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Design And Fabrication Of 3d Bioprinted Scaffold: Experimental And Machine Learning Methods, Mohan K. Dey Aug 2026

Design And Fabrication Of 3d Bioprinted Scaffold: Experimental And Machine Learning Methods, Mohan K. Dey

LSU Doctoral Dissertations

The development of reliable hydrogel-based scaffolds for extrusion bioprinting remains limited by the poor structural fidelity of low-viscosity bioinks and the lack of robust, high-throughput quality evaluation methods. This dissertation can resolve such challenges by developing the combination of optimized hydrogel formulations, cryogenic-assisted bioprinting, and artificial intelligence (AI)-based scaffold evaluation to the use of tissue engineering and preclinical cancer modelling applications. To assess the rheological behavior, printability, mechanical properties, and biocompatibility of the alginate – gelatin (Alg–Gel) system, a novel system of hydrogel was developed and characterized using Alg–Gel hydrogel system. The 7% alginate, 8% gelatin mixture was found to …


A Reduced-Order Framework For Stochastic Criticality Estimation In Granular Energetic Materials, Philip T. Melton Jul 2026

A Reduced-Order Framework For Stochastic Criticality Estimation In Granular Energetic Materials, Philip T. Melton

LSU Master's Theses

Granular energetic materials (EMs) exhibit stochastic shock initiation because pore collapse, frictional dissipation, and localized thermal activation depend on microstructural descriptors that vary between nominally identical samples. Fully resolved mesoscale and atomistic calculations can represent these mechanisms, but their computational cost limits direct ensemble evaluation of microstructure-conditioned criticality thresholds. This thesis introduces a reduced-order framework for stochastic criticality estimation in granular EMs by coupling five explicitly defined model components: first, a one-dimensional steady compaction-shock model that maps initial solid volume fraction and shock pressure to a bulk mass-specific dissipated-work budget; second, an SEM/synthetic-image segmentation workflow that extracts pore area, perimeter, …


Analysis Of Close Contact Melting, Mohana Durga Gurunadhan Apr 2024

Analysis Of Close Contact Melting, Mohana Durga Gurunadhan

LSU Master's Theses

This report presents a numerical transient analysis of Close Contact Melting (CCM), intended to help in accurate prediction of melt rate and interface configuration, which is to be utilized for a prospective frozen propellant based propulsion system. Three different substrate shapes namely- Flat, Cylindrical and Wedge, are chosen for the study. The domain discretization is based on generation of boundary fitted mesh and the time varying physical domain is transformed to a fixed computational domain, wherein the associated governing equations are solved. Apart from the conventional linear system solvers, an algebraic multigrid based solver is implemented. A non-iterative implicit/explicit melt …


Development, Implementation, And Evaluation Of Swirl-Combustion Strategies For Optimal Performance Of Ammonia As A Fuel For Gas Turbine Engines, Varun Nanjunda Rao Viswamithra Nov 2023

Development, Implementation, And Evaluation Of Swirl-Combustion Strategies For Optimal Performance Of Ammonia As A Fuel For Gas Turbine Engines, Varun Nanjunda Rao Viswamithra

LSU Doctoral Dissertations

In an effort to reduce harmful effects of greenhouse gas emissions, ammonia is being pursued as a fuel for power generation as it is a carbon-free energy source. However, the use of ammonia-air mixtures in premixed swirl combustors poses challenges due to low flame speed and reactivity resulting in combustor stability issues in addition to high Nitrous Oxide (NOx) emissions due to the presence of fuel-bound Nitrogen. The first part of this study attempts to overcome lean blowout limits of methane-ammonia-air mixtures using a novel, multi-point () injection strategy, whereby micron-sized holes on the swirler vanes generate a co-flowing stream …


Modeling Of Heat And Mass Transfer In Flat Heat Pipes, Salar Saadatian Aug 2023

Modeling Of Heat And Mass Transfer In Flat Heat Pipes, Salar Saadatian

LSU Doctoral Dissertations

Phase-change phenomenon is ubiquitous in nature and widely utilized in thermal management of computer chips. Flat heat pipes have been extensively used in thermal management of microelectronic devices. However, existing research mainly concentrates on developing numerical models and lacks a systematic analytical approach to elucidate the working mechanism of flat heat pipes. We consider a horizontal flat heat pipe with an idealized porous wick. The pores in the wick are straight circular capillaries running along and across the wick and are filled with a liquid. The rest of the pipe is filled with its vapor. The mass evaporative rate at …


