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Articles 271 - 300 of 1821
Full-Text Articles in Life Sciences
Rethinking The 3rs: From Whitewashing To Rights, Charlotte E. Blattner
Rethinking The 3rs: From Whitewashing To Rights, Charlotte E. Blattner
Humane Science Movement Collection
Few other issues have prompted as many legislators to adopt legal instruction on the “proper” use of non-human animals (hereinafter referred to as animals) in medical and scientific research. Today, the 3Rs (replacement, reduction, and refinement of animals in scientific procedures) are globally accepted by a vast majority of states (Blattner, 2014); and prominent international organizations, such as the World Organisation for Animal Health (Terrestrial Animal Health Code, 2018, Article 7(8)(3)) and the Council of Europe (Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, 1986, Articles 6(2), 7 and 8). Widespread acceptance of the …
Beyond Plausibility Checks: A Case For Moral Doubt In Review Processes Of Animal Experimentation, Mara-Daria Cojocaru, Philipp Von Gall
Beyond Plausibility Checks: A Case For Moral Doubt In Review Processes Of Animal Experimentation, Mara-Daria Cojocaru, Philipp Von Gall
Morality and Ethics of Animal Experimentation Collection
The fact that countries all over the world continue to develop new regulations for experimentation on non-human animals testament that this practice raises many doubts. Our aim in this chapter is to show that one important type of doubt should receive more attention: a particular type of moral doubt that could play a pivotal role in the ethical review of animal experiments. We assume that there are a range of emotions that indicate morally complex or problematic situations. When one or all of these emotions are experienced, we say that someone is experiencing moral doubt. To illustrate this point, we …
Human Wrongs In Animal Research: A Focus On Moral Injury And Reification, Jane Johnson, Anna Smajdor
Human Wrongs In Animal Research: A Focus On Moral Injury And Reification, Jane Johnson, Anna Smajdor
Morality and Ethics of Animal Experimentation Collection
Using arguments derived from the work of Axel Honneth (2006), we show that animal research involves an institutionalized failure to recognize nonhuman animals that not only reifies animals but the human persons engaged in this process, diminishing the scope of their moral agency and causing moral injury. In this chapter, we begin by briefly articulating the harms to animals in research and the more conventional harms to humans that can arise as a result of animal research, before making a case for the ethical damage wrought by the failures of recognition inherent within the system of animal research. We conclude …
Extrapolation Of Animal Research Data To Humans: An Analysis Of The Evidence, Rebecca Ram
Extrapolation Of Animal Research Data To Humans: An Analysis Of The Evidence, Rebecca Ram
Validation of Animal Experimentation Collection
The ethical arguments against animal experimentation remain ever-strong. In addition, the scientific case against the use of animals in research grows more compelling, with exponential progress in the development of alternative methods and new research technologies. The Dutch authorities recently announced an ambitious, but welcome, proposal to phase out “the use of laboratory animals in regulatory safety testing of chemicals, food ingredients, pesticides and (veterinary) medicines” by 2025, as well as “the use of laboratory animals for the release of biological products, such as vaccines” (Netherlands National Committee for the protection of animals used for scientific purposes, NCad, 2016, p. …
Wasted Money In United States Biomedical And Agricultural Animal Research, Jim Keen
Wasted Money In United States Biomedical And Agricultural Animal Research, Jim Keen
Biomedicine and Animal Models in Research Collection
Biomedical and agricultural animal research uses millions of experimental animals and dozens of animal species each year by choice, precedent, or regulatory mandate in basic and applied life science research and toxicity testing of drugs, chemicals, and consumer products. Animal research is a large component of the international us$270 billion government-subsidized, biomedical industrial ecosystem (Chakma et al., 2014). In the United States (us) and presumably elsewhere, about half of these funds support animal research and testing (Institute of Medicine and National Research Council, 2012). Each year at least 115 million experimental animals (mostly mice and likely a significant underestimate) are …
The Scientific Problems With Using Non-Human Animals To Predict Human Response To Drugs And Disease, Ray Greek, Lisa A. Kramer
The Scientific Problems With Using Non-Human Animals To Predict Human Response To Drugs And Disease, Ray Greek, Lisa A. Kramer
Pharmacology and Animal Models in Research Collection
Every year, and in countries around the world, significant time and resources are devoted to the noble cause of developing drugs to treat and cure human disease. With rare exception, drug interventions cannot reach commercialization without safety and efficacy having first been demonstrated in animal models. The intention of regulations, which require the use of animal models in such contexts, is to ensure that only safe and effective drugs end up being used by patients. Similarly, it is standard practice for researchers to employ animal models in their attempts to understand the way diseases present and progress in humans. Unfortunately, …
Replacing Animal Tests To Improve Safety For Humans, Kathy Archibald, Robert Coleman, Tamara Drake
