Mechanics of Materials Commons^™

Implantation Of A Capsular Tension Ring During Cataract Surgery Attenuates Predicted Remodeling Of The Post-Surgical Lens Capsule Along The Visual Axis, Kurt A. Ameku, Caleb C. Berggren, Ryan M. Pedrigi

Department of Mechanical and Materials Engineering: Faculty Publications

Introduction: Cataract surgery permanently alters the mechanical environment of the lens capsule by placing a hole in the anterior portion and implanting an intraocular lens (IOL) that has a very different geometry from the native lens. We hypothesized that implant configuration and mechanical interactions with the post-surgical lens capsule play a key role in determining long-term fibrotic remodeling.

Methods: We developed the first finite element-growth and remodeling (FE-G&R) model of the post-surgical lens capsule to evaluate how implantation of an IOL with and without a capsular tension ring (CTR) impacted evolving lens capsule mechanics and associated fibrosis over …

Engineering Neurotoxin-Functionalized Exosomes For Targeted Delivery To The Peripheral Nervous System, Mena Asha Krishnan, Olawale A. Alimi, Tianshu Pan, Mitchell Kuss, Zeljka Korade, Guoku Hu, Bo Liu, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

The administration of therapeutics to peripheral nerve tissue is challenging due to the complexities of peripheral neuroanatomy and the limitations imposed by the blood–nerve barrier (BNB). Therefore, there is a pressing need to enhance delivery effectiveness and implement targeted delivery methods. Recently, erythrocyte-derived exosomes (Exos) have gained widespread attention as biocompatible vehicles for therapeutics in clinical applications. However, engineering targeted Exos for the peripheral nervous system (PNS) is still challenging. This study aims to develop a targeted Exo delivery system specifically designed for presynaptic terminals of peripheral nerve tissue. The clostridium neurotoxin, tetanus toxin-C fragment (TTC), was tethered to the …

Yap Mechanotransduction Under Cyclic Mechanical Stretch Loading For Mesenchymal Stem Cell Osteogenesis Is Regulated By Rock, Eunju Kim, Brandon D. Riehl, Tasneem Bouzid, Ruiguo Yang, Bin Duan, Henry J. Donahue, Jung Yul Lim

Department of Mechanical and Materials Engineering: Faculty Publications

While yes-associated protein (YAP) is now recognized as a potent mechanosensitive transcriptional regulator to affect cell growth and differentiation including the osteogenic transcription of mesenchymal stem cells (MSCs), most studies have reported the YAP mechanosensing of static mechanophysical cues such as substrate stiffness. We tested MSC response to dynamic loading, i.e., cyclic mechanical stretching, and assessed YAP mechanosensing and resultant MSC osteogenesis. We showed that cyclic stretching at 10% strain and 1 Hz frequency triggered YAP nuclear import in MSCs. YAP phosphorylation at S127 and S397, which is required for YAP cytoplasmic retention, was suppressed by cyclic stretch. We also …

Balsa Bridge, Caleb T. Lovett

All Undergraduate Projects

The problem presented throughout this report was to create a small-scale bridge made entirely out of balsa wood and glue, that could withstand substantial force, as well as perform a lifting/lowering cycle. Other requirements associated with the bridge were properties of weight, deflection, size, and shape. This problem presented a challenge that tested the mathematical side of engineering, being strongly reliant on statics, mechanics of materials, and mechanical design analyses.

To approach this problem, the first step was to complete in depth calculations of the chosen design. With this done, manufacturing and assembly was able to be completed. With a …

Experimental And Finite Element Investigation Of Shear Transfer Mechanisms And Capacity Of Continuous Post-Tensioned Concrete Beams In One-Way Slab Buildings, Suman Rijal

Civil Engineering Theses - Archive

This study investigates the shear behavior and resistance mechanisms of continuous post-tensioned beams commonly used in one-way slab buildings. Combining experimental and analytical methods, the research focuses on the targeted failure regions of prestressed and non-prestressed continuous beams to gain deeper insights into their shear behavior. The large-scale specimens used in this study featured realistic parabolic tendon profiles and an average prestress level comparable to that used in actual construction. The experimental program includes three test series, with beam designs and setups refined for each series based on observations of shear crack development and progression in the preceding series. This …

Mechanics Of Pure Bending And Eccentric Buckling In High-Strain Composite Structures, Jimesh D. Bhagatji, Oleksandr G. Kravchenko, Sharanabasaweshwara Asundi

