Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

Faculty Publications

Discipline
Institution
Keyword
Publication Year
File Type

Articles 301 - 330 of 2617

Full-Text Articles in Life Sciences

Author Correction: In Situ Recording Of Mars Soundscape (Nature, (2022), 605, 7911, (653-658), 10.1038/S41586-022-04679-0), S. Maurice, B. Chide, N. Murdoch, R. D. Lorenz, D. Mimoun, R. C. Wiens, A. Stott, X. Jacob, T. Bertrand, F. Montmessin, N. L. Lanza, C. Alvarez-Llamas, S. M. Angel Ph.D., M. Aung, J. Balaram, O. Beyssac, A. Cousin, G. Delory, O. Forni, T. Fouchet, O. Gasnault, H. Grip, M. Hecht, J. Hoffman, J. Laserna, J. Lasue, J. Maki, J. Mcclean, P. Y. Meslin, S. Le Mouélic, S. Le Mouélic, A. Munguira Jul 2022

Author Correction: In Situ Recording Of Mars Soundscape (Nature, (2022), 605, 7911, (653-658), 10.1038/S41586-022-04679-0), S. Maurice, B. Chide, N. Murdoch, R. D. Lorenz, D. Mimoun, R. C. Wiens, A. Stott, X. Jacob, T. Bertrand, F. Montmessin, N. L. Lanza, C. Alvarez-Llamas, S. M. Angel Ph.D., M. Aung, J. Balaram, O. Beyssac, A. Cousin, G. Delory, O. Forni, T. Fouchet, O. Gasnault, H. Grip, M. Hecht, J. Hoffman, J. Laserna, J. Lasue, J. Maki, J. Mcclean, P. Y. Meslin, S. Le Mouélic, S. Le Mouélic, A. Munguira

Faculty Publications

In the version of this article initially published, the Acknowledgements statement was missing the text “Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration (80NM0018D0004),” which has now been inserted in the HTML and PDF versions of the article.


Structure-Property Investigations In Urea Tethered Iodinated Triphenylamines, Muhammad Saddam Hossain, Fiaz Ahmed, Stavros G. Karakalos, Mark D. Smith, Namrata Pant, Sophya V. Garashchuk, Andrew B, Greytak, Pablo Docampo, Linda S. Shimizu Jul 2022

Structure-Property Investigations In Urea Tethered Iodinated Triphenylamines, Muhammad Saddam Hossain, Fiaz Ahmed, Stavros G. Karakalos, Mark D. Smith, Namrata Pant, Sophya V. Garashchuk, Andrew B, Greytak, Pablo Docampo, Linda S. Shimizu

Faculty Publications

Herein, we report structural, computational, and conductivity studies on urea-directed self-assembled iodinated triphenylamine (TPA) derivatives. Despite numerous reports of conductive TPAs, the challenges of correlating their solid-state assembly with charge transport properties hinder the efficient design of new materials. In this work, we compare the assembled structures of a methylene urea bridged dimer of di-iodo TPA (1) and the corresponding methylene urea di-iodo TPA monomer (2) with a di-iodo mono aldehyde (3) control. These modifications lead to needle shaped crystals for 1 and 2 that are organized by urea hydrogen bonding, π⋯π stacking, I⋯I, and I⋯π interactions as determined by …


Post-Embryonic Phase Transitions Mediated By Polycomb Repressive Complexes In Plants, Valerie Hinsch, Samuel Adkins, Darren Manuela, Mingli Xu Jul 2022

Post-Embryonic Phase Transitions Mediated By Polycomb Repressive Complexes In Plants, Valerie Hinsch, Samuel Adkins, Darren Manuela, Mingli Xu

Faculty Publications

Correct timing of developmental phase transitions is critical for the survival and fitness of plants. Developmental phase transitions in plants are partially promoted by controlling relevant genes into active or repressive status. Polycomb Repressive Complex1 (PRC1) and PRC2, originally identified in Drosophila, are essential in initiating and/or maintaining genes in repressive status to mediate developmental phase transitions. Our review summarizes mechanisms in which the embryo-to-seedling transition, the juvenile-to-adult transition, and vegetative-to-reproductive transition in plants are mediated by PRC1 and PRC2, and suggests that PRC1 could act either before or after PRC2, or that they could function independently of each other. …


Prior Exposure To Microcystin Alters Host Gut Resistome And Is Associated With Dysregulated Immune Homeostasis In Translatable Mouse Models, Punnag Saha, Dipro Bose, Vitalii Stebliankin, Trevor Cickovski, Ratanesh K. Seth, Dwayne E. Porter Ph.D., Bryan W. Brooks, Kalai Mathee, Giri Narashimhan, Rita Colwell, Geoffry Ivan Scott Ph.D., Saurabh Chatterjee Ms., Ph.D Jul 2022