Application Of Direct Feedback Tunable Diode Laser Absorption Spectroscopy Within A Hybrid Rocket Combustor, Connor Becnel Oct 2022

Application Of Direct Feedback Tunable Diode Laser Absorption Spectroscopy Within A Hybrid Rocket Combustor, Connor Becnel

LSU Master's Theses

With interest in space travel and space-related science increasing in recent years, significant efforts to reduce the cost and increase the safety of rocket motors have become commonplace. Liquid rockets are currently the most commonly used system, but there is interest in the reduced complexity of hybrid rockets. For these hybrid rocket motors to become the norm, extensive research on their complex boundary layer combustion needs to be performed. Modeling these hybrid systems is of much interest to companies developing rocket motors; ultimately, small-scale experiments will help validate their behavior. This paper covers the application of a near-infrared tunable diode …


Predictive Thermal Modeling And Characterization Of Ultrasonic Consolidation Process For Thermoplastic Composites, Madeline Kirby Jul 2022

Predictive Thermal Modeling And Characterization Of Ultrasonic Consolidation Process For Thermoplastic Composites, Madeline Kirby

LSU Master's Theses

Ultrasonic consolidation (USC) of thermoplastic composites (TPCs) is a highly attractive and promising method to manufacture high-performance composites. This work focuses on USC of dry carbon fiber (CF) fabrics with high-temperature polyphenylene sulfide (PPS) films. Experimental trials to assess feasibility of the process are time-consuming. Consequently, a predictive thermal model would facilitate process parameters selection to reduce expensive trial-and-error approaches. This paper presents a 2D finite element model of samples under consolidation, incorporating equations for viscoelastic heating, matrix phase change, and material properties. Theoretical temperature profiles for nodes of interest were compared to the corresponding experimental temperature curves for various …


Micro Heat Exchanger To Cool Cerebrospinal Fluid For Brain Injury Treatment, Sachin Dahiya Jul 2022

Micro Heat Exchanger To Cool Cerebrospinal Fluid For Brain Injury Treatment, Sachin Dahiya

LSU Master's Theses

Hypothermia is accepted as a method to preserve cells and tissue. Clinical evidence shows that administration of hypothermia could lead to neuroprotection after cardiac arrest. Non-invasive methods such as surface cooling devices, drugs and cold liquid ventilation are available to induce hypothermia. These approaches for achieving hypothermia have not been optimized yet. The surface cooling methods are generally slow and may lead to additional thermal shock to the body. Here, we propose a rapid, selective cooling method for the brain using a micro heat exchanger to cool the cerebrospinal fluids (CSF). We designed and 3D printed a U-type heat exchanger …


Droplet-Based Fuel Property Measurements, Wanjun Dang Dec 2021

Droplet-Based Fuel Property Measurements, Wanjun Dang

LSU Doctoral Dissertations

Ongoing work to find renewable biofuels to function as drop-in replacements or blending components with gasoline has identified a large number of fuel candidates. Given the vast number of potential biomass-derived fuel molecules and limited sample sizes, screening tools are required to down-select candidate fuels having desired physical properties to ensure good engine performance. This work investigates approaches for rapid screening of candidate fuels using micro-liter sample sizes targeting four properties -- surface tension, viscosity, heat of vaporization (HOV), and vapor pressure. Measurement techniques for fuel properties are developed based on unit phenomena for liquid fuel droplets including droplet oscillation …


An Investigation Of The Effects Of Variable Magnetic Field Gradients On Soot And Co Emissions From Non-Premixed Hydrocarbon Flames, Edison Ekperechukwu Chukwuemeka May 2021

An Investigation Of The Effects Of Variable Magnetic Field Gradients On Soot And Co Emissions From Non-Premixed Hydrocarbon Flames, Edison Ekperechukwu Chukwuemeka

LSU Doctoral Dissertations

The interaction of the paramagnetic species in a combustion process with the mag- netic field placed in the vicinity of non-premixed flames affects the characteristics of the non-premixed flames - flame height and flame lift-off height. However, the effect of this magnetic interaction on the pollutants generated by the flame is unknown.

