Life Sciences Commons^™

Oregon State Rank Assessment For Schweinitz's Cyperus (Cyperus Schweinitzii), Nora Dunkirk

Institute for Natural Resources Publications

Oregon state conservation status assessment for Schweinitz's cyperus (Cyperus schweinitzii) using NatureServe methodology, 2026.

Insights Into Longevity And Virus-Driven Adaptation From Myotis Bat Genomes, Juan M. Vazquez, M. Elise Lauterbur, Saba Mottaghinia, Léa Gaucherand, Sarah Maesen, Michael Singer, Sarah Villa, Melanie Bucci, Devaughn Fraser, Genavieve Gray-Sandoval, Zeinab R. Haidar, Melissa Han, William Kohler, Tanya Lama, Et Al

Biological Sciences: Faculty Publications

The genus Myotis is one of the largest clades of bats, and it exhibits some of the most extreme variation in lifespans among mammals, alongside unique adaptations to viral tolerance and immune defence^1–3. Here, to study the evolution of these phenotypes, we generated cell lines and near-complete genome assemblies for eight closely related Myotis species. Using genome-wide screens of positive selection, analyses of structural variation and functional experiments in primary cells, we identify patterns of adaptation contributing to longevity, cancer resistance and viral interactions. We demonstrate distinct modes of adaptation to DNA and RNA viruses compared with all …

Nasa’S Ecostress Satellite Reveals Widespread Midday Depression In Ecosystem Evapotranspiration, Jingyi Bu, Jingfeng Xiao, Joshua B. Fisher, Yiqi Luo

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Plants often exhibit a midday depression in water use (i.e., transpiration), reflecting a constraint on their ability to sustain maximum water transport, which may occur at the cost of reduced photosynthesis. Eddy covariance observations and geostationary satellites cannot quantify this widespread phenomenon globally while resolving fine-scale spatial variability. Using evapotranspiration measurements from the ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) and machine learning, we quantify the global distribution of midday depression in evapotranspiration. Midday depression primarily occurs during peak-growing seasons in temperate zones and dry periods in the tropics, with a morning shift of the peak evapotranspiration time …

Oregon State Rank Assessment For Koehler's Rockcress (Boechera Koehleri), Lindsey K. Wise, Gabriel Campbell

Institute for Natural Resources Publications

Oregon state conservation status assessment for Koehler's rockcress (Boechera koehleri) using NatureServe methodology, 2026.

The Role Of Seed Mix Characteristics And Soil Amendments During Post-Agricultural Prairie Restoration, Valerie N. Thurston, Michaela J. Woods, Madelaine Gregory, Mary C. Lloyd, Ryan W. Mcewan

Biology Faculty Publications

Introduction: Prairie restoration on degraded lands may be influenced by seed mix characteristics, including species richness and legume establishment. Soil amendments may facilitate restoration; however, the practical usefulness of techniques such as applications of whole soil and leaf mulch remains relatively unclear.

Objectives: We assessed whether increasing species richness and legume content in seed mixes enhances prairie restoration success and examined how soil amendments interact with seed mix composition to influence cover, species richness, diversity, and legume establishment.

Methods: We conducted a field experiment on a 12-ha post-agricultural site in Ohio, U.S.A. Twenty 50 × 50 m plots received one …

Hydrogels For Local Drug Delivery In Biofilm-Associated Periprosthetic Joint Infection: Current Progress And Future Directions, Karolina Kraus, Pawel Mikziński, Bindu Subhadra, Emil Paluch

Faculty Publications - Biological Sciences

Periprosthetic joint infection (PJI) remains one of the most serious complications of arthroplasty, largely due to the formation of microbial biofilms on implant surfaces. Biofilm-associated infections exhibit increased tolerance to antimicrobial therapy and host immune responses, making eradication difficult and often requiring repeated surgical interventions. Consequently, there is a growing need for effective local therapeutic strategies capable of delivering high concentrations of antimicrobial agents directly to the site of infection while minimizing systemic toxicity. Hydrogels have emerged as promising drug delivery platforms for the management of biofilm-associated PJI. Their biocompatibility, injectability, high water content, and tunable physicochemical properties enable controlled …