Prior Exposure To Microcystin Alters Host Gut Resistome And Is Associated With Dysregulated Immune Homeostasis In Translatable Mouse Models, Punnag Saha, Dipro Bose, Vitalii Stebliankin, Trevor Cickovski, Ratanesh K. Seth, Dwayne E. Porter Ph.D., Bryan W. Brooks, Kalai Mathee, Giri Narashimhan, Rita Colwell, Geoffry Ivan Scott Ph.D., Saurabh Chatterjee Ms., Ph.D

Faculty Publications

A strong association between exposure to the common harmful algal bloom toxin microcystin and the altered host gut microbiome has been shown. We tested the hypothesis that prior exposure to the cyanotoxin microcystin-LR may alter the host resistome. We show that the mice exposed to microcystin-LR had an altered microbiome signature that harbored antibiotic resistance genes. Host resistome genotypes such as mefA, msrD, mel, ant6, and tet40 increased in diversity and relative abundance following microcystin-LR exposure. Interestingly, the increased abundance of these genes was traced to resistance to common antibiotics such as tetracycline, macrolides, glycopeptide, and aminoglycosides, crucial for modern-day …


Khsrp Loss Increases Neuronal Growth And Synaptic Transmission And Alters Memory Consolidation Through Rna Stabilization, Sarah L. Olguin, Priyanka Patel, Courtney N. Buchanan, Michela Dell'orco, Amy S. Gardiner, Robert Cole, Lauren S. Vaughn, Anitha Sundararajan, Joann Mudge, Andrea M. Allen, Pavel Ortinski, Jonathan L. Brigman, Jeffery L. Twiss, Nora L. Perrone-Bizzozero Jul 2022

Khsrp Loss Increases Neuronal Growth And Synaptic Transmission And Alters Memory Consolidation Through Rna Stabilization, Sarah L. Olguin, Priyanka Patel, Courtney N. Buchanan, Michela Dell'orco, Amy S. Gardiner, Robert Cole, Lauren S. Vaughn, Anitha Sundararajan, Joann Mudge, Andrea M. Allen, Pavel Ortinski, Jonathan L. Brigman, Jeffery L. Twiss, Nora L. Perrone-Bizzozero

Faculty Publications

KH-type splicing regulatory protein (KHSRP) regulates levels of several neuronal mRNAs linked to nervous system development and function.

The KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein linked to decay of mRNAs with AU-rich elements. KHSRP was previously shown to destabilize Gap43 mRNA and decrease neurite growth in cultured embryonic neurons. Here, we have tested functions of KHSRP in vivo. We find upregulation of 1460 mRNAs in neocortex of adult Khsrp(-/-) mice, of which 527 bind to KHSRP with high specificity. These KHSRP targets are involved in pathways for neuronal morphology, axon guidance, neurotransmission and long-term memory. Khsrp(-/-) mice …


Leaf Development In Medicago Truncatula, Liren Du, Samuel Winright Adkins, Mingli Xu Jul 2022

Leaf Development In Medicago Truncatula, Liren Du, Samuel Winright Adkins, Mingli Xu

Faculty Publications

Forage yield is largely dependent on leaf development, during which the number of leaves, leaflets, leaf size, and shape are determined. In this mini-review, we briefly summarize recent studies of leaf development in Medicago truncatula, a model plant for legumes, with a focus on factors that could affect biomass of leaves. These include: floral development and related genes, lateral organ boundary genes, auxin biosynthesis, transportation and signaling genes, and WOX related genes.


Influence Of Guideline Operationalization On Youth Activity Prevalence In The International Children’S Accelerometry Database, Catherine Gammon, Andrew J. Atkin, Kirsten Corder, Ulf Ekelund, Bjorge Herman Hansen, Lauren B. Sherar, Lars Bo Anderson, Sigmund Anderssen, Rachel Davey, Pedro C. Hallal, Russell Jago, Susi Kriemler, Peter Lund Kristensen, Soyang Kwon, Kate Nothstone, Russell R. Pate Ph.D., J. O. Salmon, Luis B. Sardinha, Esther M.F. Sluijs Jul 2022

Influence Of Guideline Operationalization On Youth Activity Prevalence In The International Children’S Accelerometry Database, Catherine Gammon, Andrew J. Atkin, Kirsten Corder, Ulf Ekelund, Bjorge Herman Hansen, Lauren B. Sherar, Lars Bo Anderson, Sigmund Anderssen, Rachel Davey, Pedro C. Hallal, Russell Jago, Susi Kriemler, Peter Lund Kristensen, Soyang Kwon, Kate Nothstone, Russell R. Pate Ph.D., J. O. Salmon, Luis B. Sardinha, Esther M.F. Sluijs

Faculty Publications

Introduction

The United Kingdom and World Health Organization recently changed their youth physical activity (PA) guidelines from 60 min of moderate- to vigorous-intensity PA (MVPA) every day, to an average of 60 min of MVPA per day, over a week. The changes are based on expert opinion due to insufficient evidence comparing health outcomes associated with different guideline definitions. This study used the International Children’s Accelerometry Database to compare approaches to calculating youth PA compliance and associations with health indicators.

