Life Sciences Commons^™

Environmental Monitoring Of Heavy Metals Status In Semiarid Lands Of Northeastern Algeria, Rania Gacem, Hana Souahi, Chemseddine Fehdi, Abderrezzeq Chebout

Journal of Bioresource Management

With the rapid development of industry, heavy metal contamination is becoming among the most important environmental problems causing worldwide concern. The purpose of this study was to evaluate the level of soil heavy metal pollution in the semi-arid areas of Northeast Algeria. To evaluate the ecological state of soils, we investigated fifteen sites. The level of heavy metals (HMs) toxicity and soil characteristics likr pH, electrical conductivity, organic matter, calcium carbonate, calcium, sodium, magnesium, phosphorus, nitrogen, and potassium were assessed during this study. The results showed that the mean values of heavy metals were as follows in ppm: Zn (41.197 …

Biochemical Markers Of Liver Toxicity Among Coal Mine Workers Of Punjab, Pakistan Suffering From Hcv, Aima Iram Batool, Asma Noreen, Naima Huma Naveed, Iram Inayat, Muhammad Fayyaz Ur Rehman, Fariha Idrees, Muhammad Ali Kanwal, Syeda Humaira Jabeen, Hakim Bibi

Journal of Bioresource Management

Hepatitis C is among the leading hepatic disorders in current period through which about 3 % world population has been anguish among them 170 million were diagnosed as persistent carriers. A great range of alteration in liver biochemical parameters were found to be allied with HCV infestation. Current study was designed to evaluate the extent of HCV mediated abnormalities in liver biochemical markers which includes ALT (alanine aminotransferase), AST (Aspartate transaminase), ALP (Alkaline Phosphatase) and serum bilirubin. The study was conducted on coal miners of Punjab province, Pakistan. HCV was primarily diagnosed through one step rapid test device after which …

In Vitro Antifungal Potential Of Vanillic Acid Against Sclerotium Rolfsii, Muhammad Yousaf, Amna Shoaib, Qudsia Fatima, Shanila Bukhari, Numan Ali, Uswa Fatima

Journal of Bioresource Management

The worldwide demand for making agriculture greener, safer, and more efficient can be met aptly by the application of biopesticides. Vanillic acid is a naturally occurring versatile phenolic molecule with promising antifungal activity, however, there have been no studies of the possible use of vanillic acid for its antifungal activity against a serious soil-borne fungal plant pathogen namely Sclerotium rolfsii. This study was performed to assess the antifungal potential of vanillic acid by analyzing growth, morphological, and biochemical changes in S. rolfsii under laboratory conditions. The results revealed that vanillic acid (0.003-0.10 %) significantly reduced fungal growth, distorted fungal …

Gabaergic Synaptic Scaling Is Triggered By Changes In Spiking Activity Rather Than Transmitter Receptor Activation, Carlos Gonzalez-Islas, Zahraa Sabra, Ming-Fai Fong, Pernille Bülow, Nicholas Au Yong, Kathrin Engisch, Peter Wenner

Biological Sciences Faculty Publications

Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity. However, recent findings have forced us to reconsider this idea as several studies suggest AMPAergic scaling is not directly triggered by changes in spiking. Moreover, studies examining homeostatic perturbations in vivo have suggested that GABAergic synapses may be more critical in terms of spiking homeostasis. Here we show results that GABAergic scaling can act to homeostatically control spiking levels. We find that increased or decreased …

Examining Parent-Of-Origin Effects On Transcription And Rna Methylation In Mediating Aggressive Behavior In Honey Bees (Apis Mellifera), Sean T. Bresnahan, Ellen Lee, Lindsay Clark, Rong Ma, Michael P. Markey, Juliana Rangel, Christina M. Grozinger, Hongmei Li-Byarlay

Biochemistry and Molecular Biology Faculty Publications

Conflict between genes inherited from the mother (matrigenes) and the father (patrigenes) is predicted to arise during social interactions among offspring if these genes are not evenly distributed among offspring genotypes. This intragenomic conflict drives parent-specific transcription patterns in offspring resulting from parent-specific epigenetic modifications. Previous tests of the kinship theory of intragenomic conflict in honey bees (Apis mellifera) provided evidence in support of theoretical predictions for variation in worker reproduction, which is associated with extreme variation in morphology and behavior. However, more subtle behaviors – such as aggression – have not been extensively studied. Additionally, the canonical epigenetic mark …

