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Articles 301 - 330 of 3598
Full-Text Articles in Life Sciences
The Trade-Off Between Tooth Strength And Tooth Penetration: Predicting Optimal Shape Of Canine Teeth, Patricia W. Freeman, Cliff A. Lemen
The Trade-Off Between Tooth Strength And Tooth Penetration: Predicting Optimal Shape Of Canine Teeth, Patricia W. Freeman, Cliff A. Lemen
University of Nebraska State Museum: Mammalogy Papers
We investigate the shape of canine teeth under the assumption that the tooth’s morphology is optimized by the evolutionary trade-off to minimize breakage and maximize ease of the penetration of prey. A series of experiments using artificial teeth to puncture the hides of a deer Odocoileus virginianus and pig Sus scrofa domesticus were conducted to establish the relationships between the tooth shape and the force needed to puncture the hide. The shapes of these teeth were also used in a beam theory analysis to calculate the strength of the teeth. Because the relative costs of puncturing and breakage were not …
Assessing Population Level Genetic Instability Via Moving Average, Samuel Mcdaniel, Rebecca Betensky, Tianxi Cai
Assessing Population Level Genetic Instability Via Moving Average, Samuel Mcdaniel, Rebecca Betensky, Tianxi Cai
Harvard University Biostatistics Working Paper Series
No abstract provided.
A Conserved Cam- And Radial Spoke–Associated Complex Mediates Regulation Of Flagellar Dynein Activity, Erin E. Dymek, Elizabeth F. Smith
A Conserved Cam- And Radial Spoke–Associated Complex Mediates Regulation Of Flagellar Dynein Activity, Erin E. Dymek, Elizabeth F. Smith
Dartmouth Scholarship
For virtually all cilia and eukaryotic flagella, the second messengers calcium and cyclic adenosine monophosphate are implicated in modulating dynein- driven microtubule sliding to regulate beating. Calmodulin (CaM) localizes to the axoneme and is a key calcium sensor involved in regulating motility. Using immunoprecipitation and mass spectrometry, we identify members of a CaM-containing complex that are involved in regulating dynein activity. This complex includes flagellar-associated protein 91 (FAP91), which shares considerable sequence similarity to AAT-1, a protein originally identified in testis as an A-kinase anchor protein (AKAP)- binding protein. FAP91 directly interacts with radial spoke protein 3 (an AKAP), which …
Source Tracking Of Microbial Intrusion In Water Systems Using Artificial Neural Networks, Minyoung Kim, Christopher Y. Choi, Charles P. Garba
Source Tracking Of Microbial Intrusion In Water Systems Using Artificial Neural Networks, Minyoung Kim, Christopher Y. Choi, Charles P. Garba
United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
A ‘‘what-if’’ scenario where biological agents are accidentally or deliberately introduced into a water system was generated, and artificial neural network (ANN) models were applied to identify the pathogenic release location to isolate the contaminated area and minimize its hazards. The spatiotemporal distribution of Escherichia coli 15597 along the water system was employed to locate pollutants by inversely interpreting transport patterns of Escherichia coli using ANNs. Results showed that dispersion patterns of Escherichia coli were positively correlated to pH, turbidity, and conductivity (R2 = 0.90–0.96), and the ANN models successfully identified the source location of Escherichia coli introduced into …
Habronyx Foerster (Hymenoptera: Ichneumonidae: Anomaloninae) In Andean And Neantarctic South America With Description Of New Species From Bolivia And Chile, Charles C. Porter
Habronyx Foerster (Hymenoptera: Ichneumonidae: Anomaloninae) In Andean And Neantarctic South America With Description Of New Species From Bolivia And Chile, Charles C. Porter
Insecta Mundi
Abstract:
