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Full-Text Articles in Life Sciences

Balance Recovery Response In Community-Dwelling Adults With Unilateral Transtibial Amputation And The Potential Benefits Of A Weight-Shifting Balance Training Intervention, Hui-Ting Shih Aug 2022

Balance Recovery Response In Community-Dwelling Adults With Unilateral Transtibial Amputation And The Potential Benefits Of A Weight-Shifting Balance Training Intervention, Hui-Ting Shih

UNLV Theses, Dissertations, Professional Papers, and Capstones

Previous studies have shown that individuals with various physical, sensory and neuromuscular impairments are at higher risks of falls. Individuals with unilateral transtibial amputation (UTTA) suffered from all these impairments, and tripping not surprisingly caused a considerable number of falls in this population. To study falls, researchers have to put participants in a well-protected environment and reproduce tripping fall scenarios. Furthermore, the perturbation delivery needs to be precise in terms of temporo-spatial timing. These features would ensure the quality of responses elicited and reproducibility of the results. Thus, in Chapter 2, we developed a treadmill-based perturbation delivery protocol and confirmed …


Investigating Conserved Mechanisms For Embryonic Eye Regrowth In Xenopus Laevis, Cindy Kha Aug 2022

Investigating Conserved Mechanisms For Embryonic Eye Regrowth In Xenopus Laevis, Cindy Kha

UNLV Theses, Dissertations, Professional Papers, and Capstones

Regeneration is a complex process to replace or restore tissue after damage. However, animals vary in their ability to regenerate tissue, and humans are limited in their abilities. Understanding how regeneration occurs in highly regenerative vertebrates, such as in Xenopus laevis frogs will lead to defining common regeneration mechanisms. In recent years, eye regeneration research in Xenopus laevis tadpoles provided new promising insight into the mechanisms necessary for repair of damaged eye tissue. Much progress has been made towards understanding the regenerative capability of the complex eye since Xenopus tadpoles can regenerate mature eye tissues, including: the optic nerve, retina, …


Strategic Plan For Genomic Competencies Into Undergraduate Nursing Curriculum, Myerann Royce M. Mangalino Aug 2022

Strategic Plan For Genomic Competencies Into Undergraduate Nursing Curriculum, Myerann Royce M. Mangalino

UNLV Theses, Dissertations, Professional Papers, and Capstones

Problem: As genomics research continues to grow in medicine and in popular culture, an educational gap in nursing is inevitable. Nurses must have a strong understanding of genetics and genomics to effectively integrate them into current practice.Objectives: The objective is to identify gaps in the current undergraduate curriculum and build threads that may be incorporated into the current curriculum to fill the identified gaps. Methods: The foundation of this project was the Essentials of Genetic and Genomic Nursing: Competencies, Curricula Guidelines, and Outcome Indicators, 2nd Edition (Consensus Panel on Genetic/Genomic Nursing Competencies, 2008). A strategic plan was created to increase …


Hyperspectral Image Analysis Of Food For Nutritional Intake, Shirin Nasr Esfahani Aug 2022

Hyperspectral Image Analysis Of Food For Nutritional Intake, Shirin Nasr Esfahani

UNLV Theses, Dissertations, Professional Papers, and Capstones

The primary object of this dissertation is to investigate the application of hyperspectral technology to accommodate for the growing demand in the automatic dietary assessment applications. Food intake is one of the main factors that contribute to human health. In other words, it is necessary to get information about the amount of nutrition and vitamins that a human body requires through a daily diet. Manual dietary assessments are time-consuming and are also not precise enough, especially when the information is used for the care and treatment of hospitalized patients. Moreover, the data must be analyzed by nutritional experts. Therefore, researchers …


Quantifying Road Bicycle Wheel Vibration, Kyle Petersen Aug 2022

Quantifying Road Bicycle Wheel Vibration, Kyle Petersen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Understanding factors that influence wheel vibration may have practical applications for cyclists and manufacturers. However, a reliable method to measure these vibrations and tools to interpret the data are needed. PURPOSE: To establish a methodology to measure vibration of the road bicycle wheel and to quantify measured vibrations resulting from changes velocity, tire pressure, and surface roughness. METHODS: A single participant cycled on stationary cycle rollers with different tire pressure, speed, and surface roughness conditions. An accelerometer was mounted to rim of the front wheel. Data were analyzed in the frequency domain following a Fourier Transformation. Data were reduced by …


