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Articles 961 - 990 of 1821
Full-Text Articles in Life Sciences
Rating Harms To Wildlife: A Survey Showing Convergence Between Conservation And Animal Welfare Views, S. Dubois, D. Fraser
Rating Harms To Wildlife: A Survey Showing Convergence Between Conservation And Animal Welfare Views, S. Dubois, D. Fraser
Environment and Nature Conservation Collection
Human activities may cause conservation concerns when animal populations or ecosystems are harmed and animal welfare concerns when individuals are harmed. In general, people are concerned with one or the other, as the concepts may be regarded as separate or even at odds. An online purposive survey of 339 British Columbians explored differences between groups that varied by gender, residency, wildlife engagement level and value orientation (conservation-oriented or animal welfare-oriented), to see how they rated the level of harm to wildlife caused by different human activities. Women, urban residents, those with low wildlife engagement, and welfare-orientated participants generally scored activities …
History Of The 3rs In Toxicity Testing: From Russell And Burch To 21st Century Toxicology, Martin L. Stephens, Nina S. Mak
History Of The 3rs In Toxicity Testing: From Russell And Burch To 21st Century Toxicology, Martin L. Stephens, Nina S. Mak
Humane Science Movement Collection
Toxicity testing is a key part of the process of assessing the hazards, safety, or risk that chemicals and other substances pose to humans, animals, or the environment. Standardized methods for such testing, typically involving animals, began to emerge during the first half of the 20th century. In 1959, British scientists William Russell and Rex Burch proposed a framework for reducing, refining, or replacing animal use in toxicology and other forms of biomedical experimentation. This “3Rs” or “alternatives” approach emerged at a time of growing sensitivity to the use of animals in experimentation, and progress in its implementation has been …
Do Painful Sensations And Fear Exist In Fish?, Lynne U. Sneddon
Do Painful Sensations And Fear Exist In Fish?, Lynne U. Sneddon
Distress Collection
The detection of pain and fear in fi sh has been subject to much debate and, since fi sh are a popular experimental model and commercially important in both angling and aquaculture, many procedures that fi sh are subjected to cause injury, fear and stress. These injuries would give rise to the sensation of pain in humans but whether fi sh have the capacity for pain is relatively under explored. Recent evidence has shown that fi sh have the same neural apparatus to detect pain that mammals and humans do, that their brain is active during a potentially painful experience, …
Evidence-Based Toxicology For The 21st Century: Opportunities And Challenges, Martin L. Stephens, Melvin E. Andersen, Richard A. Becker, Kellyn Betts, Kim Boekelheide, Ed Carney, Robert Chapin, Dennis Devlin, Suzanne C. Fitzpatrick, John R. Fowle Iii, Patricia Harlow, Thomas Hartung, Sebastian Hoffman, Michael P. Holsapple, Abigail Jacobs, Richard Judson, Olga Naidenko, Tim Pastoor, Grace Patlewicz, Andrew Rowan, Roberta Scherer, Rashid Shaikh, Ted Simon, Douglas Wolf, Joanne Zurlo
Evidence-Based Toxicology For The 21st Century: Opportunities And Challenges, Martin L. Stephens, Melvin E. Andersen, Richard A. Becker, Kellyn Betts, Kim Boekelheide, Ed Carney, Robert Chapin, Dennis Devlin, Suzanne C. Fitzpatrick, John R. Fowle Iii, Patricia Harlow, Thomas Hartung, Sebastian Hoffman, Michael P. Holsapple, Abigail Jacobs, Richard Judson, Olga Naidenko, Tim Pastoor, Grace Patlewicz, Andrew Rowan, Roberta Scherer, Rashid Shaikh, Ted Simon, Douglas Wolf, Joanne Zurlo
Toxicology and Animal Models in Research Collection
The Evidence-based Toxicology Collaboration (EBTC) was established recently to translate evidence-based approaches from medicine and health care to toxicology in an organized and sustained effort. The EBTC held a workshop on “Evidence-based Toxicology for the 21st Century: Opportunities and Challenges” in Research Triangle Park, North Carolina, USA on January 24-25, 2012. The presentations largely reflected two EBTC priorities: to apply evidence-based methods to assessing the performance of emerging pathwaybased testing methods consistent with the 2007 National Research Council report on “Toxicity Testing in the 21st Century” as well as to adopt a governance structure and work processes to move that …
Associations Of Housing, Management, Milking Activity, And Standing And Lying Behavior Of Dairy Cows Milked In Automatic Systems, Justine A. Deming, Renée Bergeron, Kenneth E. Leslie, Trevor J. Devries