Methods

Cross-sectional accelerometer data (n = 21,612, 5–18 yr) were used to examine compliance with four guideline definitions: daily …


Enhanced Force Field Analysis (E-Ffa) Templates, Alisha Redelfs, Leah D. Whigham Jun 2022

Enhanced Force Field Analysis (E-Ffa) Templates, Alisha Redelfs, Leah D. Whigham

Faculty Publications

Evaluation is an essential component of public health practice to understand the reach and impact of a program or the functioning of a system. We propose that Enhanced Force Field Analysis (E-FFA), incorporating strategic planning (force field analysis), participatory approaches, and elements of Appreciative Inquiry, is a powerful and versatile tool for evaluators, program developers, and community organizations to optimize programs, understand systems, or assess innovations. E-FFA can work with large or small groups and is flexible enough to work in many contexts.

These E-FFA printable templates include a facilitator's guide, a participant handout (2 per sheet), and scorecards (8 …


Robust Network Stability Of Mosquitoes And Human Pathogens Of Medical Importance, Donald A. Yee, Catherine Dean Bermond, Limarie J. Reyes-Torres, Nicole S. Fijman, Nicole A. Scavo, Joseph Nelsen, Susan H. Yee Jun 2022

Robust Network Stability Of Mosquitoes And Human Pathogens Of Medical Importance, Donald A. Yee, Catherine Dean Bermond, Limarie J. Reyes-Torres, Nicole S. Fijman, Nicole A. Scavo, Joseph Nelsen, Susan H. Yee

Faculty Publications

Background: The exact number of mosquito species relevant to human health is unknown, posing challenges in understanding the scope and breadth of vector–pathogen relationships, and how resilient mosquito vector–pathogen networks are to targeted eradication of vectors.

Methods: We performed an extensive literature survey to determine the associations between mosquito species and their associated pathogens of human medical importance. For each vector–pathogen association, we then determined the strength of the associations (i.e., natural infection, lab infection, lab dissemination, lab transmission, known vector). A network analysis was used to identify relationships among all pathogens and vectors. Finally, we examined how …


Luminescence And Scintillation In The Niobium Doped Oxyfluoride Rb4Ge5O9F6:Nb, Darren Carone, Vladislav V. Klepov, Scott T. Misture, Joseph C. Schaeperkoetter, Luiz G. Jacobsohn, Mina Aziziha, Juliano Schorne-Pinto, Stuart A. J. Thomson, Adrian T. Hines, Theodore M. Besmann, Hans Conrad Zur Loye Jun 2022

Luminescence And Scintillation In The Niobium Doped Oxyfluoride Rb4Ge5O9F6:Nb, Darren Carone, Vladislav V. Klepov, Scott T. Misture, Joseph C. Schaeperkoetter, Luiz G. Jacobsohn, Mina Aziziha, Juliano Schorne-Pinto, Stuart A. J. Thomson, Adrian T. Hines, Theodore M. Besmann, Hans Conrad Zur Loye

Faculty Publications

A new niobium-doped inorganic scintillating oxyfluoride, Rb4Ge5O9F6:Nb, was synthesized in single crystal form by high-temperature flux growth. The host structure, Rb4Ge5O9F6, crystallizes in the orthorhombic space group Pbcn with lattice parameters a = 6.98430(10) Å, b = 11.7265(2) Å, and c = 19.2732(3) Å, consisting of germanium oxyfluoride layers made up of Ge3O9 units connected by GeO3F3 octahedra. In its pure form, Rb4Ge5O9F6 shows neither luminescence nor scintillation but when doped …


Long Chain Fatty Acids And Virulence Repression In Intestinal Bacterial Pathogens, Mary K. Mitchell, Melissa Ellermann Jun 2022

Long Chain Fatty Acids And Virulence Repression In Intestinal Bacterial Pathogens, Mary K. Mitchell, Melissa Ellermann

