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Legacy Theses & Dissertations (2009 - 2024)

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Articles 31 - 60 of 173

Full-Text Articles in Nanoscience and Nanotechnology

Impact Of Spiro Ammonium Electrolytes On Electric Double Layer Capacitors, Donald Derosa Jan 2018

Impact Of Spiro Ammonium Electrolytes On Electric Double Layer Capacitors, Donald Derosa

Legacy Theses & Dissertations (2009 - 2024)

Electric Double Layer Capacitors (EDLC) are high power (103 W kg-1), durable (>500,000 cycles) energy storage devices that are promising candidates for Hybrid Energy Storage Systems (HESS) , automotive and smart grid applications. EDLCs when coupled with lithium ion batteries in HESS configurations for hybrid vehicles have been shown to reduce capacity related degradation by a factor of 2 and impedance related degradation by 5.9. Despite these promising advantages, the adoption of EDLCs has been hampered due to concerns regarding the low volumetric and gravimetric energy density of these devices. Researchers have attempted to address these concerns through the …

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Zno Nanowires For Advanced X-Ray Source Applications, Vance Scott Robinson Jan 2018

Zno Nanowires For Advanced X-Ray Source Applications, Vance Scott Robinson

Legacy Theses & Dissertations (2009 - 2024)

X-ray system technology trends tend towards simpler, smaller and more efficient devices. A broad range of applications are driving contemporary efforts in X-ray source miniaturization: Portable and/or remote nondestructive evaluation; High throughput protein crystallography, invasive radiotherapy; monitoring fluid flow and particulate generation in situ; and portable radiography devices for battle-front or large scale disaster triage scenarios. Most of the x-ray sources for these applications follow a top-down approach focused on improving portability, and reducing mass and/or size.

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Development Of Multilayer Titanium Nitride-Based Coatings As Corrosion Resistant Films For Stainless Steel Bipolar Plates In Pem Fuel Cells, Nicholas Padula Jan 2017

Development Of Multilayer Titanium Nitride-Based Coatings As Corrosion Resistant Films For Stainless Steel Bipolar Plates In Pem Fuel Cells, Nicholas Padula

Legacy Theses & Dissertations (2009 - 2024)

High cost and short lifetime are the two main reasons why the PEM fuel cell has not reached a widespread, disruptive level of commercialization. Conventional graphite bipolar plates are responsible for about 45% of the cost and 85% of the total weight of a single cell. These measures are linked to difficult machining of thick, brittle graphite and processing needed to render graphite non-porous. Stainless steel is suggested as the replacement bipolar plate material due to its favorable mechanical properties, ease of manufacturing and relatively low price, but requires a cost-effective coating as a non-conductive oxide forms on the bare …

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Redox-Dependent Calcium-Mediated Signaling Networks That Control The Senescence-Associated Secretory Phenotype, Akshaya Chandrasekaran Jan 2017

Redox-Dependent Calcium-Mediated Signaling Networks That Control The Senescence-Associated Secretory Phenotype, Akshaya Chandrasekaran

Legacy Theses & Dissertations (2009 - 2024)

Cellular senescence has evolved as a protective mechanism to arrest growth of cells with oncogenic potential. While senescent cells have lost the ability to divide, they remain metabolically active and adapt a deleterious senescence associated secretory phenotype (SASP) central to the progression of several age-associated disease pathologies. The SASP is mechanistically regulated by the pro-inflammatory cytokine interleukin-1 alpha (IL-1α) whose expression and activity is responsive to the senescence associated (SA) oxidant production and the accompanying disruption of calcium (Ca2+) homeostasis. Using primary IMR-90 human fetal lung fibroblasts as a model of replicative senescence, we explored the molecular underpinnings driving Ca2+ …

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Computational Optimization And Characterization Of Molecularly Imprinted Polymers, Jacob Jordan Terracina Jan 2017

Computational Optimization And Characterization Of Molecularly Imprinted Polymers, Jacob Jordan Terracina

Legacy Theses & Dissertations (2009 - 2024)

Molecularly imprinted polymers (MIPs) are a class of materials containing sites capable of selectively binding to the imprinted target molecule. Computational chemistry techniques were used to study the effect of different fabrication parameters (the monomer-to-target ratios, pre-polymerization solvent, temperature, and pH) on the formation of the MIP binding sites. Imprinted binding sites were built in silico for the purposes of better characterizing the receptor – ligand interactions. Chiefly, the sites were characterized with respect to their selectivities and the heterogeneity between sites.