Effect Of Metronome, Hospital Mattress, And Step Stool Usage On Chest Compression Rate And Depth During Cardiopulmonary Resuscitation (Cpr): A Collection Of Systematic Reviews And Meta-Analyses, Lee A. Doernte Aug 2022

Effect Of Metronome, Hospital Mattress, And Step Stool Usage On Chest Compression Rate And Depth During Cardiopulmonary Resuscitation (Cpr): A Collection Of Systematic Reviews And Meta-Analyses, Lee A. Doernte

UNLV Theses, Dissertations, Professional Papers, and Capstones

We conducted a systematic review and meta-analysis to evaluate the effects of: (1) a metronome, (2) a hospital mattress, and (3) a step stool on chest compression rate and chest compression depth during cardiopulmonary resuscitation (CPR). These studies comply with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist for searches and reporting systematic reviews. We utilized the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) to categorize the certainty of evidence.The first analysis focused on metronome usage while performing CPR. Our methods for this study were to conduct literature searches for studies comparing metronome usage to a …


Cognitive Testing For Sport Concussion: The Immediate Post-Concussion Assessment And Cognitive Testing (Impact), Julia E. Maietta Aug 2022

Cognitive Testing For Sport Concussion: The Immediate Post-Concussion Assessment And Cognitive Testing (Impact), Julia E. Maietta

UNLV Theses, Dissertations, Professional Papers, and Capstones

Sport concussion is among the most common injuries for an athlete to experience during sport participation. Because of the complex pathophysiological process that affects the brain during and after concussion, symptoms can be heterogeneous in presence and severity. Although most acute symptoms (e.g., headache, slowed processing speed, loss of consciousness, irritability, depression, anxiety) resolve within seven to 10 days for most athletes, there is evidence that higher initial symptom burden and other genetically based differences can lead to longer symptom duration and complicated recovery post-concussion. Because structural changes that commonly occur as a result of concussion (e.g., diffuse axonal injury) …


Compositional And Metabolic Responses Of Autotrophic Microbial Community To Salinity In Lacustrine Environments, Yun Fang, Jun Liu, Jian Yang, Geng Wu, Zhengshuang Hua, Hailiang Dong, Brian P. Hedlund, Brett J. Baker, Hongchen Jiang Jul 2022

Compositional And Metabolic Responses Of Autotrophic Microbial Community To Salinity In Lacustrine Environments, Yun Fang, Jun Liu, Jian Yang, Geng Wu, Zhengshuang Hua, Hailiang Dong, Brian P. Hedlund, Brett J. Baker, Hongchen Jiang

Life Sciences Faculty Research

The compositional and physiological responses of autotrophic microbiotas to salinity in lakes remain unclear. In this study, the community composition and carbon fixation pathways of autotrophic microorganisms in lacustrine sediments with a salinity gradient (82.6 g/L to 0.54 g/L) were investigated by using metagenomic analysis. A total of 117 metagenome-assembled genomes (MAGs) with carbon fixation potentially belonging to 20 phyla were obtained. The abundance of these potential autotrophs increased significantly with decreasing salinity, and the variation of sediment autotrophic microbial communities was mainly affected by salinity, pH, and total organic carbon. Notably, along the decreasing salinity gradient, the dominant lineage …


Incomplete Denitrification Phenotypes In Diverse Thermus Species From Diverse Geothermal Spring Sediments And Adjacent Soils In Southwest China, Chrisabelle C. Mefferd, Enmin Zhou, Cale O. Seymour, Noel A. Bernardo, Shreya Srivastava, Amanda J. Bengtson, Jian-Yu Jiao, Hailiang Dong, Wen-Jun Li, Brian P. Hedlund Jul 2022

Incomplete Denitrification Phenotypes In Diverse Thermus Species From Diverse Geothermal Spring Sediments And Adjacent Soils In Southwest China, Chrisabelle C. Mefferd, Enmin Zhou, Cale O. Seymour, Noel A. Bernardo, Shreya Srivastava, Amanda J. Bengtson, Jian-Yu Jiao, Hailiang Dong, Wen-Jun Li, Brian P. Hedlund

