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Full-Text Articles in Life Sciences
Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan
Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan
Turkish Journal of Veterinary & Animal Sciences
Monitoring biomarkers related to inflammation and oxidative stress is critical in dogs because parvovirus causes both inflammatory and antioxidant alterations. The aim of this study was to investigate inflammatory and antioxidant changes caused by canine parvoviral enteritis to better understand the oxidative stress process related to this disease. Thus, the total thiol, native thiol, disulfide, and ischemia-modified albumin levels of Canine parvovirus infected symptomatic puppies and healthy puppies were examined. Using the results of complete blood counts, the blood serum thiol-disulfide homeostasis and ischemia modified albumin levels of the puppies with Canine parvoviral enteritis (n = 65) and the healthy …
Antioxidant Potential Of Nanomaterials, David Gonzalez Flores, Javier Espino, Jose A. Pariente
Antioxidant Potential Of Nanomaterials, David Gonzalez Flores, Javier Espino, Jose A. Pariente
Turkish Journal of Biology
Background/aim: The novel field of nanomaterials allows infinite possibilities in order to create antioxidant therapies. The present review is aimed to describe the state of art concerning on nanomaterials and their effects on reactive oxygen species (ROS) production. A wide range of nanoparticles has been designed for this purpose, and each one possesses some particular characteristics which allow these significant antioxidant results. Several in vivo and in vitro works state the ability of these nanoparticles to mimic the redox systems of the cells, and thus, the potential role of nanoparticles as antioxidant treatment for several diseases. Materials and methods: This …
Alleviating Effects Of Salicylic Acid Spray On Stage-Based Growth And Antioxidative Defense System In Two Drought-Stressed Rice (Oryza Sativa L.) Cultivars, Asma ., Iqbal Hussain, Muhammad Yasin Ashraf, Muhammad Hamzah Saleem, Muhammad Arslan Ashraf, Baber Ali, Aisha Shereen, Ghulam Farid, Muhammad Ali, Muhammad Ubaidullah Shirazi, Ammara Saleem, Yasser S. Mostafa, Mohamed Hashem, Ghulam Yasin
Alleviating Effects Of Salicylic Acid Spray On Stage-Based Growth And Antioxidative Defense System In Two Drought-Stressed Rice (Oryza Sativa L.) Cultivars, Asma ., Iqbal Hussain, Muhammad Yasin Ashraf, Muhammad Hamzah Saleem, Muhammad Arslan Ashraf, Baber Ali, Aisha Shereen, Ghulam Farid, Muhammad Ali, Muhammad Ubaidullah Shirazi, Ammara Saleem, Yasser S. Mostafa, Mohamed Hashem, Ghulam Yasin
Turkish Journal of Agriculture and Forestry
Approximately 33% of the arable land around the world is vulnerable to drought, which is a very serious issue affecting the yield and productivity of cereal crops. Two contrasting rice (Oryza sativa L.) genotypes, HTT-138 (drought tolerant) and (HTT-39 droughtsensitive), under various levels of water treatments, i.e. control flooded (CF) as recommended for rice (control), control saturated (CS) 100% field capacity (FC), 80% FC, and 60% FC without or with foliar spray (100 mg L-1) of salicylic acid (SA) evaluated to enhance the yield for food security. The results showed that leaf gas exchange parameters, water use …
Effects Of Nitrogen Fertilizer On Capoeta Capoeta: An Immunohistopathological And Biochemical Investigation, Seda Vural Aydin, Hasan Özen, Muhi̇tdi̇n Yilmaz
Effects Of Nitrogen Fertilizer On Capoeta Capoeta: An Immunohistopathological And Biochemical Investigation, Seda Vural Aydin, Hasan Özen, Muhi̇tdi̇n Yilmaz
Turkish Journal of Zoology
Increased use of fertilizers to increase plant production causes important environmental pollution not only in soil but also in water resources. Soil structure, water quality, water systems, and biodiversity are adversely affected by the unconscious use of fertilizers. In this study, Capoeta capoeta (Guldenstaedt 1773) were used to investigate the degenerative effects of nitrogen fertilizer. Twentyfour fish were equally allocated into three groups; group 1 (control), group 2 (15 mg/L nitrogen fertilizer in water) and group 3 (15 mg/L nitrogen fertilizer in water). Fish were exposed to the fertilizer for 15 days and then the tissues of gill, liver and …
