Life Sciences Commons^™

Land Rich, Cash Poor: Hispanic Subsistence Agri-Culture On Acequia Farms Of Northern New Mexico, 1880-1950s, José A. Rivera Ph.D.

Faculty Publications

Acequia-based agriculture in Hispanic northern New Mexico originated with the arrival of settlers from the central valley of Mexico in the late sixteenth century and later following the Camino Real into the upper Río Grande and its tributaries. The high desert environment required irrigation for food production and survival. Land parcels in the rural villages of northern New Mexico were small, and crop yields were limited to home consumption on a subsistence basis, an economy that lasted well into the territorial period and statehood of New Mexico. Despite a wage economy introduced with the arrival of the railroad around 1880 …

Feasibility Of A Hip Flexion Feedback System For Controlling Exercise Intensity And Tibia Axial Peak Accelerations During Treadmill Walking, Nuno Oliveira, Chuang-Yuan Chiu

Faculty Publications

The ability to meet high exercise intensities is limited by the increased risk of injury in some clinical populations. Previous studies have linked large tibia peak positive accelerations resulting from running to increased risk of developing lower-extremity injury. The purpose of this study is to determine the feasibility of using a hip flexion feedback system (HFFS) to meet and maintain different exercise intensities while maintaining low tibia axial accelerations. Ten healthy participants were tested on a HFFS test and an independent walking/running test to meet exercise intensities of 40% and 60% of heart rate reserve (HRR). During the HFFS test, …

To Stick Or Not To Stick: The Multiple Roles Of Cell Adhesion Molecules In Neural Circuit Assembly, Trevor Moreland, Fabienne E. Poulain

Faculty Publications

Precise wiring of neural circuits is essential for brain connectivity and function. During development, axons respond to diverse cues present in the extracellular matrix or at the surface of other cells to navigate to specific targets, where they establish precise connections with post-synaptic partners. Cell adhesion molecules (CAMs) represent a large group of structurally diverse proteins well known to mediate adhesion for neural circuit assembly. Through their adhesive properties, CAMs act as major regulators of axon navigation, fasciculation, and synapse formation. While the adhesive functions of CAMs have been known for decades, more recent studies have unraveled essential, non-adhesive functions …

Pickle Associates With Histone Deacetylase 9 To Mediate Vegetative Phase Change In Arabidopsis, Tieqiang Hu, Darren Manuela, Valerie Hinsch, Mingli Xu

Faculty Publications

• The juvenile-to-adult vegetative phase change in flowering plants is mediated by a decrease in miR156 levels. Downregulation of MIR156A/MIR156C, the two major sources of miR156, is accompanied by a decrease in acetylation of histone 3 lysine 27 (H3K27ac) and an increase in trimethylation of H3K27 (H3K27me3) at MIR156A/MIR156C in Arabidopsis.

• Here, we show that histone deacetylase 9 (HDA9) is recruited to MIR156A/MIR156C during the juvenile phase and associates with the CHD3 chromatin remodeler PICKLE (PKL) to erase H3K27ac at MIR156A/MIR156C.

• H2Aub and H3K27me3 become enriched at MIR156A/MIR156C, and the recruitment of Polycomb Repressive Complex …

High Level Of Persister Frequency In Clinical Staphylococcal Isolates, Sarita Manandhar, Anjana Singh, Ajit Varma, Shanti Pandey, Neeraj Shrivastava

Faculty Publications

Staphylococcus aureus is a notorious human pathogen that causes often lethal systemic conditions that are mostly medical device associated biofilm infections. Similarly, coagulase negative staphylococci are emerging as leading pathogen for nosocomial infections owing to their ability to form biofilm on implanted medical equipment. Chronic in nature, these infections are difficult to treat. Such recalcitrance of these infections is caused mainly due to the presence of persister cells, which exhibit transient yet extreme tolerance to antibiotics. Despite tremendous clinical significance, there is lack of studies on persister cells formation among clinical bacterial isolates. Considering the importance of factors influencing persister …

