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Articles 991 - 1020 of 10915
Full-Text Articles in Life Sciences
Evaluation Of Cone And Seed Quality Of Siberian Stone Pine (Pinus Sibirica Du Tour) For Plus-Tree Selection, Svetlana Velisevich, Alexander Popov
Evaluation Of Cone And Seed Quality Of Siberian Stone Pine (Pinus Sibirica Du Tour) For Plus-Tree Selection, Svetlana Velisevich, Alexander Popov
Turkish Journal of Agriculture and Forestry
Siberian stone pine (Pinus sibirica Du Tour) is a cone-bearing species with outstanding nutritious seeds, health-supporting properties, and nut oil. Currently, the main volume of pine nuts is harvested in natural forests, which causes damage to ecosystems. The best solution to this problem would be harvesting nuts on special pine nut plantations established on the basis of high-seeding clones. However, it is hampered by the low efficiency of the existing methods for assessing plus-tree productivity. This work focused on cone analysis in two sites used for plus-tree selection: a 42-year-old sparse forest plantation and a 186-224-year-old closed natural forest. The …
Phytophthora-Citrus Interactions And Management Strategies: A Review, Anas Fadli, Hamid Benyahia, Sajjad Hussain, Rashid Iqbal Khan, Muhammad Junaid Rao, Talaat Ahmed, Veronica Ancona, Muhammad Fasih Khalid
Phytophthora-Citrus Interactions And Management Strategies: A Review, Anas Fadli, Hamid Benyahia, Sajjad Hussain, Rashid Iqbal Khan, Muhammad Junaid Rao, Talaat Ahmed, Veronica Ancona, Muhammad Fasih Khalid
Turkish Journal of Agriculture and Forestry
Citrus production is declining worldwide due to several biotic and abiotic factors. The diseases caused by Phytophthora spp. present major economic risks since they are soil-borne and spread quickly if environmental conditions are favorable, or irrigation is poorly managed. Phytophthora species are present in all citrus-producing areas around the world causing significant losses in crop yield and affecting tree health. Bark infection, damping-off, root rot, gummosis, brown rot, and cortical root rot are among the typical symptoms caused by Phytophthora spp. The pathogenicity of Phytophthora spp. depends mainly on the specific interactions between the isolates and citrus cultivars. The use …
Plant Growth-Promoting Bacteria Improve Triticum Aestivum L. Growth And Photosynthetic Activity In Sulfonamide-Contaminated Soil, Ammara Saleem, Asma Zulfiqar, Soha A. Alamoudi, Mada F. Ashkan, Eman Alhomaidi
Plant Growth-Promoting Bacteria Improve Triticum Aestivum L. Growth And Photosynthetic Activity In Sulfonamide-Contaminated Soil, Ammara Saleem, Asma Zulfiqar, Soha A. Alamoudi, Mada F. Ashkan, Eman Alhomaidi
Turkish Journal of Agriculture and Forestry
Antibiotics are disseminated by grazing animals or their feces throughout agricultural areas. These antibiotics, as environmental pollutants, have a negative impact on plant growth and physiology. Sulfonamides are frequently used to protect livestock production, but they also have a considerable negative impact on plant growth and rhizospheric bacteria. Plants are sensitive to their surroundings, and they employ their internal biological systems to deal with the threats to their growth and development. Soil microbes, which are the most common inhabitants, have amazing metabolic capacities that enable them to overcome abiotic constraints. The effects of sulfonamide stress on wheat cultivar Chakwal-50 were …
Graphene Oxide: A Promising Material For The Germination Of Melon Seeds Under Salinity Stress, Haluk Çağlar Kaymak, Meli̇ke Sevi̇m, Önder Meti̇n
Graphene Oxide: A Promising Material For The Germination Of Melon Seeds Under Salinity Stress, Haluk Çağlar Kaymak, Meli̇ke Sevi̇m, Önder Meti̇n
Turkish Journal of Agriculture and Forestry
