at the glued-layered interface. In contrast, fish scale is a natural composite that has the same material properties and, additionally, tend not to delaminate.

The focus of this study was to learn how nature integrates hard and soft materials at each length scale to form a layered …

The Role Of G-Protein Signaling In Pathogenesis In Cercospora Zeae-Maydis, Brant Smith

Graduate Theses and Dissertations

Gray leaf spot, caused by Cercospora zeae-maydis, is one of the most destructive foliar diseases of maize worldwide. C. zeae-maydis orients hyphal growth towards stomata (stomatal tropism) and forms infectious structures (appressoria) that are necessary for successful infection. Although some genes involved in pathogenesis in C. zeae-maydis have been identified, the molecular mechanisms are not well understood. In fungi, heterotrimeric G-proteins consist of three subunits (α, β, and γ) and mediate responses to environmental stimuli. They regulate diverse functions, including nutrient detection, virulence, fungal development, conidiation, secondary metabolism, and pathogenesis in many plant pathogenic fungi. This research explored the role …

Field Abundance And Performance Of Hoverflies (Diptera: Syrphidae) On Soybean Aphid, James O. Eckberg, Julie A. Peterson, Colin P. Borsh, Joe M. Kaser, Gregg A. Johnson, John C. Luhman, Donald L. Wyse, George E. Heimpel

West Central Research and Extension Center, North Platte

The management of the soybean aphid Aphis glycines Matsumara is a major challenge to soybean production in the north-central United States. The identification and characterization of the insect predator community has informed integrated pest management strategies by providing insight on predators that can suppress soybean aphid populations. Hoverflies (Diptera: Syrphidae) are known predators of A. glycines, but more information is needed on their diversity, abundance, and performance to evaluate their importance as biological control agents of A. glycines. In this study, syrphid abundance was evaluated across two growing seasons in four soybean fields in east-central Minnesota. Six methods …

Glucose-Fructose Likely Improves Gastrointestinal Comfort And Endurance Running Performance Relative To Glucose-Only, P. B. Wilson, S. J, Ingraham

Athletic Performance Research

This study aimed to determine whether glucose-fructose (GF) ingestion, relative to glucose-only, would alter performance, metabolism, gastrointestinal (GI) symptoms, and psychological affect during prolonged running. On two occasions, 20 runners (14 men) completed a 120-min submaximal run followed by a 4-mile time trial (TT). Participants consumed glucose-only (G) or GF (1.2:1 ratio) beverages, which supplied ~1.3 g/min of carbohydrate. Substrate use, blood lactate, psychological affect [Feeling Scale (FS)], and GI distress were measured. Differences between conditions were assessed using magnitude-based inferential statistics. Participants completed the TT 1.9% (−1.9; −4.2, 0.4) faster with GF, representing a likely benefit. FS ratings were …

Progesterone And Prostaglandin F2Α Induce Species-Typical Female Preferences For Male Sexual Displays In Cope's Gray Treefrog (Hyla Chrysoscelis), J. L. Ward, E. K. Love, Alexander T. Baugh, N. M. Gordon, J. C. Tanner, M. A. Bee

Biology Faculty Works

Endocrine systems play critical roles in facilitating sexual behavior in seasonally breeding vertebrates. Much of the research exploring this topic has focused on the endocrine correlates of signaling behavior in males and sexual proceptivity in females. What is less understood is how hormones promote the expression of the often complex and highly selective set of stimulus–response behaviors that are observed in naturally breeding animals. In female frogs, phonotaxis is a robust and sensitive bioassay of mate choice and is exhibited by gravid females during the breeding season. In stark contrast, females exhibit low phonotactic responsiveness outside the breeding season, but …

Viticulture Performance And Cold Hardiness Attributes Of Select Winegrape Cultivars In The Western Snake River Plain Of Idaho, Jacob Joseph Cragin