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Novel Approaches To Mitigating Bacterial Biofilm Formation And Intercellular Communication, Stephen Kasper Jan 2017

Novel Approaches To Mitigating Bacterial Biofilm Formation And Intercellular Communication, Stephen Kasper

Legacy Theses & Dissertations (2009 - 2024)

Long thought of as solitary single-cell organisms, it is now widely accepted that bacteria can act and cooperate as social organisms. Phenomena such as biofilm formation and quorum sensing (QS) are two intimately intertwined cooperative behaviors that significantly contribute to the pathogenesis of many bacteria. Biofilms are surface associated communities of bacteria encased in a secreted extracellular matrix, which provides several advantages over an individualized lifestyle, such as increased protection from antimicrobial agents as well as enhanced opportunity for the exchange of genetic material. Bacterial QS is a system of population-based communication through the production, sensing, and response to chemical …

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Towards A Biomimetic Elastin-Based Nanofiber Scaffold For Salivary Gland Tissue Regeneration And Growth Factor Delivery, Zahraa Ismail Ahmed Foraida Jan 2017

Towards A Biomimetic Elastin-Based Nanofiber Scaffold For Salivary Gland Tissue Regeneration And Growth Factor Delivery, Zahraa Ismail Ahmed Foraida

Legacy Theses & Dissertations (2009 - 2024)

Development of electrospun nanofibers that mimic the structural, mechanical and biochemical properties of natural extracellular matrices (ECMs) and the basement membranes is a promising approach for tissue regeneration. Electrospun fibers of synthetic polymers partially mimic the topography of the ECM, however, their high stiffness, poor hydrophilicity and lack of in vivo-like biochemical cues is not optimal for epithelial cell self-organization and function. In search of a biomimetic scaffold for salivary gland tissue regeneration, we utilized proteins and peptides to induce biomechanical and biochemical cues that resembles the native tissue environment. These functional molecules were introduced to our previously-developed poly lactic-co-glycolic …

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Multifunctional Nanomaterials Utilizing Hybridization Chain Reaction For Molecular Diagnostics And Bioanalytical Applications, Md Muhit Rana Jan 2017

Multifunctional Nanomaterials Utilizing Hybridization Chain Reaction For Molecular Diagnostics And Bioanalytical Applications, Md Muhit Rana

Legacy Theses & Dissertations (2009 - 2024)

DNA nanotechnology has shown great promise in molecular diagnostic, bioanalytical and biomedical applications. The great challenge of detecting target analytes, biomarkers and small molecules, in molecular diagnostics is low yield sensitivity. To address this challenge, different nanomaterials have been used for a long time and to date there is no such cost-effective bioanalytical technique which can detect these target biomarkers (DNA, RNA, circulating DNA/miRNA) or environmental heavy metal ions (Hg2+ and Ag+) in a cost-effective and efficient manner.

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Novel Uses Of Directly Patternable Silicon Oxide Based Resist For Advanced Patterning Applications, Vishal Umeshbhai Desai Jan 2017

Novel Uses Of Directly Patternable Silicon Oxide Based Resist For Advanced Patterning Applications, Vishal Umeshbhai Desai

Legacy Theses & Dissertations (2009 - 2024)

Novel applications for the directly-patternable resist material, hydrogen silsesquioxane (HSQ), were studied for multiple advanced lithography techniques. Initially, electron beam lithography (EBL) patterned low-resolution HSQ patterns were demonstrated as a mandrel in a self-aligned double patterning (SADP) approach. Using the novel EBL-SADP approach, the number of total process steps was reduced, as compared to conventional SADP methods. This work provided proof-of-concept for using HSQ resist as a directly-patternable mandrel and plasma enhanced chemical vapor deposited (PECVD) low-stress silicon nitride (LSSiN) as a spacer. Furthermore, rapid thermal annealing (RTA) was demonstrated as a method to increase the spacer etch resistance in …

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Impedance Biosensors And Deep Crater Salivary Gland Scaffolds For Tissue Engineering, Robert Arthur Schramm Jan 2017

Impedance Biosensors And Deep Crater Salivary Gland Scaffolds For Tissue Engineering, Robert Arthur Schramm

Legacy Theses & Dissertations (2009 - 2024)

