Operations Research, Systems Engineering and Industrial Engineering Commons^™

Phase I Dose Escalation Safety And Immunogenicity Trial Of Plasmodium Falciparum Apical Membrane Protein (Ama-1) Fmp2.1, Adjuvanted With As02a, In Malaria-Naive Adults At The Walter Reed Army Institute Of Research, Mark E. Polhemus, Alan J. Magill, James F. Cummings, Kent E. Kester, Chris F. Ockenhouse, David E. Lanar, Sheetij Dutta, Arnoldo Barbosa, Lorraine Soisson, Carter L. Diggs, Sally A. Robinson, John D. Haynes, V. Ann Stewart, Lisa A. Ware, Clara Brando, Urszula Krzych, Robert A. Bowden, Joe D. Cohen, Marie-Claude Dubois, Opokua Ofori-Anyinam, Els De-Kock, W. Ripley Ballou, D. Gray Heppner Jr.

United States Army: Publications

We report the first safety and immunogenicity trial of the Plasmodium falciparum vaccine candidate FMP2.1/AS02A, a recombinant E. coli-expressed protein based upon the apical membrane antigen-1 (AMA-1) of the 3D7 clone formulated with the AS02A adjuvant. We conducted an open-label, staggered-start, dose-escalating Phase I trial in 23 malaria-naıve volunteers who received 8, 20 or 40 _g of FMP2.1 in a fixed volume of 0.5mL of AS02A on a 0, 1, and 2 month schedule. Nineteen of 23 volunteers received all three scheduled immunizations. The most frequent solicited local and systemic adverse events associated with immunization were injection site pain (68%) …

An In Vitro Comparative Study On The Reactivation Of Nerve Agent-Inhibited Guinea Pig And Human Acetylcholinesterases By Oximes, Chunyuan Luo, Min Tong, Nageswararao Chilukuri, Karen Brecht, Donald M. Maxwell, Ashima Saxena

United States Army: Publications

The reactivation of nerve agent-inhibited acetylcholinesterase (AChE) by oxime is the most important step in the treatment of nerve agent poisoning. Since the evaluation of nerve agent antidotes cannot be conducted in humans, results from animal experiments are extrapolated to humans. Guinea pig is one of the animal models that is frequently used for conducting nerve agent antidote evaluations. Several investigations have demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate nerve agent-inhibited AChE. If the in Vitro oxime reactivation of nerve agent-inhibited animal AChE is similar to that of human AChE, it is likely …

A Dendroclimatic Record Of Paleoclimate Of The Last 10,000 Years, Glacier Bay National Park And Preserve: Progress Understanding Climate Change In Southeast Alaska, Daniel Lawson, Greg Wiles, David Finnegan

United States Army: Publications

Our investigations in 2007 focused on continuing collection and analyses of tree rings from living trees and building a long ring-width series from interstadial wood. These interstadial forests were extensive and their preservation, although discontinuous and fragmented, is remarkable. In situ stumps, still rooted in growth position, and logs held within sediments remain from forests that existed at various times between glaciations over approximately the last 10,000 years.
We have analyzed previous and new collections of ring-width tree-ring series, including a multiple species collection from near Excursion Ridge in the southeast portion of the Park. These tree-ring series have a …

Identification And Suitability Of A Non-Anthropomorphic Meta-Language Framework In Military Applications, Gilbert Cardona

Electronic Theses and Dissertations

Humans carry mental models concerning the behaviors, looks, and operation of products, tools, and items used in their daily lives. When these items do not fit a user's conceptual model confusion and inefficiency occur. There are four basic types of mental models based on interactive activities: 1) instructing, 2) conversing, 3) manipulating and navigating, and 4) exploring and browsing. This thesis will focus on the conversing conceptual model and its application to communications between human-agent teams to best fit a user's mental model for that communication. A non-anthropomorphic framework does not exist for use in military applications such as; target …

A Framework For The Assessment And Analysis Of Multi-Hazardsinduced Risk Resulting From Space Vehicles Operations, Serge Sala-Diakanda

