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Articles 211 - 240 of 554

Full-Text Articles in Other Mechanical Engineering

Observations Of Shear Stress Effects On Staphylococcus Aureus Biofilm Formation, Erica Sherman, Kenneth W. Bayles, Derek Moormeir, Jennifer Endres, Timothy Wei Jul 2019

Observations Of Shear Stress Effects On Staphylococcus Aureus Biofilm Formation, Erica Sherman, Kenneth W. Bayles, Derek Moormeir, Jennifer Endres, Timothy Wei

Department of Mechanical and Materials Engineering: Faculty Publications

Staphylococcus aureus bacteria form biofilms and distinctive microcolony or “tower” structures that facilitate their ability to tolerate antibiotic treatment and to spread within the human body. The formation of microcolonies, which break off, get carried downstream, and serve to initiate biofilms in other parts of the body, is of particular interest here. It is known that flow conditions play a role in the development, dispersion, and propagation of biofilms in general. The influence of flow on microcolony formation and, ultimately, what factors lead to microcolony development are, however, not well understood. The hypothesis being examined is that microcolony structures form …

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Modeling Thermal And Mechanical Cancellation Of Residual Stress From Hybrid Additive Manufacturing By Laser Peening, Guru Madireddy, Chao Li, Jingfu Liu, Michael P. Sealy Jul 2019

Modeling Thermal And Mechanical Cancellation Of Residual Stress From Hybrid Additive Manufacturing By Laser Peening, Guru Madireddy, Chao Li, Jingfu Liu, Michael P. Sealy

Department of Mechanical and Materials Engineering: Faculty Publications

Additive manufacturing (AM) of metals often results in parts with unfavorable mechanical properties. Laser peening (LP) is a high strain rate mechanical surface treatment that hammers a workpiece and induces favorable mechanical properties. Peening strain hardens a surface and imparts compressive residual stresses improving the mechanical properties of a material. This work investigates the role of LP on layer-by-layer processing of 3D printed metals using finite element analysis. The objective is to understand temporal and spatial residual stress development after thermal and mechanical cancellation caused by cyclically coupling printing and peening. Results indicate layer peening frequency is a critical process …

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Method For Fabrication Of A Soft-Matter Printed Circuit Board, Carmel Majidi, Tong Lu, Eric J. Markvicka Jul 2019

Method For Fabrication Of A Soft-Matter Printed Circuit Board, Carmel Majidi, Tong Lu, Eric J. Markvicka

Department of Mechanical and Materials Engineering: Faculty Publications

A fabrication process for soft - matter printed circuit boards is disclosed in which traces of liquid - phase Ga - In eutectic ( eGaIn ) are patterned with UV laser micromachining ( UVLM ) . The terminals of the elastomer - sealed LM circuit connect to the surface mounted chips through vertically aligned columns of eGaIn - coated ferromagnetic micro spheres that are embedded within an interfacial elastomer layer .

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Wearable Devices For Single-Cell Sensing And Transfection, Lingqian Chang, Yu-Chieh Wang, Faheem Ershad, Ruiguo Yang, Cunjiang Yu, Yubo Fan May 2019

Wearable Devices For Single-Cell Sensing And Transfection, Lingqian Chang, Yu-Chieh Wang, Faheem Ershad, Ruiguo Yang, Cunjiang Yu, Yubo Fan

Department of Mechanical and Materials Engineering: Faculty Publications

Wearable healthcare devices are mainly used for biosensing and transdermal delivery. Recent advances in wearable biosensors allow for long-term and real-time monitoring of physiological conditions at a cellular resolution. Transdermal drug delivery systems have been further scaled down, enabling wide selections of cargo, from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or …

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Influence Of Metal Additives On Microstructure And Properties Of Amorphous Metal–Sioc Composites, Kaisheng Ming, Qing Su, Chao Gu, Dongyue Xie, Yongqiang Wang, Michael Nastasi, Jian Wang Apr 2019

Influence Of Metal Additives On Microstructure And Properties Of Amorphous Metal–Sioc Composites, Kaisheng Ming, Qing Su, Chao Gu, Dongyue Xie, Yongqiang Wang, Michael Nastasi, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