Replacing Animal Tests To Improve Safety For Humans, Kathy Archibald, Robert Coleman, Tamara Drake
Application of Alternative Methods Collection
In this chapter, we propose a new, pragmatic approach that could accelerate the replacement of most, if not all, regulatory animal tests with superior tests based on human biology. We also propose that changes to the requirements for safety testing, issued by the us Food and Drug Administration (fda), must be made in order to enable the use of superior new tests, which are currently disadvantaged by the outdated language of the regulations. But first, it is imperative to establish some level of understanding of the efficacy of existing animal-based methods in order to know whether any possible replacement is …
Modernizing Biomedical Training: Replacing Live Animal Laboratories With Human Simulation, John Pawlowski, David Feinstein, Marie L. Crandall, Shalin Gala
Modernizing Biomedical Training: Replacing Live Animal Laboratories With Human Simulation, John Pawlowski, David Feinstein, Marie L. Crandall, Shalin Gala
Biomedicine and Animal Models in Research Collection
This chapter reviews the global trend towards a modernization of biomedical education in favor of simulation-based training methods, which studies confirm improve student learning and transference of applied skills to clinical practice, reduce laboratory costs, and spare animals from harmful procedures.
Animal Research For Alzheimer Disease: Failures Of Science And Ethics, John J. Pippin, Sarah E. Cavanaugh, Francesca Pistollato
Animal Research For Alzheimer Disease: Failures Of Science And Ethics, John J. Pippin, Sarah E. Cavanaugh, Francesca Pistollato
Biomedicine and Animal Models in Research Collection
This chapter addresses the epidemiology and current understanding of AD as a scientific and societal challenge, reviews the uses and results of animal research in basic science and drug development, and discusses risk factors and funding. Important follow-up topics, including current and in-development, human-relevant approaches for replacement of the failed animal research paradigm, deserve comparable treatment and hence are not addressed here. The reader is referred to the list of recommended readings at the end of the chapter for further discussion of these topics.
The Changing Paradigm In Preclinical Toxicology: In Vitro And In Silico Methods In Liver Toxicity Evaluations, Fozia Noor
Application of Alternative Methods Collection
In vitro methods, based on human primary cells, cell lines, and genetically modified reporter cell lines, have greatly expanded the scope of in vitro toxicology. Other significant progress in the area of human-induced pluripotent stem cells (hiPSCs) (Asgari et al., 2010; Schwartz et al., 2014; Shinde et al., 2016; Shtrichman, Germanguz and Itskovitz-Eldor, 2013) is allowing the application of patient and disease-specific hiPSCs (Ghodsizadeh et al., 2010; McCracken et al., 2014; Siller et al., 2013). Moreover, the tools of precise genome editing with engineered nucleases, such as the zinc finger nucleases (zfns), the transcription activator-like effecter nucleases (talens) and, more …
The Potential Of Organ On Chip Technology For Replacing Animal Testing, Malcolm Wilkinson
The Potential Of Organ On Chip Technology For Replacing Animal Testing, Malcolm Wilkinson
Human Clinical Trials Collection
The term organ on a chip is used to describe the latest stage of development of in vitro cell culture technology. Figure 26.1 shows its steady development since the 1960s. Each step forward has improved our ability to model human-clinical response to new drugs or therapies and has enabled safety risk assessment of existing cosmetics, personal care products, or other chemicals in the environment. Scientific evidence that the predictive power of in vitro tests is superior to the use of animals will trigger a major shift in the way that medical research, in many areas, is carried out. In this …
Recent Developments In Alternatives To Animal Testing, Katy Taylor
Recent Developments In Alternatives To Animal Testing, Katy Taylor
Application of Alternative Methods Collection
Methods that replace techniques that use live animals, or methods of testing substances without live animal use, are known as alternatives, replacements or non-animal methods. Some prefer the term advanced technologies given the fact that they often rely on more sophisticated technology and are more human- relevant than the animal test they replace (see Langley et al., 2015). There have been efforts to replace animal tests since the 1960s. Significant progress initially came in replacing animals used to diagnose human disease; to produce biological drugs (such as vaccines); and to safety test batches of these drugs as they were produced. …
Behavioral Research On Captive Animals: Scientific And Ethical Concerns, Kimberley Jayne, Adam See
Behavioral Research On Captive Animals: Scientific And Ethical Concerns, Kimberley Jayne, Adam See
Morality and Ethics of Animal Experimentation Collection
The first half of this chapter focuses exclusively on animals that are used in laboratory behavioral research to model wild behavior, what is typically involved, problems associated with this practice, and how behavioral research has revealed scientific problems in the animal model. The second half of this chapter then addresses the ethical questions of whether scientific curiosity of animal behavior in general provides any justification for carrying out this research in this first place, with specific focus on non-human primates (nhps).