Electronic Theses and Dissertations

With the foreseeable increase in traffic frequency to and from orbit, the safe operation of current and future space vehicles at designated spaceports has become a serious concern. Due to their high explosive energy potential, operating those launch vehicles presents a real risk to: (1) the spaceport infrastructure and personnel, (2) the communities surrounding the spaceport and (3) the flying aircrafts whose routes could be relatively close to spaceport launch and reentry routes. Several computer models aimed at modeling the effects of the different hazards generated by the breakup of such vehicles (e.g., fragmentation of debris, release of toxic gases, …

Acuta Enews January 2007, Vol. 36, No. 1

ACUTA Newsletters

In This Issue

From ACUTA Headquarters........... Jeri A. Semer, CAE, ACUTA Executive Director

Centrex Conversion to PBX.............. Ron Walczak, Walczak Technology Consultants

Tech Talk: Duduplication Reduces Storage Needs............. Kevin Tanzillo, Dux PR

DC Update............... Jeanne Jansenius, Sewanee, The University of the South

ACUTA Alert: Federal Rules Governing Destruction of Electronically Stored Information

FYI: Useful Information from the Campus.............. Student Monitor

Setting Priorities............... Geoff Tritsch, Vantage Technology Consulting Group

Web Tip: Members Post Job Openings........... Aaron Fuehrer, ACUTA Information Technology Manager

Board Report............... Riny Ledgerwood, San Diego State Univ. of Northern Iowa

Thanks to Sponsors for 2006

A Moment in Time: …

Details And Description Of Operations Research, Paul Savory

Department of Industrial and Management Systems Engineering: Reports

The ambiguous term operations research was coined during World War II. A frequent substitute is management science. Operations research is a scientific approach to analyzing problems and making decisions. It uses mathematics and mathematical modeling on computers to forecast the implications of various choices and zero in on the best alternatives. This content paper provides an overview of operations research. It highlights operations research problems, methods for solving problems, different areas of operations research, and example problems.

Peer Review Of Teaching Project: Overview Newsletter, Paul Savory, Amy M. Goodburn, Amy Nelson Burnett

Department of Industrial and Management Systems Engineering: Reports

The Peer Review of Teaching Project (PRTP) is a UNL campus program that supports teams of faculty in making visible the serious intellectual work of teaching. Begun in 1994, the project uses the same process one would use to explore a research question by having faculty inquire, analyze, and document their teaching practices and the resulting student learning and then make these results accessible for use, review, and assessment by one’s peers. The project consists of a first-year fellowship program and an advanced scholar program. Specific faculty outcomes from participating in the project include: (1) Reflecting upon, developing, and writing …

Pre/Post Assessment Of Abilities, Paul Savory

Department of Industrial and Management Systems Engineering: Instructional Materials

One approach to assess if students are learning in a course is to conduct a pre-test, post-test assessment of the course material. By comparing the two results, one can make an assessment of the knowledge learned in the course. For certain types of courses, it can be a challenge in defining an assessment instrument that measure student knowledge. This example is one I have developed for my IMSE 440/840 (Discrete Event Computer Simulation) course. Students are asked rate their ability for key course objectives defined on the course syllabus. I administer it on the first day of the course and …

More Secure Passwords, Scott Magruder, Stanley X. Lewis Jr

Journal of International Technology and Information Management

Passwords are often the first line of defense against hackers trying to logon to a user’s account. Due to this, the password that a user selects for protection of their account is critical. These passwords must be “good” passwords that are not easily cracked. However, how does the network administrator enforce this? A simple change to the login process can make the passwords chosen by users much more secure. A description of this simple process is given in this paper. The normal login process is described. A description of the how hackers attempt to crack passwords is given. The simple …

Improving The Judicial System To Handle Computer Crime, Gerald V. Post, Albert Kagan

Journal of International Technology and Information Management

This paper asked professionals in the legal system to evaluate the current state and effectiveness of laws to identify and deter computer crime. Responses were evaluated with a formal structural equation model. The results generally show that legal professionals believe potential jurors have minimal knowledge of computer crime issues. More importantly, they also believe that judges have little knowledge or experience. A similar lack of knowledge by defense attorneys indicates that it could be difficult for a person accused of computer related infractions to find adequate representation. On the other hand, more experienced participants do not believe computer laws present …

The Role Of Quantitative Analysis In The Information Security Systems Development Lifecycle, Stephen R. Rosenkranz, Michael E. Busing, Faye P. Teer, Karen A. Forcht