Life Sciences Faculty Research

A few members of the bacterial genus Thermus have been shown to be incomplete denitrifiers, terminating with nitrite (NO2−) or nitrous oxide (N2O). However, the denitrification abilities of the genus as a whole remain poorly characterized. Here, we describe diverse denitrification phenotypes and genotypes of a collection of 24 strains representing ten species, all isolated from a variety of geothermal systems in China. Confirmed terminal products of nitrate reduction were nitrite or N2O, while nitric oxide (NO) was inferred as the terminal product in some strains. Most strains produced N2O; complete denitrification was not observed. Denitrification phenotypes were …


The Effect Of Natural Disturbances On Forest Biodiversity: An Ecological Synthesis, Mari-Liis Viljur, Scott R. Abella, Martin Adamek, Janderson Batista Rodrigues Alencar, Nicholas A. Barber, Burkhard Beudert, Brahim Chergui, Chang-Yong Choi, Daniel F. R. Cleary, Thomas Seth Davis, Yanus A. Dechnik-Vazquez, William M. Downing, Andrés Fuentes-Ramirez, Kamal J. K. Gandhi, Catherine Gehring, Kostadin B. Georgiev, Mark Gimbutas, Konstantin B. Gongalsky, Anastasiya Y. Gorbunova, Cathryn H. Greenberg, Kristoffer Hylander, Erik S. Jules, Daniil I. Korobushkin, Kajar Köster, Valerie Kurth, Joseph Drew Lanham, Maria Lazarina, Alexandro B. Leverkus, David Lindenmayer, Daniel Magnabosco Marra, Pablo Martín-Pinto, Jorge A. Meave, Marco Moretti, Hyun-Young Nam, Martin K. Obrist, Theodora Petanidou, Pere Pons, Simon G. Potts, Irina B. Rapoport, Paul R. Rhoades, Clark Richter, Ruslan A. Saifutdinov, Nathan J. Sanders, Xavier Santos, Zachary Steel, Julia Tavella, Clara Wendenburg, Beat Wermelinger, Andrey S. Zaitsev, Simon Thorn Jul 2022

The Effect Of Natural Disturbances On Forest Biodiversity: An Ecological Synthesis, Mari-Liis Viljur, Scott R. Abella, Martin Adamek, Janderson Batista Rodrigues Alencar, Nicholas A. Barber, Burkhard Beudert, Brahim Chergui, Chang-Yong Choi, Daniel F. R. Cleary, Thomas Seth Davis, Yanus A. Dechnik-Vazquez, William M. Downing, Andrés Fuentes-Ramirez, Kamal J. K. Gandhi, Catherine Gehring, Kostadin B. Georgiev, Mark Gimbutas, Konstantin B. Gongalsky, Anastasiya Y. Gorbunova, Cathryn H. Greenberg, Kristoffer Hylander, Erik S. Jules, Daniil I. Korobushkin, Kajar Köster, Valerie Kurth, Joseph Drew Lanham, Maria Lazarina, Alexandro B. Leverkus, David Lindenmayer, Daniel Magnabosco Marra, Pablo Martín-Pinto, Jorge A. Meave, Marco Moretti, Hyun-Young Nam, Martin K. Obrist, Theodora Petanidou, Pere Pons, Simon G. Potts, Irina B. Rapoport, Paul R. Rhoades, Clark Richter, Ruslan A. Saifutdinov, Nathan J. Sanders, Xavier Santos, Zachary Steel, Julia Tavella, Clara Wendenburg, Beat Wermelinger, Andrey S. Zaitsev, Simon Thorn

Life Sciences Faculty Research

Disturbances alter biodiversity via their specific characteristics, including severity and extent in the landscape, which act at different temporal and spatial scales. Biodiversity response to disturbance also depends on the community characteristics and habitat requirements of species. Untangling the mechanistic interplay of these factors has guided disturbance ecology for decades, generating mixed scientific evidence of biodiversity responses to disturbance. Understanding the impact of natural disturbances on biodiversity is increasingly important due to human-induced changes in natural disturbance regimes. In many areas, major natural forest disturbances, such as wildfires, windstorms, and insect outbreaks, are becoming more frequent, intense, severe, and widespread …