When Is An Alternative Not An Alternative? Supporting Progress For Absolute Replacement Of Animals In Science, Craig Redmond
When Is An Alternative Not An Alternative? Supporting Progress For Absolute Replacement Of Animals In Science, Craig Redmond
Humane Science Movement Collection
This chapter addresses some of the areas in which animals are still used within “alternatives”-based research and calls on animal welfare and in vitro organizations to lead the debate and encourage absolute replacement of animal use in research. Without this, progress to end animal research will always remain limited, despite the paradigm shift seen in recent decades.
Research And Testing Without Animals: Where Are We Now And Where Are We Heading?, Thomas Hartung
Research And Testing Without Animals: Where Are We Now And Where Are We Heading?, Thomas Hartung
Humane Science Movement Collection
Experiments involving non-human animals (hereinafter referred to as animals) were the predominant technology in the life sciences from the 1920s to the 1970s. Increasingly, animal-based procedures have been complemented and superseded by other approaches; yet, they still have an enormous reputation as an apparent definitive answer to many scientific and, especially, regulatory questions. They have been questioned first for ethical reasons: Can we justify making animals suffer for scientific inquiry? Simply said, people have different views on this question, but the general public views animal experimentation more and more critically. The animal research community has sought a compromise between those …
Ethics, Efficacy, And Decision-Making In Animal Research, Lawrence A. Hansen, Kori Ann Kosberg
Ethics, Efficacy, And Decision-Making In Animal Research, Lawrence A. Hansen, Kori Ann Kosberg
Morality and Ethics of Animal Experimentation Collection
Few would disagree with the ethical contention that if cruelty to animals is not wrong, then nothing is wrong. In fact, it is not only wrong, but in most states in the us, it is a crime, a felony no less. And yet, intentionally inflicting pain and suffering upon animals, which meets Webster’s definition of cruelty, is routinely countenanced when vivisection (from the Latin vivi, to be alive, and secare, to cut) is performed under license for biomedical research. Deciding to embrace, or reject, or limit animal research demands our best ethical judgment; and it is complicated by factual disputes …
Elevated Sensitivity To Tactile Stimuli In Stereotypic Horses, Sabrina Briefer Freymond, Déborah Bardou, Sandrine Beuret, Iris Bachmann, Klaus Zuberbühler, Elodie Briefer
Elevated Sensitivity To Tactile Stimuli In Stereotypic Horses, Sabrina Briefer Freymond, Déborah Bardou, Sandrine Beuret, Iris Bachmann, Klaus Zuberbühler, Elodie Briefer
Personality Collection
Although stereotypic behaviors are a common problem in captive animals, why certain individuals are more prone to develop them remains elusive. In horses, individuals show considerable differences in how they perceive and react to external events, suggesting that this may partially account for the emergence of stereotypies in this species. In this study, we focused on crib-biting, the most common stereotypy displayed by horses. We compared how established crib-biters (“CB” = 19) and normal controls (“C” = 18) differed in response to a standard “personality” assessment test battery, i.e., reactivity to humans, tactile sensitivity, social reactivity, locomotor activity, and curiosity …
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente
Ethical And Scientific Pitfalls Concerning Laboratory Research With Non-Human Primates, And Possible Solutions, Constança Carvalho, Augusta Gaspar, Andrew Knight, Luís Vicente
Morality and Ethics of Animal Experimentation Collection
Basic and applied laboratory research, whenever intrusive or invasive, presents substantial ethical challenges for ethical committees, be it with human beings or with non-human animals. In this paper we discuss the use of non-human primates (NHPs), mostly as animal models, in laboratory based research. We examine the two ethical frameworks that support current legislation and guidelines: deontology and utilitarianism. While human based research is regulated under deontological principles, guidelines for laboratory animal research rely on utilitarianism. We argue that the utilitarian framework is inadequate for this purpose: on the one hand, it is almost impossible to accurately predict the benefits …
