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Full-Text Articles in Other Mechanical Engineering

3d Printing Of Multilayered Scaffolds For Rotator Cuff Tendon Regeneration, Xiping Jiang, Shaohua Wu, Mitchell Kuss, Yunfan Kong, Wen Shi, Philipp N. Streubel, Tieshi Li, Bin Duan Jan 2020

3d Printing Of Multilayered Scaffolds For Rotator Cuff Tendon Regeneration, Xiping Jiang, Shaohua Wu, Mitchell Kuss, Yunfan Kong, Wen Shi, Philipp N. Streubel, Tieshi Li, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

Repairing massive rotator cuff tendon defects remains a challenge due to the high retear rate after surgical intervention. 3D printing has emerged as a promising technique that enables the fabrication of engineered tissues with heterogeneous structures and mechanical properties, as well as controllable microenvironments for tendon regeneration. In this study, we developed a new strategy for rotator cuff tendon repair by combining a 3D printed scaffold of polylactic-co-glycolic acid (PLGA) with cell-laden collagen-fibrin hydrogels. We designed and fabricated two types of scaffolds: one featuring a separate layer-by-layer structure and another with a tri-layered structure as a whole. Uniaxial tensile tests …


Imparities Of Shear Avalanches Dynamic Evolution In A Metallic Glass, Yin Du, Qing Zhou, Qian Jia, Yidi Shi, Haifeng Wang, Jian Wang Jan 2020

Imparities Of Shear Avalanches Dynamic Evolution In A Metallic Glass, Yin Du, Qing Zhou, Qian Jia, Yidi Shi, Haifeng Wang, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

The imparities of shear avalanches dynamic evolution under nanoindentation originating from the soft regions and the stiff matrix were explored in a metallic glass by statistical and dynamic analysis. Upon the continuous indentation process, the dynamic state of the stiff matrix exhibits a transition from a chaotic behavior to a self-organized critical (SOC) behavior, whereas the soft regions are domi-nated by the SOC behavior throughout the indentation process. The mechanism was clarified by the evolution of the cut-off size of shear avalanches. These findings might advance our fundamental understanding of inhomogeneous deformation on microscale.

IMPACT STATEMENT The shear avalanches dynamic …


Foundry Sand Source Reduction Options: Life Cycle Assessment Evaluation, Samuel Ghormley, Robert Williams, Bruce Dvorak Jan 2020

Foundry Sand Source Reduction Options: Life Cycle Assessment Evaluation, Samuel Ghormley, Robert Williams, Bruce Dvorak

Department of Mechanical and Materials Engineering: Faculty Publications

Foundries represent a significant part of the world’s economy and are a large consumer of energy and producer of solid waste. Sand-handling processes can use 5–10% of a foundry’s total energy. The goal of this research was to explore source reduction and waste minimization at a foundry, using both economic and Life Cycle Assessment (LCA) techniques to compare three secondary sand-reclamation options. LCA software modeled all sand processes at a mid-sized ferrous foundry in the USA. The LCA showed all secondary reclamation technologies, while more energy intensive at the foundry, lowered life cycle environmental impacts, including GHG emissions, ecotoxicity, and …


An Overview Of Additive Manufacturing Technologies—A Review To Technical Synthesis In Numerical Study Of Selective Laser Melting, Abbas Razavykia, Eugenio Brusa, Cristiana Delprete, Reza Yavari Jan 2020

An Overview Of Additive Manufacturing Technologies—A Review To Technical Synthesis In Numerical Study Of Selective Laser Melting, Abbas Razavykia, Eugenio Brusa, Cristiana Delprete, Reza Yavari

Department of Mechanical and Materials Engineering: Faculty Publications

Additive Manufacturing (AM) processes enable their deployment in broad applications from aerospace to art, design, and architecture. Part quality and performance are the main concerns during AM processes execution that the achievement of adequate characteristics can be guaranteed, considering a wide range of influencing factors, such as process parameters, material, environment, measurement, and operators training. Investigating the effects of not only the influential AM processes variables but also their interactions and coupled impacts are essential to process optimization which requires huge efforts to be made. Therefore, numerical simulation can be an effective tool that facilities the evaluation of the AM …