Chromium Toxicity In Plants: Consequences On Growth, Chromosomal Behavior Andmineral Nutrient Status, Muhammad Hamzah Saleem, Javaria Afzal, Muhammad Rizwan, Zia-Ul-Hassan Shah, Nizamuddin Depar, Kamal Usman
Chromium Toxicity In Plants: Consequences On Growth, Chromosomal Behavior Andmineral Nutrient Status, Muhammad Hamzah Saleem, Javaria Afzal, Muhammad Rizwan, Zia-Ul-Hassan Shah, Nizamuddin Depar, Kamal Usman
Turkish Journal of Agriculture and Forestry
Chromium (Cr) is a heavy metal of commercial importance; thus, significant amounts are released in wastewaters. The mobility and distribution of metals in the environment is related not only to their concentration but also to their availability in the environment. Most chromium (Cr) exists in oxidation states ranging from 0 to VI in soils but the most stable and common forms are Cr(0), Cr(III), and Cr(VI) species. Cr can have positive and negative effects on health, according to the dose, exposure time, and its oxidation state. Its behavior in soil, its soil-plant transfer and accumulation in different plant parts vary …
The Effect Of Dystocia On Oxidative Stress, Colostral Antibody/Passive Immune Status, Andblood Gases In Damascus Goats And Their Kids, Tuğra Akkuş, Ömer Korkmaz, Bi̇rten Emre, Abuzer Kafar Zonturlu, Peli̇n Fatoş Polat Di̇nçer, Ömer Yaprakci
The Effect Of Dystocia On Oxidative Stress, Colostral Antibody/Passive Immune Status, Andblood Gases In Damascus Goats And Their Kids, Tuğra Akkuş, Ömer Korkmaz, Bi̇rten Emre, Abuzer Kafar Zonturlu, Peli̇n Fatoş Polat Di̇nçer, Ömer Yaprakci
Turkish Journal of Veterinary & Animal Sciences
The present study was conducted to investigate the effect of dystocia on oxidative stress, venous blood gases, and colostrum and serum immunoglobulins G (IgG) in Damascus goats and their kids, respectively. The study sample comprised a total of 40 Damascus goats with of their own 40 kids separated into 2 groups according to the type of birth. Group 1 consisted of goats with eutocia (n = 20) and their kids (n = 20), and Group 2 consisted of goats with dystocia (n = 20) and their kids (n = 20). Blood samples were taken from the goats and their kids …
Cryoprotective Effect Of Vaccenic Acid Supplemented In Bull Semen Extender, Fati̇h Avdatek, Umut Taşdemi̇r, Muhammed Enes İnanç, Deni̇z Yeni̇, Mehmet Fuat Gülhan, Şükrü Güngör, Ruhi̇ Türkmen, Pürhan Barbaros Tuncer
Cryoprotective Effect Of Vaccenic Acid Supplemented In Bull Semen Extender, Fati̇h Avdatek, Umut Taşdemi̇r, Muhammed Enes İnanç, Deni̇z Yeni̇, Mehmet Fuat Gülhan, Şükrü Güngör, Ruhi̇ Türkmen, Pürhan Barbaros Tuncer
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to investigate whether vaccenic acid (VA) added to TRIS semen extender has an effect on freezing bull semen. The semen was collected at intervals of three days through an artificial vagina then pooled. The pooled ejaculates were divided into five components as the control (C; no supplement) and VA (25, 50, 100, and 200 μg / mL) groups then extended with the TRIS-based medium. The samples were left in a cold air cabinet for cooling process (4 °C), then they were equilibrated for 4 h. Afterward, the samples in the groups were frozen by …
Manipulation Of Lipophilic Antioxidants To Enhance Oxidative Stress Tolerance Andnutritional Quality In Transgenic Sweetpotato, Hosoo Kim, Rengi̇n Özgür Uzi̇lday, Bariş Uzi̇lday, Soeun Kim, Chanju Lee, Sulu Park, Xiaofeng Bian, Yizhi Xie, Sang-Soo Kwak
Manipulation Of Lipophilic Antioxidants To Enhance Oxidative Stress Tolerance Andnutritional Quality In Transgenic Sweetpotato, Hosoo Kim, Rengi̇n Özgür Uzi̇lday, Bariş Uzi̇lday, Soeun Kim, Chanju Lee, Sulu Park, Xiaofeng Bian, Yizhi Xie, Sang-Soo Kwak
