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Articles 1 - 5 of 5
Full-Text Articles in Biomechanical Engineering
Mechanical Characterization And Modeling Of Rat Myocardia Under The Influence Of Epirubicin, Abdallah Mahmoud Alkhaiyat
Mechanical Characterization And Modeling Of Rat Myocardia Under The Influence Of Epirubicin, Abdallah Mahmoud Alkhaiyat
Theses and Dissertations
Cancer remains a predominant health challenge that is responsible for a significant portion of global morbidity and mortality. Epirubicin (EPI), a chemotherapeutic anti-cancer drug, has shown remarkable efficacy in combating various malignancies. However, it is known to have undesirable side effects on the heart, collectively referred to as cardiotoxicity. This research investigates the adverse effects of chemotherapy on cardiac contractility through an in vitro examination of the mechanics of healthy and infarcted animal heart tissues. Electrically stimulated slices of rat ventricular tissue were tested using an isometric force measurement tissue bath. The tissue slices were subjected to uniaxial stretching, allowing …
Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb
Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb
Theses and Dissertations
Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …
Cardiac Active Tension Modeling Via Genetic Algorithm-Optimized Fractional Order Systems, Afnan Khaled Elhamshari
Cardiac Active Tension Modeling Via Genetic Algorithm-Optimized Fractional Order Systems, Afnan Khaled Elhamshari
Theses and Dissertations
Developing a computational model to model cardiac activity has been increasingly important in recent decades. Accurate cell-level active tension modeling for cardiomyocytes is critical to understanding cardiac functionality on a patient-specific basis and developing an effective in-silico cardiac model. However, cell-level models in the literature fail to account for viscoelasticity and inter-patient variations in active tension. This research proposes a genetic algorithm-optimized, fractional order system to model cell-level active tension by extending Land’s state-of-the-art model of cardiac contraction. The model features the (left) Caputo derivative of six state variables that identify the mechanistic origins of viscoelasticity in a myocardial cell …
Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study, Omar A. Ismail
Borophene And Graphene For Non-Enzymatic Biosensor- Ab-Initio Study, Omar A. Ismail
Theses and Dissertations
Non-enzymatic glucose sensing holds promise to overcome limitations associated with glucose oxidase, such as oxygen dependence and short shelf life. This study explores the potential sensing capabilities of borophene and graphene through direct interaction with various compounds, including β-glucose, uric acid, ascorbic acid, fructose, and acetaminophen. Using Density Functional Theory (DFT), we calculated binding energies and the respective Density of States (DOS) for these adsorbates on both graphene and borophene surfaces. Preliminary results suggest that borophene might exhibit nearly twice the affinity for β-glucose compared to graphene. Moreover, the calculated Density of States reveals distinct distortions in the electronic states …
Computational Study On The Acoustic Footprint Of Stenosis In Larger Arteries, Ahmed Abdelnabi
Computational Study On The Acoustic Footprint Of Stenosis In Larger Arteries, Ahmed Abdelnabi
Theses and Dissertations
We identify a new (acoustic) frequency-stenosis relations whose frequencies fall within the recommended auscultation threshold for stethoscopy (< 120 Hz) in this study. We demonstrate that these relations can be used to extend the application of phonoangiography (the measurement of the degree of stenosis from bruits) to stethoscopes that are broadly available. The First relationship is successfully identified using an analysis limited to the acoustic signature of the von Karman vortex street, which we automatically isolate using a metric based on an area-weighted average of the Q-criteria for the post-stenotic region. Specifically, we conduct LES-CFD simulations on simplified 2D internal flow geometries that represent blood vessels with varying degrees of stenosis. Then, using the Ffowcs Williams-Hawkings (FW-H) equation, we extract their emitted acoustic signals, which we subtract from a pure signal (stenosis-free) at the same heart rate. Next, we transform this differential signal to the frequency domain and meticulously classify its acoustic signatures according to six stenosis-invariant flow phases of a cardiac cycle. Using our Q-criterion-based metric, we then automatically restrict our acoustic analysis to the noises emitted by the von Karman vortex street (phase 4). Our analysis of its acoustic signature demonstrates a strong linear relationship between the degree of steno- sis and its dominant frequency, which differs significantly from the break frequency and heart rate (previously identified dominant frequencies). For the Second relationship, we develop a frequency-stenosis scaling law for particularly supravalvular aortic stenosis that falls within the preferred frequency range (30-120 Hz) for echocardiography. We expand to 3D patient specific geometry using Simulia’s Living Heart Human Model (LHHM), which has an anatomically accurate aorta geometry. This LHHM geometry is modified with stenoses ranging from 30 to 80 percent (moderate to severe). For physiologically consistent hemodynamic boundary conditions, we expand the study to employ the Windkessel model, which has been implemented on Fluent using UDF. We demonstrate that physiological boundary conditions reduce simulation time significantly compared to static boundary conditions. The FW-H model extracted the flow-generated acoustic signal of the stenotic geometries and analysed it at clinically relevant receiver locations. A preferred receiver location consistent with clinical practise is determined, and a correlation between the degree of stenosis and the prevalent acoustic frequency (within the frequency range of 70-120 Hz) is established. The obtained second scaling law is shown to be clinically reliable in assessing stenotic severity. Future research will investigate incorporating the vibroacoustic role of adjacent organs and tissue to expand the clinical applicability of our findings. Expansion of clinical and numerical datasets will be pursued in future research to enhance the reliability of our scaling law, possibly by leveraging much-needed ML-based acceleration schemes.