It is well-known that salinity is an important adverse environmental factor (abiotic stresses) that limits plant growth, development, and productivity all over the world. Herein, we report for the first time the use of graphene oxide (GO) as a promising material against the salinity stress using melon (Cucumis melo L.) seeds as the model crop. GO as a priming material possesses various advantages such as being highly water-soluble, nontoxic, producible on a large scale from graphite, and low-cost over the existing materials. In this study, we identified the effect of different GO doses (0, 0.25, 0.50, 0.75, and 1.0 mg/mL) …
Herbicide Resistance In Avena Sterilis Subsp Ludoviciana Populations From The Wheat Fields Of Turkey, Süleyman Gürdal Türkseven, Ahmet Uludağ, Mehmet Demi̇rci̇, Ahmet Tansel Seri̇m
Herbicide Resistance In Avena Sterilis Subsp Ludoviciana Populations From The Wheat Fields Of Turkey, Süleyman Gürdal Türkseven, Ahmet Uludağ, Mehmet Demi̇rci̇, Ahmet Tansel Seri̇m
Turkish Journal of Agriculture and Forestry
Avena sterilis L. subsp ludoviciana (Durieu) Gillet and Magne (AVELU) is among the most common and economically important grass weed species, especially in wheat fields of Turkey; therefore, the herbicides with the same mode of action (ACCase and ALS/AHAS inhibitors) are used to control have been successively applied without incessant by farmers. A study was conducted to find out the extent of wild oat problems throughout Turkey including herbicide resistance. This paper includes results of determining the herbicide resistance status of AVELU populations to ACCase and ALS inhibitors that are fenoxaprop (Fen), pinoxaden (Pin), tralkoxydim (Tra), mesosulfuron+iodosulfuron (MeI), and proxycarbazone+mesosulfuron …
Biochar Mitigates Salt Stress By Regulating Nutrient Uptake And Antioxidant Activity, Alleviating The Oxidative Stress And Abscisic Acid Content In Cabbage Seedlings, Melek Eki̇nci̇, Meti̇n Turan, Ertan Yildirim
Biochar Mitigates Salt Stress By Regulating Nutrient Uptake And Antioxidant Activity, Alleviating The Oxidative Stress And Abscisic Acid Content In Cabbage Seedlings, Melek Eki̇nci̇, Meti̇n Turan, Ertan Yildirim
Turkish Journal of Agriculture and Forestry
A pot experiment was conducted to investigate the growth, physiology, and biochemistry of cabbage seedlings in response to salinity stress with biochar. The study was conducted as factorial completely randomized design with two factors; salinity levels (0 and 150 mM NaCl) and biochar doses (weighed at the rate of 0%, 2.5%, and 5% by soil weight). Growth parameters such as stem diameter, leaf area, shoot fresh weight, root fresh weight, shoot dry weight, and root dry weight of cabbage seedlings treated with 150 mM NaCl were lower than the control. Biochar amendments improved the growth parameters of cabbage seedlings under …
Inter-Primer Binding Site (Ipbs) Retrotransposon Markers Provide Insights Into Thegenetic Diversity And Population Structure Of Carrots (Daucus, Apiaceae), Mehtap Yildiz, Carlos Arbizu
Inter-Primer Binding Site (Ipbs) Retrotransposon Markers Provide Insights Into Thegenetic Diversity And Population Structure Of Carrots (Daucus, Apiaceae), Mehtap Yildiz, Carlos Arbizu
Turkish Journal of Agriculture and Forestry
Studies of genetic diversity and population structure are essential as an initial step in conservation and breeding programs for modern crops. Carrot (Daucus spp.) is among the ten most important vegetables worldwide, however, its genetic structure and phylogenetic relationships are not totally deciphered. Here, we explored the utility of 21 inter-primer binding site (iPBS) retrotransposon markers to determine the genetic diversity and population structure of 38 accessions of Daucus and one accession of a related genus. The manual scoring revealed 309 bands based on their presence/absence. The dendrogram based on the UPGMA clustering algorithm and a principal coordinate analysis (PCoA) …
Study Of Anatomical And Acc (1-Aminocyclopropane-1-Carboxylate) During Flower Budabscission Indicate An Important Role Of Alternate Bearing, Muhammet Ali̇ Gündeşli̇, Sali̇h Kafkas, Şenay Karabiyik, Si̇nan Eti̇, Nesi̇be Ebru Kafkas