South Texas Is Home To High Diversity Of Cytochrome Oxidase I Haplotypes Compared To Other Invasive Populations Of Aedes Aegypti, Rachel C. Malampy, Mariana Aguilar, Erin L. Schuenzel, Christopher J. Vitek

School of Integrative Biological & Chemical Sciences Faculty Publications

Simple Summary: The mosquito Aedes aegypti is capable of spreading a wide range of diseases that adversely affect human health. As the mosquito populations expand to new locations and increase in population, the risk to human health increases. To understand how the mosquito is spreading and the genetic composition of the current mosquito population in South Texas, partial DNA sequencing of the cytochrome oxidase I gene was completed for over 100 individuals. The large number of individuals sampled from a small geographic area resulted in new, unique sequences. These new sequences indicate the potential for new responses to pesticides and …

Determining The Feasibility Of A Habituation Assessment In Managed Red Wolves, Emily C. Lynch, Joseph W. Hinton, Jennifer B. Nagashima, Curtis Malott, Natalie J. Johnson, Emily Haering, Robin Petersen, Allison Johnson, Julie K. Young

Wildland Resources Faculty Publications

For species extirpated from the wild, ex situ breeding programs are essential for providing the individuals necessary for re-establishing wild populations through reintroductions. However, repeated exposure to humans under managed care may reduce wariness and alter behavioral responses in ways that are maladaptive after release. Although some pre-release behaviors reflect natural responses essential for survival and reproduction, others may result from habituation to humans and increase the risk of conflict, recapture, or mortality following translocation. These risks underscore the need for behavioral assessments to help identify appropriate candidates for release. However, because the assessments themselves require some exposure to humans, …

The Posture Of Recovery; A Quantitative Analysis Of Post-Exercise Heart Rate Restorateion In College Athletes, Matthew Scott Ferriter

Doctoral Dissertations and Projects

Heart rate recovery (HRR) has been frequently used as a noninvasive indicator of autonomic reactivity following high-intensity exercise. However, limited research has explored the effects of post-exercise body posture (PEBP) on HRR following acute bouts of high-intensity exercise in collegiate athletes. The purpose of this quantitative repeated-measures experimental study was to investigate if recovery posture (supine [SUP]; tripod [TRI]; standing upright [SU]) affected HRR during the first five minutes following a standardized high-intensity interval training (HIIT) session. Thirty-seven collegiate athletes completed three total testing sessions. Participants completed all three recovery posture conditions in a randomized order. Heart rate (HR) was …

Cells And Networks In Flux: Rethinking Ontogenesis And Pathogenesis, Mark L. Tykocinski

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Organ and tissue functions emerge from the coordinated activity of cell networks. Therapeutics that act on pathogenic cell networks, modulating their cellular interplay, follow naturally. Over several decades, our laboratory has developed a series of approaches for rewiring cell networks, culminating in a class of cell surface-directed signal converter proteins (SCPs) that do so by modulating juxtacrine and autocrine signaling in and among their nodal cells. A first such SCP has now produced encouraging clinical data for cancer immunotherapy. Yet, these early network-directed fusion proteins rest on a deliberately simplified picture: discrete end-cell types plugged into graphically tractable networks. That …

Relationships Between Lower Body Anthropometrics And Vertical Force-Velocity Profiles In Collegiate American Football Players, Nicholus Adam Despot

Doctoral Dissertations and Projects

The study examined the relationships between lower-body anthropometric characteristics and vertical force-velocity profiles in collegiate American football players. Although the use of force-velocity profiling has increased significantly in recent years, there has been limited research on the association between structural features and key mechanical outputs. A sample of 16 NAIA football players was used to examine how skeletal breadths, girths, and derived ratios relate to key force-velocity metrics. Anthropometric variables were collected using ISAK standards, while force-velocity profiles were obtained through a series of loaded squat jumps on a force platform. Mean propulsive force, velocity and power were used to …

Complete Genome Sequence Of Strain Dk8, A Thermoacidophilic Archaeon From Lassen Volcanic National Park, Jonathan Abshier, Kenneth Stedman

Biology Faculty Publications and Presentations

Here, we report the genome sequence of strain DK8, a thermoacidophilic archaeal isolate from the Devil's Kitchen geothermal area of Lassen Volcanic National Park, California, USA. The genome is 2,783,064 bp, with a guanine-cytosine content of 35.02%. Strain DK8 is most closely related to L.S.2.15.