Faculty Publications

When bacterial pathogens enter the gut, they encounter a complex milieu of signaling molecules and metabolites produced by host and microbial cells or derived from external sources such as the diet. This metabolomic landscape varies throughout the gut, thus establishing a biogeographical gradient of signals that may be sensed by pathogens and resident bacteria alike. Enteric bacterial pathogens have evolved elaborate mechanisms to appropriately regulate their virulence programs, which involves sensing and responding to many of these gut metabolites to facilitate successful gut colonization. Long chain fatty acids (LCFAs) represent major constituents of the gut metabolome that can impact bacterial …


Environmental And Biological Controls On Sedimentary Bottom Types In The Puquios Of The Salar De Llamara, Northern Chile, Erica P. Suosaari, Amanda M. Oehlert, Ioan Lascu, Alan W. Decho, Alan M. Piggot, Alvaro T. Palma, Paul F. Machabee, R. Pamela Reid Jun 2022

Environmental And Biological Controls On Sedimentary Bottom Types In The Puquios Of The Salar De Llamara, Northern Chile, Erica P. Suosaari, Amanda M. Oehlert, Ioan Lascu, Alan W. Decho, Alan M. Piggot, Alvaro T. Palma, Paul F. Machabee, R. Pamela Reid

Faculty Publications

The Puquios of the Salar de Llamara in the Atacama Desert, northern Chile, is a system of small lakes that is characterized by evaporitic mineral deposition and that commonly hosts microbial communities. This region is known for its extreme aridity, solar irradiance, and temperature fluctuations. The Puquios are a highly diverse ecosystem with a variety of sedimentary bottom types. Our previous results identified electrical conductivity (EC) as a first-order environmental control on bottom types. In the present paper, we extend our analysis to examine the effects of additional environmental parameters on bottom types and to consider reasons for the importance …


Intra-Axonal Translation Of Khsrp Mrna Slows Axon Regeneration By Destabilizing Localized Mrnas, Priyanka Patel, Courtney N. Buchanan, Matthew D. Zdradzinski, Pabitra K. Sahoo, Amar N. Kar, Seung Joon Lee, Lauren S. Vaughn, Anatoly Urisman, Juan Oses-Prieto, Michela Dell'orco, Devon E. Cassidy, Irene Dalla Costa, Sharmina Miller, Elizabeth Thames, Terika P. Smith, Alma L. Burlingame, Nora Perrone-Bizzozero, Jeffery L. Twiss Jun 2022

Intra-Axonal Translation Of Khsrp Mrna Slows Axon Regeneration By Destabilizing Localized Mrnas, Priyanka Patel, Courtney N. Buchanan, Matthew D. Zdradzinski, Pabitra K. Sahoo, Amar N. Kar, Seung Joon Lee, Lauren S. Vaughn, Anatoly Urisman, Juan Oses-Prieto, Michela Dell'orco, Devon E. Cassidy, Irene Dalla Costa, Sharmina Miller, Elizabeth Thames, Terika P. Smith, Alma L. Burlingame, Nora Perrone-Bizzozero, Jeffery L. Twiss

Faculty Publications

Axonally synthesized proteins support nerve regeneration through retrograde signaling and local growth mechanisms. RNA binding proteins (RBP) are needed for this and other aspects of post-transcriptional regulation of neuronal mRNAs, but only a limited number of axonal RBPs are known. We used targeted proteomics to profile RBPs in peripheral nerve axons. We detected 76 proteins with reported RNA binding activity in axoplasm, and levels of several change with axon injury and regeneration. RBPs with altered levels include KHSRP that decreases neurite outgrowth in developing CNS neurons. Axonal KHSRP levels rapidly increase after injury remaining elevated up to 28 days post …


The Dna Methylation Landscape Of Five Pediatric-Tumor Types, Alyssa C. Parker, Badí I. Quinteros, Stephen Piccolo Jun 2022

The Dna Methylation Landscape Of Five Pediatric-Tumor Types, Alyssa C. Parker, Badí I. Quinteros, Stephen Piccolo

Faculty Publications

Fewer DNA mutations have been identified in pediatric tumors than in adult tumors, suggesting that alternative tumorigenic mechanisms, including aberrant DNA methylation, may play a prominent role. In one epigenetic process of regulating gene expression, methyl groups are attached at the 5-carbon of the cytosine ring, leading to 5-methylcytosine (5mC). In somatic cells, 5mC occurs mostly in CpG islands, which are often within promoter regions. In Wilms tumors and acute myeloid leukemias, increased levels of epigenetic silencing have been associated with worse patient outcomes. However, to date, researchers have studied methylation primarily in adult tumors and for specific genes—but not …


Estimating Cardiorespiratory Fitness Without Exercise Testing Or Physical Activity Status In Healthy Adults: Regression Model Development And Validation, Robert Sloan, Marco Visentini-Scarzanella, Susumu Sawada, Xuemei Sui M.D., M.P.H., Ph.D. Jun 2022

Estimating Cardiorespiratory Fitness Without Exercise Testing Or Physical Activity Status In Healthy Adults: Regression Model Development And Validation, Robert Sloan, Marco Visentini-Scarzanella, Susumu Sawada, Xuemei Sui M.D., M.P.H., Ph.D.