An Essential Role For Tungsten In The Ecology And Evolution Of A Previously Uncultivated Lineage Of Anaerobic, Thermophilic Archaea, Steffen Buessecker, Marike Palmer, Dengxun Lai, Joshua Dimapilis, Xavier Mayali, Damon Mosier, Jian-Yu Jiao, Daniel R. Colman, Lisa M. Keller, Emily St John, Michelle Miranda, Cristina Gonzalez, Lizett Gonzalez, Christian Sam, Christipher Villa, Madeline Zhuo, Nicholas Bodman, Fernando Robles, Eric S. Boyd, Alysia D. Cox, Brian St Clair, Zheng-Shuang Hua, Wen-Jun Li, Anna-Louise Reysenbach, Matthew B. Stott, Peter K. Weber, Jennifer Pett-Ridge, Anne E. Dekas, Brian P. Hedlund, Jeremy A. Dodsworth Jun 2022

An Essential Role For Tungsten In The Ecology And Evolution Of A Previously Uncultivated Lineage Of Anaerobic, Thermophilic Archaea, Steffen Buessecker, Marike Palmer, Dengxun Lai, Joshua Dimapilis, Xavier Mayali, Damon Mosier, Jian-Yu Jiao, Daniel R. Colman, Lisa M. Keller, Emily St John, Michelle Miranda, Cristina Gonzalez, Lizett Gonzalez, Christian Sam, Christipher Villa, Madeline Zhuo, Nicholas Bodman, Fernando Robles, Eric S. Boyd, Alysia D. Cox, Brian St Clair, Zheng-Shuang Hua, Wen-Jun Li, Anna-Louise Reysenbach, Matthew B. Stott, Peter K. Weber, Jennifer Pett-Ridge, Anne E. Dekas, Brian P. Hedlund, Jeremy A. Dodsworth

Life Sciences Faculty Research

Trace metals have been an important ingredient for life throughout Earth’s history. Here, we describe the genome-guided cultivation of a member of the elusive archaeal lineage Caldarchaeales (syn. Aigarchaeota), Wolframiiraptor gerlachensis, and its growth dependence on tungsten. A metagenome-assembled genome (MAG) of W. gerlachensis encodes putative tungsten membrane transport systems, as well as pathways for anaerobic oxidation of sugars probably mediated by tungsten-dependent ferredoxin oxidoreductases that are expressed during growth. Catalyzed reporter deposition-fluorescence in-situ hybridization (CARD-FISH) and nanoscale secondary ion mass spectrometry (nanoSIMS) show that W. gerlachensis preferentially assimilates xylose. Phylogenetic analyses of 78 high-quality Wolframiiraptoraceae MAGs from terrestrial and …


Trends In Utilization Of Human Papillomavirus Vaccines And The Incidence Of Malignant Cervical Cancer In The U.S. Population: A Secondary Analysis, Myah Luna, Soumya Upadhyay Jun 2022

Trends In Utilization Of Human Papillomavirus Vaccines And The Incidence Of Malignant Cervical Cancer In The U.S. Population: A Secondary Analysis, Myah Luna, Soumya Upadhyay

Healthcare Administration and Policy Faculty Research

Background: Human papillomavirus (HPV) is a sexually transmitted infection, and HPV types 16 and 18 are responsible for approximately 66% of all U.S. cervical cancer cases in women. The quadrivalent HPV vaccine was licensed in mid-2006, and it was designed to target and protect against HPV types 6, 11, 16, and 18. The aim of this study is to examine the utilization rate of the HPV vaccine, and the trends and incidence rate of malignant cervical cancer across the United States. Methods: This study utilized data from Surveillance, Epidemiology, and End Results (SEER) and the National Immunization Survey's (NIS) teenage …


Brain Functional Topology Differs By Sex In Cognitively Normal Older Adults, Zhengshi Yang, Filippo Cieri, Jefferson W. Kinney, Jeffrey L. Cummings, Dietmar Cordes, Jessica Z K Caldwell Jun 2022

Brain Functional Topology Differs By Sex In Cognitively Normal Older Adults, Zhengshi Yang, Filippo Cieri, Jefferson W. Kinney, Jeffrey L. Cummings, Dietmar Cordes, Jessica Z K Caldwell