Study Of Anatomical And Acc (1-Aminocyclopropane-1-Carboxylate) During Flower Budabscission Indicate An Important Role Of Alternate Bearing, Muhammet Ali̇ Gündeşli̇, Sali̇h Kafkas, Şenay Karabiyik, Si̇nan Eti̇, Nesi̇be Ebru Kafkas
Turkish Journal of Agriculture and Forestry
This study investigates whether, and how, 1-aminocyclopropane-1-carboxylic acid (ACC) is concerned in flower bud abscission of pistachio (Pistacia vera L.). Abscission was studied about the activation of the abscission zone, located between shoot and flower bud, from Uzun pistachio cultivar where the abscission profiles and the scanning electron micrographs pictorial differences in the abscission program, under natural conditions of flower bud. ACC content was investigated in the flower bud abscission zone during growth and abscission using liquid chromatography coupled with electrospray tandem mass spectrometry (UPLC/ESI-MS/MS). Results showed that abscission layers were started at first 45 days after full blooming (DAFB) …
Comparative Study Of Phenolic Compounds In Olive Oils From Differentgeographic Regions, Şeyma Şi̇şi̇k Oğraş
Comparative Study Of Phenolic Compounds In Olive Oils From Differentgeographic Regions, Şeyma Şi̇şi̇k Oğraş
Turkish Journal of Agriculture and Forestry
In this study, the effect of cultivar, harvest year, and the geographic regions (Mediterranean, Aegean, Southeastern Anatolia, Marmara, and the Black Sea) on phenolic compounds of virgin olive oils were investigated. Tyrosol was the major phenolic compound in the Mediterranean, Southeastern, and Black Sea regions. Hydroxytyrosol showed the highest value (2.07 mg/kg) in the Southeastern Anatolia region and the lowest value (0.75 mg/kg) in the Marmara region. Among the phenolic acids, vanillic acid had an important place in phenolic compounds (p < 0.01). This phenolic acid gave higher values in the Marmara region compared to other regions. Flavonoids were determined as important groups of phenolic compounds in olive oils. The oils from the Southeastern Anatolia region separated from other oils with the highest levels of flavonoids such as quercetin, luteolin, and apigenin. All phenolic compounds, except transcinnamic acid and quercetin, increased in the second harvest year. Vanillic acid was the highest phenolic compound in the first year, in contrast, tyrosol had higher values than vanillic acid in the second year. Many phenolic compounds were affected by olive cultivar. Memecik has a higher content of tyrosol, vanillic acid, p-coumaric acid, ferulic acid, and quercetin in the Aegean region. However, this variety showed higher values for hydroxytyrosol, transcinnamic acid, luteolin, and apigenin in the Marmara region. Gemlik, Ayvalık, Çelebi, Domat and Memecik from Marmara regions had higher vanillic acid. Butko, Otur and Kızıl Satı showed higher tyrosol. Principal component analysis showed that phenolic compounds could play an important role in the separation of regions and cultivars.
Turkey's Largest Cinereous Vulture Population In A Recently Discovered Breeding Area Innorth-West Anatolia, Şafak Arslan, Ci̇hangi̇r Ki̇razli
Turkey's Largest Cinereous Vulture Population In A Recently Discovered Breeding Area Innorth-West Anatolia, Şafak Arslan, Ci̇hangi̇r Ki̇razli
Turkish Journal of Zoology
Studies regarding the cinereous vulture (Aegypius monachus), classified globally as near threatened, have recently accelerated in Turkey. Comprehensive studies particularly about the northwestern Anatolian population, have been conducted. Also, the genetic studies carried out, have revealed that the cinereous vulture population in Turkey is panmictic and that it has recently suffered a bottleneck. The main aim of this study conducted across the Köroğlu Mountains in Bolu was to determine the population size and the breeding success of the species. A total of 37 field surveys in 2018 and 2019 have revealed Turkey's largest breeding cinereous vulture colony and have detected …
Morphological And Molecular Characterization Of Banana Clones Growing In Turkey, Fi̇li̇z Baysal, Sezai̇ Erci̇sli̇