Strong, ductile, and irradiation-tolerant structural materials are in urgent demand for improving the safety and efficiency of advanced nuclear reactors. Amorphous ceramics could be promising candidates for high irradiation tolerance due to thermal stability and lack of crystal defects. However, they are very brittle due to plastic flow instability. Here, we realized enhanced plasticity of amorphous ceramics through compositional and microstructural engineering. Two metal–amorphous ceramic composites, Fe-SiOC and Cu-SiOC, were fabricated by magnetron sputtering. Iron atoms are preferred to form uniformly distributed nano-sized Fe-rich amorphous clusters, while copper atoms grow non-uniformly distributed nano-crystalline Cu particles. The Fe-SiOC composite exhibits high …

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Biomechanical Foot Guidance Linkage, Carl Nelson, Cale J. Stolle, Judith M. Burnfield Apr 2019

Biomechanical Foot Guidance Linkage, Carl Nelson, Cale J. Stolle, Judith M. Burnfield

Department of Mechanical and Materials Engineering: Faculty Publications

A gait replication apparatus can include a scalable mechanical mechanism configured to replicate different gaits . The scalable mechanical mechanism can include , for example , a four - bar linkage , a pantograph , a cam / Scotch - yoke mechanism , and so forth . In some embodiments , the mechanical mechanism includes a beam rotating about an axis passing proximate to its center , with a foot pedal slidably coupled with the beam , and a timing chain / belt or cable pulley - pair coupled with the foot pedal and looped about the beam . A …

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Soft , Multilayered Electronics For Wearable Devices And Methods To Produce The Same, Carmel Majidi, Michael D. Bartlett, Eric J. Markvicka Mar 2019

Soft , Multilayered Electronics For Wearable Devices And Methods To Produce The Same, Carmel Majidi, Michael D. Bartlett, Eric J. Markvicka

Department of Mechanical and Materials Engineering: Faculty Publications

Disclosed herein is an efficient fabrication approach to create highly customizable wearable electronics through rapid laser machining and adhesion - controlled soft materials assembly . Well - aligned , multi - layered materials can be created from 2D and 3D elements that stretch and bend while seamlessly integrating with rigid components such as micro chip integrated circuits ( IC ) , discrete electrical components , and interconnects . These techniques are applied using commercially available materials . These materials and methods enable custom wearable electronics while offering versatility in design and functionality for a variety of bio - monitor ing …

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Gastrointestinal Sensor Implantation System, Benjamin Terry, Weston Lewis, Wanchuan Xie, Pengbo Li, Alfred Tsubaki Mar 2019

Gastrointestinal Sensor Implantation System, Benjamin Terry, Weston Lewis, Wanchuan Xie, Pengbo Li, Alfred Tsubaki

Department of Mechanical and Materials Engineering: Faculty Publications

A gastrointestinal ( GI ) sensor deployment device is dis closed . In implementations , the sensor deployment device includes an orally - administrable capsule with a tissue cap ture device removably coupled to the orally - administrable capsule . The tissue capture device includes a plurality of fasteners for connecting the tissue capture device to GI tissue within a body . A biometric sensor is coupled to the tissue capture device for continuous or periodic monitoring of the GI tract of the body at the GI tissue attachment location . A chamber within the orally - administrable capsule is …

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Interactions Between Dislocations And Three-Dimensional Annealing Twins In Face Centered Cubic Metals, Yanxiang Liang, Xiaofang Yang, Mingyu Gong, Guisen Liu, Qing Liu, Jian Wang Mar 2019

Interactions Between Dislocations And Three-Dimensional Annealing Twins In Face Centered Cubic Metals, Yanxiang Liang, Xiaofang Yang, Mingyu Gong, Guisen Liu, Qing Liu, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

Annealing twins often form in metals with a face centered cubic structure during thermal and mechanical processing. Here, we conducted molecular dynamic (MD) simulations for copper and aluminum to study the interaction processes between {1 1 1}1/2 <1 1 0> dislocations and a three-dimensional annealing twin. Twin boundaries are characterized with Σ3{1 1 1} coherent twin boundaries (CTBs) and Σ3{1 1 2} incoherent twin boundaries (ITBs). MD results revealed that dislocation-ITB interactions affect slip transmission for a dislocation crossing CTBs, facilitating the nucleation of Lomer dislocation.