Brain Health Faculty Research

Introduction: Late onset Alzheimer’s disease (AD) is the most common form of dementia, in which almost 70% of patients are women. Hypothesis: We hypothesized that women show worse global FC metrics compared to men, and further hypothesized a sex-specific positive correlation between FC metrics and cognitive scores in women. Methods: We studied cognitively healthy individuals from the Alzheimer’s Disease Neuroimaging Initiative cohort, with resting-state functional Magnetic Resonance Imaging. Metrics derived from graph theoretical analysis and functional connectomics were used to assess the global/regional sex differences in terms of functional integration and segregation, considering the amyloid status and the contributions of …


Associations Of Dietary Antioxidants With Glycated Hemoglobin And Insulin Sensitivity In Adults With And Without Type 1 Diabetes, Arpita Basu, Amy C. Alman, Janet K. Snell-Bergeon Jun 2022

Associations Of Dietary Antioxidants With Glycated Hemoglobin And Insulin Sensitivity In Adults With And Without Type 1 Diabetes, Arpita Basu, Amy C. Alman, Janet K. Snell-Bergeon

Kinesiology and Nutrition Sciences Faculty Research

Type 1 diabetes (T1D) has been associated with increased risks of atherosclerotic cardiovascular disease, and poor glycemic control and oxidative stress play a major role in its pathology. There is a lack of data on the role of dietary antioxidant micronutrients, including vitamins and trace elements, in glycemic control in T1D. The aim of this study is to examine associations of dietary intakes of micronutrients with glycemic status. We report data from a cross-sectional analysis from the coronary artery calcification in type 1 diabetes (CACTI) study (n = 1257; T1D: n = 568; nondiabetic controls: n = 689) collected between …


Complete Genome Sequence Of Klebsiella Quasipneumoniae Subsp. Similipneumoniae Strain If3sw-P1, Isolated From The International Space Station, Natasha S. Sushenko, Nitin K. Singh, Daniel L. Vellone, Scott W. Tighe, Brian P. Hedlund, Kasthuri Venkateswaran, Duane P. Moser Jun 2022

Complete Genome Sequence Of Klebsiella Quasipneumoniae Subsp. Similipneumoniae Strain If3sw-P1, Isolated From The International Space Station, Natasha S. Sushenko, Nitin K. Singh, Daniel L. Vellone, Scott W. Tighe, Brian P. Hedlund, Kasthuri Venkateswaran, Duane P. Moser

Life Sciences Faculty Research

The 5.2-Mb circular genome of Klebsiella quasipneumoniae subsp. similipneumoniae strain IF3SW-P1, isolated from the International Space Station, was sequenced using Oxford Nanopore Technologies. The genome lacks a megaplasmid typical of hypervirulent and multidrug-resistant Klebsiella strains but does contain a chromosomally encoded OqxAB efflux pump associated with carbapenem resistance.


Is Body Composition Or Body Mass Index Associated With The Step Count Accuracy Of A Wearable Technology Device?, Jeffrey Montes, Richard D. Tandy, John C. Young, Szu-Ping Lee, James W. Navalta Jun 2022

Is Body Composition Or Body Mass Index Associated With The Step Count Accuracy Of A Wearable Technology Device?, Jeffrey Montes, Richard D. Tandy, John C. Young, Szu-Ping Lee, James W. Navalta

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 3: Issue 1, Article 5, 2022. A simple way to gauge daily physical activity levels is to use a wearable technology device to count the number of steps taken during the day. However, it is unknown whether these devices return accurate step counts for persons with different body fat percentages or body mass index scores. The purpose was to determine if there is a correlation between either body fat percentages and/or body mass index values and the percent error calculated between a manual step count and values recorded by a wearable technology device. …


Impacts Of Motor Developmental Delay On The Inter-Joint Coordination Using Kinematic Synergies Of Joint Angles During Infant Crawling, Li Zhang, Chun F. Deng, Yuan Liu, Lin Chen, Naong Xiao, Sheng J. Zhai, Wen S. Hou, Yu X. Chen, Xiao Y. Wu Jun 2022

Impacts Of Motor Developmental Delay On The Inter-Joint Coordination Using Kinematic Synergies Of Joint Angles During Infant Crawling, Li Zhang, Chun F. Deng, Yuan Liu, Lin Chen, Naong Xiao, Sheng J. Zhai, Wen S. Hou, Yu X. Chen, Xiao Y. Wu

