Life Sciences Commons^™

Time-Of-Day And Chronotype Dependent Effects Of Exercise On Migraine Load In People With Chronic Migraines: A Cross-Over Randomized Clinical Trial, Elias M. Malek

UNLV Theses, Dissertations, Professional Papers, and Capstones

Migraines are the most common cause of chronic pain. Effective, non-pharmacological strategies to reduce migraine load are needed. Exercise is an effective strategy, but it is unclear how exercise timing and temporal preference (chronotype) factors modulate the laudatory effects of exercise. Purpose: Determine the effects of; 1) time-of-day of exercise, and 2) exercise synchrony with one’s chronotype, on migraine load. Methods: Participants were 13 sedentary individuals with 8+ migraines/month (age = 30 ± 11 yrs, 167 ± 6 cm, 86 ± 28 kg). Participants were categorized into morning-/evening-types based on the Morning/Eveningness Questionnaire and instructed to complete 1 month of …

Is Dietary Teaching Via Telehealth Effective In Lowering Hgba1c In Adult Patients With Prediabetes Or Type 2 Diabetes?, Mia Mccallum-Crawford

UNLV Theses, Dissertations, Professional Papers, and Capstones

Prediabetes and Type 2 diabetes mellitus (T2DM) are two common conditions diagnosed in the primary care setting. Both conditions benefit from a healthy lifestyle, managing blood sugar levels, and getting diabetes self-management education and support (DSMES). Within the past two decades, the healthcare community in the US has witnessed a substantial rise in diabetes among adults. Overall, the self-management of diabetes continues to worsen nationally. The purpose of this project is to improve patients’ self-management of both Prediabetes and T2DM through nutrition and show how nutritional counseling via telehealth provided by a nurse practitioner can improve HgbA1C values over 3 …

Improving Self-Efficacy And Knowledge While Reducing Anxiety In High-Risk Breast Cancer Patients Through Standardized Education, Shelley Miles

UNLV Theses, Dissertations, Professional Papers, and Capstones

Breast cancer is the leading cause of death of women in the United States. Patients at high risk for developing cancer are more easily identified in today’s world. Early identification might be due to strong family history or genetic mutations, such as BRCA1 or BRCA2. Screening and risk reduction guidelines have been developed over recent years for these patients. Adherence to these guidelines continues to be a problem. The factors stemming from this problem include lack of knowledge about being high-risk, understanding the guidelines, and anxiety and depression about the perceived risk of developing breast cancer. These factors can cause …

Increasing Human Papillomavirus Vaccination Intent And Knowledge Through An Educational Intervention, Angelica E. Musumeci

UNLV Theses, Dissertations, Professional Papers, and Capstones

Human papillomavirus (HPV) is a widely discussed topic in healthcare as it affects patients of all genders and ages who partake in sexual activity. The most significant concern it poses to those at risk is HPV-related cancer. Fortunately, a vaccination exists that targets specific strains associated with these types of cancers. Despite evidence-based research supporting the vaccination’s efficacy and safety, lack of awareness and misinformation diminish the receipt of the vaccine and drive the lack of protection. Thus, educational interventions directed at parents and caregivers, which aims to improve their understanding of HPV and the vaccination’s benefits, is key to …

Differential Expression Of Cellular And Exosomal Microrna Isolated From Oral Cancer Cells And Their Resistance To Chemotherapy, Brady Petersen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: MicroRNAs are abundant small non-coding RNA with a variety of known functions, including transcriptional activation and inhibition. Recent evidence has suggested that microRNA expression may influence the responsiveness of some cancers to chemotherapy, including liver and lung cancers. Some evidence has now suggested that specific microRNAs, such as miR-21, miR-155, and miR-375, may influence oral cancer responsiveness to chemotherapy – although much remains to be discovered.

Objective: Based upon the lack of evidence in this area, the primary objective of this study was to evaluate microRNA expression and responsiveness among oral cancers.