The Interplay Between Hydrogen Sulfide And Phytohormone Signaling Pathways Under Challenging Environments, Muhammad Saad Shoaib Khan, Faisal Islam, Yajin Ye, Matthew Ashline, Daowen Wang, Biying Zhao, Zheng Qing Fu, Jian Chen

Faculty Publications

Hydrogen sulfide (H₂S) serves as an important gaseous signaling molecule that is involved in intra- and intercellular signal transduction in plant–environment interactions. In plants, H₂S is formed in sulfate/cysteine reduction pathways. The activation of endogenous H₂S and its exogenous application has been found to be highly effective in ameliorating a wide variety of stress conditions in plants. The H₂S interferes with the cellular redox regulatory network and prevents the degradation of proteins from oxidative stress via post-translational modifications (PTMs). H₂S-mediated persulfidation allows the rapid response of proteins in signaling networks …

Lis1 And Ndel1 Regulate Axonal Trafficking Of Mitochondria In Mature Neurons, Jai P. Pandey, Liang Shi, Remi A. Brebion, Deanna S. Smith

Faculty Publications

Defective mitochondrial dynamics in axons have been linked to both developmental and late-onset neurological disorders. Axonal trafficking is in large part governed by the microtubule motors kinesin-1 and cytoplasmic dynein 1 (dynein). Dynein is the primary retrograde transport motor in axons, and mutations in dynein and many of its regulators also cause neurological diseases. Depletion of LIS1, famous for linking dynein deregulation to lissencephaly (smooth brain), in adult mice leads to severe neurological phenotypes, demonstrating post-developmental roles. LIS1 stimulates retrograde transport of acidic organelles in cultured adult rat dorsal root ganglion (DRG) axons but findings on its role in mitochondrial …

Faster Intercalation Pseudocapacitance Enabled By Adjustable Amorphous Titania Where Tunable Isomorphic Architectures Reveal Accelerated Lithium Diffusivity, Wessel Van Den Bergh, Taylor Larison, Maximilliano Jesus Jara Fornerod, Prof. Stefan Guldin, Morgan Stefik

Faculty Publications

Intercalation pseudocapacitance is a faradaic electrochemical phenomenon with high power and energy densities, combining the attractive features of capacitors and batteries, respectively. Intercalation pseudocapacitive responses exhibit surface-limited kinetics by definition, without restriction from the collective of diffusion-based processes. The surface-limited threshold (SLT) corresponds to the maximum voltage sweep rate (vSLT) exhibiting a predominantly surface-limited current response prior to the onset of diffusion-limitations. Prior studies showed increased lithium diffusivity for amorphous titania compared to anatase. Going beyond prior binary comparisons, here a continuum of amorphous titania configurations were prepared using a series of calcination temperatures to tailor both amorphous …

In Situ Recording Of Mars Soundscape, S. Maurice, B. Chide, N. Murdoch, R. D. Lorenz, D. Mimoun, R. C. Wiens, A. Stott, X. Jacob, T. Bertrand, F. Montmessin, N. L. Lanza, C. Alvarez-Llamas, Stanley M. Angel, M. Aung, J. Balaram, O. Beyssac, A. Cousin, G. Delory, O. Forni, T. Fouchet, Et. Al.

Faculty Publications

Before the Perseverance rover landing, the acoustic environment of Mars was unknown. Models predicted that: (1) atmospheric turbulence changes at centimetre scales or smaller at the point where molecular viscosity converts kinetic energy into heat1, (2) the speed of sound varies at the surface with frequency^2,3 and (3) high-frequency waves are strongly attenuated with distance in CO₂ (refs.^2,3,4). However, theoretical models were uncertain because of a lack of experimental data at low pressure and the difficulty to characterize turbulence or attenuation in a closed environment. Here, using Perseverance …