Electrical & Computer Engineering Faculty Research

Motor developmental delay (MDD) usually affects the inter-joint coordination for limb movement. However, the mechanism between the abnormal inter-joint coordination and MDD is still unclear, which poses a challenge for clinical diagnosis and motor rehabilitation of MDD in infant’s early life. This study aimed to explore whether the joint activities of limbs during infant crawling are represented with kinematic synergies of joint angles, and evaluate the impacts of MDD on the inter-joint coordination using those synergies. 20 typically developing infants, 16 infants at risk of developmental delay, 11 infants at high risk of developmental delay and 13 infants with confirmed …


Diabetes-Related Outcomes Following Use Of Basal-Bolus Insulin Vs Premixed Insulin In A Va Population With Type 2 Diabetes: A Retrospective Chart Review., Ravisha Bai, Kavita Batra, Charmaine Yap, Kenneth Izuora Jun 2022

Diabetes-Related Outcomes Following Use Of Basal-Bolus Insulin Vs Premixed Insulin In A Va Population With Type 2 Diabetes: A Retrospective Chart Review., Ravisha Bai, Kavita Batra, Charmaine Yap, Kenneth Izuora

School of Medicine Faculty Presentations

No abstract provided.


It Is Time For A New Type Of Type To Facilitate Naming The Microbial World, M. Palmer, I. Sutcliffe, S. N. Venter, B. P. Hedlund Jun 2022

It Is Time For A New Type Of Type To Facilitate Naming The Microbial World, M. Palmer, I. Sutcliffe, S. N. Venter, B. P. Hedlund

Life Sciences Faculty Research

Since January 1, 2001, the only acceptable nomenclatural type for species under the International Code of Nomenclature of Prokaryotes (ICNP) has been pure cultures. Here, we argue that this requirement is discordant with the more inclusive nature of nomenclatural types accepted under other codes of nomenclature and posit that the unique rigidity of the ICNP has failed to serve the broad research community and has stifled progress. This case is based on the axiom that many archaea and bacteria are interdependent in nature and therefore difficult, if not impossible, to grow, preserve, and distribute as pure cultures. As such, a …


The Effects Of Compression Garments And Extrinsic Visual Feedback On Single-Leg Balance Control, You-Jou Hung May 2022

The Effects Of Compression Garments And Extrinsic Visual Feedback On Single-Leg Balance Control, You-Jou Hung

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 3: Issue 1, Article 4, 2022. Single-leg balance control is very important in injury prevention (such as reducing the chance of falls and ankle sprains) and sport performance. Although compression garments (CGs) have been used for various purposes, it is unclear if wearing CGs can improve single-leg balance in healthy individuals. The purpose of the study was to examine if wearing CGs (pants) could enhance single-leg balance, and to compare the impact of wearing CGs on single-leg balance between conditions with and without extrinsic visual feedback. Twenty-five healthy individuals (aged 20-30 years) participated …


Human Arhgef9 Intellectual Disability Syndrome Is Phenocopied By A Mutation That Disrupts Collybistin Binding To The Gabaa Receptor Α2 Subunit, Dustin J. Hines, April Contreras, Betsua Garcia, Jeffrey S. Barker, Austin J. Boren, Cristelle Moufawad El Achlar, Stephen J. Moss, Rochelle M. Hines May 2022

Human Arhgef9 Intellectual Disability Syndrome Is Phenocopied By A Mutation That Disrupts Collybistin Binding To The Gabaa Receptor Α2 Subunit, Dustin J. Hines, April Contreras, Betsua Garcia, Jeffrey S. Barker, Austin J. Boren, Cristelle Moufawad El Achlar, Stephen J. Moss, Rochelle M. Hines

Psychology Faculty Research

Enrichment of collybistin to parvalbumin positive clusters on the soma of pyramidal cells in mouse cortex. Collybistin (green) is strongly enriched at parvalbumin (red) clusters that surround the pyramidal cell soma. Collybistin remains enriched at the parvalbumin clusters on somas in the cortex of Gabra2-1 mice suggesting that collybistin is trafficked to these sites independent of interaction with the α2 subunit of GABAA receptors. For more information, please refer to the article by Hines et al. in this issue.