Habronyx Foerster occurs in all regions except the Afrotropical and parasitizes lepidopterous larvae (Geometridae, Noctuidae, Saturniidae, Sphingidae, Psychidae). Habronyx albifrons (Spinola) inhabits neantartic Chile and southern Argentina. It is black with a white flagellar annulus and with a strong prepectal carina on the lower half of the mesopleuron. Habronyx albifrons is redescribed and descriptions are given of two new species which belong to a group of their own: Habronyx citrinus Porter, n. sp., from central Chile; and Habronyx punensis Porter, n. sp., from the high Andean steppe of Bolivia, where it attacks noctuid larvae on Chenopodium quinoa Willd. These …
Nomenclatural Changes In The Nearctic Ochodaeinae And Description Of Two New Genera (Coleoptera: Scarabaeoidea: Ochodaeidae), M J. Paulsen
Nomenclatural Changes In The Nearctic Ochodaeinae And Description Of Two New Genera (Coleoptera: Scarabaeoidea: Ochodaeidae), M J. Paulsen
University of Nebraska State Museum: Entomology Papers
Generic placement of Nearctic species of Ochodaeinae has lagged behind changes in generic concepts in the group. In order to place Nearctic species into the appropriate genus-level taxa, several nomenclatural changes are made. The new generic name Xenochodaeus is proposed for species with an elongate, subparallel sulcus on the propygidium and a longitudinally impressed mentum. The genus contains 6 species. Xenochodaeus americanus (Westwood), new combination, is valid and is removed from synonymy with X. musculus (Say), new combination. A neotype is designated for Odontaeus musculus. Ochodaeus opacus LeConte is synonymized under X. americanus. Other new combinations include Xenochodaeus …
Ozodius, N. Gen., For The Australian Members Of The Genus Drepanocanthoides Schmidt (Coleoptera: Scarabaeidae: Aphodiinae), Paul E. Skelley
Ozodius, N. Gen., For The Australian Members Of The Genus Drepanocanthoides Schmidt (Coleoptera: Scarabaeidae: Aphodiinae), Paul E. Skelley
University of Nebraska State Museum: Entomology Papers
The genus name Drepanocanthoides Schmidt has recently been applied to Australian and North American taxa, based on generic concepts following separate designations of different type species. Drepanocanthoides, type species Aphodius walshii Horn, is a Nearctic genus that is not congeneric with the Australian members. The new name Ozodius, n. gen., is here proposed for the Australian taxa, with Aphodius neglectus Schmidt designated as the type species. All Australian members of Drepanocanthoides are transferred to Ozodius.
New South American Taxa Of Odontolochini Stebnicka And Howden (Coleoptera: Scarabaeidae: Aphodiinae), Paul E. Skelley
New South American Taxa Of Odontolochini Stebnicka And Howden (Coleoptera: Scarabaeidae: Aphodiinae), Paul E. Skelley
University of Nebraska State Museum: Entomology Papers
Recently discovered Neotropical taxa belonging in the tribe Odontolochini Stebnicka and Howden (Coleoptera: Scarabaeidae: Aphodiinae) are described. New genera are: Amerilochus, type species Amerilochus cinereus, new species; and Stebnickiella, type species Stebnickiella zosterixys, new species. Three additional new species are: Saprolochus lobatus, Saprolochus tridentatus, and Saprositellus kenodontus. Updated keys are presented to the New World genera of Odontolochini as well as keys to species in the genera Saprolochus Stebnicka and Galante and Saprositellus Balthasar. New country records are presented for Saprositellus ariquemes Stebnicka.
A New Species Of Dialeurodes Cockerell (Hemiptera: Aleyrodidae) On Schefflera Forst And Forst In Florida, G. S. Hodges, J. W. Dooley
A New Species Of Dialeurodes Cockerell (Hemiptera: Aleyrodidae) On Schefflera Forst And Forst In Florida, G. S. Hodges, J. W. Dooley
Insecta Mundi
Descriptions of pupal cases of Dialeurodes schefflerae, new species, as well as distribution records are presented. This species is known to occur in Florida, Hawaii and Puerto Rico appearing to feed only on species of Schefflera Forst and Forst. This restriction to plant hosts in the Asian genus Schefflera, along with its affinities with Dialeurodes agalmae Takahashi, Dialeurodes citri (Ashmead) and Dialeurodes kirkaldyi (Kotinsky), suggests it is an invasive species, probably endemic to the Asian region.
