Biomechanical Engineering Commons^™

Experimental, Analytical, And Numerical Evaluation Of The Mechanical Properties Of The Brain Tissue, Aref Samadidooki

LSU Doctoral Dissertations

A true understanding of the mechanisms behind most of the brain diseases is still out of reach. For several years, the interest of scientists has been focused on the genetic and biological causes, however, recent studies unraveled the importance of the biomechanics of the brain growth, folding, impact resistance, and deformation on its pathological conditions. While, a wide range of different methods have been used for characterization of the mechanical properties of the brain at the tissue level, the obtained results from different studies are extremely scattered and sometimes in contrast to one another. Since the brain tissue is extremely …

Soft-Microrobotics: The Manipulation Of Alginate Artificial Cells, Samuel Sheckman

Mechanical Engineering Research Theses and Dissertations

In this work, the approach to the manipulation of alginate artificial cell soft-microrobots, both individually and in swarms is shown. Fabrication of these artificial cells were completed through centrifugation, producing large volumes of artificial cells, encapsulated with superparamagnetic iron oxide nanoparticles; these artificial cells can be then externally stimulated by an applied magnetic field. The construction of a Permeant Magnet Stage (PMS) was produced to manipulate the artificial cells individually and in swarms. The stage functionalizes the permanent magnet in the 2D xy-plane. Once the PMS was completed, Parallel self-assembly (Object Particle Computation) using swarms of artificial cells in complex …

Blunt And Ballistic Impacts On Human Head Models: An Analytical And Numerical Study, Yongqiang Li

Mechanical Engineering Research Theses and Dissertations

Head injuries, as a leading cause of death, have become a major health care issue for civilians and soldiers. There has been an urgent need to understand mechanisms of such injuries. The objective of this dissertation research is to study some head injuries and related mechanisms using analytical and computational models.

In Chapter 2, a new analytical (non-linear) model for the impact of a solid sphere on a fluid-filled spherical shell is developed by including the stress wave propagation effect in addition to the Hertzian contact deformations and the shell membrane and bending actions. A simplified (linearized) model incorporating the …

Modeling Of Swimming Cells From Nano-Scale To Micro-Scale, Yicheng Zhao

McKelvey School of Engineering Graduate Student Theses & Dissertations

Certain human genetic diseases -- primary ciliary dyskinesia, infertility, and hydrocephalus -- are characterized by changes in beat frequency and waveform of cilia and flagella. Chlamydomonas reinhardtii, which is a single-cell green alga about ten micrometers in diameter that swims with two flagella, serves as an excellent biological model because its flagella share the same structure and genetic background as mammalian cilia and flagella. This study uses the finite element method to investigate the behavior of C. reinhardtii swimming from nano-scale to micro-scale. At the device-level, micro-scale modeling indicates that well-designed acoustic microfluidic devices can be used to trap groups …

Mimicking Blood Rheology For More Accurate Modeling In Benchtop Research, Lindsey Webb

Honors Undergraduate Theses

To confirm computer simulations and Computational Fluid Dynamics (CFD) analysis, benchtop experiments are needed with a fluid that mimics blood and its viscoelastic properties. Blood is challenging to use as a working fluid in a laboratory setting because of health and safety concerns. Therefore, a blood analogue is necessary to perform benchtop experiments. Viscosity is an important property of fluids for modeling and experiments. Blood is a shear thinning fluid, so it has a decreasing viscosity with higher shear rates. This project seeks to create a blood mimicking fluid for benchtop laboratory use. Numerous fluids with different combinations of water, …

Design And Analysis Of A 3d-Printed, Thermoplastic Elastomer (Tpe) Spring Element For Use In Corrective Hand Orthotics, Kevin Thomas Richardson

Theses and Dissertations--Mechanical and Aerospace Engineering

This thesis proposes an algorithm that determine the geometry of 3D-printed, custom-designed spring element bands made of thermoplastic elastomer (TPE) for use in a wearable orthotic device to aid in the physical therapy of a human hand exhibiting spasticity after stroke. Each finger of the hand is modeled as a mechanical system consisting of a triple-rod pendulum with nonlinear stiffness at each joint and forces applied at the attachment point of each flexor muscle. The system is assumed quasi-static, which leads to a torque balance between the flexor tendons in the hand, joint stiffness and the design force applied to …