The salivary gland is a complex, branching organ whose primary biological function is the production of the fluid critical to alimentary function and the lubrication and maintenance of the oral cavity, saliva. The most frequent disruption of the salivary organ system is one in which the rate of supply of saliva into the oral cavity is diminished, and this may vary from a minor reduction, to near cessation. Regenerative medicine is a field which seeks to find ways to overcome the symptoms of organ malfunction or damage by inducing regrowth, repair and replacement of partial or whole organ function. Historically, …

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Exploring Magnetic Nanostructures Embedded Within Single-Crystal Silicon For Generation Of Spin-Polarized Carriers, Machara Krishna Girish Malladi Jan 2017

Exploring Magnetic Nanostructures Embedded Within Single-Crystal Silicon For Generation Of Spin-Polarized Carriers, Machara Krishna Girish Malladi

Legacy Theses & Dissertations (2009 - 2024)

Integrating magnetic functionalities with silicon holds the promise of developing, in the most dominant semiconductor, a paradigm-shift information technology based on the manipulation and control of electron spin and charge. Here, we demonstrate an ion implantation approach enabling the synthesis of a ferromagnetic layer within a defect free Si environment by exploiting an additional implant of hydrogen in a region deep below the metal implanted layer. Upon post-implantation annealing, nanocavities created within the H-implanted region act as trapping sites for gettering the implanted metal species, resulting in the formation of metal nanoparticles in a Si region of excellent crystal quality. …

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Mechanisms Of Euv Exposure : Photons, Electrons And Holes, Amrit Kausik Narasimhan Jan 2017

Mechanisms Of Euv Exposure : Photons, Electrons And Holes, Amrit Kausik Narasimhan

Legacy Theses & Dissertations (2009 - 2024)

The microelectronics industry’s movement toward smaller and smaller feature sizes has necessitated a shift to Extreme Ultra-Violet (EUV) lithography to be able to pattern sub 20-nm features, much like earlier shifts from i-line to 248 nm. However, this shift from 193-nm lithography to EUV (13.5 nm) poses significant obstacles. EUV is the first optical lithography to operate in an energy range (92 eV per photon vs. 6.4 eV per photon for 193 nm lithography) above the electron binding energies of common resist atomic species. This significant energy increase complicates resist design. For exposures of equal dose, resists receive 14 times …

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Resistive Random Access Memory From Materials Development And Engineering To Novel Encryption And Neuromorphic Applications, Karsten Beckmann Jan 2017

Resistive Random Access Memory From Materials Development And Engineering To Novel Encryption And Neuromorphic Applications, Karsten Beckmann

Legacy Theses & Dissertations (2009 - 2024)

Resistive random access memory (ReRAM or RRAM) is a novel form of non-volatile memory that is expected to play a major role in future computing and memory solutions. It has been shown that the resistance state of ReRAM devices can be precisely tuned by modulating switching voltages, by limiting peak current, and by adjusting the switching pulse properties. This enables the realization of novel applications such as memristive neuromorphic computing and neural network computing. I have developed two processes based on 100 and 300mm wafer platforms to demonstrate functional HfO2 based ReRAM devices. The first process is designed for a …

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Detecting And Analyzing Trna Modification Systems And Homologs Using In Silico And Colorectal Cancer Models, Khadijah Onanuga Jan 2017

Detecting And Analyzing Trna Modification Systems And Homologs Using In Silico And Colorectal Cancer Models, Khadijah Onanuga

Legacy Theses & Dissertations (2009 - 2024)

tRNA modifications can be considered epitranscriptomic signaling components that regulate translation and play integral roles in stress response pathways. As such, tRNA modification enzymes have roles in cancer etiology and potential utility as biomarkers of pathological states. For my thesis project I have used computational and wet bench approaches to study tRNA modification systems. Chapter two of my thesis deals with tRNA modification detection, as current methods are costly, time consuming, and require RNA fragmentation. I present a single-molecule-based approach for RNA modification detection, which involves in slico studies using a 5-layered graphene nanopore. Our simulations using a 1.5 nm …

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Effect Of Ion Flux (Dose Rate) In Source-Drain Extension Ion Implantation For 10-Nm Node Finfet And Beyond On 300/450mm Platforms, Ming-Yi Shen Jan 2017

Effect Of Ion Flux (Dose Rate) In Source-Drain Extension Ion Implantation For 10-Nm Node Finfet And Beyond On 300/450mm Platforms, Ming-Yi Shen

Legacy Theses & Dissertations (2009 - 2024)