Faculty Publications

Background: Low cardiorespiratory fitness (CRF) is an independent predictor of morbidity and mortality. Most health care settings use some type of electronic health record (EHR) system. However, many EHRs do not have CRF or physical activity data collected, thereby limiting the types of investigations and analyses that can be done.

Objective: This study aims to develop a nonexercise equation to estimate and classify CRF (in metabolic equivalent tasks) using variables commonly available in EHRs.

Methods: Participants were 42,676 healthy adults (female participants: n=9146, 21.4%) from the Aerobics Center Longitudinal Study examined from 1974 to 2005. The nonexercise estimated CRF was …


Host Gut Resistome In Gulf War Chronic Multisymptom Illness Correlates With Persistent Inflammation, Dipro Bose, Somdatta Chatterjee, Ethan Older, Ratanesh Seth, Patricia Janulewicz, Punnag Saha, Ayan Mondal, Jeffrey M. Carlson, Alan W. Decho, Kimberly Sullivan, Nancy Kilmas, Stephen Lasley, Jie Li, Saurabh Chatterjee Jun 2022

Host Gut Resistome In Gulf War Chronic Multisymptom Illness Correlates With Persistent Inflammation, Dipro Bose, Somdatta Chatterjee, Ethan Older, Ratanesh Seth, Patricia Janulewicz, Punnag Saha, Ayan Mondal, Jeffrey M. Carlson, Alan W. Decho, Kimberly Sullivan, Nancy Kilmas, Stephen Lasley, Jie Li, Saurabh Chatterjee

Faculty Publications

Chronic multisymptom illness (CMI) affects a subsection of elderly and war Veterans and is associated with systemic inflammation. Here, using a mouse model of CMI and a group of Gulf War (GW) Veterans’ with CMI we show the presence of an altered host resistome. Results show that antibiotic resistance genes (ARGs) are significantly altered in the CMI group in both mice and GW Veterans when compared to control. Fecal samples from GW Veterans with persistent CMI show a significant increase of resistance to a wide class of antibiotics and exhibited an array of mobile genetic elements (MGEs) distinct from normal …


Delineating The Role Of The Msaabcr Operon In Staphylococcal Overflow Metabolism, Gc Bibek, Gyan S. Sahukhal, Mohamed O. Elasri Jun 2022

Delineating The Role Of The Msaabcr Operon In Staphylococcal Overflow Metabolism, Gc Bibek, Gyan S. Sahukhal, Mohamed O. Elasri

Faculty Publications

Staphylococcus aureus is an important human pathogen that can infect almost every organ system, resulting in a high incidence of morbidity and mortality. The msaABCR operon is an important regulator of several staphylococcal phenotypes, including biofilm development, cell wall crosslinking, antibiotic resistance, oxidative stress, and acute and chronic implant-associated osteomyelitis. Our previous study showed that, by modulating murein hydrolase activity, the msaABCR operon negatively regulates the proteases that govern cell death. Here, we report further elucidation of the mechanism of cell death, which is regulated by the msaABCR operon at the molecular level in the USA300 LAC strain. We showed …


Highly Swellable Hydrogels Prepared From Extensively Oxidized Lignin, Jihyeon Hwang, Daniella V. Martinez, Estevan J. Martinez, Gift Metavarayuth, Dustin Goodlett, Qi Wang, Mitra Ganewatta, Michael S. Kent, Chuanbing Tang Jun 2022

Highly Swellable Hydrogels Prepared From Extensively Oxidized Lignin, Jihyeon Hwang, Daniella V. Martinez, Estevan J. Martinez, Gift Metavarayuth, Dustin Goodlett, Qi Wang, Mitra Ganewatta, Michael S. Kent, Chuanbing Tang

Faculty Publications

Biopolymers such as lignin are gaining renewed appeal due to the need for sustainable materials. Herein, we used chelator-mediated Fenton (CMF) chemistry to oxidize Kraft lignin to develop sustainable super absorbent materials. The CMF chemistry adds oxygen, opens aromatic rings and increases COOH content, producing hydrophilic lignin without depolymerization. UV absorption, molecular weight, elemental analysis, and titration were used to study the chemical compositions of CMF-processed lignin. Then the chemically modified hydrophilic lignin was used to produce lignin-based hydrogels utilizing an aqueous polymerization and cross-linking reaction that enabled tunable properties. The resulting lignin hydrogels absorbed water up to 96% and …