Associations Of Housing, Management, Milking Activity, And Standing And Lying Behavior Of Dairy Cows Milked In Automatic Systems, Justine A. Deming, Renée Bergeron, Kenneth E. Leslie, Trevor J. Devries
Farm Animal Husbandry Collection
The objective of this cross-sectional study was to describe the housing, feeding management, and characteristics (parity and stage of lactation) of cows on commercial automatic milking system (AMS) dairies and their associations with the standing and lying behavior patterns and milking activity (frequency and yield) of lactating dairy cows. Thirteen AMS herds were enrolled in the study, with an average herd size of 71 ± 30 (mean ± SD; range: 34 to 131) lactating cows. All of the herds used freestall barns, each set up for free cow traffic to the AMS. On-farm measurements were taken to determine stocking density …
Canine Chronic Kidney Disease In Uk Veterinary Practices: Prevalence, Risk Factors And Survival, D. G. O'Neill, J. Elliott, D. B. Church, P. D. Mcgreevy, P. C. Thomson, D. C. Brodbelt
Canine Chronic Kidney Disease In Uk Veterinary Practices: Prevalence, Risk Factors And Survival, D. G. O'Neill, J. Elliott, D. B. Church, P. D. Mcgreevy, P. C. Thomson, D. C. Brodbelt
Epidemiology Collection
Analyses covering 107,214 dogs attending 89 UK practices aimed to estimate the prevalence and identify risk factors associated with canine chronic kidney disease (CKD) diagnosis and survival. The apparent prevalence (AP) was estimated using a cross-sectional approach while the true prevalence (TP) was estimated using Bayesian analysis. A nested case-control study design was used to evaluate risk factors. Survival analysis was conducted using the Kaplan-Meier survival curve method and multivariable Cox proportional hazards regression modelling. CKD AP was estimated at 0.21% and TP at 0.37%. CKD risk factors included increasing age, being insured and certain breeds. The median survival time …
Nursing Females Are More Prone To Heat Stress: Demography Matters When Managing Flying-Foxes For Climate Change, Stephanie T. Snoyman, Jasmina Munich, Culum Brown
Nursing Females Are More Prone To Heat Stress: Demography Matters When Managing Flying-Foxes For Climate Change, Stephanie T. Snoyman, Jasmina Munich, Culum Brown
Ecological Impacts of Climate Change Collection
Determining the underlying mechanisms responsible for species-specific responses to climate change is important from a species management perspective. The grey-headed flying-fox, Pteropus poliocephalus, is listed as vulnerable but it also a significant pest species for orchardists and thereby presents an interesting management conundrum. Over the last century, the abundance of the grey-headed flying-fox, P. poliocephalus, in Australia has decreased due to a variety of threatening processes but has increased in abundance in urban areas. These flying-foxes are highly susceptible to extreme heat events which are predicted to increase in the future under climate change scenarios. Exceptionally hot days result in …
Benchmarking Cow Comfort On North American Freestall Dairies: Lameness, Leg Injuries, Lying Time, Facility Design, And Management For High-Producing Holstein Dairy Cows, Marina A.G. Von Keyserlingk, A. K. Barrientos, K. Ito, E. Galo, Daniel M. Weary
Benchmarking Cow Comfort On North American Freestall Dairies: Lameness, Leg Injuries, Lying Time, Facility Design, And Management For High-Producing Holstein Dairy Cows, Marina A.G. Von Keyserlingk, A. K. Barrientos, K. Ito, E. Galo, Daniel M. Weary
Housing and Confinement of Farm Animals Collection
In this paper, we describe a novel approach to corporate involvement in on-farm assessment, driven by the desire to provide a service for dairy producers and to create a vehicle for engagement on issues of dairy cow welfare. This program provides producers with feedback on animal-based (including gait score, leg injuries, and lying time) and facility-based (including freestall design, bedding practices, feed bunk design and management, and stocking density) measures that can be used to better address their management goals. The aim of this paper is to describe variation in the prevalence of lameness and leg injuries, lying behavior, facility …
The Moral Status Of Invasive Animal Research, Bernard E. Rollin
The Moral Status Of Invasive Animal Research, Bernard E. Rollin
Experimentation Collection
No abstract provided.
Grey Parrot Number Acquisition: The Inference Of Cardinal Value From Ordinal Position On The Numeral List, Irene M. Pepperberg, Susan Carey
Grey Parrot Number Acquisition: The Inference Of Cardinal Value From Ordinal Position On The Numeral List, Irene M. Pepperberg, Susan Carey
Sentience Collection
No abstract provided.