Morphological And Molecular Characterization Of Banana Clones Growing In Turkey, Fi̇li̇z Baysal, Sezai̇ Erci̇sli̇
Turkish Journal of Botany
This study was conducted to estimate genetic relationships among banana clones growing in Turkey via some morphological parameters and two molecular marker systems. In terms of yield parameters such as bunch weight, hand number, fruit weight, and total fruit number, Grand Nain (GN) clone came to the forefront with the highest values. It was followed by Azman (AZ), Dwarf Cavendish (DC), and Erdemli Yerli (EY) clones, respectively. To see the variation between clones more clearly, 24 RAPD (Random Amplified Polymorphic DNA) primers and 48 SRAP (Sequence Related Amplified Polymorphism) primer combinations were used in molecular analysis. The total number of …
An Ethnobotanical Review On Medicinal Plants Of The Lamiaceae Family In Turkey, Selami̇ Selvi̇, Ridvan Polat, Uğur Çakilcioğlu, Ferhat Celep, Tuncay Di̇rmenci̇, Zafer Füsün Ertuğ
An Ethnobotanical Review On Medicinal Plants Of The Lamiaceae Family In Turkey, Selami̇ Selvi̇, Ridvan Polat, Uğur Çakilcioğlu, Ferhat Celep, Tuncay Di̇rmenci̇, Zafer Füsün Ertuğ
Turkish Journal of Botany
Medicinal plants have been used by humans for the treatment of various diseases for thousands of years from past to present. Members of the Lamiaceae family are among the most preferred medicinal plants due to the wide variety of secondary components they contain, particularly essential oils. In this review, Master?s and PhD theses and books based on ethnobotanical studies investigated between 1960 and 2021 as well as internationally recognized databases (PubMed, Scopus, Google Scholar, Web of Science, SciFinder, Springer and Elsevier) were used to determine the medicinal uses of Lamiaceae taxa among the people in Turkey. As a result of …
Ellenberg Ecological Indicator Values, Tolerance Values, Species Niche Models For Soil Nutrient Availability, Salinity, And Ph In Coastal Dune Vegetation Along A Landward Gradient (Euxine, Turkey), Hamdi̇ Güray Kutbay, Burak Sürmen
Ellenberg Ecological Indicator Values, Tolerance Values, Species Niche Models For Soil Nutrient Availability, Salinity, And Ph In Coastal Dune Vegetation Along A Landward Gradient (Euxine, Turkey), Hamdi̇ Güray Kutbay, Burak Sürmen
Turkish Journal of Botany
Coastal dunes are characterised by plant species adapted to harsh conditions. Salinity and other factors (soil pH, nutrients, and climate events) vary along the landward gradient. The current study investigated the effects of environmental factors on the occurrence and composition of coastal dune plants. Ellenberg ecological indicator values (EIVs), species tolerance values (TVs), and species niche models for salinity, nutrient availability, and soil reaction were determined. EIVs were estimated using weighted averages based on the species cover-abundance for each plot. Species TVs were calculated considering the cover-abundance and EIVs (pH, nutrient, and salinity). Species niche models were determined with the …
Morphological And Phylogenetic Studies On Whalleya, With W. Hainanensis Sp. Nov, Yin-Hui Pi, Si-Han Long, You-Peng Wu, Li-Li Liu, Xu Zhang, Qing-De Long, Yan Lin, Ying-Qian Kang, Ji-Chuan Kang, Qi Rui Li
Morphological And Phylogenetic Studies On Whalleya, With W. Hainanensis Sp. Nov, Yin-Hui Pi, Si-Han Long, You-Peng Wu, Li-Li Liu, Xu Zhang, Qing-De Long, Yan Lin, Ying-Qian Kang, Ji-Chuan Kang, Qi Rui Li
Turkish Journal of Botany
Two species of Whalleya from Guizhou and Hainan Provinces were collected during the investigation of Xylariales from 2019 to 2021. According to morphological and molecular characteristics, Whalleya hainanensis sp. nov. and W. microplaca are introduced. Whalleya hainanensis differs from W. microplaca by its obovoid or tubular perithecia and the slightly raised stromata; and differs from W. maculata by its smaller ascospores. Their detailed morphological descriptions and illustrations are provided. The taxonomic position of Whalleya is discussed.