Holotype Of Agathymus Escalantei Stallings, Turner, And Stallings, 1966 (Lepidoptera: Hesperiidae: Megathyminae), Bret M. Boyd
Holotype Of Agathymus Escalantei Stallings, Turner, And Stallings, 1966 (Lepidoptera: Hesperiidae: Megathyminae), Bret M. Boyd
Insecta Mundi
Agathymus escalantei Stallings, Turner, and Stallings, 1966 (Lepidoptera: Hesperiidae) is the only described species of Megathyminae known from a single collected individual. To date, the only images of this specimen are poor black and white illustrations published in the original description. This note presents the first color photographs of the holotype.
Nomenclatural Faux Pas For Speyeria Atlantis Greyi Moeck, 1950 (Lepidoptera: Nymphalidae), James C. Dunford, George T. Austin
Nomenclatural Faux Pas For Speyeria Atlantis Greyi Moeck, 1950 (Lepidoptera: Nymphalidae), James C. Dunford, George T. Austin
Insecta Mundi
Nomenclatural errors associated with the nymphalid butterfly, Speyeria atlantis greyi Moeck, have persisted in the literature and electronic databases. We present here a synonymy of the various combinations and misspellings associated with it and clearly indicate the correct name and spelling based on Moeck’s (1950) original description. Additionally, color images of the holotype and allotype specimens are published herein for the first time.
The Type Of Copaeodes Chromis Skinner, 1919 (Lepidoptera: Hesperiidae: Hesperiinae), George T. Austin, Andrew D. Warren
The Type Of Copaeodes Chromis Skinner, 1919 (Lepidoptera: Hesperiidae: Hesperiinae), George T. Austin, Andrew D. Warren
Insecta Mundi
The holotype of Copaeodes chromis Skinner, 1919 (Lepidoptera: Hesperiidae), housed at the Carnegie Museum of Natural History, is a typical specimen of Zariaspes mythecus Godman, 1900.
Genomic Resources For Myzus Persicae: Est Sequencing, Snp Identification, And Microarray Design, John S. Ramsey, Alex C. C. Wilson, Marin De Vos, Qi Sun, Cecilia Tamborindeguy, Agnese Winfield, Gaynor Malloch, Dawn M. Smith, Brian Fenton, Stewart M. Gray, Georg Jander
Genomic Resources For Myzus Persicae: Est Sequencing, Snp Identification, And Microarray Design, John S. Ramsey, Alex C. C. Wilson, Marin De Vos, Qi Sun, Cecilia Tamborindeguy, Agnese Winfield, Gaynor Malloch, Dawn M. Smith, Brian Fenton, Stewart M. Gray, Georg Jander
Biology Articles and Papers
Backgorund
The green peach aphid, Myzus persicae (Sulzer), is a world-wide insect pest capable of infesting more than 40 plant families, including many crop species. However, despite the significant damage inflicted by M. persicae in agricultural systems through direct feeding damage and by its ability to transmit plant viruses, limited genomic information is available for this species.