Recently Evolved Francisella-Like Endosymbiont Outcompetes An Ancient And Evolutionarily Associated Coxiella-Like Endosymbiont In The Lone Star Tick (Amblyomma Americanum) Linked To The Alpha-Gal Syndrome, Deepak Kumar, Surendra Raj Sharma, Abdulsalam Adegoke, Ashley Kennedy, Holly C. Tuten, Andrew Y. Li, Shahid Karim

Faculty Publications

Background: Ticks are hematophagous arthropods that transmit various bacterial, viral, and protozoan pathogens of public health significance. The lone star tick (Amblyomma americanum) is an aggressive human-biting tick that transmits bacterial and viral pathogens, and its bites are suspected of eliciting the alpha-gal syndrome, a newly emerged delayed hypersensitivity following consumption of red meat in the United States. While ongoing studies have attempted to investigate the contribution of different tick-inherent factors to the induction of alpha-gal syndrome, an otherwise understudied aspect is the contribution of the tick microbiome and specifically obligate endosymbionts to the establishment of the alpha-gal …

Saving The Sea Turtles Of Anguilla: Combining Scientific Data With Community Perspectives To Inform Policy Decisions, L. M. Soanes, J. Johnson, K. Eckert, K. Gumbs, L. G. Halsey, G. Hughes, K. Levasseur, Joe Quattro, R. Richardson, J. P. Skinner, S. Wynee, F. Mukhida

Faculty Publications

Historic over-exploitation and the more recent threats caused by fisheries by-catch, disease and climate change have left sea turtle populations in the Wider Caribbean at risk of extinction. In 1995, following regional declines in nesting and foraging populations, the island of Anguilla implemented a moratorium on the hunting of turtles. At the request of the Government of Anguilla for scientific data to either support or remove the moratorium, comprehensive population estimates were obtained, and foraging, nesting and migratory movements were examined. In addition, community perspectives on turtles and their protection were assessed. Between 2015 and 18 surveys of 30 nesting …

Editorial: Pathways And Processes Underpinning Axonal Biology And Pathobiology, Pabitra K. Sahoo, Dianna E. Willis, James N. Sleigh

Faculty Publications

No abstract provided.

A Qualitative Report Of The Perceptions Of The Covid-19 Pandemic From Collegiate Student-Athletes, Dylan C. Rowe, Zachary K. Winkelmann Phd, Lat, Atc, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Michelle Angelique Arent Rd, Mph, Cscs, Cissn, Alexa Jenny Chandler, Nancy A. Uriegas, Toni Torres-Mcgehee Phd, Lat, Atc

Faculty Publications

Context

The COVID-19 pandemic led to an abrupt disruption in access to services and personnel for collegiate student-athletes in the spring and summer of 2020. We sought to identify the effects of this unprecedented change by examining the psychological well-being, changes to normal routines, and return-to-play considerations of current student-athletes in order to guide support for both current and future student-athletes who may face similar situations. Methods

We utilized a phenomenological approach to interview a purposeful sample of eighteen collegiate student-athletes (7 males, 11 females; mean age = 20 years) from across the United States. The participants were interviewed using …

Identification And Characterization Of A Stem Canker And Twig Dieback Disease Of Pear Caused By Neofusicoccum Parvum In Chinese Mainland, Feng He, Jie Yang, Yancun Zhao, Pedro Laborda, Yifan Jia, Asma Safdar, Alex Machio Kange, Bingxin Li, Lan Zhou, Quan Zeng, Sally Brown, Zheng Qing Fu, Fengquan Liu

Faculty Publications

Pear (Pyrus spp.) is one of the most consumed fruits in China, but the pear production has to confront the growing threat from fatal diseases. In this study, we report two incidences of stem canker and twig dieback disease on pear plants, which led to death of pear seedlings (approximately 10% of total plants) in Guangxi and Jiangsu provinces. Using a combination of morphological and molecular diagnoses, along with pathogenicity test, the causal agent of the disease in these two locations was identified to be the fungus Neofusicoccum parvum. However, the isolates were divided into two clades: CY-2 …