Facile Production Of Large-Area Cell Arrays Using Surface-Assembled Microdroplets, Karla Perez-Toralla, Angel Olivera-Torres, Mark A. Rose, Amir Monemian Monemianesfahani, Keerthana Reddy, Ruiguo Yang, Stephen Morin Jan 2020

Facile Production Of Large-Area Cell Arrays Using Surface-Assembled Microdroplets, Karla Perez-Toralla, Angel Olivera-Torres, Mark A. Rose, Amir Monemian Monemianesfahani, Keerthana Reddy, Ruiguo Yang, Stephen Morin

Department of Mechanical and Materials Engineering: Faculty Publications

Techniques that enable the spatial arrangement of living cells into defined patterns are broadly applicable to tissue engineering, drug screening, and cell–cell investigations. Achieving large-scale patterning with single-cell resolution while minimizing cell stress/damage is, however, technically challenging using existing methods. Here, a facile and highly scalable technique for the rational design of reconfigurable arrays of cells is reported. Specifically, microdroplets of cell suspensions are assembled using stretchable surface-chemical patterns which, following incubation, yield ordered arrays of cells. The microdroplets are generated using a microfluidic- based aerosol spray nozzle that enables control of the volume/size of the droplets delivered to the …


Characteristic Boundaries Associated With Three-Dimensional Twins In Hexagonal Metals, Shujuan Wang, Mingyu Gong, Rodney J. Mccabe, Laurent Capolungo, Jian Wang, Carlos N. Tomé Jan 2020

Characteristic Boundaries Associated With Three-Dimensional Twins In Hexagonal Metals, Shujuan Wang, Mingyu Gong, Rodney J. Mccabe, Laurent Capolungo, Jian Wang, Carlos N. Tomé

Department of Mechanical and Materials Engineering: Faculty Publications

Twinning is a critically important deformation mode in hexagonal close-packed metals. Twins are three-dimensional (3D) domains, whose growth is mediated by the motion of facets bounding the 3D twin domains and influences work hardening in metals. An understanding of twin transformations therefore necessitates that the atomic-scale structure and intrinsic mobilities of facets be known and characterized. The present work addresses the former point by systematically characterizing the boundary structures of 3D { ̄1012} twins in magnesium using high-resolution transmission electron microscopy (HRTEM). Eight characteristic facets associated with twin boundaries are reported, five of which have never been experimentally observed before. …


Fluid Mechanics Education Using Japanese Anime: Examples From “Castle In The Sky” By Hayao Miyazaki, Sangjin Ryu, Haipeng Zhang, Markeya S. Peteranetz, Tareq Daher Jan 2020

Fluid Mechanics Education Using Japanese Anime: Examples From “Castle In The Sky” By Hayao Miyazaki, Sangjin Ryu, Haipeng Zhang, Markeya S. Peteranetz, Tareq Daher

Department of Mechanical and Materials Engineering: Faculty Publications

Current K-12 and undergraduate student have grown up with constant exposure to visual popular culture (e.g., movies, TV programs, graphic novels, etc.). Because youth find pop culture references in the classroom to be engaging, many science and engineering instructors have shown that examples found in visual pop culture can be used to teach science and engineering concepts.1,2 One recent study on the efficay os using pop ulture for instruction found that high school studetns learning from graphic-novel styles comics acquired deeper understanding of complex subject matter and reported higher engagement with the instructional materials as compared to students learning from …


Rotating-Liquid-Based Hydrogel Bead Generator, Haipeng Zhang, Sangjin Ryu Jan 2020

Rotating-Liquid-Based Hydrogel Bead Generator, Haipeng Zhang, Sangjin Ryu

Department of Mechanical and Materials Engineering: Faculty Publications

Hydrogel beads are widely used in various applications, but producing such beads often requires complicated devices. Instead, we propose an easy-to-adopt, cost effective, open source hydrogel bead generator. This generator consists of two modules. The first module rotates two immiscible liquids in rigid body motion: mineral oil as the continuous phase (CP) liquid on top, and a hydrogel cross-linking (CL) liquid at bottom. The second module injects a hydrogel pre-polymer solution as the dispersed phase (DP) liquid into the rotating CP liquid. As the DP liquid flows out of a syringe needle, its drops are pinched off by the shear …