Technologies To Remoisturize Alfalfa In The Windrow For Baling, Earl Creech, Ryan Larsen, Matt Yost, Mark Nelson, Mckenna Barney

All Current Publications

Having the correct moisture at the time of baling is critical to maximizing economic return. In 2020 and 2021, researchers at Utah State University studied moisturization technologies to determine their impact on alfalfa yield, quality, and economic return. This fact sheet provides a research overview and study results on bale moisture and weight, yield, quality, and visual appearance. An economic analysis is also included.

Hemodynamic Characterization Of Cardiac Dysfunction After Traumatic Brain Injury Using A Controlled Cortical Impact Model In Male Rats, Preston So, Amit Iyengar, Noah Weingarten, Mrinal Patel, Jessica Dominic, Andrew Belec, Joyce Ho, Samuel Shin, Pavan Atluri

Division of Cardiology Faculty Papers

Traumatic brain injury (TBI) is associated with cardiovascular dysfunction that worsens clinical outcomes, yet the underlying mechanisms are poorly under stood. Clinical studies are limited by heterogeneity, highlighting the need for con trolled experimental models. Controlled cortical impact (CCI) provides precise control of injury severity, and invasive pressure- volume (PV) loop analysis allows detailed hemodynamic assessment. Adult male Wistar rats underwent sham op eration or mild or severe CCI- induced TBI. PV- loop assessment and transtho racic echocardiography were performed at 8 or 24 h after TBI or sham. Serum epinephrine (EPI) and norepinephrine (NE) were quantified by ELISA. At …

Integrative Rna-Seq Analysis Reveals Stress Type-Dependent Lncrna-Centered Co-Expression Networks Across Human Cellular Stress Contexts, Christina Anastasiadi, Aggeliki Kasapi, Ioannis Sentementes, Vasileios Gouzouasis, Margaritis Tsifintaris, Antonis Giannakakis

Computational Medicine Center Faculty Papers

Long non-coding RNAs (lncRNAs) are emerging as important regulators of cellular adaptation to environmental and molecular stress, but the extent to which their responses remain reproducible and stress-type-dependent across human stress conditions remains unclear. Here, we performed an integrative transcriptomic meta-analysis of human stress-response datasets from ASTRA and GEO, focusing on normal, non-cancerous, wild-type human cell lines exposed to oxidative stress (H2O2), hypoxia, heat stress, or UV-induced DNA damage. Gene Ontology (GO) enrichment analysis of differentially expressed (DE) protein-coding mRNAs confirmed that the resulting stress-stratified comparison captured biologically coherent transcriptional programmes to oxidative stress signaling, hypoxic and metabolic adaptation, heat-induced …

For Weight Loss: Why Do Glp-1 Agonists Work, And How Can We Make Them Work Better?, Charlise Giang, Jieyi Meng, Mahmoud Ali Mohammad, Zhenqi Liu, Xinle Wu, Yi Zhu

Children’s Nutrition Research Center Staff Publications

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have revolutionized the management of not only type 2 diabetes but also obesity. However, even with rapid therapeutic advances in GLP-1RAs, questions regarding the fundamental principles of GLP-1-mediated weight loss and the enhanced efficacy of next-generation therapies remain. In this comprehensive review article, we first examine the milestones of GLP-1, from its initial discovery and biological characterization to its successful translation into clinical therapy. Furthermore, this review highlights the latest clinical trial data, specifically HbA1c reduction, weight-loss efficacy, and safety profiles, while exploring current pipelines of major pharmaceutical companies. Additionally, we delineate the mechanistic …

Land-Use Transitions And Carbon Emissions Of Aquaculture Expansion In The Brazilian Amazon, Felipe S. Pacheco, Sebastian A. Heilpern, Rafael M. Almeida, Suresh A. Sethi, Marcela Miranda, Nicholas Ray, Laura Greenstreet, Joshua Fan, Brendan H. Rappazzo, Marcelo Gomes Da Silva