Haemato Biochemical Alterations In Goats Infected With Coccidiosis, J. Anumol, P. V. Tresamol, K. Vinodkumar, M. R. Saseendranath
Haemato Biochemical Alterations In Goats Infected With Coccidiosis, J. Anumol, P. V. Tresamol, K. Vinodkumar, M. R. Saseendranath
Biochemistry Collection
Coccidiosis is an important disease which account for anaemia and associated problems like poor growth rate, suppressed resistance and high mortality in kids. While considering the various etiological factors resulting in anaemia among goats of Kerala, coccidiosis account for about 8 per cent, indicating the significance of adopting proper prevention and control measures against this disease. The present study reveals the severity and depth of anaemic changes induced by coccidia in goats. All the haematological parameters, serum biochemical parameters and serum levels of iron, copper and zinc of coccidiosis infected animals are evaluated statistically by comparing with healthy control animals.
Interactions Between Short-Beaked Common Dolphin (Delphinus Delphis) And The Winter Pelagic Pair-Trawl Fishery Ff Southwest England (Uk), Marijke N. De Boer, James T. Saulino, Mardik F. Leopold, Peter J.H. Reijnders, Mark P. Simmonds
Interactions Between Short-Beaked Common Dolphin (Delphinus Delphis) And The Winter Pelagic Pair-Trawl Fishery Ff Southwest England (Uk), Marijke N. De Boer, James T. Saulino, Mardik F. Leopold, Peter J.H. Reijnders, Mark P. Simmonds
Aquaculture Collection
During offshore and onshore studies (2004 to 2009), the interactions between pair-trawls and short-beaked common dolphins (Delphinus delphis) were studied to better understand the impact of bycatch. A ‘hotspot’ area where pair-trawls overlapped with high dolphin abundance was identified. We made comparisons between boat-based data collected in absence and presence of pair-trawlers. The relative abundance and group-size of dolphins was significantly higher in the presence of pair-trawlers. Dolphins were observed associating with towing and hauling procedures. Significantly, more carcasses occurred in areas with hauling-activity than those without. Body-temperatures obtained from carcasses found near operating pair-trawlers indicated that bycatch mostly occurred …
Size And Shape Information Serve As Labels In The Alarm Calls Of Gunnison’S Prairie Dogs Cynomys Gunnisoni, C. N. Slobodchikoff, William R. Briggs, Patricia A. Dennis, Anne-Marie C. Hodge
Size And Shape Information Serve As Labels In The Alarm Calls Of Gunnison’S Prairie Dogs Cynomys Gunnisoni, C. N. Slobodchikoff, William R. Briggs, Patricia A. Dennis, Anne-Marie C. Hodge
Veterinary Science and Medicine Collection
Some animals have the capacity to produce different alarm calls for terrestrial and aerial predators. However, it is not clear what cognitive processes are involved in generating these calls. One possibility is the position of the predator: Anything on the ground receives a terrestrial predator call, and anything in the air receives an aerial predator call. Another possibility is that animals are able to recognize the physical features of predators and incorporate those into their calls. As a way of elucidating which of these mechanisms plays a primary role in generating the structure of different calls, we performed two field …
Association Between Stall Surface And Some Animal Welfare Measurements In Freestall Dairy Herds Using Recycled Manure Solids For Bedding, A. W. Husfeldt, M. I. Endres
Association Between Stall Surface And Some Animal Welfare Measurements In Freestall Dairy Herds Using Recycled Manure Solids For Bedding, A. W. Husfeldt, M. I. Endres
Housing and Confinement of Farm Animals Collection
The objective of this cross-sectional study was to investigate the association between stall surface and some animal welfare measurements in upper Midwest US dairy operations using recycled manure solids as bedding material. The study included 34 dairy operations with herd sizes ranging from 130 to 3,700 lactating cows. Forty-five percent of the herds had mattresses and 55% had deep-bedded stalls. Farms were visited once between July and October 2009. At the time of visit, at least 50% of the cows in each lactating pen were scored for locomotion, hygiene, and hock lesions. On-farm herd records were collected for the …
Mother Goats Do Not Forget Their Kids’ Calls, Elodie F. Briefer, Mónica Padilla De La Torre, Alan G. Mcelligott
Mother Goats Do Not Forget Their Kids’ Calls, Elodie F. Briefer, Mónica Padilla De La Torre, Alan G. Mcelligott
Sentience Collection