Turkish Journal of Botany
Overproduction of reactive oxygen species (ROS) in plant cells under environmental stress cause oxidative stress, which is one of major factors limiting the plant productivity. To prevent this limitation by stress conditions, a possible strategy is to strengthen the antioxidant defense of plants by gene manipulation of antioxidant enzymes and low molecular-weight (LMW) antioxidants. LMW antioxidants are important for the plant protection to environmental stress and also have nutritional merits for humans as antiaging and antidisease molecules. Sweetpotato [Ipomoea batatas (L.) Lam] as a nutritional food crop has many advantages in terms of the cultivation on the global marginal lands. …
Transcriptome Profiles Associated With Selenium-Deficiency-Dependent Oxidative Stress Identify Potential Diagnostic And Therapeutic Targets In Liver Cancer Cells, Damla Gözen, Deni̇z Cansen Kahraman, Kübra Narci, Huma Shehwana, Özlen Konu, Rengül Çeti̇n Atalay
Transcriptome Profiles Associated With Selenium-Deficiency-Dependent Oxidative Stress Identify Potential Diagnostic And Therapeutic Targets In Liver Cancer Cells, Damla Gözen, Deni̇z Cansen Kahraman, Kübra Narci, Huma Shehwana, Özlen Konu, Rengül Çeti̇n Atalay
Turkish Journal of Biology
Hepatocellular carcinoma (HCC) is one of the most common cancer types with high mortality rates and displays increased resistance to various stress conditions such as oxidative stress. Conventional therapies have low efficacies due to resistance and off-target effects in HCC. Here we aimed to analyze oxidative stress-related gene expression profiles of HCC cells and identify genes that could be crucial for novel diagnostic and therapeutic strategies. To identify important genes that cause resistance to reactive oxygen species (ROS), a model of oxidative stress upon selenium (Se) deficiency was utilized. The results of transcriptome-wide gene expression data were analyzed in which …
Determination Of Oxidative, Genotoxic, And Histopathologic Effects Of Metal Pollution Onthe Fish Fauna Inhabiting Karasu River, Turkey, Hati̇ce Dane, Turgay Şi̇şman
Determination Of Oxidative, Genotoxic, And Histopathologic Effects Of Metal Pollution Onthe Fish Fauna Inhabiting Karasu River, Turkey, Hati̇ce Dane, Turgay Şi̇şman
Turkish Journal of Zoology
The water quality of rivers located in areas close to major cities is deteriorating significantly due to increased pollution. The Karasu River, which passes through Erzurum city Turkey, is getting polluted day by day due to domestic and industrial wastewater. In the study, various assessments were made in three different fish species to determine the impact of possible contamination here. Capoeta capoeta, Alburnus mossulensis and Squalius cephalus were caught from four stations of the river. Micronucleus test was applied to find out genotoxic alterations, and plasma total oxidant status (TOS) and total antioxidant status (TAS) were measured to determine oxidative …
Dna Damage, Oxidative Stress, Decreased Viability And Motility In Common Carp (Cyprinuscarpio L.) Spermatozoa Induced By Tryptophan, Phenylalanine And Cysteine Amino Acids During Short-Term Storage, Mahi̇r Kanyilmaz, Burak Evren İnanan
Dna Damage, Oxidative Stress, Decreased Viability And Motility In Common Carp (Cyprinuscarpio L.) Spermatozoa Induced By Tryptophan, Phenylalanine And Cysteine Amino Acids During Short-Term Storage, Mahi̇r Kanyilmaz, Burak Evren İnanan
Turkish Journal of Zoology
Free amino acids are found in spermatozoa and seminal plasma. Their qualitative and quantitative presence have been affected by many factors. Under in vitro storage conditions, their effects on spermatozoa in animal species and also human have been concerned over the last decades. In this study, the effects of tryptophan, phenylalanine and cysteine on DNA integrity, lipid peroxidation, viability and motility parameters in spermatozoa of the common carp (Cyprinuscarpio) were assessed during short-term storage. Spermatozoa were incubated at 1, 5, 25, and 50 mM of these amino acids in vitro at 4 °C in a time?dependent manner (6, 24, and …