Methods: Five commercially available oral cancer cell …

Food Insecurity And Dietary Intake In Adults With Type 2 Diabetes In Southern Nevada, Elizabeth Torres

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background Type 2 diabetes is a major public health issue and food insecurity can affect diabetes management. Food insecurity can contribute to disrupted dietary eating patterns and decreased consumptions of a variety of foods. The aim of this observational study was to determine the difference in dietary intake between food insecure and food secure individuals with type 2 diabetes, as well as by glycemic control. Methods In this cross-sectional study, 55 participants were recruited from an academic endocrinology clinic. Participants completed a 7-day food diary, a household food security questionnaire, and assessment of blood biomarkers (HbA1c). To determine the differences …

Describing Bacterial Mutagenic Hotspots And Signatures Along With The Factors That Drive Them, Carmen Vallin

UNLV Theses, Dissertations, Professional Papers, and Capstones

In my dissertation work, I investigated bacterial mutagenesis. I asked: where do mutations occur in the bacterial genome? What types of mutations occur? What factors promote or prevent mutations? And lastly, how do the answers to these questions change depending on the bacterial life cycle (When)? I used Bacillus subtilis, a Gram-positive bacterium belonging to the phylum Firmicutes, and Escherichia coli, a Gram-negative bacterium belonging to the phylum Proteobacteria, to answer these questions. B. subtilis and E. coli are model systems that have been used to gain insights into fundamental processes of mutations and evolution for nearly ~8 decades. Here, …

Diurnal Regulation Of Exercise-Induced Myocardial Signaling And Transcription, Charli Aguilar

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Exercise is well known for its many benefits on the body and most notably the heart. Recent emphasis, and significant resources, have been dedicated to elucidating the molecular mechanisms through which exercise exerts its pluripotent beneficial effects on health and the prevention of disease. A continuous evolution in this field has sought to modulate and optimize exercise in various ways to maximize the benefits. In recent years, a growing appreciation for the impact of circadian rhythms has gained traction and their influence on many essential biological functions have been integrated into exercise physiology (i.e. - chrono-exercise), as well as …

Attentional Focus And The Development Of Skilled Performance, Harjiv Singh

UNLV Theses, Dissertations, Professional Papers, and Capstones

A central question in the development of skilled movement is: how a performer should focus their attention while preparing for the execution of a motor skill? Considerable evidence has shown that directing attention towards an intended movement effect (i.e., external focus) results in performance benefits relative to focusing on body movements (i.e., internal focus). While most of the previous research has emphasized the effects of internal versus external foci, evidence also suggests that external foci located at greater distances from the body (distal foci) are more effective than external foci located in greater proximity to the body (proximal foci) and …

Quantification Of Organic Carbon Sequestered By Biogenic Iron Sulfide Minerals In Long-Term Anoxic Laboratory Incubations, Nader Nabeh, Cheyenne Brokaw, Aude Picard

Life Sciences Faculty Research

Organic carbon sequestration in sedimentary environments controls oxygen and carbon dioxide concentrations in the atmosphere. While minerals play an important role in the preservation of organic carbon, there is a lack of understanding about the formation and stability of organo-mineral interactions in anoxic environments, especially those involving authigenic iron sulfide minerals. In this study, we quantified organic carbon and nitrogen sequestered in biogenic iron sulfide minerals co-precipitated with sulfate-reducing bacteria (SRB) in freshwater and marine conditions in long-term laboratory experiments. The amounts of C and N associated with biogenic iron sulfide minerals increased with increasing cell biomass concentrations available in …

Hybrid Incompatibilities In Metrosideros, Jacyln Martinez

Undergraduate Research Symposium Podium Presentations

Prediction: Postzygotic reproductive isolating barriers, relating to hybrid incompatibilities are contributing to the speciation of Metrosideros

Recognition Memory For Auditory And Visual Objects, Sharica Lee, Alexa Salomon, Kevin Mohawk, Laura Werner

Undergraduate Research Symposium Posters

Visual object memory is superior to auditory object memory. Our past research showed that auditory memory was less sensitive to divide attention during study, which may be attributable to representational differences between auditory memory and visual memory.

In the present study, we attempted to equate auditory and visual memory representations in order to adequately investigate the impact of dividing attention on recognition memory.

Recognition memory is thought to rely on two distinct processes, recollection and familiarity. Recollection involves the retrieval of precise qualitative detail and is the most sensitive to dividing attention.

Infants' Intermodal Knowledge Of Gender Using Faces And Voices, Bijoux Cheun, Christina Saliba, Alexis Rice, Marian Espina

Undergraduate Research Symposium Posters

Infants begin to use intermodal knowledge to match male and female faces to the corresponding voice, in their first year of life.