Parent–offspring recognition is crucial for offspring survival. At long distances, this recognition is mainly based on vocalizations. Because of maturation-related changes to the structure of vocalizations, parents have to learn successive call versions produced by their offspring throughout ontogeny in order to maintain recognition. However, because of the difficulties involved in following the same individuals over years, it is not clear how long this vocal memory persists. Here, we investigated long-term vocal recognition in goats. We tested responses of mothers to their kids’ calls 7–13 months after weaning. We then compared mothers’ responses to calls of their previous kids with …
Vocal Expression Of Emotions In Mammals: Mechanisms Of Production And Evidence, Elodie Briefer
Vocal Expression Of Emotions In Mammals: Mechanisms Of Production And Evidence, Elodie Briefer
Communication Skills Collection
Emotions play a crucial role in an animal’s life because they facilitate responses to external or internal events of significance for the organism. In social species, one of the main functions of emotional expression is to regulate social interactions. There has recently been a surge of interest in animal emotions in several disciplines, ranging from neuroscience to evolutionary zoology. Because measurements of subjective emotional experiences are not possible in animals, researchers use neurophysiological, behavioural and cognitive indicators. However, good indicators, particularly of positive emotions, are still lacking. Vocalizations are linked to the inner state of the caller. The emotional state …
Individual Prey Choices Of Octopuses: Are They Generalist Or Specialist?, Jennifer A. Mather, Tatiana S. Leite, Allan T. Batista
Individual Prey Choices Of Octopuses: Are They Generalist Or Specialist?, Jennifer A. Mather, Tatiana S. Leite, Allan T. Batista
Sentience Collection
Prey choice is often evaluated at the species or population level. Here, we analyzed the diet of octopuses of different populations with the aim to assess the importance of individual feeding habits as a factor affecting prey choice. Two methods were used, an assessment of the extent to which an individual octopus made choices of species representative of those population (PSi and IS) and 25% cutoff values for number of choices and percentage intake of individual on their prey. In one population of Octopus cf vulgaris in Bermuda individuals were generalist by IS=0.77, but most chose many prey of the …
Why (And How) Personalities In Invertebrates?, Jennifer A. Mather
Why (And How) Personalities In Invertebrates?, Jennifer A. Mather
Sentience Collection
No abstract provided.
Immune Responses In Lactating Holstein Cows Supplemented With Cu, Mn, And Zn As Sulfates Or Methionine Hydroxy Analogue Chelates, L. M. Nemec, J. D. Richards, C. A. Atwell, D. E. Diaz, G. I. Zanton, T. F. Gressley
Immune Responses In Lactating Holstein Cows Supplemented With Cu, Mn, And Zn As Sulfates Or Methionine Hydroxy Analogue Chelates, L. M. Nemec, J. D. Richards, C. A. Atwell, D. E. Diaz, G. I. Zanton, T. F. Gressley
Physiology Collection
The aim of this study was to compare effects of inorganic sulfate versus chelated forms of supplemental Cu, Mn, and Zn on milk production, plasma and milk mineral concentrations, neutrophil activity, and antibody titer response to a model vaccination. Holstein cows (n = 25) were assigned in 2 cohorts based on calving date to a 12-wk randomized complete block design study. The first cohort consisted of 17 cows that had greater days in milk (DIM; mean of 77 DIM at the start of the trial) than the second cohort of 8 cows (32 DIM at the start of the trial). …
It Pays To Cheat: Tactical Deception In A Cephalopod Social Signalling System, Culum Brown, Martin P. Garwood, Jane E. Williamson
It Pays To Cheat: Tactical Deception In A Cephalopod Social Signalling System, Culum Brown, Martin P. Garwood, Jane E. Williamson
Communication Skills Collection
Signals in intraspecific communication should be inherently honest; otherwise the system is prone to collapse. Theory predicts, however, that honest signalling systems are susceptible to invasion by cheats, the extent of which is largely mediated by fear of reprisal. Cuttlefish facultatively change their shape and colour, an ability that evolved to avoid predators and capture prey. Here, we show that this ability is tactically employed by male mourning cuttlefish (Sepia plangon) to mislead conspecifics during courtship in a specific social context amenable to cheating 39 per cent of the time, while it was never employed in other social contexts. Males …
