Operations Research, Systems Engineering and Industrial Engineering Commons^™

An Analysis Of Robust Workforce Scheduling Models For A Nurse Rostering Problem, Paul K. Tower

Theses and Dissertations

Disruptions impacting workforce schedules can be costly. A 1999 study of the United Kingdom's National Health Service estimated that as much as 4% of the total resources spent on staffing were lost to schedule disruptions like absenteeism. Although disruptions can not be eliminated, workforce schedules can be improved to be more responsive to disruptions. One key area of study that has expanded over the past few years is the application of traditional scheduling techniques to re-rostering problems. These efforts have provided methods for responding to schedule disruptions, but typically require deviations to the disrupted schedule. This thesis examines five workforce …

Improved Hyperspectral Image Testing Using Synthetic Imagery And Factorial Designed Experiments, Joseph P. Bellucci

Theses and Dissertations

The goal of any remote sensing system is to gather data about the geography it is imaging. In order to gain knowledge of the earth's landscape, post-processing algorithms are developed to extract information from the collected data. The algorithms can be intended to classify the various ground covers in a scene, identify specific targets of interest, or detect anomalies in an image. After the design of an algorithm comes the difficult task of testing and evaluating its performance. Traditionally, algorithms are tested using sets of extensively ground truthed test images. However, the lack of well characterized test data sets and …

Critical Infrastructure Rebuild Prioritization Using Simulation Optimization, Namsuk Cho

Theses and Dissertations

This thesis examines the importance of a critical infrastructure rebuild strategy following a terrorist attack or natural disaster such as Hurricane Katrina. Critical infrastructures are very complex and dependent systems in which their re-establishment is an essential part of the rebuilding process. A rebuild simulation model consisting of three layers (physical, information, and spatial) captures the dependency between the six critical infrastructures modeled. We employ a simulation optimization approach to evaluate rebuild prioritization combinations with a goal of minimizing the time needed to achieve an acceptable rebuild level. We use a simulated annealing heuristic as an optimization technique that works …

Approximate Analysis Of An Unreliable M/M/2 Retrial Queue, Brian P. Crawford

Theses and Dissertations

This thesis considers the performance evaluation of an M/M/2 retrial queue for which both servers are subject to active and idle breakdowns. Customers may abandon service requests if they are blocked from service upon arrival, or if their service is interrupted by a server failure. Customers choosing to remain in the system enter a retrial orbit for a random amount of time before attempting to re-access an available server. We assume that each server has its own dedicated repair person, and repairs begin immediately following a failure. Interfailure times, repair times and times between retrials are exponentially distributed, and all …

Analyzing The Interdiction Of Sea-Borne Threats Using Simulation Optimization, Kristen L. Cavallaro

Theses and Dissertations

Worldwide, maritime trade accounts for approximately 80% of all trade by volume and is expected to double in the next twenty years. Prior to September 11, 2001, Ports, Waterways and Coastal Security (PWCS) was afforded only 1 percent of United States Coast Guard (USCG) resources. Today, it accounts for nearly 22 percent of dedicated USCG resources. Tactical assessment of resource requirements and operational limitations on the PWCS mission is necessary for more effective management of USCG assets to meet the broader range of competing missions. This research effort involves the development and validation of a discrete-event simulation model of the …

Planning And Assessing Stability Operations: A Proposed Value-Focused Thinking Approach, Gerald D. Fensterer

Theses and Dissertations

Stability operations are vital to establish peace in the aftermath of conflict. The United States is often called in for military support during conflict. The new American military paradigms include establishing peace through stability operations after a military conflict. Due to this new role, military decision makers face many difficulties in conducting successful stability operations. Compounding this problem is the limited number of resources pertaining to stability operations: experts, doctrine, knowledge, and technology. Two overarching challenges of stability operations facing decision makers are planning and prioritizing of stability operations and determining progress. This thesis applies a structured analytical approach to …

An Efficient Metaheuristic For Dynamic Network Design And Message Routing, Robert B. Hartlage