The improvement of wafer equipment productivity has been a continuous effort of the semiconductor industry. Higher productivity implies lower product price, which economically drives more demand from the market. This is desired by the semiconductor manufacturing industry. By raising the ion beam current of the ion implanter for 300/450mm platforms, it is possible to increase the throughput of the ion implanter. The resulting dose rate can be comparable to the performance of conventional ion implanters or higher, depending on beam current and beam size. Thus, effects caused by higher dose rate must be investigated further. One of the major applications …

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Modeling And Studying The Effect Of Texture And Elastic Anisotropy Of Copper Microstructure In Nanoscale Interconnects On Reliability In Integrated Circuits, Adarsh Basavalingappa Jan 2017

Modeling And Studying The Effect Of Texture And Elastic Anisotropy Of Copper Microstructure In Nanoscale Interconnects On Reliability In Integrated Circuits, Adarsh Basavalingappa

Legacy Theses & Dissertations (2009 - 2024)

Copper interconnects are typically polycrystalline and follow a lognormal grain size distribution. Polycrystalline copper interconnect microstructures with a lognormal grain size distribution were obtained with a Voronoi tessellation approach. The interconnect structures thus obtained were used to study grain growth mechanisms, grain boundary scattering, scattering dependent resistance of interconnects, stress evolution, vacancy migration, reliability life times, impact of orientation dependent anisotropy on various mechanisms, etc. In this work, the microstructures were used to study the impact of microstructure and elastic anisotropy of copper on thermal and electromigration induced failure.

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Development Of Low-Temperature Atomic Layer Deposition Of Ultra-Thin Ruco Direct Plate Liners For Flexible Electronics Applications, Dillon Alexander Gregory Jan 2016

Development Of Low-Temperature Atomic Layer Deposition Of Ultra-Thin Ruco Direct Plate Liners For Flexible Electronics Applications, Dillon Alexander Gregory

Legacy Theses & Dissertations (2009 - 2024)

Low temperature plasma-assisted atomic layer deposition-grown metal nanocomposite layers based on mixtures of ruthenium and cobalt have been investigated as potential copper adhesion/barrier layers in flexible electronics applications. The success of adapting this process to flexible electronics depends on the candidate barriers meeting several necessary properties including sufficient electrical conductivity, compatibility with Cu electroplating, and ability to prevent Cu diffusion into the substrate. Preliminary testing has shown that atomic layer deposition (ALD) can be used as a technique for depositing alloyed metallic barrier layers at the lower thermal constraints dictated by the use of polymer substrates and still produce continuous …

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Texture And Microstructure Of Ipvd Copper Manganese Seed In 1 Μm & 70 Nm Wide Damascene Trenches, Robert Stuart Brown Jan 2016

Texture And Microstructure Of Ipvd Copper Manganese Seed In 1 Μm & 70 Nm Wide Damascene Trenches, Robert Stuart Brown

Legacy Theses & Dissertations (2009 - 2024)

This thesis describes the grain texture and microstructure of Ionized Physical Vapor Deposition (iPVD) Copper Manganese seed in 1 µm and 70 nm wide damascene trenches. Using Transmission Electron Microscopy (TEM) imaging and diffraction pattern analysis, the grain size and general orientation of the grains were determined. It was found that the 1 µm wide trenches contained larger grains and more texture than that of the 70 nm wide trenches. While this thesis builds upon previous work by Brendan O’Brien in the Dunn group, one significantly different finding will be presented regarding the structure on the sidewall of the trenches. …

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The Investigation Of Nanoscale Effects On Schottky Interfaces And The Scattering Rates Of High Resistivity Metals, Christopher Anthony Durcan Jan 2016

The Investigation Of Nanoscale Effects On Schottky Interfaces And The Scattering Rates Of High Resistivity Metals, Christopher Anthony Durcan

Legacy Theses & Dissertations (2009 - 2024)

Understanding the transport of electrons through materials and across interfaces is fundamental to modern day electronics. As electrons travel, interactions with defects within the crystal lattice induce scattering which gives rise to resistivity. At the interface between two materials, electrostatic barriers exist which can impede the flow of electrons. The work of this thesis is to further the understanding of electron transport by measuring the transport across metal-semiconductor interfaces at the nanoscale and measure scattering phenomena in metals. The measurement technique ballistic electron emission microscopy (BEEM) was used due to its ability to probe the scattering processes within a metal …

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Investigating The Size Dependent Material Properties Of Nanoceria, Bushra B. Alam Jan 2016