The Effects Of Feeding Obese Rats With Bee Bread On Leptin And Ghrelin Expression, Züleyha Doğanyi̇ği̇t, Bi̇rkan Yakan, Meltem Soylu, Emi̇n Kaymak, Si̇bel Si̇li̇ci̇
The Effects Of Feeding Obese Rats With Bee Bread On Leptin And Ghrelin Expression, Züleyha Doğanyi̇ği̇t, Bi̇rkan Yakan, Meltem Soylu, Emi̇n Kaymak, Si̇bel Si̇li̇ci̇
Turkish Journal of Zoology
Obesity is an important public health problem and a risk factor for many chronic diseases, and its prevalence is increasing rapidly. In recent years there has been interest in the impact of nutrients on obesity and this has been addressed as a research topic. Bee bread is a bee product that has recently attracted attention with its macro- and micronutrients and the enzymes and biocomponents it contains. Although there are many studies on the biological properties and effects of bee bread, its effect on obesity with leptin and ghrelin has not been investigated. In this study, 40 Sprague-Dawley adult female …
Dihydroquercetin Increases The Adaptive Potential Of Wild Soybean Against Copper Sulfateand Cadmium Sulfate Toxicity, Darya Konstantinovna Chernyshuk, Lubov Yegorovna Ivachenko, Hülya Doğan, Ghulam Raza, Muhammad Amjad Ali, Kirill Sergeyevich Golokhvast, Muhammad Amjad Nawaz
Dihydroquercetin Increases The Adaptive Potential Of Wild Soybean Against Copper Sulfateand Cadmium Sulfate Toxicity, Darya Konstantinovna Chernyshuk, Lubov Yegorovna Ivachenko, Hülya Doğan, Ghulam Raza, Muhammad Amjad Ali, Kirill Sergeyevich Golokhvast, Muhammad Amjad Nawaz
Turkish Journal of Agriculture and Forestry
In this study, the mechanism of the biochemical adaptation of wild soybean to the experimentally modeled effects of cadmium sulfate and copper sulfate in approximately double permissible concentration was investigated. The extracted concentrations of cadmium and copper in the experimental soil were determined by inversion voltammetry - 1.46 and 48.25 mg/kg, respectively. Growing soybeans in soil with the addition of copper and cadmium sulfates led to an increase in the concentration of malonic dialdehyde in soybean seeds relative to control by 62% and 38%, respectively, which confirmed the strengthening of oxidative processes. There was also an increase in the specific …
Stress Response Related To Ultrasonographic Examination In Dogs, Cenker Çağri Cingi, Abdurrahman Fati̇h Fi̇dan, Durmuş Fati̇h Başer, Mehmet Uçar, Zülfükar Kadi̇r Saritaş
Stress Response Related To Ultrasonographic Examination In Dogs, Cenker Çağri Cingi, Abdurrahman Fati̇h Fi̇dan, Durmuş Fati̇h Başer, Mehmet Uçar, Zülfükar Kadi̇r Saritaş
Turkish Journal of Veterinary & Animal Sciences
This study investigated whether abdominal ultrasonography, a frequently used examination method in clinics and hospitals, causes stress in dogs. For the study, 10 healthy dogs were used. Following general examination, intravenous catheters were placed in the V. cephalica accecorius of the dogs and blood specimens were collected to obtain serum and plasma samples (minute 0). After a 30- min break, ultrasonography was applied following shaving of the abdominal region. Serum and plasma samples were collected from the intravenous catheters at the 5th, 15th, and 20th minutes of the ultrasonographic examination during which the urinary bladder, left kidney, spleen, stomach, liver, …
Regulation Of Antioxidant Activity In Maize (Zea Mays L.) By Exogenous Application Of Sulfur Under Saline Conditions, Alia Riffat, Muhammad Sajid Aqeel Ahmad
Regulation Of Antioxidant Activity In Maize (Zea Mays L.) By Exogenous Application Of Sulfur Under Saline Conditions, Alia Riffat, Muhammad Sajid Aqeel Ahmad
Turkish Journal of Botany