The Ability To Classify Patients Based On Gene-Expression Data Varies By Algorithm And Performance Metric, Stephen Piccolo, Avery Mecham, Nathan P. Golightly, Jérémie L. Johnson, Dustin B. Miller

Faculty Publications

By classifying patients into subgroups, clinicians can provide more effective care than using a uniform approach for all patients. Such subgroups might include patients with a particular disease subtype, patients with a good (or poor) prognosis, or patients most (or least) likely to respond to a particular therapy. Transcriptomic measurements reflect the downstream effects of genomic and epigenomic variations. However, high-throughput technologies generate thousands of measurements per patient, and complex dependencies exist among genes, so it may be infeasible to classify patients using traditional statistical models. Machine-learning classification algorithms can help with this problem. However, hundreds of classification algorithms exist—and …

One Planet: One Health. A Call To Support The Initiative On A Global Science-Policy Body On Chemicals And Waste, Werner Brack, Damia Barcelo Culleres, Alistair B.A. Boxall, Helene Budzinski, Sara Castiglioni, Adrian Covaci, Valeria Dulio, Beate I. Escher, Peter Fantke, Faith Kandie, Despo Fatta-Kassinos, Felix J. Hernandez, Klara Hilscherova, Juliane Hollender, Henner Hollert, Annika Jahnke, Barbara Kasprzyk-Hordern, Stuart J. Khan, Andreas Kortenkamp, Klaus Kuemmerer, Brice Lalonde, Marja H. Lamoree, Yves Levi, Pablo Antonio Lara Martin, Cassiana C. Montagner, Christian Mougin, Titus Msagati, Joerg Oehlmann, Leo Posthuma, Malcolm Reid, Martin Reinhard, Susan D. Richardson, Et. Al.

Faculty Publications

The chemical pollution crisis severely threatens human and environmental health globally. To tackle this challenge the establishment of an overarching international science–policy body has recently been suggested. We strongly support this initiative based on the awareness that humanity has already likely left the safe operating space within planetary boundaries for novel entities including chemical pollution. Immediate action is essential and needs to be informed by sound scientific knowledge and data compiled and critically evaluated by an overarching science–policy interface body. Major challenges for such a body are (i) to foster global knowledge production on exposure, impacts and governance going beyond …

The Faith, Activity, And Nutrition (Fan) Dissemination And Implementation Study: Changes In And Maintenance Of Organizational Practices Over 24 Months In A Statewide Initiative, Sarah Wilcox Phd, Kelsey R. Day, Ruth P. Saunders, Danielle E. Jake-Schoffman, Andrew T. Kaczynski, Jessica Stucker, Caroline G. Dunn, John Bernhart Ph.D.

Faculty Publications

Background

Few studies have examined the impact of ecological health promotion interventions on organizational practices over time, especially in faith-based settings. This statewide dissemination and implementation study examined change in organizational practices and their predictors across a 24-month period, as well as maintenance of change.

Methods

Using a pre-post quasi-experimental design, church coordinators from 92 United Methodist Churches in South Carolina (42% predominantly African American congregations) completed surveys at baseline, and immediate, 12-, and 24-months post-training regarding physical activity (PA) and healthy eating (HE) organizational practices consistent with the Faith, Activity, and Nutrition (FAN) program (opportunities, policies, pastor support, messages) …

The Transcription Factor Vpxlnr Is Required For The Growth, Development, And Virulence Of The Fungal Pathogen Valsa Pyri, Feng He, Alex-Machio Kange, Jie Yang, Jiaxin Xiao, Rongbo Wang, Lu Yang, Yifan Jia, Zhengqing Fu, Yancun Zhao, Fengquan Liu

Faculty Publications

Pears (Pyrus sp.) are widely cultivated in China, and their yield accounts for more than 60% of global pear production. The fungal pathogen Valsa pyri is a major causal agent of pear canker disease, which results in enormous losses of pear production in northern China. In this study, we characterized a Zn₂Cys₆ transcription factor that contains one GAL4 domain and a fungal-trans domain, which are present in VpxlnR. The vpxlnR gene expression was upregulated in the invasion stage of V. pyri. To investigate its functions, we constructed gene deletion mutants and complementary strains. We observed …