Mechanical & Aerospace Engineering Faculty Publications

To maximize the capabilities of nano- and micro-class satellites, which are limited by their size, weight, and power, advancements in deployable mechanisms with a high deployable surface area to packaging volume ratio are necessary. Without progress in understanding the mechanics of high-strain materials and structures, the development of compact deployable mechanisms for this class of satellites would be difficult. This paper presents fabrication, experimental testing, and progressive failure modeling to study the deformation of an ultra-thin composite beam. The research study examines the deformation modes of a post-deployed boom under repetitive pure bending loads using a four-point bending setup and …

Insights Into The Characterization And Degradation Of Electrospun Polycaprolactone Scaffolds For Tissue Engineering Applications, Caleb B. Wells

Theses and Dissertations

Electrospun polymeric biodegradable scaffolds are essential in tissue engineering, particularly for Engineered Tissue Vascular Grafts (ETVGs), which promise advancements in treating coronary artery disease, peripheral arterial disease, congenital cardiovascular defects, and renal disease. These scaffolds present a solution to issues with autologous graft availability and durability. While large-diameter grafts in low-pressure environments have seen success, small-diameter grafts in high-flow scenarios remain challenging. Understanding polymeric scaffold degradation and behavior during incubation, especially under dynamic mechanical loading, is vital for clinical translation of small-caliber ETVGs.

This research focuses on characterizing the mechanical and microstructural properties of electrospun polycaprolactone (PCL) scaffolds and their …

Inherently Porous Metal Structures With Sufficient Mechanical Properties Through Direct Writing Of Bio-Based Inks, Havva Eda Aysal

Graduate Theses, Dissertations, and Problem Reports (ETD)

There is currently a burgeoning interest in developing 3D printed metal structures with inherent porosity and sufficient mechanical properties for mass customization in the biomedical field. Current approaches for 3D printing of biocompatible metals rely on powder-bed fusion methods which are energy intensive and utilize large amounts of metal powder that is challenging to recycle. In addition, such methods aim on producing dense parts and porosity generation, within the printed part, is challenging due to the complex physics of the melting pool. Here, a relatively new and promising approach is undertaken to study the 3D printing of inherently porous structures …

Machine Learning For Electronic Structure Prediction, Shashank Pathrudkar

Dissertations, Master's Theses and Master's Reports

Kohn-Sham density functional theory is the work horse of computational material science research. The core of Kohn-Sham density functional theory, the Kohn-Sham equations, output charge density, energy levels and wavefunctions. In principle, the electron density can be used to obtain several other properties of interest including total potential energy of the system, atomic forces, binding energies and electric constants. In this work we present machine learning models designed to bypass the Kohn-Sham equations by directly predicting electron density. Two distinct models were developed: one tailored to predict electron density for quasi one-dimensional materials under strain, while the other is applicable …

Impact Of Quenching Intensity Conditions On Using A Finite Element Model To Investigate The Microstructure And Hardenability Of Low-Alloy Steel, J. S. Alabi, E. Heidari, M. F. Buchely, K. Chandrashekhara, S. N. Lekakh, R. J. O'Malley, V. Athavale, A. Kumar

Materials Science and Engineering Faculty Research & Creative Works

Quenching is one of the primary processes to improve mechanical properties in steels, particularly hardness. Quenching is well established for different geometries of individually treated steel components; while in-steam quenching of large diameter continuously cast steel bar has several specific features which are difficult and costly to experimentally optimize. The end-quench Jominy test has been used extensively to study the hardenability of different steel grades. Different numerical, analytical, and empirical models have been developed to simulate the Jominy process and to understand quenching of steels. However, it is not straight forward to translate experimental data from Jominy test on instream …

Impact Of Quenching Intensity Conditions On Using A Finite Element Model To Investigate The Microstructure And Hardenability Of Low-Alloy Steel, J. S. Alabi, E. Heidari, M. F. Buchely, K. Chandrashekhara, S. N. Lekakh, R. J. O'Malley, V. Athavale, A. Kumar

Materials Science and Engineering Faculty Research & Creative Works

Quenching is one of the primary processes to improve mechanical properties in steels, particularly hardness. Quenching is well established for different geometries of individually treated steel components; while in-steam quenching of large diameter continuously cast steel bar has several specific features which are difficult and costly to experimentally optimize. the end-quench Jominy test has been used extensively to study the hardenability of different steel grades. Different numerical, analytical, and empirical models have been developed to simulate the Jominy process and to understand quenching of steels. However, it is not straight forward to translate experimental data from Jominy test on instream …