Rubisco And Abiotic Stresses In Plants: Current Assessment, Abdulbaki Shehu Abdulbaki, Hameed Alsamadany, Yahya Alzahrani, Bolaji Umar Olayinka
Rubisco And Abiotic Stresses In Plants: Current Assessment, Abdulbaki Shehu Abdulbaki, Hameed Alsamadany, Yahya Alzahrani, Bolaji Umar Olayinka
Turkish Journal of Botany
Abiotic stresses are serious environmental factors militating against the production of many crops around the world. The consequence of this, is the difficulty of meeting the demands of the increasing world population. Aside from other negative effects, reduction in photosynthesis is an important feature of abiotic stresses. Abiotic stresses limit photosynthesis in a number of ways. The reduction in ribulose 1, 5-bisphosphate carboxylase/oxygenase (Rubisco) content and activity is one of the paramount ways through which abiotic stresses affect photosynthesis. Rubisco is the CO2 fixing enzyme of photosynthesis and also catalyses the photo-respiratory carbon oxidation. The enzyme has low turnover and …
Stachys Istanbulensis (Lamiaceae) A New Species From Turkey: Evidence From Morphological, Micromorphological And Molecular Analysis, Özal Güner
Turkish Journal of Botany
Stachys species show high morphological diversity and their main diagnostic characteristics are calyx and corolla length, ratio of tooth to calyx, and verticillaster arrangement. This manuscript describes and provides detailed morphological, micromorphological and molecular information about a new species, Stachys istanbulensis Ö. Güner, and its close relatives. The new species resembles S. recta complex, but is distinguished by its procumbent flowering stems, shorter calyx and teeth, congested verticillasters, creamy yellow corolla and oblong-obovoid nutlets. Moreover, the periclinal surfaces of S. istanbulensis nutlets are usually wrinkled, while those of S. recta are smooth. In addition, nrITS DNA region sequences were used …
Mthfr C677t Mutation Affects Adipogenic Differentiation Abilities Of Human Bone Marrow-Derived Mesenchymal Stem Cells, Rengi̇m Vural, Di̇cle Çeli̇k, Ersi̇n Berkay Peker, Eki̇n Köni̇, Ayşe Aydanur Kulaç, Zeynep Tokcaer Keski̇n
Mthfr C677t Mutation Affects Adipogenic Differentiation Abilities Of Human Bone Marrow-Derived Mesenchymal Stem Cells, Rengi̇m Vural, Di̇cle Çeli̇k, Ersi̇n Berkay Peker, Eki̇n Köni̇, Ayşe Aydanur Kulaç, Zeynep Tokcaer Keski̇n
Turkish Journal of Biology
The effects of 5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on human bone marrow-derived mesenchymal stem cells (hBM-MSCs) viability, morphology, physiology and differentiation capacity were investigated in this study. For this purpose, primary hBM-MSCs with wild type (WT, C/C), heterozygote (HTZ, C/T) and homozygote (HMZ, T/T) for the MTHFR gene were obtained with ethical committee permission and donor informed. Mutations were detected using RFLP and Sanger sequencing methods from genomic DNA isolated from cells, colonization properties were investigated by CFU-F test and proliferative differences were investigated by MTT test. Adipogenic, osteogenic, and chondrogenic differentiation were induced to study changes in their differentiation …
The Investigation Of Diverse Physiological And Therapeutic Impact Of Cellular-Based Products Derived From Human Cumulus Cells, Derya Burukçu, Sema Yilmaz, Oya Alagöz, Cumhur Kaan Yaltirik, Neci̇p Erkut Attar, Fi̇kretti̇n Şahi̇n, Esra Aydemi̇r Çoban
The Investigation Of Diverse Physiological And Therapeutic Impact Of Cellular-Based Products Derived From Human Cumulus Cells, Derya Burukçu, Sema Yilmaz, Oya Alagöz, Cumhur Kaan Yaltirik, Neci̇p Erkut Attar, Fi̇kretti̇n Şahi̇n, Esra Aydemi̇r Çoban
Turkish Journal of Biology
Particular somatic cells, namely cumulus cells (CCs) that support the oocyte maturation, fertility, and viability by providing the nutrients and energy to the oocyte envelop the mammalian oocyte. In this study, discarded human cumulus tissues were used to reveal the value of hyaluronic acid-rich CCs on several cellular events, including differentiation. Conditioned media, recovered from the primary culture of CCs, were introduced to the human nucleus pulposus cells (hNPCs) which were functionally distorted because of the loss of chondrogenecity. Enlightening the impact of cumulus conditioned media (CCM) on wound healing and angiogenesis was also investigated. In line with these goals, …