Usa Boccia Ball Ramp For Athletes With Quadriplegia, Alissa A. Koukourikos, Matthew Lee, Nathan Bernards

Mechanical Engineering

In this report, the design process in creating an assistive device for Boccia Classification 3 (BC3) players is outlined. The initial research steps, including research into the rules of the game, capabilities of the players, and existing products is documented to show where ideas for the product stemmed from. This transitions into requirements that the sponsor requested, and preliminary designs and ideas for the product. Finally, this report explains the details of the final design, which has been analyzed for safety, ease of use, and ability to function under different conditions. The processes of manufacturing and testing will also be …

Multiple Consecutive Recapture Of Rigid Nanoparticles Using A Solid-State Nanopore Sensor, Jungsoo Lee

Mechanical Engineering Research Theses and Dissertations

Solid‐state nanopore sensors have been used to measure the size of a nanoparticle by applying a resistive pulse sensing technique. Previously, the size distribution of the population pool could be investigated utilizing data from a single translocation, however, the accuracy of the distribution is limited due to the lack of repeated data. In this study, we characterized polystyrene nanobeads utilizing single particle recapture techniques, which provide a better statistical estimate of the size distribution than that of single sampling techniques. The pulses and translocation times of two different sized nanobeads (80 nm and 125 nm in diameter) were acquired repeatedly …

Comparative Analysis Of Impact Attenuation Properties From Soccer Headgear, Kevin G. Mciver, Goutham N. Sankaran, Justin J. Markel, Tom M. Talavage, Larry J. Leverenz, Eric A. Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

Athletes suffering from long-term neurocognitive deficiency due to subconcussive impacts is a major concern for football and soccer players today. Football players wear helmets that can help reduce injury risks like skull fractures, and these helmets must meet standard criteria that determinines how well a functional helmet should reduce accelerations of the player’s head. Currently no standard exists for testing soccer headgear despite studies demonstrating soccer players experience similar magnitudes of impacts. In this study, a modal impact hammer was used in conjunction with a Hybrid III 50th percentile test dummy head to simulate impacts experienced by soccer players to …

Biventricular Finite Element Modeling And Quantification Of 3d Langragian Strains And Torsion Using Dense Mri, Zhanqiu Liu

Theses and Dissertations--Mechanical and Aerospace Engineering

Statistical data suggests that increased use of evidence-based medical therapies has largely contributed to the decrease in American death rate caused by heart disease. And my studies are about two applications of magnetic resonance imaging (MRI) as a non-invasive approach in evidence-based health care research. In my first study, the achievement of a pulmonary valve replacement surgery was assessed on a patient with tetralogy of Fallot (TOF). In order to evaluate the remodeling of right ventricle, two biventricular finite element models were built up for pre-surgical images and post-surgical images. In my second study, 3D Lagrangian strains and torsion in …

Carbon Articulating Backpack Spine, Salvatore Monforte Iii, Darci Lawrence, Savan Patel

Mechanical Engineering

In the field, firefighters and Urban Search and Rescue (USAR) personnel need to transport variable loads efficiently, safely, and comfortably while simultaneously performing certain physical tasks. Current models of external and internal framed backpacks distribute the load of a pack efficiently, but do not allow for the natural movement of the wearer. Wolfpack Gear, Inc. proposed the need for a system which both effectively carries a load and allows for the unhindered natural movement of the user. The goal of this project was to design, build, and test an articulating backpack support system. The first stage of the project comprised …

Development Of A Shape Memory Polymer Soft Microgripper, Marshall Tatro, David J. Cappelleri, Wuming Jing

The Summer Undergraduate Research Fellowship (SURF) Symposium

The ability to control microrobots by means of magnetic fields has become of increasing interest to researchers. These robots’ ability to reach places tethered microrobots otherwise could not leads to many possible applications in the body, such as delivering drugs to targeted locations and performing biopsies. This study shows the use of shape memory polymer (SMP) to wirelessly actuate a microgripper to be used by a controllable microrobot to achieve these functions. Many smart materials were analyzed in order to find the material that most effectively would accomplish wirelessly gripping, manipulating, and releasing a microobject. Multiple microgripper designs were designed, …