Understanding Rapid Intercalation Materials One Parameter At A Time, Wessel Van Den Bergh, Morgan Stefik Jun 2022

Understanding Rapid Intercalation Materials One Parameter At A Time, Wessel Van Den Bergh, Morgan Stefik

Faculty Publications

Demand for fast, energy-dense storage drives the research into nanoscale intercalation materials. Nanomaterials accelerate kinetics and can modify reaction path thermodynamics, intercalant solubility, and reversibility. The discovery of intercalation pseudocapacitance has opened questions about their fundamental operating principles. For example, are their capacitor-like current responses caused by storing energy in special near-surface regions or rather is this response due to normal intercalation limited by a slower faradaic surface-reaction? This review highlights emerging methods combining tailored nanomaterials with the process of elimination to disambiguate cause-and-effect at the nanoscale. This method is applied to multiple intercalation pseudocapacitive materials showing that the timescales …


The Reproductive Biology Of Small Fishes And The Clutch Concept: Combining Macroscopic And Histological Approaches, David C. Heins, Nancy J. Brown-Peterson May 2022

The Reproductive Biology Of Small Fishes And The Clutch Concept: Combining Macroscopic And Histological Approaches, David C. Heins, Nancy J. Brown-Peterson

Faculty Publications

Accurate estimates of reproductive parameters important in understanding life history evolution and conservation of small fishes are dependent upon careful assignment of ovarian phases. Proper assignment is based upon the stages of propagule (oocyte) development, oocyte maturation and the location of any clutch or portion thereof within the ovaries. Macroscopic inspection and assignment of ovarian developmental phases have often been used for small freshwater fishes. By contrast, histological methods for assignment of reproductive phases have been developed and are widely used for marine fishes, but they have rarely been used for small freshwater fishes. We review oocyte development, ovum maturation, …


Can Coastal Habitats Rise To The Challenge? Resilience Of Estuarine Habitats, Carbon Accumulation, And Economic Value To Sea-Level Rise In A Puget Sound Estuary, Monica M. Moritsch, Kristin B. Bryd, Melanie Davis, Anthony Good, Judith Z. Drexler, James T. Morris, Isa Wood, Lisamarie Windham-Myers, Eric Grossman, Gynnis Nakai, Katrina L. Poppe, John M. Rybczyk May 2022

Can Coastal Habitats Rise To The Challenge? Resilience Of Estuarine Habitats, Carbon Accumulation, And Economic Value To Sea-Level Rise In A Puget Sound Estuary, Monica M. Moritsch, Kristin B. Bryd, Melanie Davis, Anthony Good, Judith Z. Drexler, James T. Morris, Isa Wood, Lisamarie Windham-Myers, Eric Grossman, Gynnis Nakai, Katrina L. Poppe, John M. Rybczyk

Faculty Publications

Sea-level rise (SLR) and obstructions to sediment delivery pose challenges to the persistence of estuarine habitats and the ecosystem services they provide. Restoration actions and sediment management strategies may help mitigate such challenges by encouraging the vertical accretion of sediment in and horizontal migration of tidal forests and marshes. We used a process-based soil accretion model (Coastal Wetland Equilibrium Model) combined with a habitat classifcation model (MOSAICS) to estimate the efects of SLR, suspended sediment, and inland habitat migration on estuarine habitats, soil carbon accumulation, and economic value of climate change mitigation of carbon accumulation (social cost of carbon dioxide) …


Financial Health Literacy And The Shared Decision-Making Process In Healthcare, Caitlin S. O'Mara, Justin P. Young, Zachary K. Winkelmann Phd, Lat, Atc May 2022

Financial Health Literacy And The Shared Decision-Making Process In Healthcare, Caitlin S. O'Mara, Justin P. Young, Zachary K. Winkelmann Phd, Lat, Atc

Faculty Publications

No abstract provided.