Cover Crop Application On Dredged Sediments Increases Corn Yield Through Microorganism-Associated Enzyme-Driven Nutrient Mineralization, Ashley N. Julian, Louise M. Stevenson, Megan A. Rúa

Biological Sciences Faculty Publications

Background & Aims

Common strategies to mitigate soil degradation of agricultural soils include cover crop application and soil amendment addition. Applying dredged sediments as a soil amendment is gaining popularity since they often provide benefits other amendments lack; however, their use with cover crops is largely unexplored. To understand how cover crop use changes the restorative properties of dredged sediments, we assessed soil physical and chemical properties, enzymatic activities, and corn yield for plots of dredged sediments with and without a cover crop.

Methods

We assessed soil texture, bulk density, water content, pH, nitrogen, phosphorus, cation exchange capacity, calcium, magnesium, …

Effects Of Pubertal Growth Variation On Knee Mechanics During Walking In Female And Male Adolescents, Andrew W. Froehle, Brian A. Edwards, Matthew Peterson, Brian Meyerson, Dana Duren

School of Health and Exercise Sciences Faculty Publications

Introduction: Puberty substantially alters the body's mechanical properties, neuromuscular control, and sex differences therein, likely contributing to increased, sex-biased knee injury risk during adolescence. Female adolescents have higher risk for knee injuries than male adolescents of similar age engaging in similar physical activities, and much research has investigated sex differences in mechanical risk factors. However, few studies address the considerable variation in pubertal growth (timing, pace), knee mechanics, and injury susceptibility within sexes, or the impact of such growth variation on mechanical injury risk.

Objectives: The present study tested for effects of variation in pubertal growth on established mechanical …

Developmental Exposure To Corn Grown On Lake Erie Dredged Material: A Preliminary Analysis, Kaylyn A. S. Flanigan, Madelyn I. Czuba, Victoria R. Riesgo, Megan A. Rúa, Louise M. Stevenson, Jari Willing

Biological Sciences Faculty Publications

While corn is considered to be a healthy food option, common agricultural practices, such as the application of soil amendments, might be introducing contaminants of concern (COC) into corn plants. The use of dredged material, which contain contaminants such as heavy metals, polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), as a soil amendment is increasing. Contaminants from these amendments can accumulate in corn kernels harvested from plants grown on these sediments and potentially biomagnify in organisms that consume them. The extent to which secondary exposure to such contaminants in corn affect the mammalian central nervous system has been virtually …

The Impact Of Study Strategies On Knowledge Growth And Summative Exam Performance In The First Year Of Medical School, Markia Black, William L. Romine, Molly Simonis, Jeffrey L. Peters, Volker Bahn, Amber Todd

Biological Sciences Faculty Publications

Although the distinction between deep and surface processing strategies, their potential to differentially impact learning, and data supporting the superiority of deep processing strategies on summative exam scores are well supported by the literature, more work is needed to understand: (1) how medical students combine study strategies into learning practices, and (2) the effectiveness of these learning practices in facilitating knowledge gains as measured by standardized test scores.

Linking Science And Literacy Through Multimodal Text Sets: Student Perspectives, Heba Abdelnaby, William L. Romine, Delinda Van Garderen, Tracey Milarsky, Ankita Agarwal, Qingli Lei, Cassandra Smith, Amy Lannin, William Folk, Rachel Juergensen

Biological Sciences Faculty Publications

We present findings of a mixed methods study examining the perceptions of students’ (with and without disabilities) understanding and engagement with multimodal STEM text sets. Exit slip and survey data were used to identify areas for improvement in the development of the multimodal STEM text sets for middle school students. Data were collected from 434 middle school students, 86 of whom had a disability, from six teachers’ classrooms in Spring 2021. Significant differences in perceptions of understanding of argumentation were reported between students with and without disabilities. However, ratings of the lessons and the quality of learning, as well as …

Measuring Claim-Evidence-Reasoning Using Scenario-Based Assessments Grounded In Real-World Issues, William L. Romine, Amy Lannin, Ankita Agarwal, Maha Kareem, Emily Burwell

