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Articles 391 - 420 of 12465
Full-Text Articles in Life Sciences
Effect Of Substrate Dispersion Method And Particle Size On In Vitro Digestibility, Gas Production Kinetics And Composition, And Fermentation Characteristics In Different Feed Types, Luiz C. O. Sousa, Ellem M. A. Matos, Ronald J. Trotta, Edenio Detmann, David L. Harmon
Effect Of Substrate Dispersion Method And Particle Size On In Vitro Digestibility, Gas Production Kinetics And Composition, And Fermentation Characteristics In Different Feed Types, Luiz C. O. Sousa, Ellem M. A. Matos, Ronald J. Trotta, Edenio Detmann, David L. Harmon
Animal and Food Sciences Faculty Publications
Our objective was to evaluate the influence of substrate dispersion method and particle size on in vitro digestibility, gas production kinetics and composition, and fermentation characteristics of different feed types. Alfalfa hay, tall fescue hay, ground corn, soybean meal, and a total mixed ration (TMR) were used as substrates. Treatments were designed according to a 2 × 2 × 5 factorial arrangement: two substrate dispersion methods (loose substrate and in filter bags), two particle sizes (1 mm and 2 mm), and five feeds. Filter bags decreased (P ≤ 0.001) digestibility and gas production compared with loose samples. Filter bags decreased …
South Asian Nutrition Guide For Heart Health: A Practical Guide To Sodium, Saturated Fat, Packaged Foods, Recipes And Meal Planning, Ashwini Wagle
South Asian Nutrition Guide For Heart Health: A Practical Guide To Sodium, Saturated Fat, Packaged Foods, Recipes And Meal Planning, Ashwini Wagle
Open Educational Resources
South Asians, including people with ancestry from India, Pakistan, Bangladesh, Sri Lanka, Nepal, Bhutan, and the Maldives, have a higher risk of cardiovascular disease and diabetes than many other populations. They often develop heart disease at younger ages and sometimes at lower body weights. (Jose, 2024; Patel et al., 2021; Volgman et al., 2018).
This increased risk is not caused by a single factor. Evidence points to a combination of inherited, metabolic, lifestyle, and social influences. Common contributors include insulin resistance, abdominal or visceral fat, type 2 diabetes, high triglycerides, low HDL cholesterol, elevated lipoprotein(a), family history, stress, migration-related changes …
Letter From The Dean, Jeff Edwards
Letter From The Dean, Jeff Edwards
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
No abstract provided.
Instructions For Authors, Discovery Editors
Instructions For Authors, Discovery Editors
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
No abstract provided.
Dietitian-Led Nutrition Care Across The Cellular Therapy Continuum Supports Weight And Strength Recovery, Ashley Pagano Ms, Rdn, Ldn, Samantha Okerson Rdn, Erin Levine Rd, Cso, Ldn, Deanna Yerg Ms, Rdn, Ldn
Dietitian-Led Nutrition Care Across The Cellular Therapy Continuum Supports Weight And Strength Recovery, Ashley Pagano Ms, Rdn, Ldn, Samantha Okerson Rdn, Erin Levine Rd, Cso, Ldn, Deanna Yerg Ms, Rdn, Ldn
Clinical Nutrition Service
No abstract provided.
High-Osmolality Medication Exposure And Length Of Stay In Icu Patients With Rectal Tubes, Kimberly Cephas Ms, Rdn, Ldn, Rachel Geosits Ms, Rdn, Cnsc, Ldn, Matthew Fair Pharmd, Hope Kincaid Mph, Cph, Alison Sutter Mph
High-Osmolality Medication Exposure And Length Of Stay In Icu Patients With Rectal Tubes, Kimberly Cephas Ms, Rdn, Ldn, Rachel Geosits Ms, Rdn, Cnsc, Ldn, Matthew Fair Pharmd, Hope Kincaid Mph, Cph, Alison Sutter Mph
Clinical Nutrition Service
No abstract provided.