Theses and Dissertations

The implementation of Net-centric warfare presents major challenges in terms of effectively and efficiently delivering critical information across the Global Information Grid. In many cases, the amount of information requested will exceed the capabilities of the network. One challenge is to dynamically design the network (assign transceivers) to maximize the amount of required information that can be transmitted and the quality of service for those transmissions - to best implement the communications tasking order. The problem is as follows: given a list of required message traffic, to include source, destination, size, and priority, design the network to maximize the delivery …

Updating Optimal Decisions Using Game Theory And Exploring Risk Behavior Through Response Surface Methodology, Jeremy D. Jordan

Theses and Dissertations

This thesis utilizes game theory within a framework for updating optimal decisions based on new information as it becomes available. Methodology is developed that allows a decision maker to change his perceived optimal policy based on available knowledge of the opponents strategy, where the opponent is a rational decision maker or a random component nature. Utility theory is applied to account for the different risk preferences of the decision makers. Furthermore, response surface methodology is used to explore good risk strategies for the decision maker to approach each situation with. The techniques are applied to a combat scenario, a football …

Prioritizing Satellite Payload Selection Via Optimization, Benjamin S. Kallemyn

Theses and Dissertations

This thesis develops optimization models for prioritizing payloads for inclusion on satellite buses with volume, power, weight and budget constraints. The first model considers a single satellite launch for which the budget is uncertain and constellation requirements are not considered. Subsequently, we include constellation requirements and provide a more enhanced model. Both single-launch models provide a prioritized list of payloads to include on the launch before the budget is realized. The single-launch models are subsequently extended to a sequence of multiple launches in two cases, both of which incorporate an explicit dependence on the constellation composition at each launch epoch. …

Automatic Target Recognition User Interface Tool, David A. Kerns

Theses and Dissertations

A computer tool to aid in selecting the best Automatic Target Recognition (ATR) algorithm is developed. The program considers many quantifiers, accepts user-defined parameters, allows for changes in the operational environment and presents results in a meaningful way. It is written for Microsoft Excel. An ATR algorithm assigns a class label to a recognized target. General designations can include "Friend" and "Foe." The error of designating "Friend" as "Foe" as well as "Foe" as "Friend" comes with a high cost. Studying each algorithm's error can minimize this cost. Receiver Operating Characteristic (ROC) curves provide only information on the probabilities given …

Mathematical Programming Model For Fighter Training Squadron Pilot Scheduling, Thomas M. Newlon

Theses and Dissertations

The United States Air Force fighter training squadrons build weekly schedules using a long and tedious process. Very little of this process is automated and optimality of any kind is nearly impossible. Schedules are built to a feasible condition only to be changed with consideration of Wing level requirements. Weekly flying schedules are restricted by requirements for crew rest, days since a pilot's last sortie, sorties in the last 30 days, and sorties in the last 90 days. By providing a scheduling model to the pilot charged with creating the schedule, valuable pilot hours could be spent in the cockpit, …

Patterns Of War Termination: A Statistical Approach, Paul D. Robinson Ii

Theses and Dissertations

This research uses an advanced statistical technique to expand upon the current understanding of war termination. Specifically, this thesis addressed questions concerning the most relevant factors toward predicting both the outcomes of interstate wars and the winners of intrastate and extra-systemic wars, within the limitations of the available data. Open-source war data from the Correlates of War Project was analyzed using both binary and multinomial logistic regression techniques. While the Correlates of War Project did not necessarily focus its data collection efforts on those variables historically associated with war termination, it did provide a sufficient number of variables with which …

Examining Clandestine Social Networks For The Presence Of Non-Random Structure, Joshua S. Seder

Theses and Dissertations

This thesis develops a tractable, statistically sound hypothesis testing framework for the detection, characterization, and estimation of non-random structure in clandestine social networks. Network structure is studied via an observed adjacency matrix, which is assumed to be subject to sampling variability. The vertex set of the network is partitioned into k mutually exclusive and collectively exhaustive subsets, based on available exogenous nodal attribute information. The proposed hypothesis testing framework is employed to statistically quantify a given partition's relativity in explaining the variability in the observed adjacency matrix relative to what can be explained by chance. As a result, valuable insight …