Biological Sciences Faculty Publications

Improving students’ use of argumentation is front and center in the increasing emphasis on scientific practice in K-12 Science and STEM programs. We explore the construct validity of scenario-based assessments of claim-evidence-reasoning (CER) and the structure of the CER construct with respect to a learning progression framework. We also seek to understand how middle school students progress. Establishing the purpose of an argument is a competency that a majority of middle school students meet, whereas quantitative reasoning is the most difficult, and the Rasch model indicates that the competencies form a unidimensional hierarchy of skills. We also find no evidence …

Exploration Of C9or72c9-500 Sk2, Sk3 Channel Expression, Teresa L. Garrett

Festival of Research

ALS (also known as Lou Gehrig's Disease) is a neurodegenerative disease that weakens muscles and impacts physical function. The C9 Gene is responsible for creating proteins that help neurons send and receive signals across the synapse. Small Conductance calcium activated potassium channels (SK channels) affect the hyperpolarization phase of an action potential. Hypothesis: SK2 and SK3 clusters of C9 positive cells should decrease in size and intensity when exposed to a disease state compared to C9 negative controls.

Comparative Bioactivity Of Peganum Harmala (Zygophyllaceae) Leaves, Flowers And Seeds Aqueous Extracts On Drosophila Melanogaster (Diptera: Drosophilidae): Mortality And Growth Inhibition Impact, Djamila Elbah, Mohamed Athamnia, Mohamed Laid Ouakid

Journal of Bioresource Management

Many plant essential oil, extracts and phytochemicals are known to possess toxic activity against Drosophila melanogaster. In the current work, the effect of aqueous leaves, flowers and seeds extracts of Peganum harmala on the fruit fly mortality and larval development were determined. The seeds extract was the most effective; 100 % of mortality was recorded for the highest concentrations (200 and 300 μg/ml) with lethal time values (LT₅₀ and LT₅₀) reached 3.72 to 4.47 and 6.61 to 8.51 days, respectively. In the other hand, the 15-day lethal concentrations, LC₅₀ and LC₉₀, were determined …

Traditional Products Made From Plant Fibers Produced By The Local Population Of The Wamba Valley In Democratic Republic Of Congo, Ntalakwa Makolo Theophane, Mayanu Pemba Bibiche, Mapey Efifi, Kidikwadi Tango Eustache, Belesi Katula Honore, Lubini Ayingweu Constantin

Journal of Bioresource Management

This study on the traditional, socio-cultural and commercial values of handicrafts based on fiber plants made by the local populations of the Wamba Valley was carried out within the framework of the development of local forest resources. The main objective was to study the socio-cultural and commercial values of handicrafts made from fiber plants in the study area with a view to considering the conservation and sustainable use of plant resources. The methodological approach was based on observations, inventories of objects made on the basis of fiber plant products supported by survey techniques. The main results show that several objects …

Tick Infestation, Distribution, Identification, And Risk Factors On Large Ruminants In Southern Regions Of Pakistan, Muhammad Jamil, Muhammad Imran, Mukhtar Ahmad, Fawad Ahmad, Mubarik Ali, Abdul Basit, Atta Ur Rehman, Gul Muhammad, Norina Jabeen

Journal of Bioresource Management

The livestock sector plays fundamental role in Pakistan's economy, and a variety of ruminants (cattle and buffaloes) are raised to meet the rising demand for milk, meat, and hide goods. Ticks are the most common vectors for the transmission of tick-borne disease and several pathogens to animals and people. Ticks are widespread in Pakistan due to the country's favorable subtropical climate, and they parasitize large and small ruminants, causing infestation and mortality, as well as economic losses to herdsmen. Therefore, the study aimed to investigate the tick’s epidemiology in large animals in the selected Southern regions of Pakistan, during the …

Early Growth Assessment Of Triplochiton Scleroxylon Progeny Development From Conserved Forests In Nigeria, Shafiu Kilishi Halidu, Olaoluwa Ayodeji Adebayo, Olufunlola Odunayo Akinola, Jude Chikezie, Christiana Adeyinka Odebunmi, Olalekan Azeez Ibrahim, Sunday Edigbo Ogbu, Oladimeji Austin Olayiwola, Munir Karounwi Adegoke Wahab