Validation Of Open Chain Model During Kinematic Analysis Of Joint Mobilization Of The Foot: An In Vitro Study, Anthony Ross Mcnally

Mechanical & Aerospace Engineering Theses & Dissertations

Joint mobilization techniques have been shown to improve dorsiflexion range of motion after ankle injury in multiple in vivo studies; however, the underlying arthrokinematic effects of this treatment still require clarification. Therefore, the purpose of this preliminary study was to determine the viability of an open kinetic chain in vitro model for applying Maitland Grade III anterior/posterior joint mobilizations to the talocrural joint while examining the osteokinematic and arthrokinematic changes at the talocrural, subtalar and hindfoot joints. Three fresh frozen cadaver lower legs had Maitland Grade III anterior-to-posterior joint mobilization applied to the talocrural joint in 2 sessions of 200 …

Team Nathan Suspension, Frankie J. Wiggins, Alex D. Seitz, Justin P. Bautista

Mechanical Engineering

Nathan Cooper is an 8-year old boy with Spinal Muscular Atrophy (SMA). SMA has affected Nathan’s muscle development and requires him to use the Standing Dani™ mobility device. The Standing Dani is a motorized standing wheelchair, or Wheelstand. Nathan controls and uses it to get around. Though the Standing Dani performs well for most functions, it has some distinct issues. The primary issue that this project addresses is its lack of suspension and the discomfort that Nathan feels as a result. After talking with our client, we developed several specifications generally related to geometry, safety, vehicle dynamics, and reliability. Many …

Understanding The Effects Of Blast Wave On The Intracranial Pressure And Traumatic Brain Injury In Rodents And Humans Using Experimental Shock Tube And Numerical Simulations, Aravind Sundaramurthy

Department of Engineering Mechanics: Dissertations, Theses, and Student Research

Blast induced neurotrauma (BINT) has been designated as the “signature injury” to warfighters in the recent military conflicts. In the past decade, conflicts in Iraq (operation Iraqi freedom) and Afghanistan (operation enduring freedom) as well as the increasing burden of the terrorism around the world resulted in an increased number of cases with blast Traumatic Brain Injury (bTBI). Recently, a lot of research has been done to study the neurological and neurochemical degenerations resulting from BINT using animal models especially rat models. However, it is not clear how and whether the biological outcomes from animal models can be translated to …

Folding Wheelchair Improvement, Matthew Edison Grace, Kevin Alan Miyamoto, Andrey Lee Oliveira

Mechanical Engineering

No abstract provided.

Measurement And Description Of Dynamics Required For In Vivo Surgical Robotics Via Kinematic Methods, Jacob G. Greenburg

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

With the goal of improved recovery times and reduced trauma to the patient there has been a substantial shift in the medical community’s demand for minimally invasive surgical (MIS) techniques. With the standardization of MIS becoming more commonplace in the medical field there are still many improvements that are desired. Traditional, manual methods of these surgeries require multiple incisions on the abdomen for the tools and instruments to be inserted. The more recent demand has been to localize the incisions into what is being referred to as a Laparoendoscopic Single-Site (LESS) surgery. Furthermore, the manual instruments that are commonly used …

Mechanics Of Blast Loading On Post-Mortem Human And Surrogate Heads In The Study Of Traumatic Brain Injury (Tbi) Using Experimental And Computational Approaches, Shailesh Govind Ganpule

Department of Engineering Mechanics: Dissertations, Theses, and Student Research

Blast induced neurotrauma (BINT) has been designated as the “signature injury” to warfighters in the recent military conflicts. The occurrence of traumatic brain injury (TBI) in blasts is controversial in the medical and scientific communities because the manifesting symptoms occur without visible injuries. Whether the primary blast waves alone can cause mechanical insult that is comparable to existing traumatic brain injury thresholds is still an open question, and this work is aimed to address this issue.