One of the major effects of salt stress is high production of reactive oxygen species that adversely affect essential cellular metabolic pathways. To limit the elevated production of reactive oxygen species, plants stimulate various types of antioxidants. In this study, sulfur was used to induce tolerance against oxidative stress through modulation of the activities of various antioxidants. Two maize genotypes (Agatti 2003 and Pak Afgoi 2003) were subjected to different salinity (25 and 75 mM) and sulfur (40 and 80 mM) treatments and a control treatment. Various antioxidants and oxidative stress determinants in maize organs (leaf, shoot, and root) were …
The Endogenous L-Cysteine Desulfhydrase And Hydrogen Sulfide Participate In Supplemented Phosphorus-Induced Tolerance To Salinity Stress In Maize (Zea Mays) Plants, Cengi̇z Kaya, Muhammad Ashraf
The Endogenous L-Cysteine Desulfhydrase And Hydrogen Sulfide Participate In Supplemented Phosphorus-Induced Tolerance To Salinity Stress In Maize (Zea Mays) Plants, Cengi̇z Kaya, Muhammad Ashraf
Turkish Journal of Botany
Although phosphorus supplementation (SP) has been shown to improve salinity tolerance in plants, crosstalk between hydrogen sulfide (H2S) or L-cysteine desulfhydrase (LDES) and SP-induced salinity tolerance needs to be elucidated. Thus, prior to initiation of stress treatment, young seedlings were transferred to aqueous solution containing the scavenger of H2S, 0.1 mM hypotaurine (HT), or the inhibitor of LDES, 0.3 mM DL-propargylglycine (PAG), for 12 h. The plants grown under control (no NaCl added) or salinity stress (SS; 100 mM NaCl) were then supplemented with SP (2.0 mM in total) as KH2PO4 for 5 weeks. SS caused a significant decrease in …
Oxidative Stress In Calves With Enzootic Pneumonia, Mustafa Özbek, Cumali̇ Özkan
Oxidative Stress In Calves With Enzootic Pneumonia, Mustafa Özbek, Cumali̇ Özkan
Turkish Journal of Veterinary & Animal Sciences
This study was performed to evaluate the oxidative stress in calves with enzootic pneumonia. Ninety calves that were 2?6 months old were used in this study. Ten of these calves were healthy and used as the control group, while 80 were diagnosed with enzootic pneumonia according to the clinical examinations. The biochemical results showed that total oxidant status (TOS), nitric oxide (NO), malondialdehyde (MDA), and sialic acid (SA) levels were higher in calves with enzootic pneumonia than in the control group. While there was a statistically significant increase in TOS, MDA, and SA concentrations, there was not any statistically significant …
Effects Of Exogenous Salicylic Acid And Sodium Nitroprusside On α-Tocopherol And Phytochelatin Biosynthesis In Zinc-Stressed Safflower Plants, Shahram Namdjoyan, Hossein Kermanian, Ali Abolhasani Soorki, Sedigheh Modarres Tabatabaei, Nazli Elyasi
Effects Of Exogenous Salicylic Acid And Sodium Nitroprusside On α-Tocopherol And Phytochelatin Biosynthesis In Zinc-Stressed Safflower Plants, Shahram Namdjoyan, Hossein Kermanian, Ali Abolhasani Soorki, Sedigheh Modarres Tabatabaei, Nazli Elyasi
Turkish Journal of Botany
The interactive effect of exogenous application of salicylic acid (SA) and sodium nitroprusside (SNP), a donor of nitric oxide, on zinc (Zn) toxicity was assessed in Zn-stressed safflower (Carthamus tinctorius L.) seedlings. Exposure to 500 μM ZnSO4.7H2O for 10 days caused an increment in the levels of malondialdehyde (MDA), H2O2, α-tocopherol, phytochelatins (PCs), and proline. Application of SA or SNP, and especially their combination, resulted in remarkable decrease in MDA, H2O2, and proline content while chlorophyll content and the activity of catalase, ascorbate peroxidase, and guaiacol peroxidase exhibited a significant induction in comparison with plants subjected to Zn treatment alone. …
Combined Extract Of Moringa Oleifera And Centella Asiatica Modulates Oxidative Stress And Senescence In Hydrogen Peroxide-Induced Human Dermal Fibroblasts, Elly Ezlinda Abdul Hisam, Mohd Salleh Rofiee, Aina Mardhia Khalid, Ahmad Firdaus Jalaluddin, Mohd Izwan Muhammad Yusof, Muhd Hanis Idris, Salfarina Ramli, Richard Johari James, Wee Jack Yoeng, Teh Lay Kek, Mohd Zaki Salleh