Peak Chlorophyll A Concentrations In The Lower Mississippi River From 1997 To 2018, R. Eugene Turner, Charles S. Milan, Erick M. Swenson, James M. Lee

Faculty Publications

Large and turbid rivers have varying temperatures, light conditions, nutrient availability, and nutrient ratios that may affect phytoplankton communities and occur within a changing world of point and nonpoint source nutrient loadings. We investigated how these physical and chemical factors affect Chlorophyll a (Chl a) concentrations in the Mississippi River, the largest river in North America, by sampling 878 times from February 1997 to December 2018 near its terminus at Baton Rouge, Louisiana. We hypothesized that nutrient concentrations and ratios were significant factors limiting phytoplankton biomass accumulations in this turbid river. The Chl a concentrations were in the "poor" water …

Us Agricultural University Students' Mental Well-Being And Resilience During The First Wave Of Covid-19: Discordant Expectations And Experiences Across Genders, Mariah D. Ehmke, Bhagyashree Katare, Kristin Kiesel, Jason S. Bergtold, Jerrod M. Penn, Kathryn A. Boys

Faculty Publications

The coronavirus disease 2019 (COVID-19) pandemic's first wave led to declining mental health and life satisfaction outcomes for college students, especially women. While women in undergraduate agricultural programs outperformed men academically prior to and during the pandemic, the achievement may have come at personal cost, especially for those women with fewer personal and environmental resiliency resources. Our research objective was to expand on personal, social, and environmental factors linked with lower mental health and life satisfaction scores for students in agriculture during the pandemic. We measured the influence of such factors across gender-based mental health and life satisfaction outcomes. Our …

The Global Virome In One Network (Virion): An Atlas Of Vertebrate-Virus Associations, Colin J. Carlson, Rory J. Gibb, Gregory F. Albery, Liam Brierley, Ryan P. Connor, Tad Dallas, Evan A. Eskew, Anna C. Fagre, Maxwell J. Farrell, Hannah K. Frank, Renata L. Muylaert, Timothée Poisot, Angela L. Rasmussen, Sadie J. Ryan, Stephanie N. Seifert

Faculty Publications

Data that catalogue viral diversity on Earth have been fragmented across sources, disciplines, formats, and various degrees of open sharing, posing challenges for research on macroecology, evolution, and public health. Here, we solve this problem by establishing a dynamically maintained database of vertebrate-virus associations, called The Global Virome in One Network (VIRION). The VIRION database has been assembled through both reconciliation of static data sets and integration of dynamically updated databases. These data sources are all harmonized against one taxonomic backbone, including metadata on host and virus taxonomic validity and higher classification; additional metadata on sampling methodology and evidence strength …

An Insight Into The Microrna Profile Of The Ectoparasitic Mite Varroa Destructor (Acari: Varroidae), The Primary Vector Of Honey Bee Deformed Wing Virus, Deepak Kumar, Mohamed Alburaki, Faizan Tahir, Michael Goblirsch, John Adamczyk, Shahid Karim

Faculty Publications

The remarkably adaptive mite Varroa destructor is the most important honey bee ectoparasite. Varroa mites are competent vectors of deformed wing virus (DWV), and the Varroa-virus complex is a major determinant of annual honey bee colony mortality and collapse. MicroRNAs (miRNAs) are 22-24 nucleotide non-coding RNAs produced by all plants and animals and some viruses that influence biological processes through post-transcriptional regulation of gene expression. Knowledge of miRNAs and their function in mite biology remains limited. Here we constructed small RNA libraries from male and female V. destructor using Illumina’s small RNA-Seq platform. A total of 101,913,208 and 91,904,732 …

Density Dependent Refueling Of Migratory Songbirds During Stopover Within An Urbanizing Coastal Landscape, Emily B. Cohen, Jill M. Lafleur, Frank R. Moore