Results
Sequencing of 16 M. persicae cDNA libraries generated 26,669 expressed sequence tags (ESTs). Aphids for library construction were raised on Arabidopsis thaliana, Nicotiana benthamiana, Brassica oleracea, B. napus, and Physalis floridana (with and without Potato leafroll virus infection). The …
National Beef Tenderness Survey- 2006: Assessment Of Warner-Bratzler Shear And Sensory Panel Ratings For Beef From Us Retail And Foodservice Establishments, K. L. Voges, C. L. Mason, J. C. Brooks, R. J. Delmore, D. B. Griffin, D. S. Hale, W. R. Henning, D. D. Johnson, C. L. Lorenzen, R. J. Maddock, R. K. Miller, J. B. Morgan, B. E. Baird, B. L. Gwartney, J. W. Savell
National Beef Tenderness Survey- 2006: Assessment Of Warner-Bratzler Shear And Sensory Panel Ratings For Beef From Us Retail And Foodservice Establishments, K. L. Voges, C. L. Mason, J. C. Brooks, R. J. Delmore, D. B. Griffin, D. S. Hale, W. R. Henning, D. D. Johnson, C. L. Lorenzen, R. J. Maddock, R. K. Miller, J. B. Morgan, B. E. Baird, B. L. Gwartney, J. W. Savell
Animal Science
Beef from retail and foodservice establishments in 11 US cities was evaluated using Warner–Bratzler shear (WBS) and consumer evaluation panels. Postmortem aging times ranged from3 to83d for retail and7 to 136d for foodservice with mean aging times of 22.6d and 30.1 d, respectively. For retail, the three cuts from the round – top round, bottom round, and eye of round – had the highest (P < 0.05) WBS values compared to cuts from the chuck, rib, and loin. Top loin steaks had the lowest(P < 0.05) WBS value compared to ribeye and top sirloin foodservice steaks. Retail bone-in top loin, top loin, ribeye, T-bone, and porterhouse received the highest (P < 0.05) ratings by consumers for overall like and like tenderness. Quality grade had little or no effect on foodservice sensory evaluations. Improvements in round tenderness are needed to increase consumer acceptability.
Xml Encoding Of Features Describing Rule-Based Modeling Of Reaction Networks With Multi-Component Molecular Complexes, Michael L. Blinov, Ion I. Moraru
Xml Encoding Of Features Describing Rule-Based Modeling Of Reaction Networks With Multi-Component Molecular Complexes, Michael L. Blinov, Ion I. Moraru
UCHC Articles - Research
Multi-state molecules and multi-component complexes are commonly involved in cellular signaling. Accounting for molecules that have multiple potential states, such as a protein that may be phosphorylated on multiple residues, and molecules that combine to form heterogeneous complexes located among multiple compartments, generates an effect of combinatorial complexity. Models involving relatively few signaling molecules can include thousands of distinct chemical species. Several software tools (StochSim, BioNetGen) are already available to deal with combinatorial complexity. Such tools need information standards if models are to be shared, jointly evaluated and developed. Here we discuss XML conventions that can be adopted for modeling …
Conjunctive Queries For A Tractable Fragment Of Owl 1.1, Markus Krotzsch, Sebastian Rudolph, Pascal Hitzler
Conjunctive Queries For A Tractable Fragment Of Owl 1.1, Markus Krotzsch, Sebastian Rudolph, Pascal Hitzler
Computer Science and Engineering Faculty Publications
Despite the success of the Web Ontology Language OWL, the development of expressive means for querying OWL knowledge bases is still an open issue. In this paper, we investigate how a very natural and desirable form of queries-namely conjunctive ones-can be used in conjunction with OWL such that one of the major design criteria of the latter-namely decidability-can be retained. More precisely, we show that querying the tractable fragment EL++ of OWL 1.1 is decidable. We also provide a complexity analysis and show that querying unrestricted EL++ is undecidable.