Journal of Bioresource Management

This study examined the intraspecific differences at the early growth of Triplochiton scleroxylon of mixed progeny origins purposively collected from Okoklo Forest Reserve (OFR), Benue State, Cross-River National Park (CRNP), Cross-River and Okomu National Park (ONP), Edo State, Nigeria. The data collected were the height, root collar diameter, internode elongation length, number of leaves and nodes of the early growth assessment of Triplochiton scleroxylon which was for a period of sixteen weeks. At the end of the 16^th week of germination, OFR Triplochiton scleroxylon provenance had the highest height (22.66 cm), root collar diameter (0.85 cm), number of leaves …

Comparison Of Biodiversity And Abundance Of Earthworms In Maize Croplands, Irrigated With Sewage And Canal Water Of District Faisalabad, Pakistan, Sana Aziz, Nazia Ehsan, Fariha Latif, Muhammad Sarfraz Ali, Sajid Abdullah

Journal of Bioresource Management

The diversity and richness of earthworms that were irrigated with canal (Chak 200 RB Lathianwala) and sewage (Chokera) water in the district of Faisalabad were determined from August to November, 2020. For collection of specimens, hand picking and digging method was used and then preserved in formalin. AAS (Atomic absorption spectrophotometer) was used to check the concentration of heavy metals in both water and soil samples. Total 10 species were identified from Chak 200 RB Lathianwala and showed Shannon-Weiner Diversity Index (H') =2.13, Evenness = 0.93 and Dominance = 0.07. The significant difference in abundance were determined (t = 7.7115, …

Morphological And Physiological Responses Of A Halophyte (Atriplex Halimus) To The Effect Of Heavy Metal Case Of Cadmium, Abderrezzeq Chebout, Hana Souahi, Zahia Kadi, Rania Gacem

Journal of Bioresource Management

Today, cadmium (Cd) contamination challenges the environmental quality and food security. This experiment was realized to study the morphological and physiological response of the halophyte species Atriplex halimus L to cadmium toxicity by applying different concentrations of Cd (0, 500, 1000, 1500, 2000 ppm) on the plant A.halimus for two weeks after 60 days of seeding. The morphological parameters and physiological wish evaluated the stem length (SL), root length (RL), leaf area (LA), chlorophylls (a, b, t and carotenoids), and the relative water content (RWC). The results show a decrease in stem elongation, (11.333 ± 3.512 cm in Cd treatments …

Evaluation Of Free Radical Scavenging  Activity Of Sauce And Formulation Of Tamarindus Indica (L.) And Prunus Domestica (L.) Fruits, Zulnoreen Sarfaraz, Mehmooda Munazir, Mubashrah Munir, Asma Ahmed, Rehana Badar, Ayesha Tahir

Journal of Bioresource Management

The formulation and sauce of Tamarindus indica  (L.) and Prusnus  dometica (L.) are very popular recipes across globe. But, not even a single study existed on free-radical scavenging activity (FRSA) of afore-mentioned recipes. So, the present study was designed to bridge this gap of information. The FRSA of individual samples were also determined and compared with that of combinations of both. The highest value for FRSA among all samples was that of T. indica (158.9732 ± 12.658 % at 100 μg ml^-1). It was followed by that of individual extract of P. domestica fruit (96.647 ± 0.554 %). …

Anti-Tick Properties/Repellency Of Neem, Azadirachta Indica On Rhipicephalus Sanguineus (Acarina) Under Laboratory Conditions, Mubarik Ali, Atta Ur Rehman, Naimat Ullah, Muhammad Tariq, Sonia Bibi, Saeed Ullah, Anila Khan, Faiqah Ramzan, Muhammad Ayub, Attia Imam, Muhammad Jamil

Journal of Bioresource Management

Animal production is highly affected due to ticks and diseases caused by ticks. Tick control is critical for the economic well-being of the animal industry. This study focused on anti-tick properties of the Neem, Azadirachta indica extracts against Rhipicephalus sanguineus in vitro conditions. R. sanguineus exhibited a high (P < 0.05) dose revolting reaction to A. indica. There were no significant differences in reaction magnanimity between both sexes. The essence also prominently (p < 0.05) retarded the shedding of 60 % of R. sanguineus engorged nymphs. It resulted in that mortality percentage increasing with an increase in the dose of A. indica. At 20 % of A. indica, 87.76 % of tick …

Rearing Of Trilocha Varians (Lepidoptera: Bombycidae) On Ficus Benjamina And Its Parasitization With Trichogramma Chilonis, Hafiz Muhammad Sajid Ali, Amna Batool, Zeeshan Javed, Abdul Ghaffar, Usama Saleem, Mubshar Saleem, Muhammad Kashif, Sajid Abbas Khan, Muhammad Ramzan