Infants have more experience with female faces which should lead to greater intermodal knowledge of female faces.

Previous studies have found inconsistent results. This could be due to the type of stimuli used.

This study uses several pairs of static and dynamic faces to investigate how methodological differences may impact infants' performance.

Palm Oil And Exported Deforestation, Anja Marcusiu, Alexis Osorio

Undergraduate Research Symposium Posters

Palm oil is used in our everyday lives through: Beautify/hygiene products; Bioenergy; Food. Indonesia and Malaysia account for 85% of the world's palm oil production, making them the largest exporters. Because palm oil is a highly productive crop and is in high demand, how do companies integrate sustainability to limit deforestation and preserve biodiversity?

Identification Of Lipid Species: Potential Biomarkers For Early Detection Of Hepatocellular Carcinoma, Kit Yee Leung, Kaylee Freitas

Undergraduate Research Symposium Posters

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. HCC is associated with cirrhosis. Poor survival rate of HCC is due to diagnosis of HCC at late stage.

Powering A Sustainable Electric Vehicle Future, Harmony Ruth, Jordan Brickman

Undergraduate Research Symposium Posters

Electric vehicle sales account for roughly 20% of total sales world wide and are projected to be 80% by 2050. China's electric vehicle market holds a 13.3% market share. China exported 550,000 electric vehicles in 2021. China represents a 54% share of the world's coal consumption as of 2020. Why study China on this issue? China is a major player in the World Economy.

The Effectiveness Of Using Motor Imagery As An Alternative To Exercise For Improving Mental Health, Madelyn Colbert

Undergraduate Research Symposium Podium Presentations

Exercise shown to improve mental health in variety of health histories. MIT shown to improve physical health in a variety of conditions when tested alone. Mental health problems and SUD have high comorbidity rates. Exercise shown to be effective recovery therapy for SUD.

The Effect Of Covid-19 On The Low-Wage Workforce Nationwide, Katie Gilbertson

Undergraduate Research Symposium Podium Presentations

Key Takeaways: 1. Each low-wage occupation pays less than the mean hourly wage in their respective MSA. 2. Least amount of wage variance among MSAs in 2019. 3. In Las Vegas 2/3 of occupational wages increased, but employment dropped in 14/15 occupations. Leisure and hospitality occupations hardest hit and slowest to recover.

Forgetting In Item Recognition And Pattern Separation, Mateo Marquez, Rhiannon Soriano Smith

Undergraduate Research Symposium Posters

Forgetting is commonly defined as the inability to access information that was once successfully encoded and could be retrieved with a cue, but now leads to memory failure (Frankland et al. 2013).

Memory representations based in the hippocampus engage in pattern separation and are more prone to decay than interference (Sadeh & Pertrzov, 2020).

Extra-hippocampal representations are more prone to interference than decay (Hardt et al. 2013).

Pattern Separation refers to keeping memory representations distinct from one another.

Is there more decay in pattern separation and more interference in item recognition?

The Influence Of Unitization On Recognition Memory, Ting Tong, Amaya D. Bolling-Mcdevitt Hernandez, Audrey Kirsch, Alanna N. Osmanski

Undergraduate Research Symposium Posters

Previous research on recognition memory assumes that associative recognition relies on recollection, whereas item recognition relies on a combination of recollection and familiarity. Unitization refers to the encoding strategy where two separate items are perceived as a single coherent entity or object. Research has demonstrated that unitization can facilitate familiarity-based recognition by generating representations of the stimulus and integrating it into a unified whole. To investigate this issue, we examined the effect of unitization on memory for word-pairs through two types of tests:

Associative Recognition: judge whether word pairs occurred together

Item Recognition: judge whether single words are old or …

Peripheral Blood Cell Counts As Potential Biomarkers For Alzheimer's Disease: A Look At Polygenetic Risk Scores, Melika Cummings, Yimei Lu, Joan Manuel Cue, Neel Patel, Jenifer Do