Direction Of Attentional Focus In Prosthetic Training: Current Practice And Potential For Improving Motor Learning In Individuals With Lower Limb Loss, Alexander Bonczyk, Maria Katrina Tillada Dimapilis, Sarah Partridge, Samantha Ruiz May 2022

Direction Of Attentional Focus In Prosthetic Training: Current Practice And Potential For Improving Motor Learning In Individuals With Lower Limb Loss, Alexander Bonczyk, Maria Katrina Tillada Dimapilis, Sarah Partridge, Samantha Ruiz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: Adopting an external focus of attention has been shown to benefit motor performance and learning. However, the potential of optimizing attentional focus for improving prosthetic motor skills in lower limb prosthesis (LLP) users has not been examined. In this study, we investigated the frequency and direction of attentional focus embedded in the verbal instructions in a clinical prosthetic training setting.

Methods: Twenty-one adult LLP users (8 female, 13 male; 85% at K3 level; mean age=50.5) were recruited from prosthetic clinics in the Southern Nevada region. Verbal interactions between LLP users and their prosthetists (mean experience=10 years, range=4-21 years) during …


Effects Of A Remote Exercise Intervention On Aerobic Endurance In Individuals With Down Syndrome, Andrew Murata, Elena Wolf, Jonathan Crimm, Benjamin Lee May 2022

Effects Of A Remote Exercise Intervention On Aerobic Endurance In Individuals With Down Syndrome, Andrew Murata, Elena Wolf, Jonathan Crimm, Benjamin Lee

UNLV Theses, Dissertations, Professional Papers, and Capstones

Purpose: Down syndrome (Ds) or Trisomy 21 is a common genetic birth condition, and those with Ds typically display decreased cardiorespiratory fitness compared to those without Ds, potentially leading to an increased risk for cardiovascular conditions and mortality. Low cardiorespiratory fitness is partially caused by low physical activity levels in this population. The COVID-19 pandemic caused community-based activity programs to shut down, as individuals with Ds are at increased risk for COVID-19 hospitalization and death. Thus, it was vital to explore alternatives of in-person exercise during the pandemic. The purpose of this study was to investigate the effects of a …


Predicting The Progression Of Diabetes Mellitus Using Dynamic Plantar Pressure Parameters, Mathew Sunil Varre May 2022

Predicting The Progression Of Diabetes Mellitus Using Dynamic Plantar Pressure Parameters, Mathew Sunil Varre

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Diabetic peripheral neuropathy is one of the common complications of type-2 diabetes mellitus (DM). Changes in the intrinsic plantar tissue coupled with repetitive mechanical loads and loss of sensation may lead to foot related complications (skin break down, ulcerations, and amputations) in persons with neuropathy if left untreated. The purpose of this dissertation was to stratify individuals with pre-diabetes, diabetes with and without neuropathy using dynamic plantar pressure parameters during walking, using machine learning algorithms.Methods: Plantar pressure data was collected from one hundred participants during walking with pressure measuring insoles fixed between the feet and thin socks. Simultaneously high-definition …


The Effects Of A Telehealth Exercise Intervention On Balance In Adults With Down Syndrome, Mark Barton, Kristina Guerrero, Andrew Martinez, Alexandria Umagat May 2022

The Effects Of A Telehealth Exercise Intervention On Balance In Adults With Down Syndrome, Mark Barton, Kristina Guerrero, Andrew Martinez, Alexandria Umagat

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: People with Down syndrome (Ds) often present with balance deficits, which compromise their safety during daily activity. While evidence shows that exercise can improve balance in the Ds population, it is unclear if a telehealth method will elicit similar benefits. We aimed to examine the effects of a virtual exercise program on balance in adults with Ds.

Methods: Twenty participants completed a 12-week telehealth exercise program based on the Mann Method. Balance testing took place before and after the intervention, which included: Timed Up and Go (TUG), Modified Clinical Test of Sensory Interaction in Balance (MCTSIB), Frailty and Injuries: …


Sight Deprivation And Metabolic Effects During The Ymca Bench Press Test, Kyle Cruz May 2022

Sight Deprivation And Metabolic Effects During The Ymca Bench Press Test, Kyle Cruz