Journal of Bioresource Management

Ficus benjamina commonly known as weeping fig is an ornamental that planted alongside the road to increase the aesthetic value. Leaf eating caterpillar, Trilocha varians was observed on Ficus benjamina and many other ornamental plants in the surrounding area of Muhammad Nawaz Shareef University. Large larval population was recorded on fig plants with 100 % defoliation. The rearing of Trilocha varians on F. benjamina was carried out under controlled conditions and parasitism of Trichogramma chilonis on eggs were checked. Incubation period was 5-6 days while single female laid 150-210 eggs in her whole life period. With five larval instars, duration …

Phenotypic Diversity Among Fennel (Foeniculum Vulgare) Germplasm Of Pakistan, Shumaila Khalil, Shazia Erum, Mahrine Rashid, Arifa Khan, Asif Javaid, Areej Abbasi, Irum Raza

Journal of Bioresource Management

Fennel is facing continuous challenge with reference to biotic and abiotic stresses that can be solved with the knowledge of available germplasm of fennel in the country or worldwide. Selection of fennel genotype on the basis of research interest can never been accomplished without gene pool. The aim of the present study was to explore the phenotypic diversity among selective fennel accession and identify lines having high yielding potential. In the present study thirty fennel accessions were sown in PGRI, NARC. Irrigation practice was carried out during the growing period. Data was recorded during different growth stages and after harvesting. …

Drought Susceptibility Index; A Preferred Criterion In Screening For Tolerance In Soybean, Muhammad Zeshan Zafer, Muhammad Hammad Nadeem Tahir, Muhammad Amir Bakhtavar, Essam Darwish, Mahmood Alam Khan, Zulqurnain Khan, Chahat Fatima, Ayesha Aftab, Shifa Ur Rahman, Shoaib Ur Rehman

Journal of Bioresource Management

Soybean (Glycine max L.) yield and yield related traits are constrained by drought. Adaptation of soybean to changing environment could be improved by exploitation and introgression of diverse germplasm in breeding program. In present study, the response to drought conditions, especially at flowering stage, was evaluated to determine the potential soybean germplasm for future soybean breeding programs in Pakistan. Field experiment was conducted under two water regimes i.e. well-water and water-limited, to assess the effect of drought in seed yield and yield related traits. Although, drought led to overall reduction of ~15 % in thousand seed weight but still …

Collection Of Ground Beetles (Coleoptera: Carabidae) In Two Types Of Arboreal Terrain In The Natural Park Of Belezma Batna (North-Eastern Algeria), Yougherta Abderrezak Habbari, Naama Frah, Meriem Bouterfa, Larbi Houichi

Journal of Bioresource Management

The inventory of the carabid family at two forest sites in the Belezma national park namely an oak grove site and a cedar site during a period ranging from May 2017 to April 2018, has shown the counting of 27 taxa that have been inventoried by Barber pitfall traps. The results showed that the Quercus ilex site has slightly more species (25 species) compared to the Cedrus atlantica one (23 species). However, the Harpalinae subfamily is quantitatively the better one represented at both sites. The Shannon and Simpson indices report slightly higher figures in the Cedrus atlantica site with respectively …

Epidemiological Survey Of Bovine Babesia And Theileria Parasites In Buffaloes In District Dera Ismail, Khyber Pakhtunkhwa, Waseem Ullah, Arsalan Khan, Akhtar Ali, Imtiaz Ali Shah, Umm E. Aimen, Imtiaz Khan, Abdul Wadood Jan, Saqib Ali Rustam

Journal of Bioresource Management

Piroplasmosis (babesiosis and theileriosis) are the leading blood parasites responsible for significant economic losses to the dairy enterprises. These parasites are transmitted by Ixodid ticks from a diseased animal to a healthy animal. This study was executed to determine the prevalence of Theileria and Babesia in water buffaloes in District Dera Ismail Khan for their risk assessment. During this trial, 350 random blood samples were obtained from buffalos within the region of District Dera Ismail Khan and examined for Babesia and Theileria parasites using Giemsa staining technique under an oil immersion lens. Forty-eight blood samples were found positive and the …