Combined Extract Of Moringa Oleifera And Centella Asiatica Modulates Oxidative Stress And Senescence In Hydrogen Peroxide-Induced Human Dermal Fibroblasts, Elly Ezlinda Abdul Hisam, Mohd Salleh Rofiee, Aina Mardhia Khalid, Ahmad Firdaus Jalaluddin, Mohd Izwan Muhammad Yusof, Muhd Hanis Idris, Salfarina Ramli, Richard Johari James, Wee Jack Yoeng, Teh Lay Kek, Mohd Zaki Salleh
Turkish Journal of Biology
Moringa oleifera Lam. and Centella asiatica (L.) Urb. leaves have been previously reported to exhibit antioxidant activity. The objective of the present study is to determine the in vitro antioxidant activity of the combined extracts of M. oleifera and C. asiatica (TGT-PRIMAAGE) and its effect on hydrogen peroxide (H$_{2}$O$_{2}$)-induced oxidative stress in human dermal fibroblasts. TGT-PRIMAAGE acted on the mechanism of hydrogen transfer as it showed scavenging activity in the DPPH assay. This is due to the presence of phenolics and flavonoids in TGT-PRIMAAGE. TGT-PRIMAAGE effectively reduced cellular generation of reactive oxygen species induced by H$_{2}$O$_{2}$. The activities of superoxide …
Oxidative Stress Upregulates The Transcription Of Genes Involved In Thiaminemetabolism, Burcu Kartal, Ahmet Akçay, Bedi̇a Palabiyik
Oxidative Stress Upregulates The Transcription Of Genes Involved In Thiaminemetabolism, Burcu Kartal, Ahmet Akçay, Bedi̇a Palabiyik
Turkish Journal of Biology
Thiamine is a major vitamin that acts as a cofactor in energy metabolism in all organisms, as well as in lipid and amino acid metabolisms, and is associated with many diseases. It is known that glucose starvation decreases the intracellular thiamine pool while increasing oxidative stress tolerance. Earlier, in whole genome analysis, we detected major differences in the expression of genes related to thiamine pathway against oxidative stress in Schizosaccharomyces pombe. We investigated the effects of oxidative stress and glucose repression to thiamine pathway in S. pombe by comparing some genes encoding key enzymes of each related pathway at the …
Effects Of Massive Ovulation On Oxidation State And Function Of The Ovaries In Laying Hens, Yu Chang, Jinghai Feng, Minhong Zhang, Liwen Jiang, Lili Zhai, Xiaolan Yang
Effects Of Massive Ovulation On Oxidation State And Function Of The Ovaries In Laying Hens, Yu Chang, Jinghai Feng, Minhong Zhang, Liwen Jiang, Lili Zhai, Xiaolan Yang
Turkish Journal of Veterinary & Animal Sciences
Modern laying hens show fast reduction in egg production rate after 60 weeks of age, which is associated with the decline in ovarian function. The aim of this study was to examine the influence of massive ovulation on the oxidation state and ovarian function in hens. In total, 48 Jing Hong hens aged 17 weeks were randomly divided into high ovulation (HO) and low ovulation (LO) groups. The LO hens were exposed to 6 h of light per day (6 L:18 D) up to 32 weeks to delay the initiation of egg production and then were switched to 16 L:8 …
Efect Of Dual Growth Factor Administration On Oxidative Markers During Acute Stage Wound Healing In Rats, Bahar Di̇ndar, Kaan Kaltalioğlu, Şule Coşkun Cevher
Efect Of Dual Growth Factor Administration On Oxidative Markers During Acute Stage Wound Healing In Rats, Bahar Di̇ndar, Kaan Kaltalioğlu, Şule Coşkun Cevher
Turkish Journal of Zoology
Wound healing is a complex process affected by various conditions, including oxidative stress. The present study explored the time-dependent effects of platelet-derived growth factor (PGDF) and vascular endothelial growth factor (VEGF) administration on oxidative markers during acute stage wound healing. Thirty-six Wistar rats were distributed into three major groups; skin wounds were inflicted in all groups. The wounds were either left untreated (control group), treated topically with blank chitosan gel (blank chitosan gel group), or treated topically with a combination of PDGF and VEGF in chitosan gel (PDGF + VEGF chitosan gel group). Wounds were sampled on postsurgery days 3 …