School of Earth, Environmental, & Marine Sciences Faculty Publications

Accounting for land-use change underlying food sector expansion is critical for conserving ecosystem integrity. This challenge is particularly acute in the Amazon, where the conversion of forests for food production is pronounced and has broad implications for global biodiversity and the cycling of water and carbon. Here, we analyze land-use transitions associated with aquaculture development in the Brazilian Amazon. We found that a 450-fold increase in aquaculture pond area from 1985 to 2022 occurred primarily on pasturelands (87%) but also included wetland conversion (4%) and deforestation (5%). Notably, continued growth can be sustained within already altered landscapes: In Rondônia, the …

Parental Thermal Environment Affects Offspring Resilience To Winter And Spring Weather Anomalies, Ruzhuo Chen, Mariel Dunn, Caroline A. Curtis, Mariana Abarca

Biological Sciences: Faculty Publications

Recent increases in the frequency and intensity of thermal anomalies can result in recurrent stressful weather events. Among annual insects, this phenomenon may expose parents and offspring to a succession of different weather anomalies (e.g. summer heatwaves and late spring frosts). Parental stress can alter offspring physiology and performance, potentially affecting their tolerance of environmental variation. We investigated the transgenerational effects of thermal anomalies on a univoltine wetland butterfly. We induced parental thermal stress by exposing pupae to a constant temperature, ranging from stressfully cold to stressfully hot (10 ◦C, 26 ◦C, 28 ◦C, 32 ◦C), for three days. Offspring …

Instruction Guide, Mark C. Hall

Analytical Biochemistry: A Practical Handbook for Undergraduates

The instruction guide provides useful information for setting up and running the lab activities each week and assessing student preparation, performance, and comprehension.

Oregon State Rank Assessment For Deer-Cabbage (Nephrophyllidium Crista-Galli), Lindsey K. Wise

Institute for Natural Resources Publications

Oregon state conservation status assessment for Deer-cabbage (Nephrophyllidium crista-galli) using NatureServe methodology, 2026.

Malnutrition Risk, Nutrition Insecurity, Barriers, And Facilitators To Dietary Management Among Adults With Inflammatory Bowel Disease In The Us Rocky Mountain Region: A Cross-Sectional Mixed-Methods Study, Heather Burr, Carrie Durward, Korry Hintze, Getrude Mphwanthe

Nutrition, Dietetics, and Food Science Student Research

We conducted an online cross-sectional study to assess malnutrition risk, food and nutrition insecurity, and perceived barriers and facilitators to dietary management among adults (18–64 years old) with a self-reported clinical diagnosis of inflammatory bowel disease (IBD) in outpatient and community settings. We assessed malnutrition risk using the Saskatchewan IBD-Nutrition Risk screening tool, food security risk using the two-item Hunger Vital Signs questionnaire, and nutrition security risk using a validated four-item tool. Open-ended questions elucidated barriers and facilitators to dietary management of IBD. Among 57 participants who self-reported a clinical diagnosis of IBD, 52.6% (n = 30/57) had ulcerative colitis, …

Comparing Non-Invasive Survey Methods For Southern Flying Squirrels (Glaucomys Volans) At The Western Edge Of Their Range, Jay E. Winfield, Jeremy A. White

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

The southern flying squirrel (Glaucomys volans) is a threatened species in Nebraska that occurs along the Missouri River in the southeastern corner of the state. Recently, a population was discovered in the city of Lincoln, but it is unknown whether this population represents a natural range expansion from the Missouri River population or whether it is isolated and results from a human-assisted movement. A survey of southern flying squirrels in Nebraska is needed, but surveys of this elusive species are challenging. This study investigated and compared two noninvasive survey techniques for rapid detection of flying squirrels: acoustic detectors …

Functional Characterization Of Fam120a As A Novel Effector In The Progranulin/Epha2 Oncogenic Axis In Bladder Cancer., Vrunda Satasiya, Canio Martinelli, Gabriel J. Pascal, Giacomo Ducci, Elisa Ventura, Stephen J. Williams, Sharon Raffaella Burk, Manuela Nana Tchamou, Shendi Shani, Michele Klain, Elena Sacco, Marco Vanoni, Antonino Belfiore, Renato V. Iozzo, Antonio Giordano, Andrea Morrione

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Bladder cancer (BC) is one of the most deadly diseases in the USA, with 84,530 new cases and 17,870 estimated deaths in 2026. The growth factor progranulin is involved in several human pathologies, including frontotemporal dementia (FTD), immune response, and cancer. We showed that in BC, progranulin and its signaling receptor, EphA2, drive tumor cell motility, invasion, and in vivo tumor formation, making it a critical pathway in tumor establishment. However, the molecular mechanisms of progranulin/EphA2 action are still poorly defined.