Schaeffler E-Axle Value Engineering, Andrew Powers

Williams Honors College, Honors Research Projects

This project aims to design a manufacturable E-Axle end housing that improves system performance while reducing cost. The project is focused on utilizing Schaeffler's manufacturing competencies to achieve a simple assembly with a significant reduction in cost per part, while using existing machines or processes within the company. The design development process will follow the conceptual design stage through Finite Element Analysis and classical engineering calculations. Cross-functional design reviews will be conducted to ensure that agreement can be reached on the manufacturing feasibility of the design. Concepts will be entered in a decision analysis sheet to identify the best one …

Functional Verification Of Additively Manufactured Metallopolymer Structures For Structural Electronics Design, Nathan D. Singhal

Honors Undergraduate Theses

As an attempt to improve the overall cost-effectiveness and ease of structural electronics manufacturing, this study characterizes the mechanical and electrical responses of structures which are fabricated from a novel metallopolymer composite material by fused deposition modeling as they are subjected to quasi-static, uniaxial mechanical tension. Baseline values of tensile properties and electrical resistivity were first obtained via ASTM D638-22 standard testing procedures and linear sweep voltammetry (LSV), respectively. A hybrid procedure to measure in-situ mechanically dependent electrical behavior was subsequently developed and implemented. The mechanical and electromechanical testing was followed by the derivation of stochastic values for several mechanical …

Experimental Characterization And Quantification Of Deformation Behavior In A Porous Carbon Fiber Network, Robert N Quammen

Theses and Dissertations--Chemical and Materials Engineering

Due to their wide range of attractive functional properties (such as low thermal conductivity and low density) porous materials are utilized in a variety of applications. In order to characterize these properties and others, the intrinsically heterogeneous microstructures of these materials need to be taken into account. These microstructures result in interactions across multiple length scales spanning several orders of magnitude. This makes the creation of robust computational models and straight-forward predictions of mechanical properties difficult for porous materials. With this in mind, this dissertation aims to provide experimental mechanical and deformation information spanning the length scales of interest for …

Simulation Of Wave Propagation In Granular Particles Using A Discrete Element Model, Syed Tahmid Hussan

College of Graduate Studies: Theses & Dissertations

The understanding of Bender Element mechanism and utilization of Particle Flow Code (PFC) to simulate the seismic wave behavior is important to test the dynamic behavior of soil particles. Both discrete and finite element methods can be used to simulate wave behavior. However, Discrete Element Method (DEM) is mostly suitable, as the micro scaled soil particle cannot be fully considered as continuous specimen like a piece of rod or aluminum. Recently DEM has been widely used to study mechanical properties of soils at particle level considering the particles as balls. This study represents a comparative analysis of Voigt and Best …

Investigating The Role Of Tesserae In Energy Absorption In Shark Cartilage, Molly Dobrow

UNF Graduate Theses and Dissertations

Unlike mammals, shark endoskeletons are composed of cartilage, which is less stiff compared to bone. Despite this structural disadvantage, sharks have risen to become apex predators, with reported maximum posterior bite force estimates approximating 5914 N in bull sharks. Shark jaws are estimated to undergo high cycle loading within the organism’s lifecycle without evidence of failure. Fatigue resistance may relate to mineral distribution within a component of the endoskeletal system – tesserae. Tesserae are thin, roughly hexagonal tiles composed of calcium phosphate hydroxyapatite (HA) crystals and grow by accretion to eventually surround the hyaline cartilage core. Though tesserae dimensions are …

Modification Of Gas Atomized Metal Powders Through Mechanical Chemical Bonding Technique, Philip Thomas Mallory

Graduate Theses, Dissertations, and Problem Reports (ETD)

Additive Manufacturing (AM) has become popular for commercial applications where high-performance parts can now be created, tested, and modified more efficiently thus expediting the design process. Because of its relatively easy access today a lot of research and improvements are coming out yearly for improved AM machines and the material used. At WVU, a new way of modifying as-receive commercial gas-atomized metal powders used in AM has been developed using Mechanical Chemical Bonding (MCB) methodology which uses high rotational blades to create an environment where it increases the particle-on-particle interaction. During this high energetic process all irregular shaped particles, with …