Interaction Of The Gram-Positive Human Pathogen Staphylococcus Aureus With Host Lipids, Sharanya Paul
Interaction Of The Gram-Positive Human Pathogen Staphylococcus Aureus With Host Lipids, Sharanya Paul
Theses and Dissertations
Staphylococcus aureus is a prominent pathogen that is known to incorporate straight-chain unsaturated fatty acids (SCUFAs) into its lipids in addition to the normally biosynthesized branched-chain fatty acids (BCFAs) and straight-chain fatty acids (SCFAs). Furthermore, it has recently been shown that the incorporation of oleic acid into S. aureus lipids significantly enhanced the growth of the organism at low temperatures due to the greater fluidity imparted to the membrane. Together with others in the Wilkinson and Dahl laboratory, I have shown that low-temperature growth is enhanced by various SCUFAs, including the human antimicrobial fatty acids sapienic acid, linoleic acid, and …
Omega-3 Fatty Acids And Bioactives In Aqueous-Extracted Oils From Seven Edible Insects, Xavier Cheseto, Chrysantus Mbi Tanga
Omega-3 Fatty Acids And Bioactives In Aqueous-Extracted Oils From Seven Edible Insects, Xavier Cheseto, Chrysantus Mbi Tanga
All Peer-Reviewed Publications
Globally, there is urgent search and research interest towards alternative sources of polyunsaturated omega-3 fatty acids (ω-3 FA) due to sustainability challenges faced by dependence on fish and plant-derived sources. Limited information exists on insects despite their promising potential. This work analyzed oils from seven insect species commonly consumed globally compared to commercial sesame oil using coupled gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). Oil yields from insects ranged between 11.1 mg/g to 115.3 mg/g. Over 67 fatty acids, α-tocopherol [vitamin E] and eight flavonoids were identified. All insect oils contained ω-3 FA [i.e., α-linolenic acid (ALA), eicosapentaenoic …
Peptidomic Profiling Of In Vitro Digesta From Diverse Microalgae Species, Sara Hamzelou, Damien Belobrajdic, Henri Brook, Wei Chen, Fletcher Hiten, Kim Lee Chang, Diane Purcell, Utpal Bose, Simone Osborne, Cassandra Pegg, Michelle L. Colgrave
Peptidomic Profiling Of In Vitro Digesta From Diverse Microalgae Species, Sara Hamzelou, Damien Belobrajdic, Henri Brook, Wei Chen, Fletcher Hiten, Kim Lee Chang, Diane Purcell, Utpal Bose, Simone Osborne, Cassandra Pegg, Michelle L. Colgrave
Research outputs 2022 to 2026
Microalgae are a sustainable protein source, yet few species are used for human nutrition. This study evaluated eight species for protein quality, digestibility, and peptide profiles after simulated gastrointestinal digestion using INFOGEST. Amino acid content, and intestinal-phase peptide mixtures were analysed by mass spectrometry. The methanol precipitation method was used to separate digested (supernatant) and undigested (pellet) peptides following in vitro INFOGEST digestion. The pellet was further separated by molecular weight into 3–10 kDa and >10 kDa fractions to isolate the lower molecular weight peptides from the higher ones. This separation method enabled the identification of potential digested peptides within …
Contents, Discovery Editors
Contents, Discovery Editors
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
No abstract provided.
Discovery: The Student Journal Of Dale Bumpers College Of Agricultural, Food And Life Sciences - Volume 27 2026, Several Authors
Discovery: The Student Journal Of Dale Bumpers College Of Agricultural, Food And Life Sciences - Volume 27 2026, Several Authors
Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences
No abstract provided.