In general, pollutant formation is promoted in most combustion systems due to in- complete combustion of the hydrocarbon due to improper mixing. Since paramagnetic combustion species such as O2, O, OH, etc interacts with magnetic fields and possess a preferential motion direction, imposing magnetic field on non-premixed flames …


Ignition And Extinction Behavior Of Fuels In A Microcombustor, Pawan Sharma Jan 2019

Ignition And Extinction Behavior Of Fuels In A Microcombustor, Pawan Sharma

LSU Doctoral Dissertations

Conventional fuel testing device-CFR engine requires large quantities of fuels, which makes it unsuitable for research of small samples of fuels. This current study seeks to address this limitation by using an externally heated microcombustor as an alternative fuel testing device. Mainly three combustion behaviors have been observed inside a microcombustor: strong flames at higher flow rates, Flames with Repetitive Extinction and Ignition (FREI) at intermediate flow rates, and weak flames at marginal flow rates. In previous studies, weak combustion behavior has been proven suitable to study fuel properties from small samples of fuels. Microcombustor experiments typically rely on flame …


A Systematic Investigation Of Condensation Heat Transfer Using Asymmetric Micro-Scale Surfaces, Emily Brown Nov 2018

A Systematic Investigation Of Condensation Heat Transfer Using Asymmetric Micro-Scale Surfaces, Emily Brown

LSU Master's Theses

Asymmetric surfaces been shown to inducing unidirectional motion in the Leidenfrost regime; however, very minimal research has been conducted to investigate whether these surface can enhance condensation through the same means. The investigation of heat transfer of ratchets in condensation is a relatively untapped area of study, specifically ratchets with superhydrophobic properties. Anticipated difficulty lies in creating surfaces features or coatings that retain the ratchets and can adequately sustain optimal wetting state of Cassie-Baxter required to improve heat transfer performance during condensation. This study serves to investigate whether ratchets are a feasible surface feature to enhance condensation heat transfer. First, …


Large Eddy Simulations Of Vertical Jets In Crossflow, Pranaya Pokharel Oct 2018

Large Eddy Simulations Of Vertical Jets In Crossflow, Pranaya Pokharel

LSU Doctoral Dissertations

Jets in crossflow (JICF) have applications ranging from oil spill to film cooling of turbine blades. Hence, an understanding of the flow physics is important. The majority of the research has been conducted for low velocity ratios between jet and crossflow with round jets. JICF is demonstrated to behave differently for high velocity ratios and different jet shapes. Circular and rectangular jets are commonly used in aircraft applications. Current study focuses on high velocity ratio JICF issuing from both circular and rectangular exit.

For simulating JICF, an in house code “Chem3D” is used with Large Eddy Simulation (LES) to model …


Micro Combustion Of Primary Reference Fuels In Narrow Heated Channels, Veerendra Naralasetti Aug 2018

Micro Combustion Of Primary Reference Fuels In Narrow Heated Channels, Veerendra Naralasetti

LSU Master's Theses

Conventional fuel testing machines like CFR engines require large quantities of fuel. The current study seeks to overcome this limitation by introducing an alternative method using a microscale combustion reactor which consumes relatively small amounts of fuel (100-250 ml). For this reason, Primary Reference Fuels (PRF’s: volumetric mixtures of n-heptane and iso-octane) which are simple surrogates of gasoline are selected to test using micro reactor. The primary goal is to determine the effectiveness of using the micro reactor setup to differentiate fuels of different octane number. Experiments with stoichiometric PRF/air mixtures are performed inside a cylindrical quartz tube of 1mm …


A Multi-Scale Approach For Modeling Shock Ignition And Burn Of Granular Hmx, Pratap Thamanna Rao Nov 2017

A Multi-Scale Approach For Modeling Shock Ignition And Burn Of Granular Hmx, Pratap Thamanna Rao

LSU Doctoral Dissertations

Deflagration-to-detonation transition (DDT) in confined, low-density granular HMX (65%-85% Theoretical Maximum Density, TMD) occurs by a complex mechanism that involves compaction shock interactions within the material. Piston driven DDT experiments indicate that detonation is abruptly triggered by the interaction of a strong burn-supported secondary shock and a piston-supported primary (input) shock, where the nature of the interaction depends on initial packing density and primary shock strength. These interactions influence transition by affecting hot-spot formation within the micro-structure during pore collapse. In this study, meso-scale simulations of hot-spot formation in shock loaded granular HMX are used to guide the development of …