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Deep Learning Segmentation Of Coronary Calcified Plaque From Intravascular Optical Coherence Tomography (Ivoct) Images With Application To Finite Element Modeling Of Stent Deployment, Yazan Gharaibeh, Pengfei Dong, David Prabhu, Chaitanya Kolluru, Juhwan Lee, Vlad Zimin, Hozhabr Mozafari, Hiram Bizzera, Linxia Gu, David Wilson Feb 2019

Deep Learning Segmentation Of Coronary Calcified Plaque From Intravascular Optical Coherence Tomography (Ivoct) Images With Application To Finite Element Modeling Of Stent Deployment, Yazan Gharaibeh, Pengfei Dong, David Prabhu, Chaitanya Kolluru, Juhwan Lee, Vlad Zimin, Hozhabr Mozafari, Hiram Bizzera, Linxia Gu, David Wilson

Department of Mechanical and Materials Engineering: Faculty Publications

Because coronary artery calcified plaques can hinder or eliminate stent deployment, interventional cardiologists need a better way to plan interventions, which might include one of the many methods for calcification modification (e.g., atherectomy). We are imaging calcifications with intravascular optical coherence tomography (IVOCT), which is the lone intravascular imaging technique with the ability to image the extent of a calcification, and using results to build vessel-specific finite element models for stent deployment. We applied methods to a large set of image data (>45 lesions and > 2,600 image frames) of calcified plaques, manually segmented by experts into calcified, lumen and …

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Strength And Plasticity Of Amorphous Silicon Oxycarbide, Kaisheng Ming, Chao Gu, Qing Su, Yongqiang Wang, Arezoo Zare, Don A. Lucca, Michael Nastasi, Jian Wang Jan 2019

Strength And Plasticity Of Amorphous Silicon Oxycarbide, Kaisheng Ming, Chao Gu, Qing Su, Yongqiang Wang, Arezoo Zare, Don A. Lucca, Michael Nastasi, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

Amorphous SiOC films were synthesized by magnetron sputtering at room temperature with/without radio frequency (RF) bias and further improved in terms of mechanical properties by ion irradiation. As-deposited SiOC films without RF bias exhibit catastrophic failure at a low stress and strain, which is ascribed to microstructural heterogeneities associated with the formation of voids during deposition, as evidenced by transmission electron microscopy. Ion irradiation unifies microstructure accompanied with eliminating the voids, resulting in a simultaneously increase in strength and plasticity (ultimate strength of 5–7 GPa and the strain to shear instability of over 20%). Homogeneous microstructures are demonstrated to ensure …

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Robotic Devicewith Compact Joint Design And Related Systems And Methods, Tom Frederick, Eric Markvicka, Shane Michael Farritor, Dmitry Oleynikov Jan 2019

Robotic Devicewith Compact Joint Design And Related Systems And Methods, Tom Frederick, Eric Markvicka, Shane Michael Farritor, Dmitry Oleynikov

Department of Mechanical and Materials Engineering: Faculty Publications

The embodiments disclosed herein relate to various robotic and/or in vivo medical devices having compact joint configurations. Other embodiments relate to various medical device components, including forearms having grasper or cautery end effectors, that can be incorporated into certain robotic and/or in vivo medical devices.

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Flaw Detection With Ultrasonic Backscatter Signal Envelopes, Yongfeng Song, Christopher M. Kube, Zuoxiang Peng, Joseph A. Turner, Xiongbing Li Jan 2019

Flaw Detection With Ultrasonic Backscatter Signal Envelopes, Yongfeng Song, Christopher M. Kube, Zuoxiang Peng, Joseph A. Turner, Xiongbing Li

Department of Mechanical and Materials Engineering: Faculty Publications

Ultrasound is a prominent nondestructive testing modality for the detection, localization, and sizing of defects in engineering materials. Often, inspectors analyze ultrasonic waveforms to determine if echoes, which stem from the scattering of ultrasound from a defect, exceed a threshold value. In turn, the initial selection of the threshold value is critical. In this letter, a time-dependent threshold or upper bound for the signal envelope is developed based on the statistics governing the scattering of ultrasound from microstructure. The utility of the time-dependent threshold is demonstrated using experiments conducted on sub-wavelength artificial defects. The results are shown to enhance current …

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Glocal Integrity In 420 Stainless Steel By Asynchronous Laser Processing, Michael P. Sealy, Haitham Hadidi, Cody Kanger, X. L. Yan, Bai Cui, J. A. Mcgeough Jan 2019

Glocal Integrity In 420 Stainless Steel By Asynchronous Laser Processing, Michael P. Sealy, Haitham Hadidi, Cody Kanger, X. L. Yan, Bai Cui, J. A. Mcgeough