Investigating The Size Dependent Material Properties Of Nanoceria, Bushra B. Alam

Legacy Theses & Dissertations (2009 - 2024)

Nanoceria is widely being investigated for applications as support materials for fuel cell catalysts, free radical scavengers, and as chemical and mechanical abrasives due to its high antioxidant capacity and its oxygen buffering capacity. This antioxidant or oxygen buffering capacity has been reported to be highly size dependent and related to its redox properties. However, the quantification of this antioxidant capacity has not been well defined or understood and has been often been carried out using colorimetric assays which do not directly correlate to ceria nanoparticle properties. Fabrication rules for developing materials with optimal antioxidant/oxygen buffering capacities are not yet …

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Development Of Enhanced Window Layers For Cigs Photovoltaic Devices, James Nicholas Alexander Jan 2016

Development Of Enhanced Window Layers For Cigs Photovoltaic Devices, James Nicholas Alexander

Legacy Theses & Dissertations (2009 - 2024)

Photovoltaic devices are among the promising options for sustainable future energy generation. Thin film solar cells have demonstrated the ability to be a low-cost solution to clean renewable energy and are cost competitive with current silicon based photovoltaic devices. One of the most promising thin film devices right now is the Copper Indium Gallium Selenide (CIGS) solar cell with maximum reported power conversion efficiency of 22.3%. The Transparent Conducting Oxide (TCO) which is the top layer of the CIGS device also known as the window layer, is responsible for collecting the electrons generated in the CIGS device and conducting them …

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Degradation And Exciton Energy Transfer Studies In Single-Walled Carbon Nanotube Bundles, Abhishek Gottipati Jan 2016

Degradation And Exciton Energy Transfer Studies In Single-Walled Carbon Nanotube Bundles, Abhishek Gottipati

Legacy Theses & Dissertations (2009 - 2024)

Single walled carbon nanotubes (SWNTs) due to their unique optical behavior, large surface area, robust mechanical strength and electrical properties make them one of the ideal candidates for sensing and opto-electronic applications. In this work, we explore the energy transfer (exciton energy transfer-EET) phenomena occurring between nanotubes in bundles, using resonance Raman spectroscopy.

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Investigation Of The Optical And Sensing Characteristics Of Nanoparticle Arrays For High Temperature Applications, Gnanaprakash Dharmalingam Jan 2016

Investigation Of The Optical And Sensing Characteristics Of Nanoparticle Arrays For High Temperature Applications, Gnanaprakash Dharmalingam

Legacy Theses & Dissertations (2009 - 2024)

The monitoring of polluting gases such as CO and NOx emitted from gas turbines in power plants and aircraft is important in order to both reduce the effects of such gases on the environment as well as to optimize the performance of the respective power system. The need for emissions monitoring systems is further realized from increased regulatory requirements that are being instituted as a result of the environmental impact from increased air travel. Specifically, it is estimated that the contributions from aircraft emissions to total NOx emissions will increase from 4% to 17% between 2008 and 2020. Extensive fuel …

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Development Of Integrated Tio₂ On Carburized Si Nanowires As A Catalyst/Support Structure For Alkaline Fuel Cells, Adam Lemke Jan 2016

Development Of Integrated Tio₂ On Carburized Si Nanowires As A Catalyst/Support Structure For Alkaline Fuel Cells, Adam Lemke

Legacy Theses & Dissertations (2009 - 2024)

Due to a combination of environmental and economic motivations, there is a strong impetus to transition away from fossil fuels towards renewable sources of energy. Critical to achieving this goal will be technologies that allow for the storage and transmission of energy derived from renewable sources. Hydrogen fuel cells may play a significant role in making this a reality, allowing for the use of hydrogen as a non-carbon based fuel, in particular for vehicle applications. Hydrogen fuel cells directly convert chemical energy into electrical energy, with only water vapor and heat as waste products.