Bioaccumulation And Oxidative Stress Impact Of Pb, Ni, Cu, And Cr Heavy Metals In Two Bryophyte Species, Pleurochaete Squarrosa And Timmiella Barbuloides, Serap Aydoğan, Bengi̇ Erdağ, Lale Aktaş
Bioaccumulation And Oxidative Stress Impact Of Pb, Ni, Cu, And Cr Heavy Metals In Two Bryophyte Species, Pleurochaete Squarrosa And Timmiella Barbuloides, Serap Aydoğan, Bengi̇ Erdağ, Lale Aktaş
Turkish Journal of Botany
This study was conducted to evaluate the bioaccumulation and oxidative stress impact of lead (Pb), nickel (Ni), copper (Cu), and chromium (Cr) in bryophyte species Pleurochaete squarrosa and Timmiella barbuloides exposed to Pb, Ni, Cu, and Cr at 1 mM concentration for 48 h. Bioaccumulation ratios in the non-Fenton metals Ni and Pb were found to be higher than in Fenton metals Cu and Cr for both moss species. Except for Cu, high levels of heavy metal accumulation caused a slight increase in dry weights of both species. Total chlorophyll and carotenoid contents of both species showed variations under Ni, …
The Application Of Mesenchymal Progenitor Stem Cells For The Reduction Of Oxidative Stress In Animals, Edyta Wojtas, Andrzej Zachwieja, Anna Zwyrzykowska, Robert Kupczynski, Krzysztof Marycz
The Application Of Mesenchymal Progenitor Stem Cells For The Reduction Of Oxidative Stress In Animals, Edyta Wojtas, Andrzej Zachwieja, Anna Zwyrzykowska, Robert Kupczynski, Krzysztof Marycz
Turkish Journal of Biology
Oxidative stress is the primary cause of lowering of the body's immune status. It arises as a result of intense metabolic processes in humans and animals that involve a decrease in antioxidant enzymes activity at the expense of increased production of free radicals and reactive oxygen species (ROS). Consequently, this leads to oxidation of lipids, proteins, DNA, and RNA, causing cell proliferation reduction, faster cell aging, and subsequent degradation. Currently, there is a search for methods to maintain an oxidation-antioxidant balance. The results of many authors' research point to the effectiveness of the use of mesenchymal stem cells (MSCs) in …
Pt(Iv), Pd(Ii), And Rh(Iii) Complexes Induced Oxidative Stress And Cytotoxicity In The Hct-116 Colon Cancer Cell Line, Petar Canovic, Jovana Bogojeski, Jelena Kosaric, Snezana Markovic, Marko Zivanovic
Pt(Iv), Pd(Ii), And Rh(Iii) Complexes Induced Oxidative Stress And Cytotoxicity In The Hct-116 Colon Cancer Cell Line, Petar Canovic, Jovana Bogojeski, Jelena Kosaric, Snezana Markovic, Marko Zivanovic
Turkish Journal of Biology
The use of transition metal complexes as appropriate analogues to cisplatin and similar anticancer drugs nowadays is of utmost importance. The inertness of Pt(IV), Pd(II), and Rh(III) complexes and the choosing of convenient ligands could offer a possible advantage in comparison to Pt(II) complexes. These advantages could be attributed to the better anticancer activity and fewer possible side effects. In this paper, we have chosen three complexes of different transition metal ions, [(TLtBu)PdIICl]ClO4, [RhIII(LH2tBu)Cl3], and [PtIV(LH2tBu)Cl3]Cl (where TLtBu is 2,6-bis[(1,3-di-tert-butylimidazolin-2-imino)methyl]pyridine and LH2tBu is 2,6-bis(5-tert-butyl-1H-pyrazol-3-yl)pyridine), for biological tests. All three complexes exerted strong prooxidative and cytotoxic effects on the human colorectal …
Neuropeptide Y Reduces Migration Capacity Of Human Choriocarcinomacell Line By Altering Oxidative/Antioxidative Status, Milos Matic, Milica Paunovic, Branka Ognjanovic, Andras Stajn, Zorica Saicic
Neuropeptide Y Reduces Migration Capacity Of Human Choriocarcinomacell Line By Altering Oxidative/Antioxidative Status, Milos Matic, Milica Paunovic, Branka Ognjanovic, Andras Stajn, Zorica Saicic
Turkish Journal of Biology