Department of Mechanical and Materials Engineering: Faculty Publications

Cold working individual layers during additive manufacturing (AM) by mechanical surface treatments, such as peening, effectively “prints” an aggregate surface integrity that is referred to as a glocal (i.e., local with global implications) integrity. Printing a complex, pre-designed glocal integrity throughout the build volume is a feasible approach to improve functional performance while mitigating distortion. However, coupling peening with AM introduces new manufacturing challenges, namely thermal cancellation, whereby heat relaxes favorable residual stresses and work hardening when printing on a peened layer. Thus, this work investigates glocal integrity formation from cyclically coupling LENS® with laser peening on 420 stainless steel.

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The Role Of Low-Level Image Features In The Affective Categorization Of Rapidly Presented Scenes, L. Jack Rhodes, Matthew Rios, Jacob M. Williams, Gonzalo Quinones, Prahalada K. Rao, Vladimir Miskovic Jan 2019

The Role Of Low-Level Image Features In The Affective Categorization Of Rapidly Presented Scenes, L. Jack Rhodes, Matthew Rios, Jacob M. Williams, Gonzalo Quinones, Prahalada K. Rao, Vladimir Miskovic

Department of Mechanical and Materials Engineering: Faculty Publications

It remains unclear how the visual system is able to extract affective content from complex scenes even with extremely brief (< 100 millisecond) exposures. One possibility, suggested by findings in machine vision, is that low-level features such as unlocalized, two-dimensional (2-D) Fourier spectra can be diagnostic of scene content. To determine whether Fourier image amplitude carries any information about the affective quality of scenes, we first validated the existence of image category differences through a support vector machine (SVM) model that was able to discriminate our intact aversive and neutral images with ~ 70% accuracy using amplitude-only features as inputs. This model allowed us to confirm that scenes belonging to different affective categories could be mathematically distinguished on the basis of amplitude spectra alone. The next question is whether these same features are also exploited by the human visual system. Subsequently, we tested observers’ rapid classification of affective and neutral naturalistic scenes, presented briefly (~33.3 ms) and backward masked with synthetic textures. We tested categorization accuracy across three distinct experimental conditions, using: (i) original images, (ii) images having their amplitude spectra swapped within a single affective image category (e.g., an aversive image whose amplitude spectrum has been swapped with another aversive image) or (iii) images having their amplitude spectra swapped between affective categories (e.g., an aversive image containing the amplitude spectrum of a neutral image). Despite its discriminative potential, the human visual system does not seem to use Fourier amplitude differences as the chief strategy for affectively categorizing scenes at a glance. The contribution of image amplitude to affective categorization is largely dependent on interactions with the phase spectrum, although it is impossible to completely rule out a residual role for unlocalized 2-D amplitude measures.

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Compliant Surgical Graspers And Methods Of Making And Using, Carl Nelson, Alan Goyzueta Jan 2019

Compliant Surgical Graspers And Methods Of Making And Using, Carl Nelson, Alan Goyzueta

Department of Mechanical and Materials Engineering: Faculty Publications

This disclosure describes compliant graspers for use in endoscopic surgeries.

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Self-Powered Ghz Solution-Processed Hybrid Perovskite Photodetectors, Jinsong Huang Jan 2019

Self-Powered Ghz Solution-Processed Hybrid Perovskite Photodetectors, Jinsong Huang

Department of Mechanical and Materials Engineering: Faculty Publications

Organic-inorganic hybrid perovskite (OIHP) based photo-responsive devices include an OIHP active layer disposed between a cathode layer and an anode layer, and an electron extraction layer disposed between the cathode layer and the active layer. The electron extraction layer includes a layer of C60 directly disposed on the active layer. The active layer includes an organometal trihalide perovskite layer (e.g., CH3NH3PbI2X, where X includes at least one of Cl, Br, or I).