3d-Printed Soy Protein And Microalga Films: A Sustainable Approach With Antioxidant Functionality, Sorour Barekat, Buse Dogan, Sibel Uzuner, Ali Ubeyitogullari
3d-Printed Soy Protein And Microalga Films: A Sustainable Approach With Antioxidant Functionality, Sorour Barekat, Buse Dogan, Sibel Uzuner, Ali Ubeyitogullari
Food Science Faculty Publications and Presentations
This study investigated the optimization and fabrication of soy protein isolate (SPI)-green microalga (MA) 3D-printed films. For optimizing 3D printing, the effects of MA concentration, nozzle size (0.52-0.81 mm), and speed (10-20 mm/s) were examined. The printed films were then dried, and color, mechanical properties, water vapor permeability, structure, and antioxidant activity were analyzed. All the formulations showed shear-thinning behavior and rapid recovery. The concentration of 3 % MA, nozzle size of 0.72 mm, and printing speed of 20 mm/s were selected as the optimized conditions for the best 3D printability. Compared with the control, their elongation at break decreased …
Edible Coatings Application For Postharvest Fruits Preservation: Bibliometric Trends, Material Design, Physiological Mechanisms, And Safety Perspectives, Muslim Qadir, Navjot Kaur, Dali Vilma Francis, Abdelmoneim K. Abdalla, Zora Singh, Zienab F.R. Ahmed
Edible Coatings Application For Postharvest Fruits Preservation: Bibliometric Trends, Material Design, Physiological Mechanisms, And Safety Perspectives, Muslim Qadir, Navjot Kaur, Dali Vilma Francis, Abdelmoneim K. Abdalla, Zora Singh, Zienab F.R. Ahmed
Research outputs 2022 to 2026
Fresh fruits play a vital role in ensuring food and nutritional security, while also making significant contributions to global trade. However, due to their highly perishable nature, they are susceptible to postharvest losses during storage, transportation, and marketing. Edible coatings (ECs) and edible films are effective postharvest preservation technologies for retarding senescence and preserving fruit quality. This review provides a comprehensive update on recent developments in ECs and films aimed at reducing postharvest losses in fresh fruits. These coatings are formulated using biopolymers, including polysaccharides, proteins, and lipids, along with food-grade additives. The review discusses how ECs modulate postharvest physiology …
Food Recognition With Visual Language Models: Search Re-Ranking Or Retrieval-Augmented Generation?, Kian Yu Gan, Phuong Anh Nguyen, Chong-Wah Ngo
Food Recognition With Visual Language Models: Search Re-Ranking Or Retrieval-Augmented Generation?, Kian Yu Gan, Phuong Anh Nguyen, Chong-Wah Ngo
Research Collection School Of Computing and Information Systems
Despite the rapid advances in Visual Language Models (VLMs), these models struggle to recognize culture-specific food items. While VLMs are effective in recognizing popular cultural dishes, their performance is suboptimal for dishes that are unique but not widely known internationally. Specifically, VLMs often generate either generic labels or hallucinated names for dishes that are localized to a particular culture. As a result, retrieval-augmented generation (RAG), which retrieves relevant recipes as references for VLMs, emerges as a promising approach. Nevertheless, recipe retrieval, which is itself imperfect, could mislead VLMs into generating inaccurate or culturally inappropriate dish names. This paper presents a …
Chia Seed Gel Powder As A Clean-Label Enhancer Of Texture, Physicochemical Quality, Antioxidant Activity, And Prebiotic Function In Probiotic Low-Fat Yogurt, Mahmoud E. A. Hamouda, Ratul Kalita, Abdelfatah K. Ali, Pratibha Chaudhary, Pramith U. Don, Omar A. A. Abdelsater, Anjali Verma, Yaser Elderwy
Chia Seed Gel Powder As A Clean-Label Enhancer Of Texture, Physicochemical Quality, Antioxidant Activity, And Prebiotic Function In Probiotic Low-Fat Yogurt, Mahmoud E. A. Hamouda, Ratul Kalita, Abdelfatah K. Ali, Pratibha Chaudhary, Pramith U. Don, Omar A. A. Abdelsater, Anjali Verma, Yaser Elderwy