Fisheries Research Report No. 168 - Sustainable Development Of Barramundi Cage Aquaculture At Lake Argyle., Brett Glencross, S. Percival, B. Jones, J Hughes
Fisheries Research Report No. 168 - Sustainable Development Of Barramundi Cage Aquaculture At Lake Argyle., Brett Glencross, S. Percival, B. Jones, J Hughes
Fisheries Research Reports
Final FRDC report and KSRP report - Project 2003/026
A preliminary sensory evaluation study was conducted to confirm the presence of a taint issue. Prior to this the issue was reliant on purchaser feedback and was not verified independently. To examine the issue of flavour taint a series of barramundi samples were collected from Lake Argyle (purged and unpurged), wild (estuarine) and marine farmed barramundi were assessed. No significant differences in flavour attributes and/or acceptability attributes were detected between the wild and farmed barramundi, provided the barramundi was either marine-farmed or purged. However, it was determined that a clear “muddy” …
Kentucky Warbler (Vol. 83, No. 4), Kentucky Library Research Collections
Kentucky Warbler (Vol. 83, No. 4), Kentucky Library Research Collections
The Kentucky Warbler
No abstract provided.
Can Semantic Web Techniques Empower Comprehension And Projection In Cyber Situational Awareness?, Amit P. Sheth
Can Semantic Web Techniques Empower Comprehension And Projection In Cyber Situational Awareness?, Amit P. Sheth
Kno.e.sis Publications
No abstract provided.
Semantic Convergence Of Wikipedia Articles, Christopher J. Thomas, Amit P. Sheth
Semantic Convergence Of Wikipedia Articles, Christopher J. Thomas, Amit P. Sheth
Kno.e.sis Publications
Social networking, distributed problem solving and human computation have gained high visibility. Wikipedia is a well established service that incorporates aspects of these three fields of research. For this reason it is a good object of study for determining quality of solutions in a social setting that is open, completely distributed, bottom up and not peer reviewed by certified experts. In particular, this paper aims at identifying semantic convergence of Wikipedia articles; the notion that the content of an article stays stable regardless of continuing edits. This could lead to an automatic recommendation of good article tags but also add …
Distribution And Habitats Of Mosquito Larvae In The Kingdom Of Tonga, Jon S. Harding, Culum Brown, Felicity Jones, Russell Taylor
Distribution And Habitats Of Mosquito Larvae In The Kingdom Of Tonga, Jon S. Harding, Culum Brown, Felicity Jones, Russell Taylor
Ecology Collection
Mosquitoes are a significant pest and human health issue in the Kingdom of Tonga. The occurrence of species and habitats used by mosquito larvae were investigated to determine the potential for control through larval habitat management. Forty-two sites, including 22 villages and 20 farm plantations on the six islands of Tongatapu, Pangaimotu, Vava’u, Pangaimotu (Vava’u group), ‘Utungake and Nuku, were surveyed in April 2006. A total of eight mosquito species were collected: Aedes aegypti (Linnaeus), Ae. horrescens (Edwards), Ae. nocturnus (Theobold), Ae. tongae (Edwards), Culex albinervis (Edwards), Cx. annulirostris (Skuse), Cx. quinquefasciatus (Say) and Cx. sitiens (Wiedemann). Several species were …
Considerations For Determining Optimal Mouse Caging Density, Charmaine Foltz, Larry Carbone, David Delong, Bernard E. Rollin, Pascalle Van Loo, Julia Whitaker, Axel Wolff
Considerations For Determining Optimal Mouse Caging Density, Charmaine Foltz, Larry Carbone, David Delong, Bernard E. Rollin, Pascalle Van Loo, Julia Whitaker, Axel Wolff
Laboratory Research and Animal Welfare Collection
At the 2006 National Meeting of the American Association of Laboratory Animal Science, a panel discussed the question of what constitutes optimal or acceptable housing density for mice. Though there is a consensus that present guidelines are somewhat arbitrarily defined, scientific research has not yet been able to provide clear recommendations for amending them. Speakers explored the many factors that influence decisions on mouse housing, including regulatory requirements, scientific data and their interpretation, financial considerations and ethical concerns. The panel largely agreed that animal well-being should be the measure of interest in evaluating housing density and that well-being includes not …