METHODS: Progranulin-dependent EphA2 interactome was explored by proteomic approaches. FAM120A or EphA2 protein levels in BC tissue microarrays …

Cross-Reactivity Of 15 Jev Antigen-Directed Rabbit Antisera With Three Clinically Important Jev Serogroup Members: Wnv, Mvev, And Slev, Sang-Im Yun, Young-Min Lee

Animal, Dairy, and Veterinary Science Faculty Publications

Japanese encephalitis virus (JEV), the prototype member of the JEV serogroup within the genus Orthoflavivirus (family Flaviviridae), is closely related to West Nile virus (WNV), Murray Valley encephalitis virus (MVEV), and St. Louis encephalitis virus (SLEV). To characterize antigenic cross-reactivity within this group, we evaluated 15 region-specific rabbit antisera, previously generated against nearly the entire JEV protein-coding region, by immunoblotting whole-cell lysates from BHK-21 cells infected with WNV, MVEV, or SLEV, with JEV included as a reference. Six antisera (α-E^N-term, α-NS2B, α-NS3^N-term, α-NS3^C-term, α-NS5^N-term, and α-NS5^C-term) robustly recognized homologous …

Malt1 Protease Inhibition Restrains Glioblastoma Progression By Reversing Tumor-Associated Macrophage-Dependent Immunosuppression In Mice, Juliana Hofstätter Azambuja, Saigopalakrishna Yerneni, Lisa Maurer, Hannah Crentsil, Gabriela Debom, Linda Klei, Mei Smyers, Chaim Sneiderman, Kristina Schwab, Rajesh Acharya, Aivi Nguyen, Josie Emery, John Little, Jeffrey Meridew, Yijen Lin Wu, Prasanna Ekambaram, Dong Hu, Pete Gough, John Bertin, Ari Melnick, Gary Kohanbash, Riyue Bao, Peter Lucas, Linda Mcallister-Lucas

College of Life Sciences Faculty Papers

MALT1 protease is an intracellular signaling molecule that promotes tumor progression via cancer cell-intrinsic and cancer cell-extrinsic mechanisms. MALT1 has been mostly studied in lymphocytes, and little is known about its role in tumor-associated macrophages. We show that MALT1 is expressed in glioblastoma (GBM)-associated macrophages. Mechanistically, GBM tumor cells induce a MALT1-NF-κB signaling axis in macrophages, leading to enhanced macrophage migration and polarization toward an immunosuppressive ('M2-like') phenotype. Inactivation of MALT1 protease promotes transcriptional reprogramming that reduces migration and restores a macrophage anti-tumor 'M1-like' phenotype. Preclinical in vivo analysis shows that MALT1 inhibitor treatment results in immuno-reactivity of GBM-associated macrophages …

Nuclear Activities And Interactome Of The Ns5 Protein Of Tick-Borne Encephalitis Virus, Maxime Chazal, Aïssatou Aïcha Sow, Elodie Le Seac'h, Dana Hawasheen, Margarida Bonifacio, Mikael Feracci, Ségolène Gracias, Adrià Sogues, Melissa Molho, Heng Pan, Boris Bonaventure, Jean-Pierre Quivy, Geneviève Almouzni, Etienne Decroly, Holly Ramage, Jeffrey R. Johnson, Vincent Caval, Nolwenn Jouvenet

Department of Microbiology and Immunology Faculty Papers

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular processes, including the interferon response. Although viral replication is cytoplasmic, the NS5 protein of several mosquito-borne orthoflaviviruses cycles between the cytoplasm and the nucleus of infected human cells. However, the nuclear localization and function of NS5 of tick-borne orthoflaviviruses, such as tick-borne encephalitis virus (TBEV), remain poorly understood. Microscopy analysis and cell fractionation revealed that the NS5 protein of TBEV localized to both the …

Phenotypic And Biochemical Responses Of High-Yield Tomato Varieties To Salinity And Drought Stress, Shahida Ferdousee, Myung Hwangbo, Md Sakil Arman, Muhammad Abul Kalam Azad, Ajit Ghosh, Jongsun Kim