Just Preservation, A. Treves, F. J. Santiago-Ávila, W. S. Lynn
Just Preservation, A. Treves, F. J. Santiago-Ávila, W. S. Lynn
Anthropogenics and Population Decline Collection
We are failing to protect the biosphere. Novel views of conservation, preservation, and sustainability are surfacing in the wake of consensus about our failures to prevent extinction or slow climate change. We argue that the interests and well-being of non-humans, youth, and future generations of both human and non-human beings (futurity) have too long been ignored in consensus-based, anthropocentric conservation. Consensus-based stakeholder-driven processes disadvantage those absent or without a voice and allow current adult humans and narrow, exploitative interests to dominate decisions about the use of nature over its preservation for futurity of all life. We propose that authentically non-anthropocentric …
Protecting Biodiversity In British Columbia: Recommendations For Developing Species At Risk Legislation, Alana R. Westwood, Sarah P. Otto, Arne Mooers, Chris Darimont, Karen E. Hodges, Chris Johnson, Brian M. Starzomski, Cole Burton, Kai M. A. Chan, Marco Festa-Bianchet, Shaun Fluker, Sumeet Gulati, Aerin L. Jacob, Dan Kraus, Tara G. Martin, Wendy J. Palen, John D. Reynolds, Jeannette Whitton
Protecting Biodiversity In British Columbia: Recommendations For Developing Species At Risk Legislation, Alana R. Westwood, Sarah P. Otto, Arne Mooers, Chris Darimont, Karen E. Hodges, Chris Johnson, Brian M. Starzomski, Cole Burton, Kai M. A. Chan, Marco Festa-Bianchet, Shaun Fluker, Sumeet Gulati, Aerin L. Jacob, Dan Kraus, Tara G. Martin, Wendy J. Palen, John D. Reynolds, Jeannette Whitton
Threatened and Endangered Animal Populations Collection
British Columbia has the greatest biological diversity of any province or territory in Canada. Yet increasing numbers of species in British Columbia are threatened with extinction. The current patchwork of provincial laws and regulations has not effectively prevented species declines. Recently, the Provincial Government has committed to enacting an endangered species law. Drawing upon our scientific and legal expertise, we offer recommendations for key features of endangered species legislation that build upon strengths and avoid weaknesses observed elsewhere. We recommend striking an independent Oversight Committee to provide recommendations about listing species, organize Recovery Teams, and monitor the efficacy of actions …
Perceptions Of On-Farm Emergency Slaughter For Dairy Cows In British Columbia, Katherine E. Koralesky, David Fraser
Perceptions Of On-Farm Emergency Slaughter For Dairy Cows In British Columbia, Katherine E. Koralesky, David Fraser
Slaughter and Slaughtering Practices Collection
Some jurisdictions permit on-farm emergency slaughter (OFES) as one end-of-life option for dairy cows and other animals that cannot be transported humanely but are deemed fit for human consumption. Anecdotal reports suggest that OFES is controversial among dairy industry professionals, but to date their perceptions of OFES have not been studied systematically. Twentyfive individual interviews and 3 focus groups with 40 dairy producers, veterinarians, and other professionals in British Columbia, Canada, revealed positive and negative perceptions of OFES influenced by (1) individual values, (2) the perceived operational legitimacy of OFES, and (3) concern over social responsibility and public perception of …
On Neglected Taxa: Protostomes And The Evolution Of Myelination, Michaella P. Andrade, Charles Morphy D. Santos
On Neglected Taxa: Protostomes And The Evolution Of Myelination, Michaella P. Andrade, Charles Morphy D. Santos
Animal Sentience
Understanding the evolution of nervous and sensory systems in animals is key to understanding the distribution of animal sentience. However, the use of model organisms – mostly vertebrates, and especially mammals – often biases comparative analyses. Sneddon et al. (2018a,b) point out that using nonhuman animals as models helps us better understand the multifaceted aspects of animal pain and sentience. Several concerns need to be considered in dealing with model organisms. Here we discuss how models that are unrepresentative phylogenetically influence hypotheses about the evolution of the myelination in animals. Greater effort is needed to escape “vertebrate-centrism” in evolutionary research.