Nutrition, Dietetics, and Food Science Student Research
This study evaluated the effect of incorporating chia seed gel powder (CSGP) as a natural, clean-label stabilizer on the physicochemical, functional, microbiological, microstructural, antioxidant, and sensory properties of probiotic low-fat yogurt (PLFY) during 21 days of refrigerated storage. Six formulations were prepared using 0–2.5% CSGP, including Control (0% CSGP), YOG1 (0.5% CSGP), YOG2 (1.0% CSGP), YOG3 (1.5% CSGP), YOG4 (2.0% CSGP), and YOG5 (2.5% CSGP). Results showed that increasing CSGP levels noticeably enhanced the total solids, protein content, viscosity, hardness, and water-holding capacity of the PLFY (p < 0.05), while consistently reducing syneresis. Antioxidant activity also rose with higher CSGP concentrations, with YOG5 exhibiting the greatest DPPH scavenging activity (35.12%). Confocal laser scanning microscopy revealed a denser and more uniform protein network in PLFY fortified with CSGP, consistent with rheological measurements showing increased storage (G′) and loss (G″) moduli. Probiotic viability significantly increased (p < 0.05) in CSGP-added samples, indicating a potential prebiotic effect of CSGP. Sensory results demonstrated that although higher CSGP levels slightly darkened the yogurt color, body, texture, flavor, and total sensory scores improved markedly, with YOG5 gaining the highest total score (81.77). The results demonstrate that CSGP acts as a highly effective, multifunctional ingredient that enhances texture, stability, probiotic viability, and antioxidant capacity, making it a strong clean-label candidate for developing high-quality, functional probiotic low-fat yogurt.
Investigating The Incorporation Of Milled Rice In Brewing Non-Alcoholic Beer To Enhance Sensory Quality, Christian Schubert, Rahul Sen, Nils Rettberg, Scott Lafontaine
Investigating The Incorporation Of Milled Rice In Brewing Non-Alcoholic Beer To Enhance Sensory Quality, Christian Schubert, Rahul Sen, Nils Rettberg, Scott Lafontaine
Food Science Faculty Publications and Presentations
The influence of substituting barley malt with milled rice on the sensory and chemical characteristics of nonalcoholic beers (NAB) was investigated. Physicochemical and volatile analyses were conducted on the NABs. Original gravities ranged from 6.71% w/w (100% barley malt) to 7.15% w/w (100% rice), with alcohol contents between 0.33% v/v (70% barley/30 %rice) and 0.45 % v/v (100% rice). Color decreased from 10.8 EBC (100% barley malt) to 3.3 EBC (100% rice). Descriptive analysis sensory evaluations by trained panelists in the United States and European Union were used to characterize the sensory profiles of the NABs. Principal component analysis showed …
Comparative Effects Of Gamma Irradiation And Chemical Treatments On Superficial Scald And Quality Of ‘Granny Smith’ Apples, Francisco E. Loayza, Michelle Tu, Hagop S. Atamian, Anuradha Prakash
Comparative Effects Of Gamma Irradiation And Chemical Treatments On Superficial Scald And Quality Of ‘Granny Smith’ Apples, Francisco E. Loayza, Michelle Tu, Hagop S. Atamian, Anuradha Prakash
Food Science Faculty Articles and Research
Fresh produce is highly perishable, necessitating various postharvest treatments to minimize quality loss, extend shelf-life, and facilitate international trade. This study investigated the potential of a single low-dose gamma irradiation treatment as an alternative to commercially used chemical treatments for protecting ‘Granny Smith’ apples against insect pests and postharvest disorders. ‘Granny Smith’ apples harvested in 2019 and 2020 were treated with gamma irradiation at doses of 240 or 860 Gray (Gy) or with commercial chemical applications of 1-methylcyclopropene (1-MCP), diphenylamine (DPA), or methyl bromide (MeBr). The impact on fruit quality, physiology, and the development of postharvest disorders was evaluated after …