Biomorphic Study Of Rhipicephalus Sanguineus (Acari: Ixodidae) Under Laboratory Conditions, Habib Ullah, Atta Ur Rehman, Naimat Ullah, Muhammad Tariq, Umer Farooq, Sonia Bibi, Anila Khan, Muhammad Jamil, Faiqah Ramzan, Muhammad Ayub

Journal of Bioresource Management

Rhipicephalus sanguineus can complete up to four generations per year, depending on factors such as climate and host availability. Biomorphic studies of R. sanguineus were conducted under laboratory conditions. The larval, nymphal and adult ticks were fed on sheep at 25⁰C, 60 % relative humidity (RH) and exposed to daylight. The incubation period was lasted 35 days. The average mean of premoulting and moulting period of larvae was 70 ± 0.91 and 7.4 ± 0.6 days, respectively. The time durations of premoulting and moulting of nymphs were 62 ± 1.66 and 13 ± 6.4 days, respectively. The …

Effects Of Fertilizers On Copper And Nickel Accumulation And Human Health Risk Assessment Of Vegetables And Food Crops, Kafeel Ahmad, Sana Rani, Zafar Iqbal Khan, Shahzad Akhtar, Asma Ashfaq, Iqra Anwar, Hafsa Memona, Aima Iram Batool, Muhammad Nadeem, Javed Shoukat, Ijaz Rasool Noorka, Shahzadi Mahpara, Mumtaz Akhtar, Muhammad Ameer Hamza, Ilker Ugulu, Hamid Raza, Iram Saba, Abrar Hussain, Shamayem Aslam, Mobeen Fatima, Muhammad Umer Farooq Awan, Anum Bashir

Journal of Bioresource Management

Despite the fact that fertilizers have been used for millennia for sustainable crop production, this high and considerable dependence on fertilizers heightens environmental concerns with the indirect human exposure due to accumulation of toxins in food chain via soil contamination. The purpose of this study is to evaluate the application of fertilizers to the soil and their effect on the accumulation of copper and nickel in spinach (Spinacia oleracea), garlic (Allium sativum), wheat (Triticum aestivum), maize (Zea mays), and barley (Hordeum vulgare); as well as potential health concerns associated with …

Potential Of Constructed Wetlands For The Treatment Of Heavy Metals From Wastewater, Hasnain Raza, Qurat Ul Ain, Haseena Bibi, Tehmina Bibi, Huda Bilal

Journal of Bioresource Management

Overpopulation, urbanization, and economic race increase the pressure on freshwater resources resulting in water scarcity challenges around the globe. Moreover, the generation of wastewater is also enhancing the scarcity threats for freshwater resources. Water scarcity issues forced the policymaker, thinker, scientist, and researcher to think about non-conventional water resources to cope with the increasing demands. This wastewater recycling and treatment play an evident role to fulfill the growing demand for freshwater in socioeconomic sectors especially, for agriculture, due to its 70 % dependency on freshwater resources. Different wastewater treatment methods along with merits and demerits are in practice for the …

The Effects Of Chronic Hypercarbia On Morphological And Ventilatory Development In Crayfish, Cassandra Poeppelman, Josh Hivner, Lynn K. Hartzler

Festival of Research

Instances of abnormally high CO2 levels are becoming increasingly common in freshwater ecosystems undergoing eutrophication. Chronic hypercarbia (long-term elevation of the partial pressure of carbon dioxide (Pco2)) is pervasive in these eutrophic ecosystems. Elevated Pco2 increases the ventilation and metabolism of some tadpoles and aquatic frogs and hinders their morphological development23. We expect that chronic hypercarbia will affect most aquatic organisms in the same way, but it remains to be verified that chronic hypercarbic conditions also alter aquatic organisms similarly to intermittent and acute hypercarbic challenges.

The Influence Of Als-Associated Matr3 Toxicity On Cell Size In The Yeast Model, Rahul Shah, Fawaz Ghouse, Widad El-Zein, Quan Zhong, Shulin Ju

Festival of Research

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease1. The pathology of ALS is described as the progressive degeneration of motor neurons that initially leads to atrophy of the voluntary muscles followed by the involuntary muscles1,2. Ultimately, the cause of death is pulmonary distress due to loss of function of the diaphragm2. Life expectancy after diagnosis is usually one year, and there are currently no cures or effective treatments for this fatal disease3. Approximately 90% of all ALS cases are sporadic meaning that the disease is developed randomly, while around 10% of the cases are familial meaning that the disease …