Reduced migration capacity of trophoblast cells leads to poor placentation and correlates with severe pregnancy disorders such as intrauterine growth restriction and preeclampsia. Neuropeptide Y (NPY) is sympathetic cotransmitter involved in various physiological processes and its levels are significantly increased in preeclamptic pregnancy compared to healthy pregnancy. In this study the prooxidative role of NPY and its effects on migration capacity of human trophoblast cell line JEG-3 were investigated together with the effects of nitric oxide (NO) depletion, a molecule that was shown to play an important role in promoting cell migration. The cells were treated for 24 h (short-term …
Differential Oxidative Response To Fluoropyrimidines In Colorectal Cancer Cell Lines, Ufuk Özer, Karen Wood Barbour
Differential Oxidative Response To Fluoropyrimidines In Colorectal Cancer Cell Lines, Ufuk Özer, Karen Wood Barbour
Turkish Journal of Biology
Colorectal cancer (CRC) is the second most common human malignancy in women and the third in men, accounting for approximately 8% of cancer-related deaths and 1.3 million newly diagnosed cases annually worldwide. CRC cell lines differ in morphological features, growth rate, and their genetic alterations, implicating the extent of variability among the lines. The goal of the current study was to investigate the phenotypes of CRC lines related to NADPH oxidase (NOX) activity and expression of NOX2 subunits in response to fluoropyrimidines. NOX activity in response to 5'-fluoro-2'-deoxyuridine (FdUrd) and VAS2780 was measured in CRC cell lines. Cells were treated …
Involvement Of Amp-Activated Protein Kinase In The Protective Effectof Melatonin Against Renal Ischemia Reperfusion Injury, Kaouther Hadj Ayed Tka, Asma Mahfoudh Boussaid, Kaouther Kessabi, Rym Kammoun, Imed Messaoudi, Sonia Ghoul Mazgar, Joan Rosello Catafau, Hassen Ben Abdennebi
Involvement Of Amp-Activated Protein Kinase In The Protective Effectof Melatonin Against Renal Ischemia Reperfusion Injury, Kaouther Hadj Ayed Tka, Asma Mahfoudh Boussaid, Kaouther Kessabi, Rym Kammoun, Imed Messaoudi, Sonia Ghoul Mazgar, Joan Rosello Catafau, Hassen Ben Abdennebi
Turkish Journal of Biology
We investigated the implication of AMP-activated protein kinase (AMPK) in melatonin-induced protection in a renal ischemia/reperfusion (I/R) model. Animals were divided into four groups: rats of the sham group were not subjected to renal I/R. Rats in the I/R group received the vehicle 30 min before renal ischemia for 1 h followed by reperfusion for 6 h. Rats in the Mel+I/R group received melatonin (10 mg/kg) 30 min before the onset of I/R. Rats in the Mel+I/R+araA group received araA (AMPK inhibitor, 100 μg/kg per min for 10 min) just before melatonin administration. The results showed that melatonin treatment induced …
The Cytotoxic Activity Of Sanguinarine In C32 Human Amelanotic Melanoma Cells, Sabina Ioana Cojocaru, Miruna Silvia Stan, Mihai Anton, Mihaela Rocsana Luca, Gogu Ghiorghita, Gheorghe Stoian, Anca Dinischiotu
The Cytotoxic Activity Of Sanguinarine In C32 Human Amelanotic Melanoma Cells, Sabina Ioana Cojocaru, Miruna Silvia Stan, Mihai Anton, Mihaela Rocsana Luca, Gogu Ghiorghita, Gheorghe Stoian, Anca Dinischiotu
Turkish Journal of Biology
Sanguinarine, an alkaloid present in various medicinal plants, has been associated with detrimental effects on different types of cancer cells. The aim of our study was to analyze the cytotoxic effects of sanguinarine on C32 human amelanotic melanoma cells. The cells were exposed to various concentrations of sanguinarine (0.5, 1, and 2 μM) for 24 h and displayed a dose-dependent decrease in cell viability; the sanguinarine-induced oxidative stress in C32 cells affected the activity of antioxidant enzymes and generated lipid peroxidation. Moreover, we observed an enhanced expression of heat shock proteins 60, 70, and 90 in response to the stress …
Redox Gene Expression Of Adipose-Derived Stem Cells In Response To Soft Hydrogel, Fahsai Kantawong, Thasaneeya Kuboki, Satoru Kidoaki
Redox Gene Expression Of Adipose-Derived Stem Cells In Response To Soft Hydrogel, Fahsai Kantawong, Thasaneeya Kuboki, Satoru Kidoaki
Turkish Journal of Biology
No abstract provided.