In Silico Analysis Of Xth Gene Family From Barley (Hordeum Vulgare L.) And Their Comparative Expression Analysis During Germination, Hülya Akdemi̇r Koç, Merve Seven, Ümi̇t Cem Derman, Andrew John Harvey
In Silico Analysis Of Xth Gene Family From Barley (Hordeum Vulgare L.) And Their Comparative Expression Analysis During Germination, Hülya Akdemi̇r Koç, Merve Seven, Ümi̇t Cem Derman, Andrew John Harvey
Turkish Journal of Botany
Changes in plant cell walls are critical for expansion and growth. Xyloglucan endotransglycosylase/hydrolase (XTH) enzymes are the major modifiers of xyloglucan within the cell wall and are present as large gene families. Despite the paucity of xyloglucan in barley, our analyses of the barley genome revealed at least 42 XTH genes, the most XTH members recorded for a monocot genome to date. In this paper, we show a detailed look at the barley XTH gene family, including detailed bioinformatics analyses of conserved protein motifs and structure, phylogenetic relationships, and a comparison of the expression patterns during germination and seedling growth …
New Species And New Record In Agaricus Subg. Minores From India, Entaj Tarafder, Arun Kumar Dutta, Krishnendu Acharya
New Species And New Record In Agaricus Subg. Minores From India, Entaj Tarafder, Arun Kumar Dutta, Krishnendu Acharya
Turkish Journal of Botany
Two new species of Agaricus, namely A. midnapurensis and A. purpureosquamulosus, belonging to A. subg. Minores, are proposed here as new to science based on specimens collected in West Bengal, India. Agaricus midnapurensis is distinguished by its medium-sized basidiomata with a pileus covered by greyish brown to brown or dark brown squamules, ellipsoid to broadly ellipsoid basidiospores with a mean value of 7.3 × 5.4 µm, and broadly clavate to pyriform cheilocystidia, 22-28 × 10-14 µm. Agaricus purpureosquamulosus has purplish coloured pileus squamules, ellipsoid to elongate basidiospores with a mean value of 7.3 × 4.5 µm, and clavate cheilocystidia measuring …
Shackletonia Backorii - A New Species Of Lichenised Fungus From James Ross Island (Antarctic Peninsula), Mehmet Gökhan Halici, Mi̇that Güllü, Ekrem Bölükbaşi, Merve Kahraman Yi̇ği̇t
Shackletonia Backorii - A New Species Of Lichenised Fungus From James Ross Island (Antarctic Peninsula), Mehmet Gökhan Halici, Mi̇that Güllü, Ekrem Bölükbaşi, Merve Kahraman Yi̇ği̇t
Turkish Journal of Botany
The new lichen species Shackletonia backorii Halıcı, Güllü & Kahraman is described from James Ross Island, which is located in the North-East Antarctic Peninsula region. The new species is morphologically most similar to S. insignis (Søchting & Øvstedal) Søchting, Frödén & Arup, which was described from Livingstone Island (North-West Antarctic Peninsula region). These two species have a similar bluish grey to blackish thallus with a microfruticose and coralloid structure and red brown or almost black zeorine apothecia, but S. backorii has rhomboid ascospores and grows on soil whereas S. insignis has ellipsoid ascospores and occurs in sheltered crevices of rocks. …
Genome-Wide Identification And Evolutionary Analysis Of Cngc Gene Families In Sixteen Brassicaceae Plant Genomes, Akram Ali Baloch, Kaleem U. Kakar, Asma Abro, Muhammad Mushtaq, Zarqa Nawaz, Abrar Hussain
Genome-Wide Identification And Evolutionary Analysis Of Cngc Gene Families In Sixteen Brassicaceae Plant Genomes, Akram Ali Baloch, Kaleem U. Kakar, Asma Abro, Muhammad Mushtaq, Zarqa Nawaz, Abrar Hussain
Turkish Journal of Botany
Cyclic nucleotide-gated channels (CNGCs) are ligand-gated calcium signaling channels, play vital biological functions. Nonetheless, the CNGC gene families have not been well studied in Brassicaceae which includes commercially important and evolutionary model crops. Here, using in silico approaches, we recognized 414 CNGC genes in sixteen sequenced genomes of Brassicaceae species, which represent 10 genera of 8 tribes, ranging between 10-51 genes. These CNGCs can be classified into four main groups (I-IV) and two subgroups (IV-A and IV-B), of which, Group-II CNGC is the oldest that has gradually disappeared from the Arabis alpina L. genome. These results present a comprehensive overview …
Regulatory Roles Of An Atypical Ubiquitin Ligase Ube2o In Orphans Of Multi-Protein Complexes For Degradation, Yi Lv, Feiyue Xing