Journal of International Technology and Information Management

Today’s numerous Quantitative Analysis (QA) tools have been successfully utilized to solve business problems in diverse applications. However, the application of QA tools in solving information security problems has been sparse. Devising the means and ways to use QA tools in resolving industry-wide security problems has the potential to yield enormous global economic benefit. The purpose of this paper is to explore the use of QA tools as a means of improving the processes involved in the Information Security Systems Development Lifecycle (SecSDL). Information security professionals use the SecSDL as a guide for formulating a comprehensive information security program. The …

A Framework And Guide For Understanding The Creation Of Consumer Trust, Joseph A. Cazier

Journal of International Technology and Information Management

This paper develops a framework and model for building trust by combining research on the creation of trust with the dimensions of trust: ability, benevolence and integrity. By combining these dimensions in a matrix with the types of trust production based on characteristics, process and institutions, the paper develops a robust 3 x 3 matrix with which to categorize and understand trust production. The framework is developed and analyzed in the light of literature on consumer trust. This framework can help researchers, practitioners and consumers understand trust creation and assist businesses in developing a comprehensive strategy for managing trust.

An Application Of The Deming Management Method For Information Technology Projects, Jack T. Marchewka

Journal of International Technology and Information Management

Although the ideas and teachings of W. Edwards Deming have been implemented in organizations world- wide for over the past 50 years, only three studies have empirically tested a theoretical model grounded in the Deming Management Method. These studies focused on the manufacturing and services area. Today, quality management continues to be an area of interest both in project management and software engineering. The focus of this study is to test the Deming Management Method in information technology (IT) projects. A survey of 63 IT professionals provides empirical support for the Deming Management Method and its application to IT projects. …

Machining Process Changes As A Function Of Surface Roughness, Specific To Machining Cylindrical Bores, Thomas Patrick Olsen

Dissertations and Theses @ UNI

Manufacturing professionals are challenged everyday to produce products to higher quality standards in a way that is economical and efficient. Manufacturing needs to minimize non value added costs such as reducing inventory, (non machined and finished goods), reduce work in process, and most of all eliminate waste. To exist, customers must be satisfied at the time of purchase and throughout the products lifecycle. To be competitive and remain a world class manufacture, companies must be flexible and be willing to change. Single point flexible manufacturing versus fixed spindle rigid machining greatly improves the ability to make changes. If a process …

Development Of Integrated Process Simulation System Model For Spent Fuel Treatment Facility (Sftf) Design, Yitung Chen, Sean Hsieh

Separations Campaign (TRP)

The major objectives will lead to a creation of framework that combines all the strengths of AMUSE’s complicated calculations, well-established commercial system process package and ISOPro’s flexible parameter optimization modules. Development of the process simulation code can be done using the solvent extraction process at Argonne National Laboratory in collaboration with the research team from Mechanical Engineering Department at UNLV.

Research accomplishments:

• Integrated the ASPEN-Plus process model with the ISOPro system engineering modeling package, developed by the UNLV team.
• Tested the simplified system process integration using the ISOPro package.
• Generated complete version of the ISOPro package user manual and tutorial. …

Improving Factory Layout Under A Mixed Floor And Overhead Material Handling Condition, Manocher Djassemi

Industrial Technology and Packaging

Purpose –In spite of having a number of general-purpose algorithms for solving plant layout problems, facility planners may still face a challenging task to adjust these algorithms to handle special, but not uncommon, layout problems. The purpose of this study is to propose a new method for addressing the impact of overhead space utilization on a plant layout solution.