Composite Flours For Sustainable Food Systems: Integrating Nutritional, Environmental, And Climate Resilience Strategies, Rashmi H. Poojara, Soumya P S, Alvina Rose, Niva Somarajan
Composite Flours For Sustainable Food Systems: Integrating Nutritional, Environmental, And Climate Resilience Strategies, Rashmi H. Poojara, Soumya P S, Alvina Rose, Niva Somarajan
Journal of Environmental Science and Sustainable Development
Composite flour blends prepared from cereals, millets, tubers, legumes, and vegetables have gained increasing attention due to their potential to enhance nutritional quality, improve functional properties, and support sustainable food systems. Previous studies have largely focused on individual nutritional or functional attributes, with limited integration of environmental and health perspectives. This review aimed to systematically analyze how composite flours simultaneously influence nutritional quality, functional performance, health relevance, and environmental sustainability within a unified analytical framework. A systematic literature review was conducted following PRISMA guidelines. Peer-reviewed studies published between 2014 and 2025 were retrieved from PubMed, Scopus, Web of Science, and …
Concentration-Dependent Effects Of Green Tea Extract On The Growth And Metabolism Of Lacticaseibacillus Rhamnosus: An In Vitro Analysis, Jingxian Zeng, Francesco Noci, Kishor Keekan, Ulrich Hoeche
Concentration-Dependent Effects Of Green Tea Extract On The Growth And Metabolism Of Lacticaseibacillus Rhamnosus: An In Vitro Analysis, Jingxian Zeng, Francesco Noci, Kishor Keekan, Ulrich Hoeche
SURE Journal: Science Undergraduate Research Experience Journal
Green tea extract (GTE) is widely recognised for its bioactive compounds, which exhibit potential health benefits, including modulation of gut microbiota. However, the concentration-dependent effects of GTE on specific probiotic strains remain underexplored. The aim of this study was to systematically evaluate the concentration-dependent effects of green tea extract (GTE) on Lacticaseibacillus rhamnosus (L. rhamnosus). The promoting and inhibiting effects of GTE in the range of 0–50 mg/mL were analysed in vitro by OD₆₀₀ growth curve, pH change and colony forming unit (CFU) count. The experimental results showed that the concentration range of 0.05–2.05 mg/mL in the low concentration group …
Developing A Tool To Measure Resistance To Sustainable Food Choices: A Pilot Study In Ireland And The Netherlands, Kate Flanagan, Bart Sinteur, Patricia J. Bulsing, John M. Kearney
Developing A Tool To Measure Resistance To Sustainable Food Choices: A Pilot Study In Ireland And The Netherlands, Kate Flanagan, Bart Sinteur, Patricia J. Bulsing, John M. Kearney
SURE Journal: Science Undergraduate Research Experience Journal
Consumer uptake of a sustainable diet is critical for addressing environmental challenges and promoting public health. Understanding why consumers resist adopting sustainable eating habits can inform targeted interventions and policies. This pilot study examines whether a newly developed scale can effectively detect consumer resistance to a sustainable diet. Currently, there is a lack of research on a tool to measure consumer resistance to a sustainable diet, highlighting the need for a reliable instrument.
The aim of this study is to develop a scale, based on existing literature, to measure consumer resistance to a sustainable diet. Additionally, the study aims to …
Editorial-Sure Journal Volume 7, Issue 2, Geraldine M. Dowling, Eva Campion, Sinead Loughran, Ariane Perez-Gavilan, Josephine Treacy
Editorial-Sure Journal Volume 7, Issue 2, Geraldine M. Dowling, Eva Campion, Sinead Loughran, Ariane Perez-Gavilan, Josephine Treacy
SURE Journal: Science Undergraduate Research Experience Journal
No abstract provided.