In the first part of this dissertation, mechanics of primary blast loading on Realistic Explosive Dummy (RED) head with and without helmets is studied …

Stress And Strain Adaptation In Load-Dependent Remodeling Of The Embryonic Left Ventricle, Christine Buffinton

Faculty Journal Articles

Altered pressure in the developing left ventricle (LV) results in altered morphology and tissue material properties. Mechanical stress and strain may play a role in the regulating process. This study showed that confocal microscopy, three-dimensional reconstruction, and finite element analysis can provide a detailed model of stress and strain in the trabeculated embryonic heart. The method was used to test the hypothesis that end-diastolic strains are normalized after altered loading of the LV during the stages of trabecular compaction and chamber formation. Stage-29 chick LVs subjected to pressure overload and underload at stage 21 were reconstructed with full trabecular morphology …

Viscoelastic Anisotropic Finite Element Mixture Model Of Articular Cartilage Using Viscoelastic Collagen Fibers And Validation With Stress Relaxation Data, Matthew Alexander Griebel

Master's Theses

Experimental results show that collagen fibers exhibit stress relaxation under tension and a highly anisotropic distribution. To further develop the earlier model of Stender [1], the collagen constituent was updated to reflect its intrinsic viscoelasticity and anisotropic distribution, and integrated with an existing mixture model with glycosaminoglycans and ground substance matrix. A two-term Prony series expansion of the quasi-linear viscoelastic model was chosen to model the viscoelastic properties of the collagen fibers. Material parameters were determined by using the simplex method to minimize the sum of squared errors between model results and experimental stress relaxation data of tissue in tension. …

Access|Closure Balloon Catheter Redesign Project, Keenan Bamburg, Yvette Castillo, Elizabeth Eskildsen

Mechanical Engineering

No abstract provided.

Strider, Eric Johnson, Alex Trask, Ricardo Garcia

Mechanical Engineering

No abstract provided.

Mechanical Simulation Of Articular Cartilage Based On Experimental Results, Kevin Matthew Stewart

Master's Theses

Recently, a constituent based cartilage growth finite element model (CGFEM) was developed in order to predict articular cartilage (AC) biomechanical properties before and after growth. Previous research has noted limitations in the CGFEM such as model convergence with growth periods greater than 12 days. The main aims of this work were to address these limitations through (1) implementation of an exact material Jacobian matrix definition using the Jaumann-Kirchhoff (J-K) method and (2) quantification of elastic material parameters based upon research findings of the Cal Poly Cartilage Biomechanics Group (CPGBG). The J-K method was successfully implemented into the CGFEM and exceeded …

The Setting And Control Of Disc Ploughs, P A. Taylor

Journal of the Department of Agriculture, Western Australia, Series 4

THE trailed disc plough is the most commonly used tillage implement in Australian broadacre farming, yet it is considered in some areas to be difficult to set and to operate. These notes provide information resulting from C.S.I.R.O. research to assist operators in the control and operation of trailed disc ploughs.

Australian Tractor Test Report No. 53 : Chamberlain Countryman 354, G H. Vasey, W. F. Baillie

Journal of the Department of Agriculture, Western Australia, Series 4

AUSTRALIAN TRACTOR TEST REPORT

No. 53 - CHAMBERLAIN COUNTRYMAN 354

THE Chamberlain Countryman 354 is a broad-acres cultivation tractor of 77 drawbar horsepower with 87 h.p. at the P.T.O.

Four Mobile Picking And Pruning Platforms For Orchards, J C. Rowbotham

Journal of the Department of Agriculture, Western Australia, Series 4

Shifting ladders around the orchard takes a great deal of time and effort at picking and pruning time.

This article describes four home made labour savers which take most of the ladder work out i f these operations.

Australian Tractor Test Report No. 52 : Chamberlain Champion 306, G H. Vasey, W. F. Baillie

Journal of the Department of Agriculture, Western Australia, Series 4

AUSTRALIAN TRACTOR TEST REPORT

No. 52 - CHAMBERLAIN CHAMPION 306

THE Chamberlain Champion 306 is a general purpose farm tractor of 57 drawbar horsepower with 68 h.p. at the P.T.O.