Spatial Distributions Of Heating, Cooling, And Industrial Degree-Days In Turkey, Ilhami Yildiz, B. Sosaoglu
Spatial Distributions Of Heating, Cooling, And Industrial Degree-Days In Turkey, Ilhami Yildiz, B. Sosaoglu
BioResource and Agricultural Engineering
The degree-day method is commonly used to estimate energy consumption for heating and cooling in residential, commercial and industrial buildings, as well as in greenhouses, livestock facilities, storage facilities and warehouses. This article presents monthly and yearly averages and spatial distributions of heating, cooling, and industrial degree-days at the base temperatures of 18 °C and 20 °C, 18 °C and 24 °C, and 7 °C and 13 °C, respectively; as well as the corresponding number of days in Turkey. The findings presented here will facilitate the estimation of heating and cooling energy consumption for any residential, commercial and industrial buildings …
Biofuel Feedstocks: The Risk Of Future Invasions, Joseph M. Ditomaso, Jacob N. Barney, Allison M. Fox
Biofuel Feedstocks: The Risk Of Future Invasions, Joseph M. Ditomaso, Jacob N. Barney, Allison M. Fox
All U.S. Government Documents (Utah Regional Depository)
In an effort to decrease greenhouse gas emissions, expand domestic energy production, and maintain economic growth, public and private investments are being used to pursue dedicated feedstock crops for biofuel production. Unlike food crops grown for grain-based ethanol (e.g., corn), which require high inputs of fertilizers and pesticides and typically are grown on prime agricultural land, proposed lignocellulose-based energy crops (e.g., switchgrass) typically have a neutral or negative carbon budget, require relatively few economic or environmental inputs, and can be cultivated on marginal, lower-productivity land. Thus, a rapidly growing industry related to crop selection, cultivar improvement, and conversion technilogies is …
Little Bluestem In The Landscape, Heidi Kratsch, Graham Hunter
Little Bluestem In The Landscape, Heidi Kratsch, Graham Hunter
Gardening
No abstract provided.
Aquaculture Of Coral, Live Rocks And Associated Products. Draft Final 'Policy' Paper., Department Of Fisheries Western Australia
Aquaculture Of Coral, Live Rocks And Associated Products. Draft Final 'Policy' Paper., Department Of Fisheries Western Australia
Fisheries Management Papers
Aquarium enthusiasts use corals, live rock and associated products (e.g. sand) to enhance the aesthetics or function of the marine aquaria they keep and enjoy. There is a large and growing market for these products.
The Department of Fisheries has prepared this draft ‘Final Policy Paper’ as the second phase in the development of a management framework for the aquaculture of coral and live rock. The document outlines the position and needs of the emerging industry and identifies the management arrangements and policies the Department of Fisheries is proposing to implement.
Fish And Coral Reef Communities Of The Parque Nacional Sistema Arrecifal Veracruzano (Veracruz Coral Reef System National Park) Veracruz, Mexico: Preliminary Results, Marcos Alberto Rangel Avalos, Lance K. B. Jordan, Brian K. Walker, David S. Gilliam, Elvira Carvajal Hinojosa, Richard E. Spieler
Fish And Coral Reef Communities Of The Parque Nacional Sistema Arrecifal Veracruzano (Veracruz Coral Reef System National Park) Veracruz, Mexico: Preliminary Results, Marcos Alberto Rangel Avalos, Lance K. B. Jordan, Brian K. Walker, David S. Gilliam, Elvira Carvajal Hinojosa, Richard E. Spieler
Marine & Environmental Sciences Faculty Proceedings, Presentations, Speeches, Lectures