Spilling The Tea: Effects Of Uv Disinfection On Bioactive Compounds In South African Rooibos Tea, Sora Ghanem, Leah Ankiah, Yusra Ahmed
Spilling The Tea: Effects Of Uv Disinfection On Bioactive Compounds In South African Rooibos Tea, Sora Ghanem, Leah Ankiah, Yusra Ahmed
Student Scholar Symposium
This study investigated the effects of ultraviolet (UV) light disinfection on key bioactive flavonoid compounds in rooibos tea (Aspalathus linearis). There is an interest in non-thermal food preservation technologies, and UV treatment offers potential advantages for beverage processing. However, concerns exist regarding possible degradation of health-promoting compounds during treatment. Rooibos tea samples were subjected to five UV exposure intensities (0, 25, 50, 75, and 100 mJ/cm²), and concentrations of four major flavonoids (aspalathin, orientin, vitexin, and rutin) were measured using high performance liquid chromatography (HPLC). Surprisingly, most flavonoids showed stability or slight concentration increases at higher UV doses. Aspalathin concentrations …
Rapid Detection Of Chicken Residues On Poultry Plant Surfaces Using Color And Fluorescence Spectrometry, Clark Griscom, Dongyi Wang, Corliss A. O'Bryan, Rimmo Room, Philip G. Crandall
Rapid Detection Of Chicken Residues On Poultry Plant Surfaces Using Color And Fluorescence Spectrometry, Clark Griscom, Dongyi Wang, Corliss A. O'Bryan, Rimmo Room, Philip G. Crandall
Food Science Faculty Publications and Presentations
Color and fluorescence spectrometry were evaluated as rapid, objective tools for verifying the cleanliness of poultry-processing food-contacting surfaces contaminated with a model chicken solution across six common materials. Both techniques detected chicken residues at dilutions several orders of magnitude below human visual and olfactory thresholds, with stainless steel and blue plastic yielding the largest color differences between clean and contaminated states and fluorescence measurements remaining highly sensitive on all tested surfaces. Representative limits of detection were on the order of 1:50-1:100 dilution of chicken residue for color measurements on most surfaces and approximately 1:50 for fluorescence measurements, compared with human …
The Effects Of Added Xanthan Gum On The Acceptability Of Gluten-Free Shortcake, Samuel Garrett, Seth Beach, Maiya Zepeda
The Effects Of Added Xanthan Gum On The Acceptability Of Gluten-Free Shortcake, Samuel Garrett, Seth Beach, Maiya Zepeda
Student Scholar Symposium
The Effects of Added Xanthan Gum on the Acceptability of Gluten-Free Shortcake
Introduction: The incidence of celiac disease and gluten sensitivity has increased, driving demand for gluten-free (GF) baked goods. However, replicating the texture and structure provided by gluten remains a challenge. Xanthan gum, a common additive in GF baking, may improve texture and overall product acceptability. This study evaluates whether adding xanthan gum to a homemade GF flour blend improves the quality of GF shortcake.
Methods: A control shortcake made with all-purpose flour was compared to three GF versions: 1) commercial GF flour, 2) homemade GF flour blend (white …
Effects Of Plant Based Egg Replacers On Flavor And Sensory Characteristics Of Banana Bread, Daniela Mason, Sarah Harris, Anniston Drummonds
Effects Of Plant Based Egg Replacers On Flavor And Sensory Characteristics Of Banana Bread, Daniela Mason, Sarah Harris, Anniston Drummonds
Student Scholar Symposium
This abstract assesses the differences in the characteristics of baked goods using alternative ingredients, and informs about the benefits of opting for natural, whole-foods when cooking.
Photoflow Synthesis And Characterization Of Cis- And Trans-N-Isohumulone, Gregory M. Giovine, Bradley Gallow, Trevor Smith, Bruce Hamper
Photoflow Synthesis And Characterization Of Cis- And Trans-N-Isohumulone, Gregory M. Giovine, Bradley Gallow, Trevor Smith, Bruce Hamper
Undergraduate Research Symposium
Previously published efforts by the Hamper group demonstrated the viability of photochemistry in the isomerization of n-humulone to n-isohumulone. Photochemical isomerization reactions of n-humulone performed under 400nm light over 8 hours resulted in high yields (84% reported) of largely trans-n-isohumulone (>95%). These promising results invited further examination of the photochemical process and the application of photoflow procedure. Herein we report the beginnings of a comprehensive slate of n-humulone isomerization reactions performed under iterative photoflow conditions.