Assistive Rehabilitation Elliptical System, Carl Nelson, Cale J. Stolle, Judith M. Burnfield, Thad W. Buster, Bernadette Mccrory Jan 2020

Assistive Rehabilitation Elliptical System, Carl Nelson, Cale J. Stolle, Judith M. Burnfield, Thad W. Buster, Bernadette Mccrory

Department of Mechanical and Materials Engineering: Faculty Publications

An elliptical system is disclosed having a crank assembly configured to be adjusted in length to accommodate users having varying gaits. In some embodiments, the crank assembly includes a crank and an axle connection bracket that is slidably adjustable with respect to the crank. For example, the crank assembly can include a crank link having a longitudinal body, where the longitudinal body is connected to the crank at one end and includes a longitudinal slots slidably coupled with the axle connection bracket. The axle connection bracket is configured to slide through a plurality of positions along the longitudinal body. In …


Role Of Active Nanoliposomes In The Surface And Bulk Mechanical Properties Of Hybrid Hydrogels, R. Kadri, J. Bacharouch, K. Elkhoury, G. Ben Messaoud, C. Kahn, S. Desobry, M. Linder, Ali Tamayol, G. Francius, J.F. Mano, L. Sanchez-Gonzalez, E. Arab-Tehrany Jan 2020

Role Of Active Nanoliposomes In The Surface And Bulk Mechanical Properties Of Hybrid Hydrogels, R. Kadri, J. Bacharouch, K. Elkhoury, G. Ben Messaoud, C. Kahn, S. Desobry, M. Linder, Ali Tamayol, G. Francius, J.F. Mano, L. Sanchez-Gonzalez, E. Arab-Tehrany

Department of Mechanical and Materials Engineering: Faculty Publications

Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering


Narrow Band Perovskite Single Crystal Photodetectors With Tunable Spectral Response, Jinsong Huang, Yanjun Fang Jan 2020

Narrow Band Perovskite Single Crystal Photodetectors With Tunable Spectral Response, Jinsong Huang, Yanjun Fang

Department of Mechanical and Materials Engineering: Faculty Publications

Photoelectronic devices using perovskite single-crystal materials having a narrow spectral response, e.g., with a full-width-at-half-maximum response of less than about 20 nm, are provided. The response spectra are continuously (in frequency band) settable or tunable, e.g., from blue to red, by changing the halide composition and thus the band gap of the single crystals. The narrow-band response can be explained by the strong surface charge recombination of the excess carriers lose to the crystal surfaces generated by short wavelength light. The excess carriers generated by below-band gap excitation locate away from the surfaces and can be much more efficiently collect …


Crystallographic Orientation Dependence [email protected] Mechanical Responses Of Fecral Micropillars, Dongyue Xie, Binqiang Wei, Wenqian Wu, Jian Wang Jan 2020

Crystallographic Orientation Dependence [email protected] Mechanical Responses Of Fecral Micropillars, Dongyue Xie, Binqiang Wei, Wenqian Wu, Jian Wang

Department of Mechanical and Materials Engineering: Faculty Publications

Iron-chromium-aluminum (FeCrAl) alloys are used in automobile exhaust gas purifying systems and nuclear reactors due to its superior high-temperature oxidation and excellent corrosion resistance. Single-phase FeCrAl alloys with a body centered cubic structure plastically deform through dislocation slips at room temperature. Here, we investigated the orientation dependence of mechanical responses of FeCrAl alloy through testing single-crystal and bi-crystal micropillars in a scanning electron microscopy at room temperature. Single-crystal micropillars were fabricated with specific orientations which favor the activity of single slip system or two slip systems or multiple slip systems. The strain hardening rate and flow strength increase with increasing …


Hydrogel Microphone, Li Tan, Yang Gao, Qin Zhou, Yongmei Chen Jan 2020

Hydrogel Microphone, Li Tan, Yang Gao, Qin Zhou, Yongmei Chen

Department of Mechanical and Materials Engineering: Faculty Publications

A device includes a capacitive sensor having a hydrogel structure that includes a first surface and a second surface. A first electrode is provided at the first surface of the hydrogel structure, the first electrode including a network of conductive nanoparticles extending into the hydrogel structure. A second electrode is provided at the second surface of the hydrogel structure.


