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Full-Text Articles in Biology and Biomimetic Materials

Development And Characterization Of A Pro-Angiogenic Peptide Amphiphile For Deep Dermal Burn Healing Via Spray Delivery, Loria Dimartino May 2025

Development And Characterization Of A Pro-Angiogenic Peptide Amphiphile For Deep Dermal Burn Healing Via Spray Delivery, Loria Dimartino

Honors Theses

Severe burns and other dermatological injuries are frequently accompanied by a range of comorbidities and aesthetic challenges that patients must contend with. The complexity of burn care is exacerbated by the lack of a standardized surgical protocol, as treatment strategies are tailored to individual patient factors, including overall health status, wound size and location, as well as the expertise and resources available to the surgical team. Most commonly, deep dermal burns are treated through grafting, which effectively covers the injury site, but requires the creation of a second wound on the body of approximately the same size. This produces a …


Co-Assembly Behavior Of Neutral And Zwitterionic Amphiphilic Block Copolymers In The Fabrication Of Glassy Polymer Vesicles, Elina Ghimire May 2020

Co-Assembly Behavior Of Neutral And Zwitterionic Amphiphilic Block Copolymers In The Fabrication Of Glassy Polymer Vesicles, Elina Ghimire

Honors Theses

Polymersomes, also known as polymer vesicles, are hollow capsules fabricated through the solution assembly of amphiphilic block copolymers. Polymer vesicles have garnered a great deal of interest in materials science because of their potential application in areas such as drug delivery, diagnostics and imaging, gene therapy, and as nanoreactors. The goal of this project is to understand the factors that affect the arrangement of triblocks in vesicle membrane via the study of the co-assembly behavior of linear amphiphilic triblocks with different hydrophilic blocks. We investigated the self- and co-assembly behavior of amphiphilic triblock copolymers with neutral hydrophilic blocks. Moreover, we …


Thiol–Ene Photopolymerization: A Simple Route To Pro-Antimicrobial Networks Via Degradable Acetals (Pandas), William Martin May 2018

Thiol–Ene Photopolymerization: A Simple Route To Pro-Antimicrobial Networks Via Degradable Acetals (Pandas), William Martin

Honors Theses

The World Health Organization (WHO) has brought the growing epidemic of antibiotic resistance bacteria to the attention of the public and has expressed the need for the development of new methods of defense. In this direction, bioactive aldehyde essential oils have been shown to effectively act as antibiotic and antifungal agents. These bioactive compounds, when used in their pure form, are volatile and lack environmental stability. In this thesis, we describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) using thiol-ene photopolymerization. PANDAs were used as a new model for the high loading and release of bioactive aldehyde-containing compounds …


Cellulose Reinforced Thermoplastic Composites By In-Situ Ring-Opening Polymerization, Shahab Kashani Rahimi Aug 2017

Cellulose Reinforced Thermoplastic Composites By In-Situ Ring-Opening Polymerization, Shahab Kashani Rahimi

Dissertations

Over the past two decades, the increasing concern about the negative environmental impacts of synthetic materials has led to rising interests in utilizing renewable natural resources to develop polymer materials with comparable properties and performance to their synthetic counterparts. One of the major fields of interest is polymer composites where the replacement of synthetic fibers with bio renewable natural fibers is of great potential. However, the processing difficulties, in terms of fiber dispersion and thermal stability have limited the application of cellulosic fibers to polymers with low processing temperatures which are mostly hydrophobic polymers. As a result, the true reinforcing …


A Platform For Fast Detection Of Let-7 Micro Rna Using Polyaniline Fluorescence And Image Analysis Techniques, Partha P. Sengupta Dec 2015

A Platform For Fast Detection Of Let-7 Micro Rna Using Polyaniline Fluorescence And Image Analysis Techniques, Partha P. Sengupta

Master's Theses

The project describes a new strategy for transducing hybridization events through modulating intrinsic properties of the electroconductive polymer polyaniline (PANI). When DNA based probes electrostatically interact with PANI, its fluorescence properties are increased, a phenomenon that can be enhanced by UV irradiation. Hybridization of target nucleic acids results in dissociation of probes causing PANI fluorescence to return to basal levels. By monitoring restoration of base PANI fluorescence as little as 10-11 M (10 pM) of target oligonucleotides could be detected within 15 minutes of hybridization. Detection of complementary oligos was specific, with introduction of a single mismatch failing to …