Design/methodology/approach –A new method for adjusting material flow under a mixed floor and overhead material handling condition is incorporated in an existing plant layout procedure. A case study involving the layout improvement in a lawn mower engine assembly facility …

Diversifying Biological Fuel Cell Designs By Use Of Nanoporous Filters, Justin C. Biffinger, Ricky Ray, Brenda Little, Bradley R. Ringeisen

United States Navy: Publications

The use of proton exchange membranes (PEMs) in biological fuel cells limits the diversity of novel designs for increasing output power or enabling autonomous function in unique environments. Here we show that selected nanoporous polymer filters (nylon, cellulose, or polycarbonate) can be used effectively in place of PEMs in a miniature microbial fuel cell (mini-MFC, device cross-section 2 cm²), generating a power density of 16 W/m³ with an uncoated graphite felt oxygen reduction reaction (ORR) cathode. The incorporation of polycarbonate or nylon membranes into biological fuel cell designs produced comparable power and durability to Nafion-117 membranes. Also, …

Genetically Attenuated Plasmodium Berghei Liver Stages Induce Sterile Protracted Protection That Is Mediated By Major Histocompatibility Complex Class I–Dependent Interferon-Y–Producing Cd8+ T Cells, Ousman Jobe, Joanne Lumsden, Ann-Kristin Mueller, Jackie Williams, Hilda Silva-Rivera, Stefan H. I. Kappe, Robert J. Schwenk, Kai Matuschewski, Urszula Krzych

United States Army: Publications

At present, radiation-attenuated plasmodia sporozoites (y-spz) is the only vaccine that induces sterile and lasting protection in malaria-naive humans and laboratory rodents. However, g-spz are not without risks. For example, the heterogeneity of the y-spz could explain occasional breakthrough infections. To avoid this possibility, we constructed a double-knockout P. berghei parasite by removing 2 genes, UIS3 and UIS4, that are up-regulated in infective spz.We evaluated the double-knockout Pbuis3(-)/4(-) parasites for protective efficacy and the contribution of CD8+ T cells to protection. Pbuis3(-)/4(-) spz induced sterile and protracted protection in C57BL/6 mice. Protection was linked to CD8+ …

Design For Auditory Displays: Identifying Temporal And Spatial Information Conveyance Principles, Ali Ahmad

Electronic Theses and Dissertations

Designing auditory interfaces is a challenge for current human-systems developers. This is largely due to a lack of theoretical guidance for directing how best to use sounds in today's visually-rich graphical user interfaces. This dissertation provided a framework for guiding the design of audio interfaces to enhance human-systems performance. This doctoral research involved reviewing the literature on conveying temporal and spatial information using audio, using this knowledge to build three theoretical models to aid the design of auditory interfaces, and empirically validating select components of the models. The three models included an audio integration model that outlines an end-to-end process …

Decision-Maker Trade-Offs In Multiple Response Surface Optimization, Alicia Hawkins

Electronic Theses and Dissertations

The focus of this dissertation is on improving decision-maker trade-offs and the development of a new constrained methodology for multiple response surface optimization. There are three key components of the research: development of the necessary conditions and assumptions associated with constrained multiple response surface optimization methodologies; development of a new constrained multiple response surface methodology; and demonstration of the new method. The necessary conditions for and assumptions associated with constrained multiple response surface optimization methods were identified and found to be less restrictive than requirements previously described in the literature. The conditions and assumptions required for a constrained method to …

Stress, Fatigue And Workload: Determining The Combined Affect On Human Performance, Jessica Mock-Mclaughlin

Electronic Theses and Dissertations

This research generated a model that will help to predict, prevent, control and mitigate the occurrence of task related factors that negatively influence stress, fatigue, and workload; thus enhancing human performance. Past research efforts involving stress, fatigue and workload identified factors that influence a change in performance (Lan, Ji and Looney, 2003, and Hancock & Warm, 1989). Also, while some mathematical models have been developed within each respective area, however, there is no evidence of an integrated model describing the combined affect of stress, fatigue and workload. To respond to this research gap, a quantitative model representing the state of …

Optimization Models For Emergency Relief Shelter Planning For Anticipated Hurricane Events, Abeer Tarief Sharawi

Electronic Theses and Dissertations

Natural disasters, specifically hurricanes, can cause catastrophic loss of life and property. In recent years, the United States has endured significant losses due to a series of devastating hurricanes (e.g., Hurricanes Charley and Ivan in 2004, and Hurricanes Katrina and Wilma in 2005). Several Federal authorities report that there are weaknesses in the emergency and disaster planning and response models that are currently employed in practice, thus creating a need for better decision models in emergency situations. The current models not only lack fast communication with emergency responders and the public, but are also inadequate for advising the pre-positioning of …

Developing A Spatial Interface For Information Visualization And Management In A Crisis Response Scenario, Anthony Costello