Intelligence, Complexity, And Individuality In Sheep, Lori Marino, Debra Merskin
Intelligence, Complexity, And Individuality In Sheep, Lori Marino, Debra Merskin
Animal Sentience
Domestic sheep (Ovis aries) are among the earliest animals domesticated for human use. They are consumed worldwide as mutton, hogget, and lamb, kept as wool and milk producers, and used extensively in scientific research. The popular stereotype is that sheep are docile, passive, unintelligent, and timid, but a review of the research on their behavior, affect, cognition, and personality reveals that they are complex, individualistic, and social.
Sacrificial Lambs, Clive Phillips
Sacrificial Lambs, Clive Phillips
Animal Sentience
Sheep evolved from the mouflon as mountain animals, able to escape predation by leaping between rock ledges. Their defense was their agility. Humans brought them to the plains, where the agility was less useful, but their lack of aggression, speed or weaponry against predators made them a prime target to become one of man’s meat providers. A perfect animal in many ways, with extraordinary perceptive powers and some remarkable cognitive skills, they are often treated with complete disregard for their welfare. Yet sheep themselves won’t tell us this, for a sheep that alerted others to its weakness really would be …
Pulling The Wool From Our Eyes, Jennifer Vonk
Pulling The Wool From Our Eyes, Jennifer Vonk
Animal Sentience
Marino & Merskin review evidence of the complexity of sheep cognition, concluding that researchers ought to feel sheepish about misrepresenting ovine cognitive capacities. However, the failure to situate the data in critical context risks pulling the wool over readers’ eyes.
Is Knowing Enough To Change Human Attitudes And Actions?, Liv Baker
Is Knowing Enough To Change Human Attitudes And Actions?, Liv Baker
Animal Sentience
Marino & Merskin present evidence on key aspects of cognition, such as theory of mind, learning, emotional valence, and sociality, to make a convincing argument that sheep are due consideration as individual sentient beings. With this information, what will it take to produce a real, meaningful shift in our attitudes and actions towards other animals, including a species as disadvantaged as sheep? What else do we need to know?
Reflections On Sheep Rearing, Joyce D'Silva
Reflections On Sheep Rearing, Joyce D'Silva
Animal Sentience
Sheep rearing has an incredibly long history. Sometimes this alone can give credibility and status to a human practice. In the twenty-first century, it may be time to reassess our treatment of sheep and their place in nature. “Just because we’ve always done it” no longer has validity by itself. There are many other human practices which used to be accepted widely in certain societies and which we now may find abhorrent. With sheep intelligence now rightly regarded as an acceptable area of research within the academic community, it is a good time to reflect on our treatment of these …
Casting A Sheep’S Eye On Science, David M. Peña-Guzmán
Casting A Sheep’S Eye On Science, David M. Peña-Guzmán
Animal Sentience
Marino & Merskin review evidence that sheep are not just passive and reactive creatures. They have personalities that vary from individual to individual and endure over time. It follows that we must rethink what it means to study them scientifically.
Far More To Sheep Than Meets The Casual Eye, Bernard Rollin
Far More To Sheep Than Meets The Casual Eye, Bernard Rollin
Animal Sentience
Marino & Merskin’s survey of the cognitive and social capacities of sheep is an eye-opener about the individuality and emotionality of this most maligned of all farm animals. My own eyes had already been opened by an adopted orphaned lamb, so much more like a dog as a companion animal than the mindless robot I had been conditioned to expect. I am morally certain that Marino & Merskin’s survey will have a similar effect on readers open to changing their minds.
Smart Sheep Need More Protection, Michael L. Woodruff
Smart Sheep Need More Protection, Michael L. Woodruff
Animal Sentience
The target article unequivocally establishes that sheep are far more intelligent and cognitively sophisticated than is generally acknowledged. For this reason, the authors advocate for significantly more stringent regulation of agricultural and research practices when sheep are used. I briefly review the existing US regulations governing the use of sheep in research and discuss the extent to which they are applied to sheep. I then discuss weaknesses in the current regulations, concluding that they should be changed to mandate housing all research animals in environments that accommodate the psychosocial needs of each species.