Corrigendum To “Yi-Qi-Xuan-Fei Formula Ameliorate Chronic Obstructive Pulmonary Disease By Remodeling Lung And Intestinal Florase In Rat Models” [J Food Drug Anal 33(3) (2025) 252-276]
Journal of Food and Drug Analysis
No abstract provided.
Economic Evaluation Of Ai-Assisted Technologies In Healthcare: A Systematic Review, Wen-Tung Wu, Yi-Wen Chao, Tsung-Kun Lin, Ching-Kuo Huang, Ping-Hsuan Hsieh
Economic Evaluation Of Ai-Assisted Technologies In Healthcare: A Systematic Review, Wen-Tung Wu, Yi-Wen Chao, Tsung-Kun Lin, Ching-Kuo Huang, Ping-Hsuan Hsieh
Journal of Food and Drug Analysis
Artificial intelligence (AI) technologies are increasingly integrated into healthcare, yet their economic value remains uncertain. Traditional economic evaluation methods may not adequately capture the unique features of AI, including dynamic model evolution, scalability, and broader societal impacts. This systematic review synthesized existing evidence on the cost-effectiveness of AI-based healthcare interventions and assessed the methodological rigor of published studies. A comprehensive search identified health economic evaluations of AI applications published between September 2019 and March 2025, following PRISMA and SWiM guidelines and registered in PROSPERO (CRD42025641230). Eligible studies were full economic evaluations comparing AI-based interventions with non-AI alternatives, and data were …
Combination Treatment Of Cordycepin And Radiation Induces Apoptosis Accompanied By Protective Autophagy In Tm3 Mouse Leydig Progenitor Cells, Yu-Yan Lan, Yi-Ping Lee, Wei-Ru Huang, Chun-Ying Yu, Lyh-Jyh Hao, Chun-Hung Lin, Bu-Miin Huang
Combination Treatment Of Cordycepin And Radiation Induces Apoptosis Accompanied By Protective Autophagy In Tm3 Mouse Leydig Progenitor Cells, Yu-Yan Lan, Yi-Ping Lee, Wei-Ru Huang, Chun-Ying Yu, Lyh-Jyh Hao, Chun-Hung Lin, Bu-Miin Huang
Journal of Food and Drug Analysis
Leydig cells are anatomically located in the testicular interstitial tissue, and their main function is to produce and secrete testosterone and indirectly support spermatogenesis. We previously reported that the combination treatment of cordycepin and radiation can effectively induce Leydig tumor cell apoptosis through cell cycle arrest, caspase activation, endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) accumulation, and DNA damage. However, there is still a lack of scientific evidence for the susceptibility of normal Leydig cells to the combination treatment. In the present study, mouse TM3 Leydig progenitor cells were used as a model to evaluate the effects and mechanisms …
Development Of An Untargeted Metabolomics Analytical Protocol For Fecal Samples By Liquid Chromatography–Mass Spectrometry, Tsai-Wei Ting, Chih-Ning Cheng, Chieh-Chang Chen, Ching-Hua Kuo
Development Of An Untargeted Metabolomics Analytical Protocol For Fecal Samples By Liquid Chromatography–Mass Spectrometry, Tsai-Wei Ting, Chih-Ning Cheng, Chieh-Chang Chen, Ching-Hua Kuo
Journal of Food and Drug Analysis
Gut microbiota has recently gained attention for its role in regulating multiple host pathways and contributing to disease developments. Fecal metabolomics using liquid chromatography—mass spectrometry (LC—MS) offers a promising approach to study gut microbial metabolites; however, it remains technically challenging due to the complex, heterogeneous nature of fecal samples and the lack of standardized protocols. This study aimed to establish a robust and reproducible untargeted fecal metabolomics workflow. We systematically evaluated sample preparation parameters―including sample amount, extraction solvent, numbers of extraction, and sample-to-solvent ratio―and assessed method reproducibility. Additionally, we compared three LC—MS data acquisition workflows using 10 samples from inflammatory …