Effective resource management requires robust baseline datasets and efficient monitoring programs to identify and quantify temporal change. The Parque Nacional Sistema Arrecifal Veracruzano (Veracruz Coral Reef System National Park) encompasses a total of 52000ha including 23 coral reefs in two island groups separated by the mouth of the Jamapa River; one near the port of Veracruz, Mexico and one approximately 20km south near Punta Antón Lizardo. Both groups receive substantial fisheries pressure and other anthropogenic impacts. Using non-destructive, visual methods we surveyed fish and benthic assemblages at 18 sites, which included 10 individual coral reefs within the Park. For fishes, …
Additive And Synergistic Bactericidal Activity Of Antibodies Directed Against Minor Outer Membrane Proteins Of Neisseria Meningitidis, Vincent E. Weynants, Christiane M. Feron, Karine K. Goraj, Martine P. Bos, Philippe A. Denoeal, Vincent G. Verlant, Jan Tommassen, Ian R. A. Peak, Ralph C. Judd, Michael P. Jennings, Jan T. Poolman
Additive And Synergistic Bactericidal Activity Of Antibodies Directed Against Minor Outer Membrane Proteins Of Neisseria Meningitidis, Vincent E. Weynants, Christiane M. Feron, Karine K. Goraj, Martine P. Bos, Philippe A. Denoeal, Vincent G. Verlant, Jan Tommassen, Ian R. A. Peak, Ralph C. Judd, Michael P. Jennings, Jan T. Poolman
Biological Sciences Faculty Publications
Neisseria meningitidis serogroup B is a major cause of bacterial meningitis in younger populations. The available vaccines are based on outer membrane vesicles obtained from wild-type strains. In children less than 2 years old they confer protection only against strains expressing homologous PorA, a major, variable outer membrane protein (OMP). We genetically modified a strain in order to eliminate PorA and to overproduce one or several minor and conserved OMPs. Using a mouse model mimicking children's PorA-specific bactericidal activity, it was demonstrated that overproduction of more than one minor OMP is required to elicit antibodies able to induce complement-mediated killing …
Fisheries Research Report 167 - Digital Video Techniques For Assessing Population Size Structure And Habitat Of Greenlip And Roe's Abalone., A.M. Hart, Frank Fabris
Fisheries Research Report 167 - Digital Video Techniques For Assessing Population Size Structure And Habitat Of Greenlip And Roe's Abalone., A.M. Hart, Frank Fabris
Fisheries Research Reports
Final FRDC report- Project 2002/079
A digital video image (DVI) stock monitoring programme was developed for the Haliotis laevigata and H. roei abalone fisheries in Western Australia. The program used industry divers to collect stock density and length-frequency data using digital video from 51 survey sites across the fishery, while image extraction, data processing and storage is carried out by research staff. Training videos, DVDs, and a comprehensive suite of experimental tests on both abalone species were utilised to achieve this outcome. Comparisons between DVI data collected by industry divers, and fishery independent survey (FIS) data showed mean legal sized …
Design, Synthesis, And Evaluation Of 10-N-Substituted Acridones As Novel Chemosensitizers In Plasmodium Falciparum, Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, Rolf Winter, Michael Riscoe
Design, Synthesis, And Evaluation Of 10-N-Substituted Acridones As Novel Chemosensitizers In Plasmodium Falciparum, Jane X. Kelly, Martin J. Smilkstein, Roland A. Cooper, Kristin D. Lane, Robert A. Johnson, Aaron Janowsky, Rozalia A. Dodean, Rolf Winter, Michael Riscoe
Collected Faculty Scholarship
A series of novel 10-N-substituted acridones, bearing alkyl side chains with tertiary amine groups at the terminal position, were designed, synthesized, and evaluated for the ability to enhance the potency of quinoline drugs against multidrug-resistant (MDR) Plasmodium falciparum malaria parasites. A number of acridone derivatives, with side chains bridged three or more carbon atoms apart between the ring nitrogen and terminal nitrogen, demonstrated chloroquine (CQ)-chemosensitizing activity against the MDR strain of P. falciparum (Dd2). Isobologram analysis revealed that selected candidates demonstrated significant synergy with CQ in the CQ-resistant (CQR) parasite Dd2 but only additive (or indifferent) interaction in the CQ-sensitive …