Regulatory Roles Of An Atypical Ubiquitin Ligase Ube2o In Orphans Of Multi-Protein Complexes For Degradation, Yi Lv, Feiyue Xing
Turkish Journal of Biology
UBE2O as an atypical ubiquitin-conjugating enzyme possesses an E2-E3 hybrid enzyme activity. It can regulate substrate levels or transcriptional activities by cooperating with other E3 ubiquitin ligases or forming homomeric complexes displaying intrinsic E2 and E3 activities. UBE2O controls the quality of cell proteome including protein degradation, modification, transport and location. Recent studies reveal that UBE2O plays a vital role in intracellular protein ubiquitination processes by regulating BMP/SMAD, TRAF/ NF-κB, mTOR/HIF1a and IL-1ß/IRAK4 signaling pathways, c-Maf stability and BAP1 subcellular location, which is proposed as a quality control supervisor of multiprotein complexes for degradation. Its abnormality leads to a variety …
Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan
Development A Novel Multi-Epitope Dna Vaccine Against Human Sars Coronavirus-2: An Immunoinformatics Designing Study, Afshin Samimi Nemati, Sako Mirzaie, Mohammad Reza Masoumian, Fatemeh Sheikhi, Mostafa Jamalan
Turkish Journal of Biology
Human SARS coronavirus 2 (SARS-CoV-2) causes the current global COVID-19 pandemic. The production of an efficient vaccine against COVID-19 is under heavy investigation. In this study, we have designed a novel multiepitope DNA vaccine against SARS-CoV-2 using reverse vaccinology and DNA vaccine approaches. Applying these strategies led to reduce the time and costs of vaccine development and also improve the immune protective characteristics of the vaccine. For this purpose, epitopes of nucleocapsid, membrane glycoprotein, and ORF8 proteins of SARS-CoV-2 chose as targets for B and T-cell receptors. Accordingly, DNA sequences of selected epitopes have optimized for protein expression in the …
Palmitic Acid Declines Glucose Uptake In Hepg2 Cells Via Modulating Phosphoglucomutase 1 To Repress Phosphatidylinositol 3 Kinase/Protein Kinase B And Jnk Pathways Via Inducing Microrna-124-3p, Linghui Zhang, Shengli Zhang
Palmitic Acid Declines Glucose Uptake In Hepg2 Cells Via Modulating Phosphoglucomutase 1 To Repress Phosphatidylinositol 3 Kinase/Protein Kinase B And Jnk Pathways Via Inducing Microrna-124-3p, Linghui Zhang, Shengli Zhang
Turkish Journal of Biology
Diabetes resulting from insufficient insulin secretion or insulin resistance (IR) is a highly prevalent metabolic disease. Since microRNAs have been linked with elevated IR, the current research hypothesized that miR-124-3p has a role in IR and the establishment of IR and type 2 diabetes (T2DM). The study aimed to explore the molecular mechanisms of miR-124-3p which influence IR leading to T2DM establishment. HepG2 cells were cultured in vitro, and palmitic acid (PA) was used to construct the IR cell model. In the IR model, transfection of miR-124-3p or phosphoglucomutase 1 (PGM1) linked plasmids were transfected into HepG2 cells. RT-qPCR was …
Enlightening The Molecular Mechanisms Of Type 2 Diabetes With A Novel Pathway Clustering And Pathway Subnetwork Approach, Burcu Güngör, Mi̇ray Ünlü Yazici, Gökhan Göy, Mustafa Temi̇z
Enlightening The Molecular Mechanisms Of Type 2 Diabetes With A Novel Pathway Clustering And Pathway Subnetwork Approach, Burcu Güngör, Mi̇ray Ünlü Yazici, Gökhan Göy, Mustafa Temi̇z
Turkish Journal of Biology
Type 2 diabetes mellitus (T2D) constitutes 90% of the diabetes cases, and it is a complex multifactorial disease. In the last decade, genome-wide association studies (GWASs) for T2D successfully pinpointed the genetic variants (typically single nucleotide polymorphisms, SNPs) that associate with disease risk. In order to diminish the burden of multiple testing in GWAS, researchers attempted to evaluate the collective effects of interesting variants. In this regard, pathway-based analyses of GWAS became popular to discover novel multigenic functional associations. Still, to reveal the unaccounted 85 to 90% of T2D variation, which lies hidden in GWAS datasets, new post-GWAS strategies need …
Demethylase Fto Inhibits The Development Of Prostate Cancer By Upregulating Egr2 Expression In An M6a Manner, Zhenyu Wang, Huami̇n Sun, Hua Zhu, Donghua Gu, Xi̇nfeng Chen, Yongsheng Pan, Bi̇ng Zheng, Dongrong Yang