Low Velocity Impact Of Hybrid Stacked Steel Plates, H. Hadidi, R. Q. Feng, M. P. Sealy Jan 2020

Low Velocity Impact Of Hybrid Stacked Steel Plates, H. Hadidi, R. Q. Feng, M. P. Sealy

Department of Mechanical and Materials Engineering: Faculty Publications

Designing and manufacturing high-strength, low-weight parts with enhanced impact resistance is highly sought after in the transportation industry. The most common methods to improve strength-to-weight ratios of impact targets is a composite material composition or a favorable geometric design. An alternative method to improve impact performance is functionally gradient mechanical properties in a single material by hybrid additive stacking. In this study, low-velocity impact tests were conducted on hybrid stacked 1070 steel plates where individual layers were subjected to shot peening (SP) to functionally grade mechanical properties. Hybrid additive stacking refers to secondarily processing preferential layers within a stacked build …


Challenges In Path Planning Of High Energy Density Beams For Additive Manufacturing, Karunakaran K. P, Seema Negi, Arun Nambolan, Yogesh Patil, Milan Pandya, Sajan Kapil, Dmitriy Trushnikov, Michael P. Sealy, Alain Bernard Jan 2020

Challenges In Path Planning Of High Energy Density Beams For Additive Manufacturing, Karunakaran K. P, Seema Negi, Arun Nambolan, Yogesh Patil, Milan Pandya, Sajan Kapil, Dmitriy Trushnikov, Michael P. Sealy, Alain Bernard

Department of Mechanical and Materials Engineering: Faculty Publications

As there are no cutting forces in High Energy Density (HED) beams like lasers and Electron Beam (EB), their speeds are limited only by their positioning systems. On the other hand, as the entire matrix of the 3D printed part has to be addressed by the thin beam in multiple passes in multiple layers, they have to travel several kilometers in tiny motions. Therefore, the acceleration of the motion system becomes the limiting factor than velocity or precision. The authors have proposed an area-filling strategy for EB to fill the layer with optimal squares to exploit analog and hardware computing. …


Buckling Load Study On Pop Nut (Rivet) Using Finite Element Analysis, Saurabh Shankar Shegokar Jan 2020

Buckling Load Study On Pop Nut (Rivet) Using Finite Element Analysis, Saurabh Shankar Shegokar

Dissertations, Master's Theses and Master's Reports

This study highlights the material behavior in riveting operation that includes buckling load analysis using ABAQUS. Finite Element Analysis is used to find the buckling load vs. Displacement results and validated with the results obtained in physical testing of rivet (POP Nut). A mesh sensitivity study is performed using ABAQUS to understand the optimum mesh size for this analysis. An axisymmetric model with contact properties is created and simulated to reduce the simulation time using ABAQUS. The results obtained through Finite Element Analysis show a good resemblance with the testing results. Design changes were suggested to achieve better results that …


Development Of Bio-Based 2t Engine Oil In Marine Engine Application / Babooraman Shanmuganathan, Babooraman Shanmuganathan Jan 2020

Development Of Bio-Based 2t Engine Oil In Marine Engine Application / Babooraman Shanmuganathan, Babooraman Shanmuganathan

Student Works (2020-2029)

Two-storke enginers are simple and lightweight two-cycle spark ignition engine with no oil sump is needed. The use of bio-based lubricants was analyzed to replace commercial mineral and synthetic-based lubricants. Lubricants were prepared by mixing three components of oil which comprise of base oil, additives, and solvent. In this research, four samples of base oil had been prepared with a different weight ratio of the PFAD-NPGester and Type II mineral. Then each of the simples were added with a similiar weight ratio of additives and solvent. A commercial lubricant was used as areference lubricant to be compared with samples prepared. …


Generalized Ultrasonic Scattering Model For Arbitrary Transducer Configurations, Andrea P. Arguelles, Joseph A. Turner Dec 2019

Generalized Ultrasonic Scattering Model For Arbitrary Transducer Configurations, Andrea P. Arguelles, Joseph A. Turner

