Life Sciences Commons^™

A Study Of Critical Value Notification In The Outpatient Setting: The Relationship Between Physician Response And Patient Outcomes, Kristie Renee Finney

Theses and Dissertations

Critical values are laboratory values that represent a life-threatening condition for which there is a treatment available. Laboratories make immediate notifications to ordering providers when critical values are identified so that they may quickly act to initiate a treatment for their patient. The majority of laboratories apply the inpatient critical value list to the outpatient setting, although there are many differences between an acutely ill inpatient population and an ambulatory outpatient population. The goal of this study was to determine if providers responded to the critical values in the outpatient setting and to determine if there was a difference in …

Behavioral Responses Of Sub-Adult Atlantic Sturgeon (Acipenser Oxyrinchus Oxyrinchus) To Electromagnetic And Magnetic Fields Under Laboratory Conditions, Andrew Mcintyre Iii

Theses and Dissertations

Electromagnetic fields (EMF) produced by high voltage (HV), submarine transmission cables leading from offshore wind energy generation facilities could affect foraging or migratory behaviors of electro-receptive fishes, including endangered Atlantic Sturgeon. However, no published studies have quantitatively evaluated the possible behavioral effects of EMF exposure on sturgeon during residence in coastal waters. This study evaluated behavioral responses by sub-adult Atlantic Sturgeon to electromagnetic and magnetic fields under controlled laboratory conditions. Fabricated EMF generators were used to emulate a range of field EMF conditions that migratory fishes could encounter in proximity to submarine HV sources. Sensor arrays and digital video recorders …

Mast Cell Activation By Diverse Stimuli Can Be Suppressed By Steroid Therapy And Targeting The Fyn-Stat5b Cascade, Anuya Paranjape

Theses and Dissertations

Mast cells are critical effectors of allergic disease that can be activated by numerous stimuli. We have examined mast cell control by the inflammatory cytokine, IL-33, as well as IgG. In the first study reported here, we found that the synthetic glucocorticoid, dexamethasone, potently and rapidly suppressed IL-33-induced cytokine production from murine bone marrow–derived and peritoneal mast cells, as well as human mast cells. Dexamethasone also antagonized IL-33-mediated enhancement of IgE-induced cytokine production and migration. Although dexamethasone had no effect on IL-33-induced phosphorylation of MAP kinases or NFκB p65 subunit, it antagonized AP-1 and NFκB-mediated transcriptional activity. Finally, intraperitoneal administration …

Nitrosative Stress Sensing In Porphyromonas Gingivalis: Structure And Function Of The Heme Binding Transcriptional Regulator Hcpr, Benjamin R. Belvin

Theses and Dissertations

Porphyromonas gingivalis, a Gram negative anaerobe implicated in the progression of periodontal disease, is capable of surviving and causing infection despite high levels of reactive nitrogen species found in the oral cavity due to its efficient nitrosative stress response. HcpR is an important sensor-regulator that plays a vital step in the initiation of the nitrosative stress response in many Gram negative anaerobic bacteria. We employ a combination of X-ray crystallography, SAXS, resonance Raman spectroscopy, UV-Vis spectroscopy, and molecular biology techniques to better understand this key regulator. Knockout of the hcpR gene in W83 P. gingivalis results in the inability of …

The Effect Of Chronic Nutrient Addition From Wastewater On Forest Ecosystems At The Rice Rivers Center, Michael Beck

Theses and Dissertations

Wastewater application to land can be a useful tool for mitigating impacts of nutrient enrichment on aquatic systems. A land application treatment system at VCU’s Rice Rivers Center in Charles City County, VA provided an opportunity to study the impact of wastewater addition on the biogeochemistry of forests representative of the Mid-Atlantic Coastal Plain. Nutrient concentrations in throughfall and leachate were measured at Treatment and Control sites to assess differences in nutrient deposition and retention. Wastewater amended plots from the Walter L. Rice education building received 20-fold (N) and 6-fold (P) higher inputs relative to Control plots and plots located …

Patient-Specific Inference Of Average Glucose From Glycated Hemoglobin, Roy Malka, David M. Nathan, John M. Higgins

Biology and Medicine Through Mathematics Conference

No abstract provided.

Symmetries Constrain Dynamics In A Family Of Balanced Neural Networks, Andrea Barreiro, J Nathan Kutz, Eli Shlizerman

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Multi-Level Model Of Synergistic T Cell Activation, Anna Konstorum, Anthony Vella, Reinhard C. Laubenbacher

Biology and Medicine Through Mathematics Conference

No abstract provided.

Anticipating Elimination Of Mosquito-Borne Diseases, Suzanne M. O'Regan, Jonathan Lillie, John M. Drake

Biology and Medicine Through Mathematics Conference

No abstract provided.