Demethylase Fto Inhibits The Development Of Prostate Cancer By Upregulating Egr2 Expression In An M6a Manner, Zhenyu Wang, Huami̇n Sun, Hua Zhu, Donghua Gu, Xi̇nfeng Chen, Yongsheng Pan, Bi̇ng Zheng, Dongrong Yang
Turkish Journal of Biology
Fat mass and obesity-associated protein (FTO) is a demethylase and plays a vital role in various cancers. However, the regulation mechanism of FTO in prostate cancer (PCa) remains unclear. This study aimed to elucidate the mechanism of FTO in PCa. The function and mechanism of FTO-mediated in PCa were determined by gain-of-function assays and RNA-seq. We found that FTO expression in PCa tissues and two PCa cell lines were significantly lower than that in adjacent tissues and normal cell line. PCa cells after overexpression of FTO showed a significant lower in proliferation, migration, and invasion capabilities. RNA-seq displayed that FTO …
Inhibition Of Trpv4 Attenuates Ferroptosis Against Lps-Induced Ali Via Ca2+ Pathway, Junying Cai, Guohai Xu, Yue Lin, Bin Zhou, Zhenzhong Luo, Shuchun Yu, Jun Lu
Inhibition Of Trpv4 Attenuates Ferroptosis Against Lps-Induced Ali Via Ca2+ Pathway, Junying Cai, Guohai Xu, Yue Lin, Bin Zhou, Zhenzhong Luo, Shuchun Yu, Jun Lu
Turkish Journal of Biology
Acute lung injury (ALI) is an inflammation of the lungs with high incidence rate and mortality. Ferroptosis is a new cell death, which has influence in body organs. Transient receptor potential vanillin-4 (TRPV4) channel is a key mediator of Ca2+, its activation induces ferroptosis. The purpose of the study is to investigate the function of TRPV4 on ferroptosis in ALI mice induced by lipopolysaccharide (LPS). In vitro, the regulation of TRPV4 on Ca2+ and ferroptosis was detected by CCK-8, fluorescent probe, and western blot in BEAS-2B cells. In vivo, the role of TRPV4 antagonists on ALI mice …
Adoptive T-Cell Therapies To Overcome T Cell-Dependent Immune Dysregulations In Covid-19, Sevgi̇ Kalkanli Taş, Merve Sai̇de Uzunoğlu, Ayli̇n Seher Uzunoğlu, Duygu Kirkik, Derya Altunkanat, Nevi̇n Kalkanli
Adoptive T-Cell Therapies To Overcome T Cell-Dependent Immune Dysregulations In Covid-19, Sevgi̇ Kalkanli Taş, Merve Sai̇de Uzunoğlu, Ayli̇n Seher Uzunoğlu, Duygu Kirkik, Derya Altunkanat, Nevi̇n Kalkanli
Turkish Journal of Biology
Coronavirus disease 2019 (COVID-19) pandemic has been an important global interest that affected millions of people, and it requires a deep investigation of the disease immunology for developing further therapeutic applications. Adoptive T cell therapy promises to address T cell-dependent immune dysregulation in COVID-19 patients by the generation of specific T cell clones against virus-specific antigens. Additionally, targeting B cell-dependent protection through COVID-19 vaccines, which have been developed in the recent year, possessed sufficient prevention for spreading the virus, since the cases and deaths related to COVID-19 tend to decrease after the vaccination. However, adoptive cell therapies are now encouraging …
The Comparison Of Differentially Expressed Micrornas In Bag-1 Deficient And Wild Type Mcf-7 Breast Cancer Cells By Small Rna Sequencing, Peli̇n Özfi̇li̇z Kilbaş, Gi̇zem Alkurt, Pinar Obakan Yerli̇kaya, Ajda Çoker Gürkan, Gi̇zem Di̇nler Doğanay, Eli̇f Damla Arisan
The Comparison Of Differentially Expressed Micrornas In Bag-1 Deficient And Wild Type Mcf-7 Breast Cancer Cells By Small Rna Sequencing, Peli̇n Özfi̇li̇z Kilbaş, Gi̇zem Alkurt, Pinar Obakan Yerli̇kaya, Ajda Çoker Gürkan, Gi̇zem Di̇nler Doğanay, Eli̇f Damla Arisan
Turkish Journal of Biology
The multifunctional BAG-1 (Bcl-2 athanogene-1) protein promotes breast cancer survival through direct or indirect interaction partners. The number of the interacting partners determines its cellular role in different conditions. As well as interaction partner variability, the amount of BAG-1 protein in the cells could cause dramatic alterations. According to previous studies, while the transient silencing of Bag-1 enhanced drug-induced apoptosis, deletion of BAG-1 could induce stemness properties and Akt-mediated actin remodeling in MCF-7 breast cancer cells. Considering the heterogeneity of breast cancer and the variability of BAG-1 -mediated cell response, it has become essential to determine microRNA (miRNA) functions in …