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9r Phase Enabled Superior Radiation Stability Of Nanotwinned Cu Alloys Via In Situ Radiation At Elevated Temperature, Cuncai Fan, Dongyue Xie, Jin Li, Zhongxia Shang, Youxing Chen, Sichuang Xue, Jian Wang, Meimei Li, Anter El-Azab, Haiyan Wang, Xinghang Zhang Jan 2019

9r Phase Enabled Superior Radiation Stability Of Nanotwinned Cu Alloys Via In Situ Radiation At Elevated Temperature, Cuncai Fan, Dongyue Xie, Jin Li, Zhongxia Shang, Youxing Chen, Sichuang Xue, Jian Wang, Meimei Li, Anter El-Azab, Haiyan Wang, Xinghang Zhang

Department of Mechanical and Materials Engineering: Faculty Publications

Nanotwinned metals exhibit outstanding radiation tolerance as twin boundaries effectively engage, transport and eliminate radiation-induced defects. However, radiation-induced detwinning may reduce the radiation tolerance associated with twin boundaries, especially at elevated temperatures. Here we show, via in-situ Kr ion irradiation inside a transmission electron microscope, that 3 at. % Fe in epitaxial nanotwinned Cu (Cu97Fe3) significantly improves the thermal and radiation stability of nanotwins during radiation up to 5 displacements-per-atom at 200 °C. Such enhanced stability of nanotwins is attributed to a diffuse 9R phase resulted from the dissociation of incoherent twin boundaries in nanotwinned Cu …

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Relative Contributions Of Intracranial Pressure And Intraocular Pressure On Lamina Cribrosa Behavior, Junfei Tong, Deepta Ghate, Sachin Kedar, Linxia Gu Jan 2019

Relative Contributions Of Intracranial Pressure And Intraocular Pressure On Lamina Cribrosa Behavior, Junfei Tong, Deepta Ghate, Sachin Kedar, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

Purpose. To characterize the relative contributions of intraocular pressure (IOP) and intracranial pressure (ICP) on lamina cribrosa (LC) behavior, specifically LC depth (LCD) and LC peak strain. Methods. An axially symmetric finite element model of the posterior eye was constructed with an elongated optic nerve and retro-orbital subarachnoid space ensheathed by pia and dura mater. -e mechanical environment in LC was evaluated with ICP ranging from 5 to 15mmHg and IOP from 10 to 45 mmHg. LCD and LC peak strains at various ICP and IOP levels were estimated using full factorial experiments. Multiple linear regression analyses were …

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Design Rules For Additive Manufacturing – Understanding The Fundamental Thermal Phenomena To Reduce Scrap, M. Reza Yavari, Kevin D. Cole, Prahalada K. Rao Jan 2019

Design Rules For Additive Manufacturing – Understanding The Fundamental Thermal Phenomena To Reduce Scrap, M. Reza Yavari, Kevin D. Cole, Prahalada K. Rao

Department of Mechanical and Materials Engineering: Faculty Publications

The goal of this work is to predict the effect of part geometry and process parameters on the direction and magnitude of heat flow heat flux in parts made using metal additive manufacturing (AM) processes. As a step towards this goal, the objective of this paper is to develop and apply the mathematical concept of heat diffusion over graphs to approximate the heat flux in metal AM parts as a function of their geometry. This objective is consequential to overcome the poor process consistency and part quality in AM. Currently, part build failure rates in metal AM often exceed 20%, …

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Resistance To Helium Bubble Formation In Amorphous Sioc/Crystalline Fe Nanocomposite, Qing Su, Tianyao Wang, Jonathan Gigax, Lin Shao, Michael Nastasi Jan 2019

Resistance To Helium Bubble Formation In Amorphous Sioc/Crystalline Fe Nanocomposite, Qing Su, Tianyao Wang, Jonathan Gigax, Lin Shao, Michael Nastasi

Department of Mechanical and Materials Engineering: Faculty Publications

The management of radiation defects and insoluble He atoms represent key challenges for structural materials in existing fission reactors and advanced reactor systems. To examine how crystalline/amorphous interface, together with the amorphous constituents affects radiation tolerance and He management, we studied helium bubble formation in helium ion implanted amorphous silicon oxycarbide (SiOC) and crystalline Fe composites by transmission electron microscopy (TEM). The SiOC/Fe composites were grown via magnetron sputtering with controlled length scale on a surface oxidized Si (100) substrate. These composites were subjected to 50 keV He+ implantation with ion doses chosen to produce a 5 at% peak He …

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Fast Growth Of Thin Mapbi3 Crystal Wafers On Aqueous Solution Surface For Efficient Lateral-Structure Perovskite Solar Cells, Ye Liu, Qingfeng Dong, Yanjun Fang, Yuze Lin, Yehao Deng, Jinsong Huang Jan 2019