Undergraduate Research Symposium Posters

Blood-based biomarkers for neurodegenerative illnesses such as Alzheimer's disease (AD) have been extensively researched. Alzheimer's disease (AD) is a progressive neurological illness whose progression has been ascribed to gene expression. However, the pathophysiology of these disorders and its relationship to other abnormalities remain unknown. AD has been connected to PBCs, which include erythrocytes, platelets, and leukocytes and have a complicated interaction with the brain system. The pathogenesis of PBCs has been related to a negative influence on established neurodegenerative illnesses such as Alzheimer's. Candidate gene association studies have become more common as progress in mapping the human genome has increased …

Microbial Contamination On Ambulance Surfaces: A Systematic Literature Review, Adam Obenza, Patricia Cruz, Mark Buttner, D. Woodard

Environmental & Global Health Faculty Research

Healthcare-associated infections (HAIs) are infections that patients acquire while receiving medical treatment in a healthcare facility. During ambulatory transport, the patient may be exposed to pathogens transmitted from emergency medical service (EMS) personnel or EMS surfaces. The aim of this study was to determine whether organisms commonly associated with HAIs have been detected on surfaces in the patient-care compartment of ambulances. Five electronic databases – PubMed, Scopus, Web of Science, Embase and Google Scholar were used to search for articles using inclusion and exclusion criteria following the PRISMA checklist. Inclusion criteria consisted of articles published in English, between 2009 and …

Phenotypic Disruption Of Cuticular Hydrocarbon Production In Hybrids Between Sympatric Species Of Hawaiian Picture-Wing Drosophila, Thomas J. Fezza, Matthew S. Siderhurst, Eric B. Jang, Elizabeth A. Stacy, Donald K. Price

Life Sciences Faculty Research

Interspecies hybrids can express phenotypic traits far outside the range of parental species. The atypical traits of hybrids provide insight into differences in the factors that regulate the expression of these traits in the parental species. In some cases, the unusual phenotypic traits of hybrids can lead to phenotypic dysfunction with hybrids experiencing reduced survival or reproduction. Cuticular hydrocarbons (CHCs) in insects are important phenotypic traits that serve several functions, including desiccation resistance and pheromones for mating. We used gas chromatography mass spectrometry to investigate the differences in CHC production between two closely related sympatric Hawaiian picture-wing Drosophila species, Drosophila …

Senior Hunger In The Mountain West, 2019, Ally M. Beckwith, Caitlin J. Saladino, William E. Brown Jr.

Health

This fact sheet highlights data on senior hunger in the Mountain West region in 2019 as originally reported in Feeding America’s The State of Senior Hunger annual series. This report focuses on the extent of food insecurity among seniors in the United States. Seniors are defined as those who are 60 years of age or older.

Sources Of Information That Introduced Exercise Science Students To Their Major, Erin Vanderbunt, Doug Brtek

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 3: Issue 1, Article 3, 2022. This study examined the most influential sources of information that first introduced exercise science undergraduate students to their current major and sought to determine if any differences existed between demographic variables. An electronic questionnaire ranking the level of influence of 27 potential sources of information was completed by 131 exercise science students at a regional, midwestern university. Personal experience with the major, health care professionals in the major, and friend or family member in the major were among the highest non-college related sources, while college introductory courses …

Not Only Severe Events: Moderate Dry Periods Impact The Hydraulic Functioning And Survival Of Planted Ponderosa Pine Seedlings, Carolyn R. Koehn, Matthew D. Petrie, Robert M. Hubbard

Life Sciences Faculty Research

Juvenile tree survival will increasingly shape the persistence of ponderosa pine forests in the western United States. In contrast to severe pulse disturbances that induce widespread adult and juvenile tree mortality, moderate periods of low rainfall and warm temperatures may reduce forest persistence by killing juvenile trees at the seedling stage. Intensification of these periods in a changing climate could therefore increasingly restrict both natural regeneration and artificial regeneration of planted seedlings. We conducted a controlled field experiment at a single site in the Front Range of Colorado, USA, to determine the responses and survival of 3 Colorado subpopulations of < 1 year old potted ponderosa pines to moderately dry conditions, variation in small rainfall events based on observed patterns, and shaded and unshaded microsite environments. Near surface soil moisture increased slightly following small rainfall events, but declined over the 45-day experimental period. Seedling transpiration and associated canopy cooling declined after ∼13 days, and further declines in transpiration and canopy cooling suggest that the majority of trees in lower rainfall treatments experienced hydraulic dysfunction between days ∼20–30. After 45 days, mortality across all subpopulations and treatments, inferred by relative water loss, exceeded 90–95%. Despite some uncertainty pertaining to the stress tolerance of nursery grown versus naturally germinated conifers, our results show that planted ponderosa pine seedlings < 1 year old are unlikely to survive moderate dry periods of 20+ days relying on small rainfall events. Although microsite conditions and soil moisture availability shaped tree hydraulic functioning early in the experiment (days 1–13), later functioning was shaped predominately by the legacy of rainfall treatments. Our results illustrate the importance of moderate dry events that occur consistently as part of seasonal variation in climate, and show how their intensification may constitute a sustained press that limits opportunities for natural and artificial regeneration.