School of Earth, Environmental, & Marine Sciences Faculty Publications

Abiotic stresses can influence plant growth and productivity by causing physiological, biochemical, molecular, and morphological changes. Salinity and drought are increasing in frequency and intensity because of climate change. Therefore, this study assessed four high-yield tomato cultivars under 150 mM NaCl and 260 mM mannitol treatments to characterize physiological (i.e., chlorophyll level, root/shoot length, and relative water content) and biochemical responses (i.e., GLY I/II and DLDH enzyme activities, proline, and hydrogen peroxide). Results indicated that the four BARI tomato varieties showed genotype- and treatment-specific physiological and biochemical responses rather than a single uniform tolerance pattern. BARI tomato 2 maintained relatively …

Ai-Enhanced Fluorescein Angiography Detection Of Diabetes-Induced Silent Retinal Capillary Dropout And Rna-Seq Identification Of Pre-Symptomatic Biomarkers, Yiyan Peng, Huishi Toh, Dennis Clegg, Peng Jiiang

Biological, Geological, and Environmental Faculty Publications

Objective: Retinal capillary dropout, characterized by acellular capillaries or "ghost vessels," is an early pathological sign of diabetic retinopathy (DR) that remains undetectable through standard clinical imaging techniques until visible morphological changes, such as microaneurysms or hemorrhages, occur. This study aims to develop a non-destructive artificial intelligence (AI)-based method using fluorescein angiography (FA) images to detect early-stage, silent retinal capillary dropout.

Methods: We utilized 94 FA images and corresponding destructive retinal capillary density measurements obtained through retinal trypsin digestion from 51 Nile rats. Early capillary dropout was defined as having an acellular capillary density of >= 18 counts per mm2. …

Phenological Plasticity Provides Limited Resilience To Climate Warming In A Sea Turtle Species With Temperature-Dependent Sex Determination, Blair P. Bentley, Lisa M. Komoroske, Cintia M. Santos, Armando J. B. Santos, Estefany Argueta, Vic Quennessen, Christina M. Coppenrath, Camille Kynoch, Vincent S. Saba, Claudio Bellini, Rafaely N. M. S. Ventura, J. Wilson White, Mariana M. P. B. Fuentes

Biological Sciences: Faculty Publications

Anthropogenic climate change is threatening global biodiversity, with sea turtles particularly vulnerable as offspring sex and developmental success are strongly influenced by incubation temperature. Behavioral plasticity, including the seasonal distribution of reproductive output, may provide short-term mechanisms for mitigating these impacts. Here, we investigated season-wide hatchling sex ratios and emergence success in a small population of green turtles (Chelonia mydas), tracking individual females across their nesting seasons. Sex ratios varied markedly through the nesting season, with later nests producing a greater proportion of male hatchlings. Moreover, sex ratios were relatively consistent among nests laid by individual females. Overall, females producing …

Dose-Expansion Study Of Obi-999, A Globo H-Targeting Antibody-Drug Conjugate, In Patients With Advanced Solid Tumors, Apostolia Maria Tsimberidou, Darren Sigal, Anna Varghese, Daniel Vaena, Li-Yuan Bai, Ming-Huang Chen, Chun-Nan Yeh, Chia-Jui Yen, Mehmet A Baysal, Abhijit Chakraborty, Ingly Lee, Chi-Sheng Shia, Konul Ristoski, Dong Xu

Children’s Nutrition Research Center Staff Publications

Background: OBI-999 is an antibody-drug conjugate consisting of the Globo H-targeting antibody OBI-888 linked to the cytotoxic payload monomethyl auristatin E. In a dose-escalation study, the OBI-999 recommended phase 2 dose (RP2D) was 1.2 mg/kg every 3 weeks. This dose-expansion study evaluated the efficacy and safety of OBI-999 in patients with pancreatic cancer, colorectal cancer (CRC), or other tumor types ("basket cohort") and tumoral Globo H H-scores ≥100 (NCT04084366).

Patients and methods: Patients were treated at RP2D of OBI-999. We assessed response, progression-free survival (PFS), treatment-emergent adverse events (TEAEs), and pharmacokinetics of OBI-999.

Results: Of 29 patients treated, …