The Influence Of Temperature Variation On Dengue Fever: A Model-Based Investigation, Michael A. Robert, Paula D. Weber, Rebecca C. Christofferson, Christopher N. Mores, Helen J. Wearing

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Models Of Biofilm For Antimicrobial Persistence, Jia Zhao

Biology and Medicine Through Mathematics Conference

No abstract provided.

Toward Adaptive Control Of Acute Inflammation, Judy D. Day, Seddik M. Djouadi, Ouassim Bara, Gregory L. Zitelli

Biology and Medicine Through Mathematics Conference

No abstract provided.

Homeolog Specific Expression Bias, Ronald D. Smith

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Endotoxin-Induced Inflammation In Young Men, Renee Brady

Biology and Medicine Through Mathematics Conference

No abstract provided.

Dynamics Of Two Pathogens In A Single Tick Population, Alexis White

Biology and Medicine Through Mathematics Conference

No abstract provided.

Hill's Diagrammatic Method And Reduced Graph Powers, Gregory D. Smith, Richard Hammack

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modelling The Polarization, Migration And Neuromast Deposition In The Zebrafish Posterior Lateral Line System, Hildur Knutsdottir

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Models Of Hiv And Hpv Coinfection, Samantha Erwin, Meghna Verma, Vida Abedi, Raquel Hontecillas-Magarzo, Stefan Hoops, Josep Bassaganya-Riera, Stanca M. Ciupe

Biology and Medicine Through Mathematics Conference

No abstract provided.

Growth Dynamics For Pomacea Maculata, Lihong Zhao, Karyn L. Sutton, Jacoby Carter

Biology and Medicine Through Mathematics Conference

No abstract provided.

Spatial Patterning In The York River Tidal Marshes Through The Interaction Of Cordgrass, Mussels And Sediment, Sofya Zaytseva, Leah Shaw, Rom Lipcius, Junping Shi

Biology and Medicine Through Mathematics Conference

No abstract provided.

Investigations Of The Effects Of Different Ventilation Structures On Physiologically Based Pharmacokinetic Modeling (Pbpk) Simulations, Karen A. Yokley

Biology and Medicine Through Mathematics Conference

No abstract provided.

Explicitly Separating Growth And Motility In A Glioblastoma Tumor Model, Tracy Stepien, Erica Rutter, Meng Fan, Yang Kuang

Biology and Medicine Through Mathematics Conference

No abstract provided.

Needle In The Haystack: Combining Intravital Imaging And Mathematical Modeling To Understand How Vaccine-Induced T Cells Find Malaria-Infected Cells In Murine Livers, Vitaly V. Ganusov, Ian Cockburn, Reka Kelemen

Biology and Medicine Through Mathematics Conference

No abstract provided.

Force Generation And Contraction Of Random Actomyosin Bundles., Dietmar B. Oelz

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling Tracheal Occlusion In The Embryonic Lung, Uduak George

Biology and Medicine Through Mathematics Conference

No abstract provided.

Movement And Dynamics Of Norway Rats In An Urban Landscape, Rosalyn Rael, Caz Taylor

Biology and Medicine Through Mathematics Conference

No abstract provided.

A Theoretical Model Of The Increase In Venous Oxygen Saturation Levels In Advanced Glaucoma Patients, Julia C. Arciero

Biology and Medicine Through Mathematics Conference

No abstract provided.

Wilson-Cowan Coupled Dynamics In A Model Of The Cortico-Striato-Thalamo-Cortical Circuit, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Grunt Variation In The Oyster Toadfish Opsanus Tau: Effect Of Size And Sex, Michael L. Fine, Tyler D. Waybright

Biology Publications

As in insects, frogs and birds, vocal activity in fishes tends to be more developed in males than in females, and sonic swimbladder muscles may be sexually dimorphic, i.e., either larger in males or present only in males. Male oyster toadfish Opsanus tau L produce a long duration, tonal boatwhistle advertisement call, and both sexes grunt, a short duration more pulsatile agonistic call. Sonic muscles are present in both sexes but larger in males. We tested the hypothesis that males would call more than females by inducing grunts in toadfish of various sizes held in a net and determined incidence …

Planar Cell Polarity Genes Frizzled3a, Vangl2, And Scribble Are Required For Spinal Commissural Axon Guidance, Simon D. Sun, Ashley M. Purdy, Gregory S. Walsh

Biology Publications

Background

A fundamental feature of early nervous system development is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. Spinal commissural neurons are an attractive model to investigate the multiple guidance cues that control growth cone navigation both pre- and post-midline crossing, as well as along both the dorsal–ventral (D–V) and anterior–posterior (A–P) axes. Accumulating evidence suggests that guidance of spinal commissural axons along the A–P axis is dependent on components of the planar cell polarity (PCP) signaling pathway. In the zebrafish, the earliest born spinal commissural neuron to navigate the midline …