Fast Growth Of Thin Mapbi3 Crystal Wafers On Aqueous Solution Surface For Efficient Lateral-Structure Perovskite Solar Cells, Ye Liu, Qingfeng Dong, Yanjun Fang, Yuze Lin, Yehao Deng, Jinsong Huang

Department of Mechanical and Materials Engineering: Faculty Publications

Solar-grade single or multiple crystalline wafers are needed in large quantities in the solar cell industry, and are generally formed by a top-down process from crystal ingots, which causes a significant waste of materials and energy during slicing, polishing, and other processing. Here, a bottom-up technique that allows the growth of wafer-size hybrid perovskite multiple crystals directly from aqueous solution is reported. Single-crystalline hybrid perovskite wafers with centimeter size are grown at the top surface of a perovskite precursor solution. As well as saving raw materials, this method provides unprecedented advantages such as easily tunable thickness and rapid growth of …

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Wearable Devices For Single Cell Sensing And Transfection, Lingqian Chang, Yu-Chieh Wang, Faheem Ershad, Ruiguo Yang, Cunjiang Yu, Yubo Fan Jan 2019

Wearable Devices For Single Cell Sensing And Transfection, Lingqian Chang, Yu-Chieh Wang, Faheem Ershad, Ruiguo Yang, Cunjiang Yu, Yubo Fan

Department of Mechanical and Materials Engineering: Faculty Publications

Transdermal drug delivery systems have been successful for decades. Now these devices can be further scaled down, and their applications have been extended to wide selections of cargo, ranging from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles and vaccines). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or potential for single-cell biosensing and transfection in the skin or other organs, …

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Segregation Of Mo Atoms Into Stacking Faults In Crfeconimo Alloy, Kaisheng Ming, Xiaofang Bi, Jian Wang Jan 2019

Segregation Of Mo Atoms Into Stacking Faults In Crfeconimo Alloy, Kaisheng Ming, Xiaofang Bi, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

Solute segregation at dislocations can impede the motion of dislocations, strengthening materials. Here, we study the formation and role of solute segregation at dislocations in CrFeCoNiMo high-entropy alloys (HEAs) by high-angle annular dark-field scanning transmission electron microscopy imaging and mechanical testing both deformed and annealed samples. Mo atoms exhibit pronounced segregation into the planar-extended core of dislocations, i.e. stacking faults, causing the increase in the yield strength while the loss of the ductility. This work suggests that mechanical properties of HEAs can be tailored by alloying additional elements that are in favor of segregation into dislocations.

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Optimization Of Protein-Protein Interaction Measurements For Drug Discovery Using Afm Force Spectroscopy, Yongliang Yang, Bixi Zeng, Zhiyong Sun, Amir Monemianesfahani, Jing Hou, Nian-Dong Jiao, Lianqing Liu, Liangliang Chen, Marc D. Basson, Lixin Dong, Ruiguo Yang, Ning Xi Jan 2019

Optimization Of Protein-Protein Interaction Measurements For Drug Discovery Using Afm Force Spectroscopy, Yongliang Yang, Bixi Zeng, Zhiyong Sun, Amir Monemianesfahani, Jing Hou, Nian-Dong Jiao, Lianqing Liu, Liangliang Chen, Marc D. Basson, Lixin Dong, Ruiguo Yang, Ning Xi

Department of Mechanical and Materials Engineering: Faculty Publications

Increasingly targeted in drug discovery, protein-protein interactions challenge current high throughput screening technologies in the pharmaceutical industry. Developing an effective and efficient method for screening small molecules or compounds is critical to accelerate the discovery of ligands for enzymes, receptors and other pharmaceutical targets. Here, we report developments of methods to increase the signal-to-noise ratio (SNR) for screening protein-protein interactions using atomic force microscopy (AFM) force spectroscopy. We have demonstrated the effectiveness of these developments on detecting the binding process between focal adhesion kinases (FAK) with protein kinase B (Akt1), which is a target for potential cancer drugs. These developments …

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Local Control Robotic Surgical Devices And Related Methods, Eric Markvicka, Tom Frederick, Jack Mondry, Joe Bartels, Shane Michael Farritor Jan 2019

Local Control Robotic Surgical Devices And Related Methods, Eric Markvicka, Tom Frederick, Jack Mondry, Joe Bartels, Shane Michael Farritor

Department of Mechanical and Materials Engineering: Faculty Publications

The various robotic medical devices include robotic devices that are disposed within a body cavity and positioned using a support component disposed through an orifice or opening in the body cavity. Additional embodiments relate to devices having arms coupled to a device body wherein the device has a minimal profile such that the device can be easily inserted through smaller incisions in comparison to other devices without such a small profile. Further embodiments relate to methods of operating the above devices.