The Effects Of Nuclear Factor Erythroid 2 (Nfe2)-Related Factor 2 (Nrf2) Activation In Preclinical Models Of Peripheral Neuropathic Pain, Paramita Basu, Dayna L. Averitt, Camelia Maier, Arpita Basu

Kinesiology and Nutrition Sciences Faculty Research

Oxidative stress, resulting from an imbalance between the formation of damaging free radicals and availability of protective antioxidants, can contribute to peripheral neuropathic pain conditions. Reactive oxygen and nitrogen species, as well as products of the mitochondrial metabolism such as superoxide anions, hydrogen peroxide, and hydroxyl radicals, are common free radicals. Nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) is a transcription factor encoded by the NFE2L2 gene and is a member of the cap ‘n’ collar subfamily of basic region leucine zipper transcription factors. Under normal physiological conditions, Nrf2 remains bound to Kelch-like ECH-associated protein 1 in the cytoplasm …

The Antarctic Weddell Seal Genome Reveals Evidence Of Selection On Cardiovascular Phenotype And Lipid Handling, Hyun Ji Noh, Jason Turner-Maier, S. Anne Schulberg, Michael L. Fitzgerald, Jeremy Johnson, Kaitlin N. Allen, Luis A. Huckstadt, Annabelle J. Batten, Jessica Alfoldi, Daniel P. Costa, Elinor K. Karlsson, Warren M. Zapol, Emmanuel S. Buys, Kerstin Lindbald-Toh, Allyson G. Hindle

Life Sciences Faculty Research

The Weddell seal (Leptonychotes weddellii) thrives in its extreme Antarctic environment. We generated the Weddell seal genome assembly and a high-quality annotation to investigate genome-wide evolutionary pressures that underlie its phenotype and to study genes implicated in hypoxia tolerance and a lipid-based metabolism. Genome-wide analyses included gene family expansion/contraction, positive selection, and diverged sequence (acceleration) compared to other placental mammals, identifying selection in coding and non-coding sequence in five pathways that may shape cardiovascular phenotype. Lipid metabolism as well as hypoxia genes contained more accelerated regions in the Weddell seal compared to genomic background. Top-significant genes were SUMO2 and EP300; …

Angular Momentum In Skilled Kicking Pullover Performed By Elementary School Children, Yutaka Shimizu, Saburo Nishimura, Shoichi Matsushita

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 3: Issue 1, Article 2, 2022. This study aimed to clarify the differences in body positions and the role of the swing leg, support leg, and head-arm-trunk segment in generating and maintaining angular momentum of the whole body about a horizontal bar as well as how to improve the skill level of successful kicking pullover attempts. Two-dimensional kinematic parameters of successful kicking pullover attempts and body composition indices of 26 fifth-grade elementary school children were collected. Their techniques were classified into excellent and good groups based on the subjective evaluation of three evaluators. …

Velocity-Based Training: Current Concepts And Future Directions, Toby Brooks, Wil Fleming, Larry Munger, Katie Munger

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology 3(1): Article 1, 2022. Velocity-based training (VBT) is a current approach to resistance training that relies on measured bar, implement, and/or athlete speed to formulate and adjust training for both long-term programming and daily training sessions. Relying on a number of available tools of varying levels of accuracy, VBT can help the strength and conditioning specialist and/or the rehabilitation professional to not only better predict strength and power over time, but also to adjust training loads in order to maximize training response in a given session. While the appeal and price points of available …