Wild Justice Redux: What We Know About Social Justice In Animals And Why It Matters, Jessica Pierce, Marc Bekoff
Wild Justice Redux: What We Know About Social Justice In Animals And Why It Matters, Jessica Pierce, Marc Bekoff
Ethology Collection
Social justice in animals is beginning to attract interest in a broad range of academic disciplines. Justice is an important area of study because it may help explain social dynamics among individuals living in tightly- knit groups, as well as social interactions among individuals who only occasionally meet. In this paper, we provide an overview of what is currently known about social justice in animals and offer an agenda for further research. We provide working definitions of key terms, outline some central research questions, and explore some of the challenges of studying social justice in animals, as well as the …
Effect Of Pen Size, Group Size, And Stocking Density On Activity In Freestall-Housed Dairy Cows, E. Telezhenko, Marina A.G. Von Keyserlingk, A. Talebi, Daniel M. Weary
Effect Of Pen Size, Group Size, And Stocking Density On Activity In Freestall-Housed Dairy Cows, E. Telezhenko, Marina A.G. Von Keyserlingk, A. Talebi, Daniel M. Weary
Housing and Confinement of Farm Animals Collection
The purpose was to determine the effects of the physical dimensions of the pen and group size and stocking density on cow activity. Cows (randomly assigned to 4 groups of 6 animals each) were tested in pens with 24 or 12 lying places and in groups with 12 or 6 cows. All groups were tested in each of the 4 treatments with treatment order allocated using a 4 × 4 Latin square. The distance moved and the number of movements were calculated using 5-min scan sampling of video recordings over a 48-h period. Time spent lying down, number of lying …
Plasticity Of Boldness In Rainbow Trout, Oncorhynchus Mykiss: Do Hunger And Predation Influence Risk-Taking Behaviour?, Jack S. Thomson, Phillip C. Watts, Tom G. Pottinger, Lynne U. Sneddon
Plasticity Of Boldness In Rainbow Trout, Oncorhynchus Mykiss: Do Hunger And Predation Influence Risk-Taking Behaviour?, Jack S. Thomson, Phillip C. Watts, Tom G. Pottinger, Lynne U. Sneddon
Ethology Collection
Boldness, a measure of an individual's propensity for taking risks, is an important determinant of fitness but is not necessarily a fixed trait. Dependent upon an individual's state, and given certain contexts or challenges, individuals may be able to alter their inclination to be bold or shy in response. Furthermore, the degree to which individuals can modulate their behaviour has been linked with physiological responses to stress. Here we attempted to determine whether bold and shy rainbow trout, Oncorhynchus mykiss, can exhibit behavioural plasticity in response to changes in state (nutritional availability) and context (predation threat). Individual trout were initially …
Blood Cortisol Concentrations Predict Boldness In Juvenile Mulloway (Argyosomus Japonicus), Vincent Raoult, Culum Brown, Amina Zuberi, Jane E. Williamson
Blood Cortisol Concentrations Predict Boldness In Juvenile Mulloway (Argyosomus Japonicus), Vincent Raoult, Culum Brown, Amina Zuberi, Jane E. Williamson
Sentience Collection
There is a growing interest in animal personality because individual variation is the substrate of the evolutionary process. Despite revelations that personality traits affect key fitness variables, little is known about the proximate mechanisms generating consistent behavioural differences between individuals. Boldness, the propensity to take risks, is one of the most widely studied aspects of personality in fishes. We assessed the position of juvenile Argyosomus japonicus on the ‘‘boldness–shyness’’ continuum by repeatedly recording the time taken to exit a refuge and explore a novel environment. Stress-related hormone concentrations after exposure to a mild stressor were analysed 1 month before behavioural …
An Hsus Report: Food Safety Risks Associated With U.S. Horse Slaughter, The Humane Society Of The United States
An Hsus Report: Food Safety Risks Associated With U.S. Horse Slaughter, The Humane Society Of The United States
Impact of Animal Agriculture
Meat originating from U.S. horses may contain residues from substances banned by the U.S. Food and Drug Administration and the European Union for use in animals intended for consumption. Phenylbutazone, for example, is commonly administered to U.S. horses and has been associated with life-threatening reactions in humans. Requiring a thorough drug history for each U.S. horse intended for human consumption may help circumvent human health risks.