Department of Mechanical and Materials Engineering: Faculty Publications

Ultrasonic scattering in polycrystalline media is directly tied to microstructural features. As a result, modeling efforts of scattering from microstructure have been abundant. The inclusion of beam modeling for the ultrasonic transducers greatly simplified the ability to perform quantitative, fully calibrated experiments. In this article, a theoretical scattering model is generalized to allow for arbitrary source and receiver configurations, while accounting for beam behavior through the total propagation path. This extension elucidates the importance and potential of out-of-plane scattering modes in the context of microstructure characterization. The scattering coefficient is explicitly written for the case of statistical isotropy and ellipsoidal …


Generalized Ultrasonic Scattering Model For Arbitrary Transducer Configurations, Andrea P. Arguelles, Joseph A. Turner Dec 2019

Generalized Ultrasonic Scattering Model For Arbitrary Transducer Configurations, Andrea P. Arguelles, Joseph A. Turner

Department of Mechanical and Materials Engineering: Faculty Publications

Ultrasonic scattering in polycrystalline media is directly tied to microstructural features. As a result, modeling efforts of scattering from microstructure have been abundant. The inclusion of beam modeling for the ultrasonic transducers greatly simplified the ability to perform quantitative, fully calibrated experiments. In this article, a theoretical scattering model is generalized to allow for arbitrary source and receiver configurations, while accounting for beam behavior through the total propagation path. This extension elucidates the importance and potential of out-of-plane scattering modes in the context of microstructure characterization. The scattering coefficient is explicitly written for the case of statistical isotropy and ellipsoidal …


Multi-Scale Modeling Of The Lamellar Unit Of Arterial Media, Hozhabr Mozafari, Lulu Wang, Yuguo Lei, Linxia Gu Nov 2019

Multi-Scale Modeling Of The Lamellar Unit Of Arterial Media, Hozhabr Mozafari, Lulu Wang, Yuguo Lei, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

The heterogeneity of the lamellar unit (LU) of arterial media plays an important role in the biomechanics of artery. Current two-component (fibrous component and a homogenous matrix) constitutive model is inappropriate for capturing the micro-structural variations in the LU, such as contraction/relaxation of vascular smooth muscle cells (VSMCs), fragmentation of the elastin layer, and deposition/disruption of the collagen network. In this work, we developed a representative volume element (RVE) model with detailed micro-configurations, i.e., VSMCs at various phenotypes, collagen fibers, and elastin laminate embedded in the ground substance. The fiber architecture was generated based on its volume fraction and orientations. …


Beyond The Toolpath: Site-Specific Melt Pool Size Control Enables Printing Of Extra-Toolpath Geometry In Laserwire-Based Directed Energy Deposition, Brian T. Gibson, Bradley S. Richardson, Tayler W. Undermann, Lonnie J. Love Oct 2019

Beyond The Toolpath: Site-Specific Melt Pool Size Control Enables Printing Of Extra-Toolpath Geometry In Laserwire-Based Directed Energy Deposition, Brian T. Gibson, Bradley S. Richardson, Tayler W. Undermann, Lonnie J. Love

Department of Mechanical and Materials Engineering: Faculty Publications

A variety of techniques have been utilized in metal additive manufacturing (AM) for melt pool size management, including modeling and feed-forward approaches. In a few cases, closed-loop control has been demonstrated. In this research, closed-loop melt pool size control for large-scale, laser wire-based directed energy deposition is demonstrated with a novel modification, i.e., site-specific changes to the controller setpoint were commanded at trigger points, the locations of which were generated by the projection of a secondary geometry onto the primary three-dimensional (3D) printed component geometry. The present work shows that, through this technique, it is possible to print a specific …


Effect Of Silica Fume In Concrete On Mechanical Properties And Dynamic Behaviors Under Impact Loading, Shijun Zhao, Qing Zhang Oct 2019

Effect Of Silica Fume In Concrete On Mechanical Properties And Dynamic Behaviors Under Impact Loading, Shijun Zhao, Qing Zhang

Department of Mechanical and Materials Engineering: Faculty Publications

The effect of silica fume (SF) in concrete on mechanical properties and dynamic behaviors was experimentally studied by split Hopkinson pressure bar (SHPB) device with pulse shaping technique. Three series of concrete with 0, 12%, and 16% SF as a cement replacement by weight were produced firstly. Then the experimental procedure for dynamic tests of concrete specimens with SF under a high loading rate was presented. Considering the mechanical performance and behaviors of the concrete mixtures, those tests were conducted under five different impact velocities. The experimental results clearly show concrete with different levels of SF is a strain-rate sensitive …