The Mitogenome Relationships And Phylogeography Of Barn Swallows (Hirundo Rustica), Gianluca Lombardo, Nicola Rambaldi Migliore, Giulia Colombo, Marco Rosario Capodiferro, Giulio Formenti, Manuela Caprioli, Elisabetta Moroni, Leonardo Caporali, Hovirag Lancioni, Simona Secomandi, Cristina Cereda, Valerio Carelli, Lauren Gillespie, Yang Liu, Yosef Kiat, Alfonso Marzal, Cosme López-Calderón, Javier Balbontín, Timothy Mousseau, Piotr Matyjasiak, Anders Pape Møller, Et. Al. May 2022

The Mitogenome Relationships And Phylogeography Of Barn Swallows (Hirundo Rustica), Gianluca Lombardo, Nicola Rambaldi Migliore, Giulia Colombo, Marco Rosario Capodiferro, Giulio Formenti, Manuela Caprioli, Elisabetta Moroni, Leonardo Caporali, Hovirag Lancioni, Simona Secomandi, Cristina Cereda, Valerio Carelli, Lauren Gillespie, Yang Liu, Yosef Kiat, Alfonso Marzal, Cosme López-Calderón, Javier Balbontín, Timothy Mousseau, Piotr Matyjasiak, Anders Pape Møller, Et. Al.

Faculty Publications

The barn swallow (Hirundo rustica) poses a number of fascinating scientific questions, including the taxonomic status of postulated subspecies. Here, we obtained and assessed the sequence variation of 411 complete mitogenomes, mainly from the European H. r. rustica, but other subspecies as well. In almost every case, we observed subspecies-specific haplogroups, which we employed together with estimated radiation times to postulate a model for the geographical and temporal worldwide spread of the species. The female barn swallow carrying the Hirundo rustica ancestral mitogenome left Africa (or its vicinity) around 280 thousand years ago (kya), and her descendants …


Cross-Modal Perception Of Identity By Sound And Taste In Bottlenose Dolphins, Jason N. Bruck, Sam F. Walmsley, Vincent M. Janik May 2022

Cross-Modal Perception Of Identity By Sound And Taste In Bottlenose Dolphins, Jason N. Bruck, Sam F. Walmsley, Vincent M. Janik

Faculty Publications

While studies have demonstrated concept formation in animals, only humans are known to label concepts to use them in mental simulations or predictions. To investigate whether other animals use labels comparably, we studied cross-modal, individual recognition in bottlenose dolphins (Tursiops truncatus) that use signature whistles as labels for conspecifics in their own communication. First, we tested whether dolphins could use gustatory stimuli and found that they could distinguish between water and urine samples, as well as between urine from familiar and unfamiliar individuals. Then, we paired playbacks of signature whistles of known animals with urine samples from either the same …


Dyt-Prkra Mutation P222l Enhances Pact's Stimulatory Activity On Type I Interferon Induction, Lauren S. Vaughn, Kenneth Frederick, Samuel B. Burnett, Nutan Sharma, D. Cristopher Bragg, Sarah Camargos, Francisco Cardoso, Rekha C. Patel May 2022

Dyt-Prkra Mutation P222l Enhances Pact's Stimulatory Activity On Type I Interferon Induction, Lauren S. Vaughn, Kenneth Frederick, Samuel B. Burnett, Nutan Sharma, D. Cristopher Bragg, Sarah Camargos, Francisco Cardoso, Rekha C. Patel

Faculty Publications

DYT-PRKRA (dystonia 16 or DYT-PRKRA) is caused by mutations in the PRKRA gene that encodes PACT, the protein activator of interferon (IFN)-induced double-stranded (ds) RNA-activated protein kinase (PKR). PACT participates in several cellular pathways, of which its role as a PKR activator protein during integrated stress response (ISR) is the best characterized. Previously, we have established that the DYT-PRKRA mutations cause enhanced activation of PKR during ISR to sensitize DYT-PRKRA cells to apoptosis. In this study, we evaluate if the most prevalent substitution mutation reported in DYT-PRKRA patients alters PACT’s functional role in induction of type …


Oxen: Status, Uses And Practices In The U.S.A., Encouraging A Historic Tradition To Thrive, Andrew B. Conroy May 2022

Oxen: Status, Uses And Practices In The U.S.A., Encouraging A Historic Tradition To Thrive, Andrew B. Conroy

Faculty Publications

Oxen in the United States of America have played an important role throughout its history. Unlike other countries,oxen were never completely given up for horses, mules, or tractors. Instead, the culture of keeping oxen has been maintained by a small group of teamsters in the North- eastern states collectively called New England. Their continued presence has been largely due to agricultural fairs and exhibitions where they have been used in competition for the last 200 years. Ox teamsters were sur- veyed in 2021via social media using Qualtrics. The 423 ox teamsters responding owned 1791 oxen in 39 states, with the …


Unusual High-Frequency Mechanical Properties Of Polymer-Grafted Nanoparticle Melts, Mayank Jhalaria, Yu Chang, Yucheng Huang, Brian C. Benicewicz, Sanat K. Kumar, George Fytas May 2022

Unusual High-Frequency Mechanical Properties Of Polymer-Grafted Nanoparticle Melts, Mayank Jhalaria, Yu Chang, Yucheng Huang, Brian C. Benicewicz, Sanat K. Kumar, George Fytas