Change-Point Methods For Overdispersed Count Data, Brian A. Wilken

Theses and Dissertations

A control chart is often used to detect a change in a process. Following a control chart signal, knowledge of the time and magnitude of the change would simplify the search for and identification of the assignable cause. In this research, emphasis is placed on count processes where overdispersion has occurred. Overdispersion is common in practice and occurs when the observed variance is larger than the theoretical variance of the assumed model. Although the Poisson model is often used to model count data, the two-parameter gamma-Poisson mixture parameterization of the negative binomial distribution is often a more adequate model for …

Creating An Internet Repository For Course Portfolios, Paul Savory, Amy M. Goodburn, Amy Nelson Burnett

Department of Industrial and Management Systems Engineering: Faculty Publications

Our ITLE grant has supported the development of www.courseportfolio.org – an internet repository for faculty-written course portfolios documenting best practices and evidence of student learning occurring in the classroom.

Synthesis Of Gold Micro- And Nano-Wires By Infiltration And Thermolysis, E.A. Olevsky, X. Wang, E. Bruce, M.B. Stern, S. Wildhack, F. Aldinger

Industrial and Manufacturing Engineering

An approach for synthesizing micro- and nano-sized gold wires by infiltration and thermolysis is investigated. A porous ZrO₂ ceramic preform with aligned pores obtained by unidirectional freezing and freeze-drying is employed as an infiltration template. The sintered porous ZrO₂ preform is then infiltrated by a brushing gold solution. The thermolysis is conducted at 600 °C in air. Micro- and nano-sized gold wires are developed within the walls of the pores after thermolysis. The diameter of the gold wires ranges from several hundred nanometers to several microns.

Acuta Enews February 2007, Vol. 36, No. 2

ACUTA Newsletters

In This Issue

Nominate Now for ACUTA Board of Directors 2007-08

From the President.............. Carmine Piscopo, RCDD, Providence College

Nominations Still Open for Institutional Excellence Awards............. Pat Todus, Northwestern Univ.

Tech Talk: Visibility for Your School and ACUTA............. Kevin Tanzillo, Dux PR

DC Update............ Jeanne Jansenius, Sewanee, The University of the South

Overheard on the Listserv: Pricing VoIP

FYI: Useful Information from the Campus........... Student Monitor

Web Tip: What's New on ACUTA Website...... Aaron Fuehrer, ACUTA Information Technology Manager

Board Report.......... Riny Ledgerwood, San Diego State Univ., ACUTA Sec./Treasurer

Info Links............ Randy Hayes, Univ. of Northern Iowa

Remembering Harry Kyle …

Quality Of Service Routing Strategy Using Supervised Genetic Algorithm, Zhaoxia Wang, Yugeng Sun, Zhiyong Wang, Huayu Shen

Research Collection School Of Computing and Information Systems

A supervised genetic algorithm (SGA) is proposed to solve the quality of service (QoS) routing problems in computer networks. The supervised rules of intelligent concept are introduced into genetic algorithms (GAs) to solve the constraint optimization problem. One of the main characteristics of SGA is its searching space can be limited in feasible regions rather than infeasible regions. The superiority of SGA to other GAs lies in that some supervised search rules in which the information comes from the problems are incorporated into SGA. The simulation results show that SGA improves the ability of searching an optimum solution and accelerates …

Towards Efficient Planning For Real World Partially Observable Domains, Pradeep R. Varakantham

Research Collection School Of Computing and Information Systems

My research goal is to build large-scale intelligent systems (both single- and multi-agent) that reason with uncertainty in complex, real-world environments. I foresee an integration of such systems in many critical facets of human life ranging from intelligent assistants in hospitals to offices, from rescue agents in large scale disaster response to sensor agents tracking weather phenomena in earth observing sensor webs, and others. In my thesis, I have taken steps towards achieving this goal in the context of systems that operate in partially observable domains that also have transitional (non-deterministic outcomes to actions) uncertainty. Given this uncertainty, Partially Observable …

Determining Continual Improvement Process Methods Within Quality Management Systems, Diane M. Bové

Theses

Institutionalized standards require organizations to actively define and implement quality management systems, which includes active participation in continual improvement efforts. Interpretations and practices vary on implementation methodology.

Traditional views of quality do not integrate the technical disciplines into a defined science which would support a standardized approach for continual improvement implementation.