System And Method For Sensing Wind Flow Passing Over Complex Terrain, Saleh Nabi, Piyush Grover, Mithu Debnath Sep 2019

System And Method For Sensing Wind Flow Passing Over Complex Terrain, Saleh Nabi, Piyush Grover, Mithu Debnath

Department of Mechanical and Materials Engineering: Faculty Publications

A wind flow sensing system determines a first approximation of the velocity field at each of the altitudes by simulating computational fluid dynamics ( CFD ) of the wind flow with operating parameters reducing a cost function of a weighted combination of errors , determines a horizontal derivative of vertical velocity at each of the altitudes from the first approximation of the velocity fields , and determines a second approximation of the velocity fields using geometric relationships between a velocity field for each of the altitudes , projections of the measurements of radial velocities on the three - dimensional axes …


Multi-Agent Control System And Method, Piyush Grover, Karthik Elamvazhuthi Sep 2019

Multi-Agent Control System And Method, Piyush Grover, Karthik Elamvazhuthi

Department of Mechanical and Materials Engineering: Faculty Publications

Motion of multiple agents with identical non - linear dynamics is controlled to change density of the agents from the initial to the final density . A first control problem is formulated for optimizing a control cost of changing density of the agents from the initial density to the final density subject to dynamics of the agents in a density space . The first control problem , which is a non - linear non - convex problem over a multi - agent control and a density of the agents , is trans formed into a second control problem over the …


3d Printing Of Silk Fibroin-Based Hybrid Scaffold Treated With Platelet Rich Plasma For Bone Tissue Engineering, Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Reid Patrick, Xiaohong Qin, Bin Duan Sep 2019

3d Printing Of Silk Fibroin-Based Hybrid Scaffold Treated With Platelet Rich Plasma For Bone Tissue Engineering, Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Reid Patrick, Xiaohong Qin, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

3D printing/bioprinting are promising techniques to fabricate scaffolds with well controlled and patient-specific structures and architectures for bone tissue engineering. In this study, we developed a composite bioink consisting of silk fibroin (SF), gelatin (GEL), hyaluronic acid (HA), and tricalcium phosphate (TCP) and 3D bioprinted the silk fibroin-based hybrid scaffolds. The 3D bioprinted scaffolds with dual crosslinking were further treated with human platelet-rich plasma (PRP) to generate PRP coated scaffolds. Live/Dead and MTT assays demonstrated that PRP treatment could obviously promote the cell growth and proliferation of human adipose derived mesenchymal stem cells (HADMSC). In addition, the treatment of PRP …


3d Printing Of Silk Fibroin-Based Hybrid Scaffold Treated With Platelet Rich Plasma For Bone Tissue Engineering, Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Reid Patrick, Xiaohong Qin, Bin Duan Sep 2019

3d Printing Of Silk Fibroin-Based Hybrid Scaffold Treated With Platelet Rich Plasma For Bone Tissue Engineering, Liang Wei, Shaohua Wu, Mitchell Kuss, Xiping Jiang, Runjun Sun, Reid Patrick, Xiaohong Qin, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

3D printing/bioprinting are promising techniques to fabricate scaffolds with well controlled and patient-specific structures and architectures for bone tissue engineering. In this study, we developed a composite bioink consisting of silk fibroin (SF), gelatin (GEL), hyaluronic acid (HA), and tricalcium phosphate (TCP) and 3D bioprinted the silk fibroin-based hybrid scaffolds. The 3D bioprinted scaffolds with dual crosslinking were further treated with human platelet-rich plasma (PRP) to generate PRP coated scaffolds. Live/Dead and MTT assays demonstrated that PRP treatment could obviously promote the cell growth and proliferation of human adipose derived mesenchymal stem cells (HADMSC). In addition, the treatment of PRP …


Experimental Evaluation Of Self-Expandable Metallic Tracheobronchial Stents, Yanli Wang, Pengfei Dong, Jingyao Ke, Xiang Shen, Zongming Li, Kewei Ren, Xinwei Han, Linxia Gu Aug 2019