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Medical Inflation, Attachment And Delivery Devices And Related Methods, Mark Rentschler, Shane Michael Farritor Jan 2019

Medical Inflation, Attachment And Delivery Devices And Related Methods, Mark Rentschler, Shane Michael Farritor

Department of Mechanical and Materials Engineering: Faculty Publications

The various embodiments disclosed herein relate to procedural space maintenance devices, medical device positioning devices, and devices that provide both procedural space maintenance and device positioning. Further embodiments relate to medical device insertion and/or retraction devices.

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High Strength, Deformable Nanotwinned Al–Co Alloys, S. Xue, Qiang Li, D. Y. Xie, Y. F. Zhang, Han Wang, Haiyan Wong, J. Wang, Xinghang Zhang Jan 2019

High Strength, Deformable Nanotwinned Al–Co Alloys, S. Xue, Qiang Li, D. Y. Xie, Y. F. Zhang, Han Wang, Haiyan Wong, J. Wang, Xinghang Zhang

Department of Mechanical and Materials Engineering: Faculty Publications

Aluminum (Al) alloys have been widely used in the transportation industry. However, most highstrength Al alloys to date have limited mechanical strength, on the order of a few hundred MPa, which is much lower than the flow stress of high-strength steels. In this study, we show the fabrication of nanocrystalline Al alloys with high-density growth twins enabled by a few atomic percent of Co solute. In situ uniaxial compression tests show that the flow stress of Al–Co solid solution alloys exceeds 1.5 GPa, while good work hardening capability is maintained. This study provides a new perspective on the design of …

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A Sensorless Force-Feedback System For Robot-Assisted Laparoscopic Surgery, Baoliang Zhao, Carl A. Nelson Jan 2019

A Sensorless Force-Feedback System For Robot-Assisted Laparoscopic Surgery, Baoliang Zhao, Carl A. Nelson

Department of Mechanical and Materials Engineering: Faculty Publications

The existing surgical robots for laparoscopic surgery offer no or limited force feedback, and there are many problems for the traditional sensor-based solutions. This paper builds a teleoperation surgical system and validates the effectiveness of sensorless force feedback. The tool-tissue interaction force at the surgical grasper tip is estimated using the driving motor’s current, and fed back to the master robot with a position-force bilateral control algorithm. The stiffness differentiation experiment and tumor detection experiment were conducted. In the stiffness differentiation experiment, 43 out of 45 pairs of ranking relationships were identified correctly, yielding a success rate of 96%. In …

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Effects Of Compositional Tailoring On Drug Delivery Behaviours Of Silica Xerogel/Polymer Core-Shell Composite Nanoparticles, Wenfei Huang, Chi Pong Tsui, Chak Yin Tang, Linxia Gu Jan 2019

Effects Of Compositional Tailoring On Drug Delivery Behaviours Of Silica Xerogel/Polymer Core-Shell Composite Nanoparticles, Wenfei Huang, Chi Pong Tsui, Chak Yin Tang, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

Conventional core-shell polymer nanoparticles usually exhibit a rapid release rate with their release kinetics mainly adjusted through changing composition of the polymer shells, limiting their applications for prolonged drug delivery. As a solution to these problems, silica xerogel/polymer core-shellstructured composite nanoparticles have been proposed. Different with our previous work centring on studying process variables, we here focused on investigating the effects of key compositional variables on essential properties of the composite nanoparticles. The drug release profiles (in vitro) were well interpreted by the Baker and Lonsdale model on a predicted two-stage basis. The first stage (<1 day) was well controlled from 18.6% to 45.9%; the second stage (1–14 days) was tailored in a range from 28.7 to 58.2% by changing the composition of the silica xerogel cores and polymeric shells. A substantial achievement was reducing the release rate by more than 40 times compared with that of conventional polymer nanoparticles by virtue of the silica xerogel cores. A semi-empirical model was also established in the first attempt to describe the effects of polymer concentration and drug loading capacity on the size of the composite nanoparticles. All these results indicated that the composite nanoparticles are promising candidates for prolonged drug delivery applications.

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