In order to optimize improvement efforts, a conceptual hypothesis is proposed to integrate quality through combining and collaborating implementation efforts of engineering, control, assurance, improvement and costs. The purpose of this thesis is to establish a roadmap to assist in choosing effective quality improvement methodologies and toolsets that assist …

A Biofilm Enhanced Miniature Microbial Fuel Cell Using Shewanella Oneidensis Dsp10 And Oxygen Reduction Cathodes, Justin C. Biffinger, Jeremy Pietron, Ricky Ray, Brenda J. Little, Bradley R. Ringeisen

United States Navy: Publications

Aminiature-microbial fuel cell (mini-MFC, chamber volume: 1.2 mL)was used to monitor biofilm development from a pure culture of Shewanella oneidensis DSP10 on graphite felt (GF) under minimal nutrient conditions. ESEM evidence of biofilm formation on GF is supported by substantial power density (per device cross-section) from the mini-MFC when using an acellular minimal media anolyte (1500mW/m²). These experiments demonstrate that power density per volume for a biofilm flow reactor MFC should be calculated using the anode chamber volume alone (250 W/m³), rather than with the full anolyte volume. Two oxygen reduction cathodes (uncoated GF or a …

Enterprise Resource Planning (Erp): A Review Of The Literature, Young Moon

Mechanical and Aerospace Engineering - All Scholarship

This article is a review of work published in various journals on the topics of Enterprise Resource Planning (ERP) between January 2000 and May 2006. A total of 313 articles from 79 journals are reviewed. The article intends to serve three goals. First, it will be useful to researchers who are interested in understanding what kinds of questions have been addressed in the area of ERP. Second, the article will be a useful resource for searching for research topics. Third, it will serve as a comprehensive bibliography of the articles published during the period. The literature is analysed under six …

Backward And Forward Compatibility, Jianbiao Pan, Jasbir Bath, Xiang Zhou, Dennis Willie

Industrial and Manufacturing Engineering

In response to the European Union (EU) Restriction of Hazardous Substances (RoHS) and other countries’ impending lead-free directives, the electronics industry is moving toward lead-free soldering. Total lead-free soldering requires not only lead-free solder paste but also lead-free printed circuit board (PCB) finish and lead-free component/packages. Transitioning tin-lead (SnPb) soldering to totally lead-free soldering is a complex issue and involves movement of the whole electronics industry supply chain. In reality, there is a transition period.

Remediation Of Rdx- And Hmx-Contaminated Groundwater Using Organic Mulch Permeable Reactive Barriers, Farrukh Ahmad, Stephen P. Schnitker, Charles J. Newell

United States Army: Publications

Organic mulch is a complex organic material that is typically populated with its own consortium of microorganisms. The organisms in mulch breakdown complex organics to soluble carbon, which can then be used by these and other microorganisms as an electron donor for treating RDX and HMX via reductive pathways. A bench-scale treatability study with organic mulch was conducted for the treatment of RDX- and HMX-contaminated groundwater obtained from a plume at the Pueblo Chemical Depot (PCD) in Pueblo, Colorado. The site-specific cleanup criteria of 0.55 ppb RDX and 602 ppb HMX were used as the logical goals of the study. …

Weak Base Dispiro-1,2,4-Trioxolanes: Potent Antimalarial Ozonides, Yuanqing Tang, Yuxiang Dong, Sergio Wittlin, Susan A. Charman, Jacques Chollet, Francis C. K. Chiu, William N. Charman, Hugues Matile, Heinrich Urwyler, Arnulf Dorn, Saroj Bajpai, Xiaofang Wang, Maniyan Padmanilayam, Jean M. Karle, Reto Brun, Jonathan L. Vennerstrom

United States Army: Publications

Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.