Electronic Theses and Dissertations

The focus of this study was to investigate how a spatial interface can be effectively utilized to support information presentation and information integration via human-centric data visualization, leading to decreased cognitive load, more accurate situation awareness, and subsequently, improved task performance. In high tempo, information intensive environments like those managed by an emergency operations center (EOC), information organization tools are essential. Though users can be trained to use conventional email software applications efficiently, the constraints of the information management paradigms inherent to conventional systems may limit a user's ability to gather context and create an accurate picture of the situation. …

Using Surrogate Measures To Predict Patient Satisfaction In The Emergency Department, Erica Egri

Electronic Theses and Dissertations

With healthcare organizations struggling to remain competitive and financially stable in a market where minimizing costs is a priority, hospital administrators feel the sense of urgency when it comes to keeping patients satisfied with services in order to expand volume and market share. The Emergency Department is considered the front door of a healthcare organization, and keeping its visitors satisfied in order to guarantee a future visit or a referral to a friend or family member is a must. While patient input on the services received in a healthcare facility is essential to improving quality of care, the costs associated …

Buffer Techniques For Stochastic Resource Constrained Project Scheduling With Stochastic Task Insertions Problems, Jennifer Grey

Electronic Theses and Dissertations

Project managers are faced with the challenging task of managing an environment filled with uncertainties that may lead to multiple disruptions during project execution. In particular, they are frequently confronted with planning for routine and non-routine unplanned work: known, identified, tasks that may or may not occur depending upon various, often unpredictable, factors. This problem is known as the stochastic task insertion problem, where tasks of deterministic duration occur stochastically. Traditionally, project managers may include an extra margin within deterministic task times or an extra time buffer may be allotted at the end of the project schedule to protect the …

Mass Customization Strategies And Their Relationship To Lean Production In The Homebuilding Industry, Isabelina Nahmens

Electronic Theses and Dissertations

Current housing trends point to an increasing interest from homebuyers to demand houses that reflect their personal and unique styles, and which are individually configured according to these needs (NAHB, 2004). These homebuyers in turn are unwilling to settle for standard models that sacrifice what they really want in a home. At the same time this creates pressure on builders who are reluctant to sacrifice production efficiencies by deviating from standard models. Such customization desired by demanding customers can disrupt the entire estimating, production, delivery and management process, making it even more difficult to manage homebuilding efficiently and effectively. The …

Optimizing The Design Of Multimodal User Interfaces, Leah Reeves

Electronic Theses and Dissertations

Due to a current lack of principle-driven multimodal user interface design guidelines, designers may encounter difficulties when choosing the most appropriate display modality for given users or specific tasks (e.g., verbal versus spatial tasks). The development of multimodal display guidelines from both a user and task domain perspective is thus critical to the achievement of successful human-system interaction. Specifically, there is a need to determine how to design task information presentation (e.g., via which modalities) to capitalize on an individual operator's information processing capabilities and the inherent efficiencies associated with redundant sensory information, thereby alleviating information overload. The present effort …

Cognitive Learning From Computer-Based Information Systems By Incorporating Knowledge Construction Interventions, Wajdi Wazzan

Electronic Theses and Dissertations

The aim of the present study was to develop and empirically evaluate different categories of instructional activities, which stimulate the generation and construction of knowledge on the part of an individual student. These generative activities are primed by prompts or scaffolds, which can easily be inserted into specific curriculum addressing any domain of knowledge. To assess the manner in which the knowledge construction interventions influence the learning outcomes from computerized information systems, we have developed an online computer-based information system that describes the functions and mechanisms associated with the bus system of the US army Abrams M1A2 tank. Seven versions …

Management Systems Fit For Organizational Performance, Rey Diaz

Electronic Theses and Dissertations

The present study identifies the dimensions and variables using prior research within each of the constructs under the management systems, fit and, organizational strategy, structure, lifecycle and performance. The constructs from the research model were defined with a combination of direct, calculated and coded measures. Context analysis for each case categorized management systems design into either prescriptive or descriptive. The selected performance measures have been extensively investigated in the research fields associated with organizational management. The study uses the multiple case study design with cross-sectional data spanning from 1991 to 2005 and involving 19 aerospace companies in the United States. …