Faculty Publications

Refueling performance is the primary currency of a successful migration as birds must maintain energy stores to achieve an optimal travel schedule. Migrating birds can anticipate heightened energy demand, not to mention increased uncertainty that energy demands will be satisfied, especially within an urbanizing landscape following long-distance flights. We tested the expectation that refueling performance of songbirds is reduced as densities increase at stopover sites in an urbanizing coastline of the Gulf of Mexico. We measured the density of migrating birds, their refueling performance, and arthropod abundance in two large tracts of contiguous forest paired with two small isolated patches …

Longitudinal Association Of Biological Maturation With Physical Activity Behaviors In Girls Transitioning From 5th To 7th Grade, Russell R. Pate, Marsha Dowda Ph.D., Rod L. Dishman, Joseph Gorab, Agnes Bucko, Ruth P. Saunders Ph.D.

Faculty Publications

Introduction

This longitudinal study determined if social cognitive variables influence physical activity in girls stratified on the basis of maturity status.

Methods

Participants attended South Carolina public schools (Mage in 5th grade = 11.1 years) and included a cohort of 529 girls who provided physical activity data in the 5th grade and in 6th and/or 7th grade. The measure of maturity status was age at peak height velocity (APHV) estimated from maturity offset when the children were in the 5th grade. The Earlier Maturity (EM) group included girls whose APHV was one standard deviation or more below the mean APHV …

Amorphization Of Pseudocapacitive T−Nb2O5 Accelerates Lithium Diffusivity As Revealed Using Tunable Isomorphic Architectures, Wessel Van Den Bergh, Sean Wechsler, Hasala Nadeesini Lokupitiya, Lauren Jarocha, Kwangnam Kim, James Chapman, Kyoung E. Kweon, Brandon C. Wood, Steve Heald, Morgan Stefik Phd

Faculty Publications

Intercalationpseudocapacitancecan combinecapacitor-likepower densitieswith battery-likeenergy densities.Such surface-limitedbehaviorrequiresrapid diffusionwhere amorphizationcan increasesolid-statediffusivity.Here intercalationpseudoca-pacitivematerialswith tailoredextentsof amorphizationin T-Nb2O5are first reported.Amorphizationwas characterizedwithWAXS, XPS, XAFS, and EPR which suggesteda peroxide-rich(O22) surface that was consistentwith DFT predictions.A seriesof tunableisomorphicarchitecturesenabledcomparisonswhileindependentlyvaryingtransportparameters.Throughprocessof elimination,solid-statelithium diffusionwas identifiedas thedominantdiffusive-constraintdictatingthe maximumvoltagesweep rate for surface-limitedkinetics(vSLT), termed the Surface-LimitedThreshold(SLT). ThevSLTincreasedwith amorphizationhoweverstable cycling requiredcrystallineT-Nb2O5. A current-responsemodel using series-impedanceswell-matchedtheseobservations.This perspectiverevealedthat amorphizationof T-Nb2O5enhancedsolid-statediffusionby 12.2% and increasedsurface-limitationsby 17.0% (stablesamples).This approachenabledretaining95% lithiationcapacityat ~800mVs1(1,600C-rate equivalent).

Investigation Of Eating Disorder Risk And Body Image Dissatisfaction Among Female Competitive Cheerleaders, Allison B. Smith, Jennifer L. Gay, Eva V. Monsma, Shawn M. Arent, Mark A. Sarzynski, Dawn M. Emerson, Toni M. Torres-Mcgehee

Faculty Publications

Social agents associated with cheerleading environments are increasingly linked to body image dissatisfaction (BID) and eating disorders (ED). This study examined ED risk across team type, squad type, and position. An additional purpose determined BID in clothing type (daily clothing, midriff uniform, and full uniform), and meta-perceptions from the perspective of peers (MP peers), parents (MP parents), and coaches (MP coaches). Female cheerleaders ( = 268) completed an online survey which included demographics, the Eating Attitudes Test-26, and pathogenic behavior questions. Body image perceptions were assessed by using the Sex-Specific Figural Stimuli Silhouettes. Overall, 34.4% of cheerleaders ( = 268; …