Social Effects On Vocal Ontogeny In An Ungulate, The Goat, Capra Hircus, Elodie F. Briefer, Alan G. Mcelligott
Social Effects On Vocal Ontogeny In An Ungulate, The Goat, Capra Hircus, Elodie F. Briefer, Alan G. Mcelligott
Sentience Collection
Vocal plasticity is the ability of an individual to modify its vocalizations according to its environment. Humans benefit from an extreme form of vocal plasticity, allowing us to produce a wide range of sounds. This capacity to modify sounds has been shown in three bird orders and in a few nonhuman mammal species, all characterized by complex vocal communication systems. In other mammals, there is no evidence for a social impact on vocal development. We investigated whether contact calls were affected by social environment and kinship during early ontogeny in goats, a highly vocal and social species. To test the …
Using Grizzly Bears To Assess Harvest-Ecosystem Tradeoffs In Salmon Fisheries, Taal Levi, Chris T. Darimont, Misty Macduffee, Marc Mangel, Paul C. Paquet, Christopher C. Wilmers
Using Grizzly Bears To Assess Harvest-Ecosystem Tradeoffs In Salmon Fisheries, Taal Levi, Chris T. Darimont, Misty Macduffee, Marc Mangel, Paul C. Paquet, Christopher C. Wilmers
Aquaculture and Fisheries Collection
Implementation of ecosystem-based fisheries management (EBFM) requires a clear conceptual and quantitative framework for assessing how different harvest options can modify benefits to ecosystem and human beneficiaries. We address this social-ecological need for Pacific salmon fisheries, which are economically valuable but intercept much of the annual pulse of nutrient subsidies that salmon provide to terrestrial and aquatic food webs. We used grizzly bears, vectors of salmon nutrients and animals with densities strongly coupled to salmon abundance, as surrogates for ‘‘salmon ecosystem’’ function. Combining salmon biomass and stock-recruitment data with stable isotope analysis, we assess potential tradeoffs between fishery yields and …
The Effect Of Neutering On The Risk Of Urinary Incontinence In Bitches – A Systematic Review, W. Beauvais, J. M. Cardwell, D. C. Brodbelt
The Effect Of Neutering On The Risk Of Urinary Incontinence In Bitches – A Systematic Review, W. Beauvais, J. M. Cardwell, D. C. Brodbelt
Endocrinology Collection
An increased risk of urinary incontinence in bitches has often been associated with previous ovariohysterectomy but remains controversial. The objective of this study was to evaluate the strength of evidence for an association between neutering or age at neutering and urinary incontinence in bitches and to estimate the magnitude of any effect found. A systematic review of peer‐reviewed original English analytic journal articles was conducted, based on Cochrane guidelines (Higgins and Green 2009) Of 1,853 records screened, seven studies were identified that examined the effect of neutering or age at neutering on the risk of urinary incontinence but …
The Use Of Biomarkers Of Toxicity For Integrating In Vitro Hazard Estimates Into Risk Assessment For Humans, Bas Blaauboer, Kim Boekelheide, Harvey Clewell, Mardas Daneshian, Milou M.L. Dingemans, Alan M. Goldberg, Marjoke Heneweer, Joanna Jaworska, Nynke I. Kramer, Marcel Leist, Hasso Seibert, Emanuela Testai, Rob J. Vandebriel, James D. Yager, Joanne Zurlo
The Use Of Biomarkers Of Toxicity For Integrating In Vitro Hazard Estimates Into Risk Assessment For Humans, Bas Blaauboer, Kim Boekelheide, Harvey Clewell, Mardas Daneshian, Milou M.L. Dingemans, Alan M. Goldberg, Marjoke Heneweer, Joanna Jaworska, Nynke I. Kramer, Marcel Leist, Hasso Seibert, Emanuela Testai, Rob J. Vandebriel, James D. Yager, Joanne Zurlo
in Vitro Research Models Collection
The role that in vitro systems can play in toxicological risk assessment is determined by the appropriateness of the chosen methods, with respect to the way in which in vitro data can be extrapolated to the in vivo situation. This report presents the results of a workshop aimed at better defining the use of in vitro-derived biomarkers of toxicity (BoT) and determining the place these data can have in human risk assessment. As a result, a conceptual framework is presented for the incorporation of in vitro-derived toxicity data into the risk assessment process. The selection of BoT takes into account …
Tool Use In Fishes, Culum Brown
Tool Use In Fishes, Culum Brown
Sentience Collection
Tool use was once considered the sole domain of humans. Over the last 40 years, however, it has become apparent that tool use may be widespread across the animal kingdom. Pioneering studies in primates have shaped the way we think about tool use in animals, but have also lead to a bias both in terms of our expectations about which animals should be capable of using tools and the working definition of tool use. Here I briefly examine tool use in terrestrial animals and consider the constraints of the current working definition of tool use in fishes. Fishes lack grasping …