Experimental Evaluation Of Self-Expandable Metallic Tracheobronchial Stents, Yanli Wang, Pengfei Dong, Jingyao Ke, Xiang Shen, Zongming Li, Kewei Ren, Xinwei Han, Linxia Gu

Department of Mechanical and Materials Engineering: Faculty Publications

The self-expandable metallic stents have been widely used in tracheobronchial obstruction or fistulation, including the J-shaped and Y-shaped stents, named after the shape of the branch-stem junction of the stent. However, there is scarce data on the mechanical performance of these tracheobronchial stents, which is essential for optimal stent implantation. In this work, eight self-expandable metallic tracheobronchial stents in three types (i.e., straight, J-shaped, and Y-shaped), with or without cover, were characterized. The compression resistance of the stems was investigated through both compression and indentation tests. The bending resistance of the branches in the J-shaped and Y-shaped stents was assessed …


Interface Effects On He Ion Irradiation In Nanostructured Materials, Wenfan Yang, Jingyu Pang, Shijian Zheng, Jian Wang, Xinghang Zhang, Xiuliang Ma Aug 2019

Interface Effects On He Ion Irradiation In Nanostructured Materials, Wenfan Yang, Jingyu Pang, Shijian Zheng, Jian Wang, Xinghang Zhang, Xiuliang Ma

Department of Mechanical and Materials Engineering: Faculty Publications

In advanced fission and fusion reactors, structural materials suffer from high dose irradiation by energetic particles and are subject to severe microstructure damage. He atoms, as a byproduct of the (n) transmutation reaction, could accumulate to form deleterious cavities, which accelerate radiation-induced embrittlement, swelling and surface deterioration, ultimately degrade the service lifetime of reactor materials. Extensive studies have been performed to explore the strategies that can mitigate He ion irradiation damage. Recently, nanostructured materials have received broad attention because they contain abundant interfaces that are efficient sinks for radiation-induced defects. In this review, we summarize and analyze the current understandings …


The Linc Complex, Mechanotransduction, And Mesenchymal Stem Cell Function And Fate, Tasneem Bouzid, Eunju Kim, Brandon D. Riehl, Amir Monemian Esfahani, Jordan Rosebohm, Ruiguo Yang, Bin Duan, Jung Yul Lim Aug 2019

The Linc Complex, Mechanotransduction, And Mesenchymal Stem Cell Function And Fate, Tasneem Bouzid, Eunju Kim, Brandon D. Riehl, Amir Monemian Esfahani, Jordan Rosebohm, Ruiguo Yang, Bin Duan, Jung Yul Lim

Department of Mechanical and Materials Engineering: Faculty Publications

Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent years, increasing evidence points to nuclear envelope proteins as a key player in sensing and relaying mechanical signals in MSCs to modulate cellular form, function, and differentiation. Of particular interest is the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex that includes nesprin and SUN. In this review, the way in which cells can sense external mechanical environments through an intact nuclear envelope and LINC complex proteins will be briefly described. Then, …


On The Measurement Of Energy Dissipation Of Adhered Cells With The Quartz Microbalance With Dissipation Monitoring, Amir Monemian Esfahani, Weiwei Zhao, Jennifer Y. Chen, Changjin Huang, Ning Xi, Jun Xi, Ruiguo Yang Aug 2019

On The Measurement Of Energy Dissipation Of Adhered Cells With The Quartz Microbalance With Dissipation Monitoring, Amir Monemian Esfahani, Weiwei Zhao, Jennifer Y. Chen, Changjin Huang, Ning Xi, Jun Xi, Ruiguo Yang

Department of Mechanical and Materials Engineering: Faculty Publications

We previously reported the finding of a linear correlation between the change of energy dissipation (ΔD) of adhered cells measured with the quartz crystal microbalance with dissipation monitoring (QCM-D) and the level of focal adhesions of the cells. To account for this correlation, we have developed a theoretical framework for assessing the ΔD-response of adhered cells. We rationalized that the mechanical energy of an oscillating QCM-D sensor coupled with a cell monolayer is dissipated through three main processes: the interfacial friction through the dynamic restructuring (formation and rupture) of cell-extracellular matrix (ECM) bonds, the interfacial viscous damping by the liquid …