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Articles 31 - 37 of 37
Full-Text Articles in Biomechanical Engineering
Side-To-Side Comparison Of Total Shoulder Arthroplasty And Intact Function In Individuals, Sarah Rose Walden
Side-To-Side Comparison Of Total Shoulder Arthroplasty And Intact Function In Individuals, Sarah Rose Walden
Electronic Theses and Dissertations
Total Shoulder Arthroplasty (TSA) is a surgery which replaces the shoulder joint, or the interface between the humerus and the scapula glenoid. To test TSA success, most prior research compares patients with TSA to healthy controls. However, the shoulder anthropometry, motion, and musculature of individuals varies widely across the population making it important to assess TSA performance in individuals. The overall goal of this study is to determine if patients with one of two TSA implant designs on one side achieve the same range of motion as their intact side, and if so to find if they compensate using increased …
Finite Element And Probabilistic Analysis Of Soft Tissue Structures Of The Human Lumbar Spine, Dana Joseph Coombs
Finite Element And Probabilistic Analysis Of Soft Tissue Structures Of The Human Lumbar Spine, Dana Joseph Coombs
Electronic Theses and Dissertations
Human lumbar spine mechanics are influenced by soft tissue structures. Understanding and properly modeling these structures can help determine pathology, treatment, and implant design and performance. Finite element models of the L4-L5 level of the lumbar spine are often used, which include a representation of the intervertebral disc and spinal ligaments. Validation of these models are typically based on torque rotation data from a single subject or the models use average properties reported in literature. However, experimental testing reports variation up to 40% in ligament stiffness and even greater variability for annulus fibrosis properties. Probabilistic approaches enable consideration of the …
Statistical Modeling To Investigate Anatomy And Function Of The Knee, Lowell Matthew Smoger
Statistical Modeling To Investigate Anatomy And Function Of The Knee, Lowell Matthew Smoger
Electronic Theses and Dissertations
The natural knee is a hinge joint with significant functional requirements during activities of daily living; as a result, acute and chronic injuries can occur. Pathologies are influenced by joint anatomy and may include patellar maltracking, cartilage degeneration (e.g. osteoarthritis), or acute injuries such as meniscal or ligamentous tears. Population variability makes broadly applicable conclusions about etiology of these conditions from small-scale investigations challenging. The work presented in this dissertation is a demonstration of statistical modeling approaches to evaluate population variability in anatomy of the knee and function of its tibiofemoral (TF) and patellofemoral (PF) joints. Three-dimensional (3D) computational models …
Probabilistic Musculoskeletal Simulation Methods To Address Intersegmental Dependencies Of The Knee, Hip, And Spine, Casey A. Myers
Probabilistic Musculoskeletal Simulation Methods To Address Intersegmental Dependencies Of The Knee, Hip, And Spine, Casey A. Myers
Electronic Theses and Dissertations
Orthropaedic clinical practice in the area of the knee, hip, and spine has benefited from the concept of regional interdependence, where interventions applied to one region can influence the outcome and function of other regions of the body that may be seemingly unrelated to the applied intervention. An understanding of the biomechanical mechanisms that describe clinical practice involving knee, hip, and spine regional interdependence can improve treatment of a wide range of pathological conditions. Improvement in this area can be particularly impactful on the outcomes of patients with total joint replacement, where pathology and compensatory strategies develop during multi-joint interactions. …
Evaluation Of Novel High-Density Emg Feedback Parameters On The Spatial Distribution Of Trapezius Muscle Activity, Brecca M. Gaffney
Evaluation Of Novel High-Density Emg Feedback Parameters On The Spatial Distribution Of Trapezius Muscle Activity, Brecca M. Gaffney
Electronic Theses and Dissertations
Each year, 17.9% of adults working in a computer-dominated work environment develop an episode of chronic neck and shoulder pain. An effective treatment method for chronic pain is postural correction through therapist. The understanding of the relation between cervicoscapular posture and trapezius muscle activity is not fully understood because the anatomy of the scapula is not accessible for direct observation. Until recently, the spatial distribution of trapezius muscle activity could not be measured due to the limitation in size of detection zone in traditional bipolar electrodes. The primary goal of postural correction when treating cases of chronic neck and shoulder …
Cavitation In Pharmaceutical Manufacturing And Shipping, Donn Sederstrom
Cavitation In Pharmaceutical Manufacturing And Shipping, Donn Sederstrom
Electronic Theses and Dissertations
Therapeutic proteins are used to successfully treat hemophilia, Crohn's Disease, diabetes, and cancer. Recent product recalls have occurred because of sub-visible particle formation resulting from the inherent instability of proteins. It has been suggested that particle formation is associated with late stage processing steps of filling, shipping, and delivery. Previous work at the University of Denver demonstrated that fluid cavitation can generate a large number of sub-visible protein particles in ultra clean formulations, but that mitigation can be achieved with fluid property manipulation. The goal of this research was to (1) assess the risk of cavitation under common pharmaceutical manufacturing …
Label-Free Biochemical Recognition Using Mems Resonators For Microarray Technology, Babak Tousifar
Label-Free Biochemical Recognition Using Mems Resonators For Microarray Technology, Babak Tousifar
Electronic Theses and Dissertations
Highly sensitive biosensors capable of detecting and characterizing smallest quantities of cellular and molecular targets are needed in pharmaceutical and medical diagnostics industries. In this work, the importance of biological target recognition specifically proteins through microarray technologies has been discussed and the most successful tools and techniques have been studied. Moreover, a thermally actuated Micro Electro-Mechanical Systems (MEMS) resonator has been demonstrated and fabricated in this work as an accurate, reliable and low cost biotechnology tool. As a proof of concept, amine to epoxide coupling of octadecylamine to functionalized silicon dioxide surface have been shown through resonator frequency monitoring. The …