Boise State University Theses and Dissertations

This two part study was carried out in the Snake River Valley American viticulture area (SRV AVA) in Idaho. This area is a northern latitude, high elevation plateau where growing season is delimited by cold temperature. For the first part of the study, the performance of red and white-skinned winegrape cultivars (Vitis vinifera, L.) were compared to that of the widely grown cultivars Merlot and Cabernet Sauvignon. Phenology, juice composition, yield, cold injury, and cold hardiness were observed during the 2011 and 2012 growing seasons. Phenological events occurred later in the cooler 2011 season than the warmer 2012 …

Plant Toxins Influence Diet Selection And Intestinal Parasites In A Specialist Herbivore, Marcella Rene Fremgen

Boise State University Theses and Dissertations

Herbivores select plants and patches that generally maximize nutrient intake and minimize intake of plant secondary metabolites (PSMs). Protein is important for growth, reproduction and maintenance, but maximizing intake of protein is often limited by concentrations of PSMs that are potentially toxic to herbivores and energetically expensive to process. However, the consequences of ingesting PSM are often dose-dependent. At high doses, PSMs generally have negative physiological effects and are avoided, but some PSMs can be therapeutic against parasites at low doses and could therefore be selected. We used Greater Sage-grouse (Centrocercus urophasianus, hereafter, sage-grouse) to test how PSMs influence …

Effects Of Bone Morphogenetic Protein-2 And Parathyroid Hormone-Related Peptide On Collagen Xi During Skeletal Development, Neda Shefa

Boise State University Theses and Dissertations

Long bones develop via endochondral ossification, a process in which cartilage precedes bone. During endochondral ossification prechondrogenic cells undergo proliferation and apoptose as cells of the periosteum differentiate into bone. The process of endochondral ossification is regulated by a group of endocrine as well as paracrine molecules that includes bone morphogenetic protein-2 (BMP-2) and parathyroid hormone-related peptide (PTHrP). Collagens are extracellular matrix molecules that are present in a spatiotemporal manner during endochondral ossification. Collagen XI alpha 1 (Col11a1) is a minor fibrillar collagen that is alternatively spliced during development and can result in up to eight different spliceforms. During endochondral …

Mycorrhizal Roots In A Temperate Forest Take Up Organic Nitrogen From 13c- And 15n-Labeled Organic Matter, Matthew A. Vadeboncoeur, Andrew P. Ouimette, Erik A. Hobbie

All Materials

Background and Aims

The importance of the uptake of nitrogen in organic form by plants and mycorrhizal fungi has been demonstrated in various ecosystems including temperate forests. However, in previous experiments, isotopically labeled amino acids were often added to soils in concentrations that may be higher than those normally available to roots and mycorrhizal hyphae in situ, and these high concentrations could contribute to exaggerated uptake.

Methods

We used an experimental approach in which we added ¹³C-labeled and ¹⁵N-labeled whole cells to root-ingrowth cores, allowing proteolytic enzymes to release labeled organic nitrogen at a natural rate, as …

Semi-Automated Object-Based Classification Of Coral Reef Habitat Using Discrete Choice Models, Steven Saul, Samuel J. Purkis

Marine & Environmental Sciences Faculty Articles

As for terrestrial remote sensing, pixel-based classifiers have traditionally been used to map coral reef habitats. For pixel-based classifiers, habitat assignment is based on the spectral or textural properties of each individual pixel in the scene. More recently, however, object-based classifications, those based on information from a set of contiguous pixels with similar properties, have found favor with the reef mapping community and are starting to be extensively deployed. Object-based classifiers have an advantage over pixel-based in that they are less compromised by the inevitable inhomogeneity in per-pixel spectral response caused, primarily, by variations in water depth. One aspect of …

Describing The Prevalence And Awareness Of Sport-Related Concussion In University Intramural And Club Sport Participants, Makenzie L. Brown

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Concussion injuries are growing in number among athletes across the nation. The majority of concussion research to date focuses on collegiate and high school athletes. University athletes make up a small percentage of the student body population compared to the large number of students that participate in club and intramural sports. These students participate in the same sports, assume the same risks, and may experience the same adverse effects of concussion, often without appropriate medical oversight.

Purpose: The purpose of this study was to determine if concussion is a problem among intramural and club sport participants, if these participants …