Synthesis And Antimalarial Activity Of New Isotebuquine Analogues, Olga V. Miroshnikova, Thomas H. Hudson, Lucia Gerena, Dennis E. Kyle, Ai J. Lin

United States Army: Publications

Amodiaquine (AQ) and tebuquine are 4-aminoquinoline antimalarials with Mannich base side chain and are highly effective against chloroquine (CQ)-resistant strains of Plasmodium falciparum. Clinical use of AQ has been severely restricted due to hepatoxicity and agranulocytosis side effects associated with its long term use. Lysosomal accumulation and bioactivation to generate reactive quinoneimine metabolite are implicated to be the cause of the observed AQ toxicities. To avoid the quinoneimine formation and thus the toxicity, a series of isotebuquine analogues and their N^ω-oxides with hydroxy group meta to the amino rather than in para position of the aniline moiety …

Army Research Needs For Automated Neuropsychological Tests: Monitoring Soldier Health And Performance Status, Karl E. Friedl, Stephen J. Grate, Susan P. Proctor, James W. Ness, Brian J. Lukey, Robert L. Kane

United States Army: Publications

Information on the mental status of soldiers operating at the limits of human tolerance will be vital to their management in future deployments; it may also allow earlier intervention for conditions such as undiagnosed Gulf War illnesses and Parkinson’s Disease. The Army needs a parsimonious set of neuropsychological tests that reliably identify subtle changes for: (1) early detection of individual health and military performance impairments and (2) management of occupational and deployment health risks. Testing must characterize cognitive lapses in healthy individuals faced with relevant operational stressors (i.e., anxiety, information overload, thermal strain, hypoxia, fatigue, head impact, chemical or radiation …

Thermally Driven Assembly Of Nanoparticles In Polymer Matrices, Philip J. Costanzo, Frederick L. Beyer

United States Army: Publications

Thermally responsive bulk polymer films utilizing reversible Diels-Alder chemistry have been developed. Gold nanoparticles (AuNPs) were passivated with thiol-terminated poly(styrene)-b-poly(ethylene glycol) (PS-b-PEG) copolymer ligand, where the PS and PEG blocks are joined via a Diels-Alder (DA) linkage. The ligand-functionalized nanoparticles were dispersed within a microphase-separated PS-b-poly(methyl methacrylate) (PS-b-PMMA) block copolymer. Nanoparticle location was dictated by the compatibility of the external shell with the block copolymer matrix. As cast, the PEG shell compatibilized the nanoparticles with the PMMA domains. Subsequent thermal treatment caused the Diels-Alder linkages between the polymer blocks to dissociate, leaving the AuNPs functionalized by PS ligands. Immiscibility within …

Improved Formulation Of A Recombinant Ricin A-Chain Vaccine Iincreases Its Stability And Effective Antigenicity, John H. Carra, Robert W. Wannemacher, Ralph F. Tammariello, Changhong Y. Lindsey, Richard E. Dinterman, Rowena D. Schokman, Leonard A. Smith

United States Army: Publications

Ricin is a potent toxin associated with bioterrorism for which no vaccine or specific countermeasures are currently available. A stable, non-toxic and immunogenic recombinant ricin A-chain vaccine (RTA 1-33/44-198) has been developed by protein engineering. We identified optimal formulation conditions for this vaccine under which it remained stable and potent in storage for up to 18 months, and resisted multiple rounds of freeze–thawing without stabilizing co-solvents. Reformulation from phosphate buffer to succinate buffer increased adherence of the protein to aluminum hydroxide adjuvant from 15 to 91%, with a concomitant increase of nearly threefold in effective antigenicity in a mouse model. …

A Refined Pharmacophore Identifies Potent 4-Amino-7-Chloroquinoline-Based Inhibitors Of The Botulinum Neurotoxin Serotype A Metalloprotease, James C. Burnett, Dejan Opsenica, Kamaraj Sriraghavan, Rekha G. Panchal, Gordon Ruthel, Ann R. Hermone, Tam L. Nguyen, Tara A. Kenny, Douglas J. Lane, Connor F. Mcgrath, James J. Schmidt, Jonathan L. Vennerstrom, Rick Gussio, Bogdan A. Solaja, Sina Bavari

United States Army: Publications

We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including antimalarial drugs) contained a 4-amino-7-chloroquinoline (ACQ) substructure and a separate positive ionizable amine component. The same antimalarials have also been found to interfere with BoNT/A translocation into neurons, via pH elevation of the toxin-mediated endosome. Thus, this structural class of small molecules may serve as dual-function BoNT/A inhibitors. In this study, we used a refined pharmacophore for BoNT/A LC inhibition to identify four new, potent inhibitors of this structural class (IC50’s ranged from 3.2 to 17 …