Faculty Publications

Brillouin light spectroscopy is used to measure the elastic moduli of spherical polymer-grafted nanoparticle (GNP) melts as a function of chain length at fixed grafting density (0.47  chains/nm2) and nanoparticle radius (8 nm). While the moduli follow a rule of mixtures (Wood’s law) for long chains, they display enhanced elasticity and anomalous dissipation for graft chains <1⁢0⁢0  kDa. GNP melts with long polymers at high 𝜎 have a dry zone near the GNP core, surrounded by a region where the grafts can interpenetrate with chain fragments from adjacent GNPs. We propose that the departures from Wood’s law for short chains are due to the effectively larger silica volume fraction in the region where sound propagates—this is caused by the short, interpenetrated chain fragments being pushed out of the way. We thus conclude that transport mechanisms (of gas, ions, sound, thermal phonons) in GNP melts are radically different if interpenetrated chain segments can be “pushed out of the way” or not. This provides a facile new means for manipulating the properties of these materials.


The Heritage Family Study: A Review Of The Effects Of Exercise Training On Cardiometabolic Health, With Insights Into Molecular Transducers, Mark A. Sarzynski Ph.D., Faha, Facsm, Treva K. Rice, Jean-Pierre Després, Louis Pérusse, Angelo Tremblay, Philip R. Stanforth, André Tchernof, Jacob L. Barber, Francesco Falciani, Clary Clish, James S. Skinner, D. C. Rao, Claude Bouchard May 2022

The Heritage Family Study: A Review Of The Effects Of Exercise Training On Cardiometabolic Health, With Insights Into Molecular Transducers, Mark A. Sarzynski Ph.D., Faha, Facsm, Treva K. Rice, Jean-Pierre Després, Louis Pérusse, Angelo Tremblay, Philip R. Stanforth, André Tchernof, Jacob L. Barber, Francesco Falciani, Clary Clish, James S. Skinner, D. C. Rao, Claude Bouchard

Faculty Publications

The aim of the HERITAGE Family Study was to investigate individual differences in response to a standardized endurance exercise program, the role of familial aggregation, and the genetics of response levels of cardiorespiratory fitness and cardiovascular disease and diabetes risk factors. Here we summarize the findings and their potential implications for cardiometabolic health and cardiorespiratory fitness. It begins with overviews of background and planning, recruitment, testing and exercise program protocol, quality control measures, and other relevant organizational issues. A summary of findings is then provided on cardiorespiratory fitness, exercise hemodynamics, insulin and glucose metabolism, lipid and lipoprotein profiles, adiposity and …


Research Report: High Tunnel Tomato Fruit Cluster Pruning, Caterina Roman, Rebecca G. Sideman May 2022

Research Report: High Tunnel Tomato Fruit Cluster Pruning, Caterina Roman, Rebecca G. Sideman

Faculty Publications

Tomatoes are a high value crop grown worldwide. Indeterminate varieties are commonly grown in high tunnel structures throughout New England for the fresh market. Indeterminate tomato plants often suffer from a phenomenon called ‘June drop’ in which the plant’s first four to five cluster of fruit set perfectly but the subsequent two to three clusters have poor set and plant productivity drops suddenly. While cluster thinning (e.g., reducing the number of fruit allowed to mature per cluster) has been successfully shown to increase fruit size, it has generally not increased marketable yield. We hypothesized that reducing the fruit load by …


Impact Of Climate Change On Hydrochemical Processes At Two High-Elevation Forested Watersheds In The Southern Appalachians, United States, Hailong Huang, Wei Wu, Katherine Elliott, Chelcy Miniat, Charles Driscoll May 2022

Impact Of Climate Change On Hydrochemical Processes At Two High-Elevation Forested Watersheds In The Southern Appalachians, United States, Hailong Huang, Wei Wu, Katherine Elliott, Chelcy Miniat, Charles Driscoll

Faculty Publications

Climate change increasingly affects primary productivity and biogeochemical cycles in forest ecosystems at local and global scales. To predict change in vegetation, soil, and hydrologic processes, we applied an integrated biogeochemical model Photosynthesis-EvapoTranspration and BioGeoChemistry (PnET-BGC) to two high-elevation forested watersheds in the southern Appalachians in the US under representative (or radiative) concentration pathway (RCP)4.5 and RCP8.5 scenarios. We investigated seasonal variability of the changes from current (1986–2015) to future climate scenarios (2071–2100) for important biogeochemical processes/states; identified change points for biogeochemical variables from 1931 to 2100 that indicate potential regime shifts; and compared the climate change impacts of a …