Investigation Of Eating Disorder Risk And Body Image Dissatisfaction Among Female Competitive Cheerleaders, Allison B. Smith, Jennifer L. Gay, Eva V. Monsma, Shawn M. Arent Phd, Cscs*D, Fissn, Facsm, Fnak, Mark A. Sarzynski Ph.D., Faha, Facsm, Dawn M. Emerson Ph.D., Lat, Atc, Toni Torres-Mcgehee Phd, Lat, Atc

Faculty Publications

Social agents associated with cheerleading environments are increasingly linked to body image dissatisfaction (BID) and eating disorders (ED). This study examined ED risk across team type, squad type, and position. An additional purpose determined BID in clothing type (daily clothing, midriff uniform, and full uniform), and meta-perceptions from the perspective of peers (MP peers), parents (MP parents), and coaches (MP coaches). Female cheerleaders (n = 268) completed an online survey which included demographics, the Eating Attitudes Test-26, and pathogenic behavior questions. Body image perceptions were assessed by using the Sex-Specific Figural Stimuli Silhouettes. Overall, 34.4% of cheerleaders (n …

Foods And Beverages Provided In Out Of School Hours Care Services: An Observational Study, Ruth K. Crowe, Yasmine C. Probst, Jennifer A. Norman, Susan E. Furber, Rebecca M. Stanley, Sarah T. Ryan, Cecilia Vuong, Megan L. Hammersley, Karen Wardle, Lisa Franco, Michael Beets Med, Mph, Phd, Robert Weaver Med, Phd, Marc Davis, Christine Innes-Hughes, Anthony D. Okely

Faculty Publications

Introduction: Out of school hours care (OSHC) is a fastgrowing childcare setting in Australia, however the types of foods and beverages ofered are relatively unknown. This study describes the food and beverages ofered and inves‑ tigates sectorlevel and settinglevel factors which may impact OSHC in meeting the Australian Dietary Guidelines (ADG). Methods: This crosssectional, observational study was conducted in 89 OSHC services (between 2018 and 2019). Food and beverages ofered, kitchen facilities and menus were captured via direct observation. Foods were cat‑ egorised into fve food groups or discretionary foods, based on the ADG, and frequencies determined. Short inter‑ views …

Relationship Between Oxidative Stress And Lifespan In Daphnia Pulex, Benedicth Ukhueduan, Charles Schumpert, Eunsuk Kim, Jeffry L. Dudycha, Rekha C. Patel

Faculty Publications

Macromolecular damage leading to cell, tissue and ultimately organ dysfunction is a major contributor to aging. Intracellular reactive oxygen species (ROS) resulting from normal metabolism cause most damage to macromolecules and the mitochondria play a central role in this process as they are the principle source of ROS. The relationship between naturally occurring variations in the mitochondrial (MT) genomes leading to correspondingly less or more ROS and macromolecular damage that changes the rate of aging associated organismal decline remains relatively unexplored. MT complex I, a component of the electron transport chain (ETC), is a key source of ROS and the …

Early-Stage Studies To Larger-Scale Trials: Investigators’ Perspectives On Scaling-Up Childhood Obesity Interventions, L. Von Klinggraeff, Roddrick Dugger, A. D. Okely, D. Lubans, R. Jago, S. Burkart

Faculty Publications

Background

Pilot/feasibility studies play an important role in the development and refinement of behavioral interventions by providing information about feasibility, acceptability, and potential efficacy. Despite their importance and wide-spread use, the approaches taken by behavioral scientists to scale-up early-stage studies to larger-scale trials has received little attention. The aim of our study was to understand the role that pilot studies play in the development and execution of larger-scale trials.

Methods

We conducted interviews with childhood obesity researchers who had published pilot behavioral interventions and larger-scale trials of the same or similar interventions. Questions were asked about the role of pilot …