UNLV Theses, Dissertations, Professional Papers, and Capstones

Several studies have investigated the effect of sensory deprivation, particularly sight. However, very few have demonstrated the impact of sight deprivation while exercising to cadence blindfolded. This study aimed to determine exercise performance during a common muscular endurance evaluation, the YMCA Bench Press Test (YBPT), while blindfolded compared to a sighted condition. Twenty-five healthy participants (11 male, 14 female, 168 ± 7.7cm, 68 ± 11.7kg, 23 ± 7.5% fat mass) were recruited from the University of Nevada, Las Vegas student populations and communities. After a YBPT familiarization session, participants completed testing in a counterbalanced order, following the same procedures. A …


The Effect Of Attachment Design And Aligner Material On The Efficiency Of Maxillary Canine Distalization In Premolar Extraction Cases, Najem Anbari May 2022

The Effect Of Attachment Design And Aligner Material On The Efficiency Of Maxillary Canine Distalization In Premolar Extraction Cases, Najem Anbari

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Clear Aligner Therapy (CAT) is regarded as a popular esthetic alternative to conventional orthodontic treatment with fixed labial appliances. The mechanism of action, force delivery and limitation of this treatment modality remain largely unknown despite its popularity, the high demand and the relatively long evolutionary track of clear aligners. There are only few studies that addressed the elements that influence the efficiency of clear aligners, namely, the attachment design and aligner materials. It is widely believed that clear aligners are not suitable for extraction cases due to their lack of control over the root movement.

Objectives: This in vitro …


Increasing Genetic Testing Rates To Improve Early Detection And Prevention Of Breast And Ovarian Cancer In Women, Makensey Beth Durrant May 2022

Increasing Genetic Testing Rates To Improve Early Detection And Prevention Of Breast And Ovarian Cancer In Women, Makensey Beth Durrant

UNLV Theses, Dissertations, Professional Papers, and Capstones

Screening rates for cancer related genetic mutations are low in the primary care setting, despite evidence-based guidelines recommending screening in all patients who meet criteria. Genetic mutations, such as the breast cancer susceptibility 1 and 2 (BRCA1/2) gene mutations, drastically increase breast and ovarian cancer risk in patients. The United States Preventive Services Task Force (USPSTF) and the National Comprehensive Cancer Network (NCCN) provide evidence-based guidelines on criteria for genetic testing in women at risk for breast and ovarian cancer related gene mutations. Primary care providers (PCPs), including advanced practice registered nurses (APRNs), are at the front lines of preventative …


The Effects Of Executive Function Between Anxiety And Math Achievement In Adolescents, Mckenzie Hall May 2022

The Effects Of Executive Function Between Anxiety And Math Achievement In Adolescents, Mckenzie Hall

UNLV Theses, Dissertations, Professional Papers, and Capstones

Anxiety in Children can develop into pervasive disorders in adulthood if not treated. Research shows dysfunctional Executive Function (EF) and anxiety are both shown to have a negative impact on math achievement in children and adolescents (Trezise & Reeve, 2018; Kalaycioglu, 2015; Owens, Stevenson, Hadwin & Norgate, 2012). Chung, Weyandt, and Swentosky (2014) found biological and neuropsychological support for EF as a unitary and multifaceted processor for regulating our emotional states as well as our daily procedures. Anderson’s (2002) model of Executive Control System (ECS) allows the factors of EF to be examined using a developmental approach towards EF processes. …


Investigation Of Swimming Physiology And Swimming Kinematics While Wearing Different Triathlon Wetsuit Styles At Submaximal Front Crawl Swimming In Recreational Population, Boram Lim May 2022

Investigation Of Swimming Physiology And Swimming Kinematics While Wearing Different Triathlon Wetsuit Styles At Submaximal Front Crawl Swimming In Recreational Population, Boram Lim

UNLV Theses, Dissertations, Professional Papers, and Capstones

Triathlon wetsuits are commonly used due to the potential benefits in swimming performance and thermoregulation. Triathletes may select different wetsuit styles depending on many factors such as temperature regulation, swimming technique, body type, and training purpose. However, there is a lack of empirical evidence for how different wetsuit styles affect physiological responses and swimming kinematics during submaximal swimming intensity. Therefore, this studyaimed to investigate the physiological responses and swimming kinematics during submaximal intensity front crawl swimming while wearing different wetsuit styles. Fourteen participants (n=6 male, n=8 female; all recreational triathletes or swimmers) completed a swimming graded exercise test (GXT) wearing …