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Tailoring The Optical Properties Of Silicon With Ion Beam Created Nanostructures For Advanced Photonics Applications, Perveen Akhter Jan 2016

Tailoring The Optical Properties Of Silicon With Ion Beam Created Nanostructures For Advanced Photonics Applications, Perveen Akhter

Legacy Theses & Dissertations (2009 - 2024)

In today’s fast life, energy consumption has increased more than ever and with that the demand for a renewable and cleaner energy source as a substitute for the fossil fuels has also increased. Solar radiations are the ultimate source of energy but harvesting this energy in a cost effective way is a challenging task. Si is the dominating material for microelectronics and photovoltaics. But owing to its indirect band gap, Si is an inefficient light absorber, thus requiring a thickness of solar cells beyond tens of microns which increases the cost of solar energy. Therefore, techniques to increase light absorption …

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Strong Metal Support Interaction Of Pt On Tio₂ Grown By Atomic Layer Deposition And Physical Vapor Deposition For Fuel Cell Applications, Robin Paul Hansen Jan 2016

Strong Metal Support Interaction Of Pt On Tio₂ Grown By Atomic Layer Deposition And Physical Vapor Deposition For Fuel Cell Applications, Robin Paul Hansen

Legacy Theses & Dissertations (2009 - 2024)

Several roadblocks prevent the large-scale commercialization of hydrogen fuel cells, including the stability of the Pt catalysts and their substrates, as well as the high cost of Pt. This is particularly true for the cathode, which requires a higher Pt loading because of the slow kinetics of the oxygen reduction reaction (ORR). The problem with the stability of the substrate can be solved by replacing the traditional carbon support with a conductive metal oxide such as reduced TiO2, which will not easily corrode and should result in longer lasting fuel cells. In this study, Pt was deposited either by atomic …

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Magnetoresistance Of A Low-K Dielectric, Brian Thomas Mcgowan Jan 2016

Magnetoresistance Of A Low-K Dielectric, Brian Thomas Mcgowan

Legacy Theses & Dissertations (2009 - 2024)

Low-k dielectrics have been incorporated into advanced computer chip technologies as a part of the continuous effort to improve computer chip performance. One drawback associated with the implementation of low-k dielectrics is the large leakage current which conducts through the material, relative to silica. Another drawback is that the breakdown voltage of low-k dielectrics is low, relative to silica [1]. This low breakdown voltage makes accurate reliability assessment of the failure mode time dependent dielectric breakdown (TDDB) in low-k dielectrics critical for the successful implementation of these materials. The accuracy with which one can assess this reliability is currently a …

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Optical Metrology For Cigs Solar Cell Manufacturing And Its Cost Implications, Sravan Kumar Sunkoju Jan 2016

Optical Metrology For Cigs Solar Cell Manufacturing And Its Cost Implications, Sravan Kumar Sunkoju

Legacy Theses & Dissertations (2009 - 2024)

Solar energy is a promising source of renewable energy which can meet the demand for clean energy in near future with advances in research in the field of photovoltaics and cost reduction by commercialization. Availability of a non-contact, in-line, real time robust process control strategies can greatly aid in reducing the gap between cell and module efficiencies, thereby leading to cost-effective large-scale manufacturing of high efficiency CIGS solar cells. In order to achieve proper process monitoring and control for the deposition of the functional layers of CuIn1-xGaxSe2 (CIGS) based thin film solar cell, optical techniques such as spectroscopic reflectometry and …

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Nanotechnology & Human Stem Cells : Applications In Cardiogenesis And Neurogenesis, Martin Lyubomirov Tomov Jan 2016

Nanotechnology & Human Stem Cells : Applications In Cardiogenesis And Neurogenesis, Martin Lyubomirov Tomov

Legacy Theses & Dissertations (2009 - 2024)

Human stem cell research holds an unprecedented promise to revolutionize the way we approach medicine and healthcare in general, moving us from a position of mostly addressing the symptoms to a state where treatments can focus on removing the underlying causes of a condition. Stem cell research can shed light into normal developmental pathways, as we are beginning to replicate them in a petri dish and can also be used to model diseases and abnormal conditions. Direct applications can range from finding cures for single or multigene diseases to demonstrating that we can replace these genes with a normal copy. …

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The Gammaturc Nanomachine Mechanism And Future Applications, Timothy Riehlman Jan 2016

The Gammaturc Nanomachine Mechanism And Future Applications, Timothy Riehlman

Legacy Theses & Dissertations (2009 - 2024)

The complexity and precision of the eukaryotic cell’s cytoskeletal network is unrivaled by any man-made systems, perfected by billions of years of evolution, mastering elegant processes of self-assembly, error correction, and self-repair. Understanding the capabilities of these networks will have important and far reaching applications in human medicine by aiding our understanding of developmental processes, cellular division, and disease mechanisms, and through biomimicry will provide insights for biosynthetic manufacturing at the nanoscale and across scales. My research utilizes cross species techniques from Human to the model organism of Fission Yeast to investigate the structure and mechanisms of the g-tubulin ring …

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